• Title/Summary/Keyword: Side-Effects

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Complex Korean Medicine Therapy for Hypoestrogenic Side Effects of Gonadotropin Releasing Hormone Agonist Administration to Postoperative Endometriosis Patient: A Case Report (자궁내막증 수술 후 GnRH-agonist 투여 중인 환자의 저에스트로겐 부작용에 대한 복합 한의 치료: 증례보고)

  • Park, Hye-Rin;Jo, Hee-Geun;Jo, Hyun-Jeong;Choi, Ji-Hyun
    • The Journal of Korean Obstetrics and Gynecology
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    • v.31 no.4
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    • pp.188-196
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    • 2018
  • Objectives: This study is to report the clinical effectiveness of the complex Korean medicine therapy on a postoperative endometriosis patient's hypoestrogenic side effects who is treated with GnRH-agonist injection. Methods: The patient in this case was diagnosed with endometriosis and has been treated with GnRH-a injection after laparoscopic operation. The patient complained hot flash and sweating mainly after GnRH-a treatment. The patient received complex Korean medicine therapy during 10 days admission period. The clinical effects were evaluated through KI (Kupperman's Index) and SF-36 (36 item Short Form Health Survey). Results: After the complex Korean medicine therapy, the various clinical symptoms including hot flash and sweating were improved. Also, the quality of life was enhanced. Conclusions: This case report shows that the complex Korean medicine therapy was effective for treating hypoestrogenic side effects occurred after GnRH-a treatment in postoperative endometriosis patient.

Numerical Investigation of Jet Interaction for Missile with Continuous Type Side Jet Thruster

  • Kang, Kyoung Tai;Lee, Eunseok;Lee, Soogab
    • International Journal of Aeronautical and Space Sciences
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    • v.16 no.2
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    • pp.148-156
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    • 2015
  • A continuous type side jet controller which has four nozzles with thrust control devices was considered. It is deployed to a missile for high maneuverability and fast controllability in the terminal guidance phase. However, it causes more complex aerodynamic jet interactions between the side jet and the supersonic free stream than does the conventional impulse type side jet with a small single thruster. In this paper, a numerical investigation of the jet interference effects for the missile equipped with a continuous type side jet thruster is presented. A three-dimensional flow field was simulated by using a commercial unstructured-based CFD solver. The numerical simulation method was validated through comparison with wind tunnel test results for the single jet. The method of defining jet direction for this type of side jet control to minimize simulation cases was also introduced. Flow fields investigation and jet interaction effects for various flow conditions, jet pressure ratios and defined jet direction conditions were performed. From the numerical simulation for the continuous type side jet, extensive aerodynamic interference data were obtained to construct an aerodynamic coefficients database for precise missile control.

Effects of Mulligan's Mobilization with Movement on Talofibular Interval in Subjects with Chronic Ankle Instability

  • Koh, Eun-Kyung;Jung, Do-Young
    • The Journal of Korean Physical Therapy
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    • v.28 no.5
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    • pp.303-307
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    • 2016
  • Purpose: This study was conducted to determine the effects of Mulligan's mobilization with movement (MWM) on changes in the talofibular interval in the sagittal plane in subjects with chronic ankle instability (CAI). Methods: Sixteen subjects with chronic ankle instability participated in this study. The talofibular intervals were measured from US images, and the weight-bearing lunge test was used to assess dorsiflexion of the ankle joint. Each dependent variable were measured on the both affected side and sound side in three trials in pre- and post-MWM. Dependent variables were examined with a two-way mixed-design analysis of variance (ANOVA). The two factors were side (sound side versus affected side) and intervention (pre- versus post-intervention). For post hoc analysis, paired t-tests were performed to compare the dependent variables. A p<0.05 was considered to indicate significance. Results: Dorsiflexion and talofibular interval differed significantly pre- and post-intervention (p<0.05). Post-hoc analysis revealed that the talofibular interval post-MWM was significantly less than that pre-MWM on the both the affected and sound side (p<0.05). The ankle dorsiflexion in the post-MWM group was significantly greater than that in the pre-MWM group on the affected side and the sound side (p<0.05). Conclusion: The Mulligan's MWM decreased the talofibular interval in subjects with CAI. These findings suggest that the MWM technique can change the position of the talus relative to the fibular in the weight bearing position.

Effects of Variable Block Size Motion Estimation in Transform Domain Wyner-Ziv Coding

  • Kim, Do-Hyeong;Ko, Bong-Hyuck;Shim, Hiuk-Jae;Jeon, Byeung-Woo
    • Proceedings of the Korean Society of Broadcast Engineers Conference
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    • 2009.01a
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    • pp.381-384
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    • 2009
  • In the Wyner-Ziv coding, compression performance highly depends on the quality of the side information since better quality of side information brings less channel noise and less parity bit. However, as decoder generates side information without any knowledge of the current Wyner-Ziv frame, it doesn't have optimal criterion to decide which block is more advantageous to generate better side information. Hence, in general, fixed block size motion estimation (ME) is performed in generating side information. By the fixed block size ME, the best coding performance cannot be attained since some blocks are better to be motion estimated in different block sizes. Therefore if there is a way to find appropriate ME block of each block, the quality of the side information might be improved. In this paper, we investigate the effects of variable block sizes of ME in generating side information.

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Control of Damping Forces by Side Clearance in Leaf Spring Damper (겹판스프링댐퍼에서 측면틈새에 의한 감쇠력 조절)

  • 김종수;김상도;제양규
    • Tribology and Lubricants
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    • v.16 no.1
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    • pp.27-32
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    • 2000
  • This paper describes that the leaf spring damper (LSD) developed by authors can be controled by side clearance between side covers and leaf springs. The test rig and two prototype dampers with different side clearance were manufactured. Experiments were performed to investigate the effects of side clearance on the damping of the leaf spring damper. The stiffness and damping coefficients are obtained from the displacements and the reaction forces generated by rotating the eccentric shaft. All dynamic coefficients are plotted with the excitation frequency which is adjusted by rotating speed of the shaft.

The Effects of The Lower Extremity Muscle Strengthening Exercise on Walking and Balance of Children with Cerebral Palsy (하지근력강화운동이 뇌성마비 아동의 균형과 보행에 미치는 영향)

  • Ryu, In-Jung;Son, Kyung-Hyun
    • Journal of Korean Physical Therapy Science
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    • v.18 no.2
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    • pp.17-28
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    • 2011
  • Purpose: The aim of this study was to ascertain the effects of the lower extremity muscle strengthening exercise on balance and ambulation of children with cerebral palsy. Methods: 10 subjects who participated in this research undertook the 12-week the lower extremity muscle strengthening exercise program, which consisted of a series of mat exercises and sling exercises. The statistical significances were examined by using Wilcoxon signed-rank test, a non-parametric test, for evaluating the improvement of balance and ambulation of the subjects. In order to evaluate the correlation among the variables, Pearson's correlation coefficients were also calculated. In all statistical analyses the significance level was selected as ${\alpha}$=0.05. Results: Berg balance scale(BBS) was significantly increased after the intervention(p<.05). Percentage weight bearing(PWB) was decreased after the intervention, but there was no significant difference. Time up and go test(TUG) value was significantly decreased(p<.05). Gait velocities was increased after the intervention, but there was no significance. Stride length, step lengths of the affected side and the sound side were significantly increased after the intervention(p<.05). In the correlation analyses of the measures before the intervention, TUG had significant negative correlation to BBS and gait velocity(p<.05). Stride length, step lengths of the sound side and the affected side had significant positive correlation between themselves(p<.01). In the correlation analyses of the measures after the intervention, TUG had significant negative correlation to BBS and gait velocity(p<.05). BBS revealed significant positive correlations to stride length, step lengths of the sound side and the affected side(p<.05). Stride length, step lengths of the sound side and the affected side had significant positive correlation between themselves(p<.01). Conclusion: Based upon the outcomes as above, it is likely that the muscle strength exercises have substantial effects on balance and ambulation of children with cerebral palsy. Thus various lower extremity muscle strengthening exercise programs are required to be studied and developed in order to contribute to functional improvements of children with cerebral palsy.

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Survey for the Side effects of Radiation Therapy Following Breast Cancer Surgery : Comparision of Modified Raidcal Mastectomy and Breast Conservative Surgery (유방암 환자의 수술후 방사선치료의 부작용의 변화 : 유방절제술과 유방보존술의 비교)

  • Chon, Myong-Hui
    • Journal of Haehwa Medicine
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    • v.5 no.2
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    • pp.473-484
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    • 1997
  • This study was performed to survey the specific information about the time of onset, frequency, duration, and severity of the side effect of radiation therapy following breast cancer surgery, and identify the difference of these data according to the type of breast cancer surgery : modified radical mastectomy(MRM) vs. breast consevative operation(BCO). 38 breast cancer patients were interviewed with side effect profile about radiation therapy. Interview was done weekley from the start of radiation therapy through 6 weeks and 3 month follow-up interview was done at 3 month after completion of the treatment. The results are as follow : 1. Total score of side effect experienced by the breast cancer patients was rapidly increased at 2-3 week after intiating treatement and continousely raised maintaing high score until completion of the treatement. Some problems like cough, dyspnea and pain were more experienced after treatment. 2. Patients with modified radical mastectomy showed more total score of side effects than patients with breast conservative operation. And both patients with MRM and BCO experienced similar pattern of side effect to radiation therapy. Through these data we concluded that side effect to radiation therapy was not ended at completion of treatement. Patents will continously experiend various problems and suffer from not only acute side effects like skin problem, sore throat and swollowing difficulty but also late effect of the radiation therapy. Clinically these data can be used for oncologic nurse to provide informational interventions to prepare breast cancer patients for the radiation therapy.

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Effect of Non-paralyzed side and Paralyzed side of Elastic Band Combined with Proprioceptive Neuromuscular Facilitation Lower Extremity Patterns on Balance in Chronic Stroke Patients (비 마비 측과 마비 측에 적용한 탄력밴드를 결합한 고유수용성 신경근 촉진법 하지패턴이 만성 뇌졸중 환자의 균형에 미치는 영향)

  • Lee, Young-Min;Ham, Min-Sik;Kim, Taek-Soo
    • PNF and Movement
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    • v.13 no.4
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    • pp.181-188
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    • 2015
  • Purpose: This study aimed to examine the effects of proprioceptive neuromuscular facilitation (PNF) lower extremity patterns combined with elastic bands applied to stroke patients diagnosed with hemiplegia through self-training using the non-paralyzed side approach and the paralyzed side approach, and to investigate the differences in the effects. Methods: Nine chronic stroke patients who were being treated not more than twice a week at H, K, R, and C hospitals located in Gangwon-do, performed self-training for 16 minutes, two times per day for four weeks between August and October 2015. The subjects' balance ability was measured using the Tetrax stability index, the weight distribution index, the Berg Balance Scale (BBS), and the Timed Up and Go (TUG) test before the experiment and four weeks later. Among the statistical methods, paired t-tests were conducted for intra-group comparison of the measurements taken before and after the experiment, and independent t-tests were conducted for inter-group comparison of the ex post facto values. The statistical significance level was set to 0.05. Results: When the lower extremity patterns were applied to the non-paralyzed side group and the paralyzed side group, significant intra-group differences were observed for the Tetrax stability index, the weight distribution index, the Berg Balance Scale (BBS), and Timed Up and Go (TUG) tests (p<0.05); however, the inter-group comparisons showed no significant differences. Conclusion: The non-paralyzed side approach was found to be easy for patients to participate in and it also affected the patients' paralyzed side. Although the paralyzed side approach produced good exercise effects in a short period of time, it could result in adverse effects, such as a decrease in motivation and self-confidence. Therefore, these approaches are considered to be more effective when they are selectively applied depending on the purpose of the intervention and the degree of a patients' participation.

Effect of Deer Blood on Reduction of the Side Effects of Chemotherapeutic Drugs (녹혈의 화학요법 항암제 부작용 억제 효능)

  • Kim, Han-Seob;Hong, Soon-Bok;Sung, Hyun-Jea;Moon, Geun-Ah;Yoon, Yoo-Sik
    • Korean Journal of Pharmacognosy
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    • v.34 no.2 s.133
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    • pp.145-149
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    • 2003
  • Many chemotherapeutic drugs were developed and contributed to the increase of cure rate of cancer, however severe side effect of these drugs is a major cause of poor quality of life of cancer patients. Effect of deer blood on cancer therapy was investigated in mouse tumor model. Deer blood itself was shown to have mild antitumor activity. However it has significant effect on the reduction of the side effects of chemotherapy. Deer blood recovered the reduction of WBC and platelet (myelotoxicity) during fluorouracil chemotherapy. Deer blood also recovered the increase of serum blood urea nitrogen (BUN; indicator of renal toxicity) and increase of serum amylase activity (AMY; indicator of pancreatic toxicity) almost to the control level during cisplatin chemotherapy. Fluorouracil and cisplatin are major chemotherapeutic drugs which are currently used in clinical cancer therapy, and the results strongly suggest that deer blood can be used for reducing the side effects and improving the quality of life during chemotherapy of cancer patients.

Experimental investigation of Reynolds number effects on 2D rectangular prisms with various side ratios and rounded corners

  • Wang, Xinrong;Gu, Ming
    • Wind and Structures
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    • v.21 no.2
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    • pp.183-202
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    • 2015
  • Experiments on two-dimensional rectangular prisms with various side ratios (B/D=2, 3, and 4, where B is the along-wind dimension, and D is the across-wind dimension) and rounded corners (R/D=0%, 5%, 10%, and 15%, where R is the corner radius) are reported in this study. The tests were conducted in low-turbulence uniform flow to measure the wind pressures on the surfaces of 12 models for Reynolds numbers ranging from $1.1{\times}10^5$ to $6.8{\times}10^5$. The aerodynamic force coefficients were obtained by integrating the wind pressure coefficients around the model surface. Experimental results of wind pressure distributions, aerodynamic force coefficients, and Strouhal numbers are presented for the 12 models. The mechanisms of the Reynolds number effects are revealed by analyzing the variations of wind pressure distributions. The sensitivity of aerodynamic behavior to the Reynolds number increases with increasing side ratio or rounded corner ratio for rectangular prisms. In addition, the variations of the mean pressure distributions and the pressure correlations on the side surfaces of rectangular prisms with the rounded corner ratio are analyzed at $Re=3.4{\times}10^5$.