• 대한공업교육학회지
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• 제33권1호
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• pp.149-168
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• 2008

이 연구의 목적은 공업계열 전문계고등학교의 디지털 논리 회로 과목에서 '조합 논리 회로'단원에 시뮬레이션 수업을 적용하여 학생들의 디지털 논리회로에 대한 학업성취도에 미치는 효과를 알아보는 데 있다. 이 연구를 위해 경상북도에 소재한 공업계열 전문계고등학교 3학년 2개 학급을 실험 집단과 통제 집단으로 선정하였고, 3개의 영가설을 설정하여 검증하였다. 실험 설계는 이질통제집단 전후검사 설계를 사용하였다. 실험은 총 6차시에 걸쳐 이루어 졌으며, 실험 집단에는 PSpice 시뮬레이션 수업을 적용한 후 브레드보드를 이용한 실습을 실시하였고, 통제 집단에는 전통적인 강의식 수업을 적용한 후 브레드보드를 이용한 실습을 실시하였다. 자료의 통계 처리는 SPSSWIN (ver 10.0) 프로그램을 사용하였고, 두 집단의 평균 차이가 통계적으로 유의미한지 알아보기 위해 유의수준 .05로 설정하여 독립표본 t-검증을 하였다. 이 연구에서 얻어진 결론은 다음과 같다. 첫째, 시뮬레이션 수업은 집단 유형에 따른 학업성취 전체 영역에 대해서는 효과적인 수업 방법이라고 할 수 없다. 그러나 심동적 영역에서는 학업 성취도 향상에 효과적이었다. 둘째, 시뮬레이션 수업은 학업 수준에 따른 학업성취 전체 영역에 대해서는 효과적인 수업 방법이라고 할 수 없다. 그러나 인지적 영역과 심동적 영역에서는 중 하위 집단에, 정의적 영역에서는 하위 집단에 효과적이었다. 셋째, 시뮬레이션 수업은 실습 소요 시간의 단축에 효과적인 수업 방법이라고 할 수 없다. 그러나 하위 집단의 실습 소요 시간의 단축에는 효과적이었다. 이상의 연구 결과 시뮬레이션 수업은 주로 심동적 영역에서 효과적이었고, 상위 집단보다는 하위 집단으로 갈수록 학업 성취에 있어서 효과적이라는 것을 알 수 있었다. 그러므로 다양한 교수 학습 방법을 활용함으로써 학습 효과를 높일 수 있다는 점을 시사해 준다.

• 대한토목학회논문집
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• 제11권4호
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• pp.189-200
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• 1991

대수층에서 약액주입에 의한 차수효과를 검토하고자 동수조건을 변화시킬 수 있는 1.5 shot system의 특별주입장치에 의해 유속변화에 따른 시료토의 고결상태를 확인 조사하고, 약액의 내구성을 파악하기 위해 변수위투수시험에 의해 시간의 경과에 따른 투수계수변화를 측정하였다. 동수지반에서 차수효과(내구성)를 증대시키기 위해서는 약액의 지하수에 희석, 유실되지 않도록 유속에 반하여 gel-time을 짧게 하는 한편, 약액의 농도, 주입량(주입률) 및 주입속도를 높혀 주며, 반응율이 큰 경화제를 사용한다든지 약액 중의 수분을 작게 되도록 배합하는 등의 조치가 유효하며 직접적인 방안으로는 주입공의 간격을 좁히거나 주입열수를 늘리는 등의 대책이 필요하며 더욱 이들 제 계수는 실내주입시험 및 현장시험주입 등에 의한 자료를 바탕으로 결정함이 바람직하다.

• 노동경제논집
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• 제33권2호
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• pp.1-26
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• 2010

기존의 직업탐색이론을 한 단계 진전시킬 수 있는 '엄친아효과' 개념을 도입하고 그것이 청년층 미취업탈출확률에 미치는 효과를 부모님의 학력, 임시 일용직 비율, 대 중소기업 임금격차 비율 등의 대리변수들로 측정하고자 하였다. 추정 결과, 최근으로 올수록 소위 '엄친아효과'는 점차 강화되고 있다는 사실이 확인된다. 정책 함의로는 청년층의 구직기간 축소와 실업탈출 확률의 제고라는 측면에서 노동시장에서 임금이나 일자리 질의 격차가 계속 확대되는 것은 결코 바람직하지 못하며, 또한 청년층 실업문제가 단순히 노동시장 정보의 정확한 제공만으로는 쉽게 해결되기 어렵다는 점 등을 도출해 낼 수 있다.

• 대한정형도수물리치료학회지
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• 제24권1호
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• pp.7-14
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• 2018

Background: The purpose of this study is to investigate the effects of Mulligan's bent leg raise (BLR), two leg rotation (TLR) and straight leg raise with traction (traction SLR) technique on the change of shortened hamstring length. Methods: Sixty subjects participated in this study. The subjects were randomly assigned to either the BLR group (n=20) or TLR group (n=20) or traction SLR group (n=20). 90-90 SLR test was performed for evaluation of hamstring shortening at initial time of study. After intervention, immediate effect(immediately after intervention) and effect of maintenance (after 60 minutes from intervention) were assessed. Results: All three groups showed significant differences in the immediate evaluation and the post evaluation after 60 minutes on the change of shortened hamstring length compared to the initial evaluation. When three groups were compared, in the immediate effect, BLR and traction SLR groups were higher than TLR group (p<.05). And the effect after 60 minutes, BLR group was higher than the other two groups (p<.05). Conclusion: In the results of this study, three groups showed immediately and lasting effectiveness in flexibility of shortened hamstring. In addition, BLR and traction SLR groups were more flexible than TLR group in the immediate evaluation and BLR group had better maintenance of flexibility than the other two groups in the post evaluation after 60 minutes.

• 동의신경정신과학회지
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• 제19권1호
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• pp.43-54
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• 2008

Objective: The aim of this study is to evaluate the anticonvulsive effects of Gamiheichumhwan extract and to explain its action in GABAergic neuromodulation of the rat brain. Method: The extracts of Gamiheichumhwan were investigated for their inhibitory effect on GABA transaminase activity, their influence on brain GABA and glutamate levels, their agonistic activity on GABA/benzodiazepine receptor and anticonvulsive action using in vitro and in vivo assays. Results: 1. The extract inhibited dose-dependently GABA transaminase (GABA-T) activity by 4.6% and 18.9%, respectively at dosages of 250 mg/kg and 500mg/kg mouse (p.o.). 2. Brian GABA level was increased to 72.0% and brain glutamate level was decreased to 9.6% at a dosage of 500 mg/kg mouse (p.o.). 3. The extract suppressed [3H]Ro15-1788 binding to rat cerebral cortical membrane by $81.4{\pm}0.8%$ at a dosage of 3.2 mg, suggesting its agonistic activity on GABA/benzodiazepin receptor. 4. The extract showed anticonvulsive effect by lengthening the onset time of convulsion, shortening the convulsion duration and diminishing the lethality. Conclusion : It is suggested that Gamiheichumhwan can be used to somnipathy and adapted to treatment and prevention of epilepsy or convulsion.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 추계학술대회
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• pp.107-107
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• 2019

Ulcerative colitis (UC) is one of inflammatory bowel disease (IBD), characterized by chronic inflammatory response and dysregulation of immune function. The severity of US has been influenced by environmental factors and food habit. The immune modulatory, anti-inflammatory and steroidal medicine have been used for the treatment of UC. However, long-term administration of those medicine is accompanied with side-effect. So, it is necessary to develop the non side-effect medicine using natural product. Prebiotics influences intestinal condition and food consumption. The heredity, immunity and environmental condition are related with occurrence of UC. In recent study, UC patients had lower level of prebiotics such as Lactobacillus and Bifidobacterium compared with healthy people. Also, previous study announced that imbalance of enteric flora aggravates the severity of UC. The effectiveness of probiotics might affect colon ability and viable bacteria also could promote the proliferation of beneficial intestinal bacteria. Prebiotics, such as herbal medicine, could lead to balance of intestinal bacteria or increase beneficial bacteria. So, proper choice of herbal medicine could control the intestinal condition. This study aimed to investigate the effect of mixture of probiotics and prebiotics (synbiotics) on dextran sulfate sodium (DSS)-induced UC in vivo. The synbiotics consist of Lactobacillus buchneri, Polymnia sonchifolia and Glycine max Merr. in this study. To evaluate the effect of synbiotics, 3% DSS was administered in BALB/c mice and synbiotics was daily administered for experimental days. The administration of synbiotics regulated colon length shortening, body weight change and disease activity index effectively. Also, extract of synbiotics upregulated survival ability of Lactobacillus buchneri in gut condition. These results suggest that mixture of probiotics and prebiotics, called as synbiotics, could influence intestinal condition also regulate the colon disease. Synbiotics might be a therapeutic agent for treatment of UC.

• Natural Product Sciences
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• 제29권1호
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• pp.42-49
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• 2023

This study investigated the effect of ethanol extracts of horsetail, alfalfa, ortie, chêne and aleppo oak on blood coagulation in vitro. Extraction was performed by the maceration method. Extracts were mixed with platelet and plasma, then prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet aggregation tests were conducted. Alfalfa extract had a dose-dependent effect on the PT. Ortie, and horsetail, reduced the PT significantly compared to control group. Alfalfa, horsetail, and ortie reduced the APTT, but their effect was insignificant compared to the control group. The pooled extract showed the highest effect compared to the single extracts in a dose-dependent manner. Horsetail and alfalfa induced platelet aggregation in response to arachidonic acid but not in response to collagen. In the case of ortie, no aggregation occurred regarding the arachidonic acid, and incomplete was observed in response to collagen. Interestingly, blood clotting occurred immediately after adding the chêne, aleppo oak and the pooled extract, and therefore platelet poor plasma (PPP) and platelet rich plasma (PRP) became jelly. Generally, chêne and aleppo oak, as well as pooled extract, were more effective in inducing both primary and secondary coagulation pathways via shortening the PT and APTT, and induction of platelet aggregation.

• 대한한방소아과학회지
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• 제32권3호
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• pp.16-25
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• 2018

Objectives The purpose of this study is to investigate the anti-inflammatory effect of Lonicera Japonica-Glycyrrhiza Uralensis decoction extracts (LGE) on ulcerative colitis in children and adolescents. Methods Colitis was induced by DSS (Dextran Sulfate Sodium) in C57BL/6 mice. The sample mice were divided into group of four. The mice in the control group were not inflammation-induced. The control group was composed of untreated ulcerative colitis elicited mice. The mice in the experimental group were administered with Pentasa and another experimental group mice were treated with LGE after colitis elicitation. The effects on ulcerative colitis were evaluated by the morphological changes of colonic mucosa, decrease in the effect of pro-inflammatory cytokines ($TNF-{\alpha}$ and $NF-{\kappa}B$) and inflammatory cytokines (iNOS and COX-2) in the mucosa. Results LGE showed protective effects in DSS induced ulcerative colitis. LGE inhibited shortening of colon length and relieved the hemorrhagic erosion in colonic mucosa. LGE decreased pro-inflammatory cytokines ($TNF-{\alpha}$ and $NF-{\kappa}B$) and inflammatory cytokines (iNOS and COX-2). According to the GC/MS analysis, N-methyl pyrrolidone (NMP) was identified. Conclusions The result shows the clinical efficacy of LGE and demonstrates possible treatment options for ulcerative colitis. Further investigations for biological activity and chemical analysis of LGE will be needed.

• 대한약리학회지
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• 제12권1호
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• pp.45-55
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• 1976

The effect of positive inotropic agents on the contractile properties of myocardial muscle were studied in the cat papillary muscle preparation. For the purpose, the effects of ouabain $(1{\times}10^{-6}g/ml)$, norepinephrine (0.05r/m1) and Aconiti tuber butanol fraction (AF(5), $1{\times}10^{-4}$, $5{\times}10^{-4}$, $1{\times}10^{-3}$, $2{\times}10^{-3}g/ml$) on the contractile dynamics of the papillary muscle preparation isolated from right ventricle of cat were observed in terms of the characteristics of isometric twitch and the lengh-tension relation, the force-velocity relation and the load-extension relation of the series elastic component of contractile model of A.V. Hill. All the studied inotropic drugs similary increased the rate and the intensity of the developed isometric tension, while shortened the time from onset of contraction to peak tension and the total duration of contraction. In the afterloaded simultaneous isotonic and isometric contraction, they also similary increased the maximal velocity of shortening accompanied with the increasing the maximum developed force. In the load-extension relation all the drugs, however, had no appreciable influence on the properties of the series elastic component. Increasing the concentration, Aconiti tuber butanol fraction produced more pronounced effect on all the studied parameters of isometric and isotonic contraction of cat papillary muscle preparation. From the aspect of contractile dynamics, it seemed that the positive inotropic effect of ouabain, norepinephrine and Aconiti tuber butanol fraction are similary achieved through an influence on the behavior of the contractile component only.

• 대한한방내과학회지
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• 제31권4호
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• pp.731-751
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• 2010

Objectives : The present study aimed to find out the effect of Sagunja-tang on the prevention and treatment of inflammatory bowel disease using mice with TNBS-induced inflammatory bowel disease. Methods : Mice with TNBS-induced inflammatory bowel disease were medicated with Sagunja-tang, and the weight changes, colon length, lipid peroxidation, and myeloperoxidase activity were observed. Levels of the inflammatory markers interleukin (IL)-$1{\beta}$ and cyclooxygenase-2 (COX-2), its transcription factor activation, phospho-NF-${\kappa}$B (pp65), in the colon by enzyme-linked immunosorbent assay and immunoblot analysis were also measured. Finally, the activation of fecal bacterial enzyme, ${\beta}$-glucuronidase and degradation activation of fecal glycosaminoglycan (GAG) and hyaluronic acid were observed. Results : We found that oral administration of Sagunja-tang inhibited TNBS-induced colon shortening and also inhibited myeloperoxidase activity in the colon of mice as well as IL-$1{\beta}$ and COX-2 expression. Sagunja-tang also inhibited TNBSinduced lipid peroxidation and pp65 activation in the colon of mice. In addition, Sagunja-tang inhibited ${\beta}$-glucuronidase activation and fecal hyaluronic acid degradation activation. Conclusions : It is supposed that Sagunja-tang has a potential therapeutic effect on inflammatory bowel disease through the inhibition of both NF-${\kappa}$B activation and lipid peroxidation, and the improvement of intestinal conditions.