• Journal of the Korean Society for Nondestructive Testing
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• v.14 no.2
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• pp.122-131
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• 1994

Journal bearings in the rotating machineries are vulnerable to the contamination or the insufficient supply of lubricating oil, which is likely to be the cause of unexpected shutdown or malfunction of these systems. Various destructive and nondestructive testing methods had been used for the reduction of maintenance cost and the operational safety problems due to the accidents related to bearing damages. In this experimental approach, acoustic emission monitoring is employed to the detection of incipient failure caused by intervention of foreign particles most probable in the journal bearing systems. Experimental schedules for the intervention of foreign particles was composed to be more quantitative and systematic than last study in consideration of minimum oil film thickness and particle size. The experiment was conducted under such designed conditions as inserting alumina particles to the lubrication layer in the simulated journal bearing system. Several parameters such as AE rms level, waveform, AE energy distribution and other AE event parameters are used for analysis and characterization of damage source. The results showed that the history of damage was well correlated with the changes of AE rms level and the type of damage source signal can be verified using other informations such as waveform, distributions of AE parameters etc.

• Toxicological Research
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• v.17
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• pp.47-57
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• 2001

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and its pathology is characterized by the presence of numerous numbers of senile plaques and neurofibrillary tangles. Several genetic and transgenic studies have indicated that excess amount of $\beta$-amyloid protein (A$\beta$) is produced by mutations of $\beta$TEX>$\beta$-amyloid precursor protein and causes learning impairment. Moreover, $A\beta$ has a toxic effect on cultured nerve cells. To prepare AD model animals, we have examined continuous (2 weeks) infusion of $A\beta$ into the cerebral ventricle of rats. Continuous infusion of $A\beta$ induces learning impairment in water maze and passive avoidance tasks, and decreases choline acetyltransferase activity in the frontal cortex and hippocampus. Immunohistochemical analysis revealed diffuse depositions of $A\beta$ in the cerebral cortex and hippocampus around the ventricle. Furthermore, the nicotine-evoked release of acetylcholine and dopamine in the frontal cortex/hippocampus and striatum, respectively, is decreased in the $A\beta$-infused group. Perfusion of nicotine (50 $\mu\textrm{M}$) reduced the amplitude of electrically evoked population spikes in the CA1 pyramidal cells of the control group, but not in those of the $A\beta$-infused group, suggesting the impairment of nicotinic signaling in the $A\beta$-infused group. In fact, Kd, but not Bmax, values for ［$^3H$］ cytisine binding in the hippocampus significantly increased in the $A\beta$-infused rats. suggesting the decrease in affinity of nicotinic acetylcholine receptors. Long-term potentiation (LTP) induced by tetanic stimulations in CA1 pyramidal cells, which is thought to be an essential mechanism underlying learning and memory, was readily observed in the control group, whereas it was impaired in the $A\beta$-infused group. Taken together, these results suggest that $A\beta$ infusion impairs the signal transduction mechanisms via nicotinic acetylcholine receptors. This dysfunction may be responsible, at least in part, for the impairment of LTP induction and may lead to learning and memory impairment. We also found the reduction of glutathione- and Mn-superoxide dismutase-like immunoreactivity in the brains of $A\beta$-infused rats. Administration of antioxidants or nootropics alleviated learning and memory impairment induced by $A\beta$ infusion. We believe that investigation of currently available transgenic and non-transgenic animal models for AD will help to clarify the pathogenic mechanisms and allow assessment of new therapeutic strategies.

• Microbiology and Biotechnology Letters
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• v.44 no.4
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• pp.442-451
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• 2016

The aim of this study was to investigate the anti-inflammatory effect of Sargassum miyabei Yendo ethanol extract (SMYEE) using RAW 264.7 cells and croton oil-induced Balb/c mice. SMYEE inhibited the production of pro-inflammatory cytokines [interleukin (IL)-6, tumor necrosis factor $(TNF)-{\alpha}$, and $IL-1{\beta}$] and nitric oxide in lipopolysaccharide (LPS)-induced inflammatory response. In addition, SMYEE suppressed the expression of inducible nitric oxide, cyclooxygenase-2, and nuclear factor-kappa B. Further, SMYEE inhibited the expression of mitogen-activated protein kinases (MAPKs), such as extra cellular signal-regulated kinase 1/2, p38, and c-Jun N-terminal kinase. In ear edema test, edema formation in the SMYEE treatment was lower than that in the positive control and was similar to that in the prednisolone treatment group. Photomicrographs of mice ear tissue showed a reduction in dermal thickness and number of infiltrated mast cells. Therefore, our results indicate that SMYEE exerts an anti-inflammatory effect via inhibition of nuclear factor ${NF}-{\kappa}B$ and MAPK activation and can be used as a natural source of anti-inflammatory compounds.

• Ocean and Polar Research
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• v.33 no.3
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• pp.309-319
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• 2011

This is a preliminary study of the feasibility of obtaining reliable tidal current harmonic constants, using one month of current observations, to verify the accuracy of a tidal model. An inference method is commonly used to separate out the tidal harmonic constituents when the available data spans less than a synodic period. In contrast to tidal constituents, studies of the separation of tidal-current harmonics are rare, basically due to a dearth of the long-term observation data needed for such experiments. We conducted concurrent and monthly harmonic analyses for tidal current velocities and heights, using 2 years (2006 and 2007) of current and sea-level records obtained from the Tidal Current Signal Station located in the narrow waterway in front of Incheon Lock, Korea. Firstly, the l-year harmonic analyses showed that, with the exception of $M_2$ and $S_2$ semidiurnal constituents, the major constituents were different for the tidal currents and heights. $K_1$, for instance, was found to be the 4th major tidal constituent but not an important tidal current constituent. Secondly, we examined monthly variation in the amplitudes and phase-lags of the $S_2$ and $K_1$ current-velocity and tide constituents over a 23-month period. The resultant patterns of variation in the amplitudes and phase-lags of the $S_2$ tidal currents and tides were similar, exhibiting a sine curve form with a 6-month period. Similarly, variation in the $K_1$ tidal constant and tidal current-velocity phase lags showed a sine curve pattern with a 6-month period. However, that of the $K_1$ tidal current-velocity amplitude showed a somewhat irregular sine curve pattern. Lastly, we investigated and tested the inference methods available for separating the $K_2$ and $S_2$ current-velocity constituents via monthly harmonic analysis. We compared the effects of reduction in monthly variability in tidal harmonic constants of the $S_2$ current-velocity constituent using three different inference methods and that of Schureman (1976). Specifically, to separate out the two constituents ($S_2$ and $K_2$), we used three different inference parameter (i.e. amplitude ratio and phase-lag diggerence) values derived from the 1-year harmonic analyses of current-velocities and tidal heights at (near) the short-term observation station and from tidal potential (TP), together with Schureman's (1976) inference (SI). Results from these four different methods reveal that TP and SI are satisfactorily applicable where results of long-term harmonic analysis are not available. We also discussed how to further reduce the monthly variability in $S_2$ tidal current-velocity constants.

• Journal of Korean Tunnelling and Underground Space Association
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• v.22 no.1
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• pp.135-144
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• 2020

Since the depth of tunneling with tunnel boring machine (TBM) becomes deeper and deeper, the expense for site investigation for coring and geophysical survey increases to obtain the sufficient accuracy. The tunnel ahead prediction methods have been introduced to overcome this limitation in the stage of site investigation. Probe drilling can obtain the core and borehole images from a borehole. However, the space in TBM for the probe drilling equipment is restricted and the core from probe drilling cannot reflect the whole tunnel face. Seismic methods such as tunnel seismic prediction (TSP) can forecast over 100 m ahead from the tunnel face though the signal is usually generated using the explosive which can affect the stability of segments and backfill grout. Electromagnetic methods such as tunnel electrical resistivity prospecting system (TEPS) offer the exact prediction for a conductive zone such as water-bearing zone. However, the number of electrodes installed for exploration is limited in small diameter TBM and finally the reduction of prediction ranges. In this study, the theoretical equations for the electrical resistivity survey whose electrodes are installed in the face and side of TBM to minimize the installed electrodes on face. The experimental tests were conducted to verify the derived equations.

• Investigative Magnetic Resonance Imaging
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• v.20 no.1
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• pp.44-52
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• 2016

Purpose: To quantitatively and qualitatively compare fat-suppressed MRI quality using iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) with that using frequency selective fat-suppression (FSFS) T2- and postcontrast T1-weighted fast spin-echo images of the head and neck at 3T. Materials and Methods: The study was approved by our Institutional Review Board. Prospective MR image analysis was performed in 36 individuals at a single-center. Axial fat suppressed T2- and postcontrast T1-weighted images with IDEAL and FSFS were compared. Visual assessment was performed by two independent readers with respect to; 1) metallic artifacts around oral cavity, 2) susceptibility artifacts around upper airway, paranasal sinus, and head-neck junction, 3) homogeneity of fat suppression, 4) image sharpness, 5) tissue contrast of pathologies and lymph nodes. The signal-to-noise ratios (SNR) for each image sequence were assessed. Results: Both IDEAL fat suppressed T2- and T1-weighted images significantly reduced artifacts around airway, paranasal sinus, and head-neck junction, and significantly improved homogeneous fat suppression in compared to those using FSFS (P < 0.05 for all). IDEAL significantly decreased artifacts around oral cavity on T2-weighted images (P < 0.05, respectively) and improved sharpness, lesion-to-tissue, and lymph node-to-tissue contrast on T1-weighted images (P < 0.05 for all). The mean SNRs were significantly improved on both T1- and T2-weighted IDEAL images (P < 0.05 for all). Conclusion: IDEAL technique improves image quality in the head and neck by reducing artifacts with homogeneous fat suppression, while maintaining a high SNR.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.4
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• pp.415-422
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• 2019

Human epidermal stem cells(ESCs) residing in the basement membrane of the skin have an important role in maintenance of skin homeostasis of epidermal layer. Although, ESCs provide new cells to repair damaged tissue in response to tissue injury, subsets of stem cells remain in the quiescent state protected from differentiation and senescence for prolonged survivals. In this perspective, the stem cell niche, which is specific microenvironment composed of niche cells and an extracellular matrix(ECM), supplies the relevant signal to save stem cells from microenvironmental damages. The expression of stemness marker on the surface of ESCs contributes to the attachment on their ECM of the basement membrane, which lead to growth potential and apoptotic resistance against environmental stimuli. In this study, we observed that UV irradiation, a major factor of environmental stimuli, reduced the expression of α2, β1 and α6 integrin in ESCs. Rhus Semialata M extract(RSE) showed inhibitory effect on the UVB-induced reduction of integrin expression. Furthermore, RSE could upregulate the expression of Col-IV and Laminin, which contribute to the attachment of ESCs. These results indicated that RSE could be a potent ingredient for the protection of ESCs from UV irradiation by increasing the expression of integrin and substrate ECM components at their niche.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.38 no.1
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• pp.27-34
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• 2001

The multiplication algorithm using the primitive irreducible trinomial $x^m+x+1$ over $GF(2^m)$ was proposed by Mastrovito. The multiplier proposed in this paper consisted of the multiplicative operation unit, the primitive irreducible operation unit and mod operation unit. Among three units mentioned above, the Primitive irreducible operation was modified to primitive irreducible trinomial $x^m+x+1$ that satisfies the range of 1$x^m,{\cdots},x^{2m-2}\;to\;x^{m-1},{\cdots},x^0$ is reduced. In this paper, the primitive irreducible polynomial was reduced to the primitive irreducible trinomial proposed. As a result of this reduction, the primitive irreducible trinomial reduced the size of circuit. In addition, the proposed design of multiplier was suitable for VLSI implementation because the circuit became regular and modular in structure, and required simple control signal.

• Journal of Advanced Navigation Technology
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• v.14 no.5
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• pp.684-690
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• 2010

Recently, the NG(Next Generation) system is studied for supporting convergence of various services and multi mode of single terminal. And a demand of user for taking the various services is getting increased, for supporting these services, many systems being able to transmit a large message have been appeared. In the NG system, it has to be supporting the CDMA and WCDMA besides the tele communication systems using OFDM method with single terminal An intergrated system can be improved with adopting of SoC technique. For adopting SoC technique on the intergrated terminal, we have to solve the non linear problem of HPA(High Power Amplifier). Nonlinear characteristic of HPA distorts both amplitude and phase of transmit signal, this distortion cause deep adjacent channel interference. We adopt a polynomial pre-distortion technique for this problem. In this paper, a noble modem design for NG mobile communication service and a method using polynomial pre-distorter with PAPR technique for counterbalancing nonlinear characteristic of the HPA are proposed.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.8
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• pp.1507-1514
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• 2015

Non-orthogonal multiple access (NOMA) is a promising candidate for 5G networks. NOMA achieves superior spectral efficiency than conventional orthogonal multiple access (OMA), as in NOMA multiple users uses the same time and frequency resources. Multiple-input-multiple-output (MIMO) is one another promising technique that can enhance system performance. In this paper we present a spectral and energy efficient multiple antenna based NOMA scheme, known as spatially modulated NOMA. In the proposed scheme the cell edge users are multiplexed in spatial domain, which means the information to cell edge users is conveyed using the transmit antenna indices. In NOMA the performance of cell edge users are deeply effected as it treats signals of others as noise. The proposed scheme achieves superior spectral efficiency than the conventional NOMA. The number of decoding steps involved in decoding NOMA signal reduces by one as cell edge user is multiplexed in spatial domain. The proposed scheme is more energy efficient as compare to conventional NOMA. All of the three gains high spectral, energy efficiency and one step reduction in decoding comes at cost of multiple transmit antennas at base station.