• Molecular & Cellular Toxicology
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• v.5 no.3
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• pp.257-264
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• 2009

Gardenia yellow, extracted from gardenia fruit, has been widely used as a coloring agent for foods, and thus, safety of its usage is of prime importance. In the current study, short-term genotoxicity assays were conducted to evaluate the potential genotoxic effects of gardenia yellow. The gardenia yellow used was found to contain 0.057 mg/g of genipin, a known biologically active compound of the gardenia fruit extract. Ames test did not reveal any positive results. No clastogenicity was detected by a chromosomal aberration test, even on evaluation at the highest feasible concentration of gardenia yellow. Gardenia yellow was also shown to be non-genotoxic using an in vitro comet assay and a micronucleus test with L5178Y cells, although a marginal increase in DNA damage and micronuclei frequency was reported in the respective assays. Additionally, in vivo micronucleus test results clearly demonstrated that oral administration of gardenia yellow did not induce micronuclei formation in the bone marrow cells of male ICR mice. Taken together, our results indicate that gardenia yellow is not mutagenic to bacterial cells, and that it does not cause chromosomal damage in mammalian cells, either in vitro or in vivo.

• Journal of Gastric Cancer
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• v.16 no.2
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• pp.63-71
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• 2016

Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery for the treatment of early gastric cancer (EGC), aiming to decrease the complication rate and improve postoperative quality of life. According to the Japanese gastric cancer treatment guidelines, PPG can be performed for cT1N0M0 gastric cancer located in the middle-third of the stomach, at least 4.0 cm away from the pylorus. Although the length of the antral cuff gradually increased, from 1.5 cm during the initial use of the procedure to 3.0 cm currently, its optimal length still remains unclear. Standard procedures for the preservation of pyloric function, infra-pyloric vessels, and hepatic branch of the vagus nerve, make PPG technically more difficult and raise concerns about incomplete lymph node dissection. The short- and long-term oncological and survival outcomes of PPG were comparable to those for distal gastrectomy, but with several advantages such as a lower incidence of dumping syndrome, bile reflux, and gallstone formation, and improved nutritional status. Gastric stasis, a typical complication of PPG, can be effectively treated by balloon dilatation and stent insertion. Robot-assisted pylorus-preserving gastrectomy is feasible for EGC in the middle-third of the stomach in terms of the short-term clinical outcome. However, any benefits over laparoscopy-assisted PPG (LAPPG) from the patient's perspective have not yet been proven. An ongoing Korean multicenter randomized controlled trial (KLASS-04), which compares LAPPG and laparoscopy-assisted distal gastrectomy for EGC in the middle-third of the stomach, may provide more clear evidence about the advantages and oncologic safety of PPG.

• Proceedings of KOSOMES biannual meeting
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• 2008.05a
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• pp.169-171
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• 2008

The objective of this paper is to explore the short-term variability of sea surface temperature (SST) and chlorophyll a (Chl-a) derived from satellite in the upwelling region of the southeast coast of Korea in summer. We particularly emphasize the spatial variability of SST and Chl-a in the East Korean Warm Current (EKWC) during summer monsoon. Spatial distribution of SST and Chl-a in the EKWC are described using SeaWiFS and AVHRR images in August, 2007. Spatial distribution of SST and Chl-a around EKWC can be classified into four categories in the profile of SST and Chl-a images: (1) coastal cold water region, (2) cold water region of thermal front, (3) warm water region, (4) cold water of offshore region.

• Journal of the Korea Society of Computer and Information
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• v.25 no.4
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• pp.19-27
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• 2020

In this paper, we propose a machine learning method for diagnosing the failure of a gas pressure regulator. Originally, when implementing a machine learning model for detecting abnormal operation of a facility, it is common to install sensors to collect data. However, failure of a gas pressure regulator can lead to fatal safety problems, so that installing an additional sensor on a gas pressure regulator is not simple. In this paper, we propose various machine learning approach for diagnosing the abnormal operation of a gas pressure regulator with only the flow rate and gas pressure data collected from a gas pressure regulator itself. Since the fault data of a gas pressure regulator is not enough, the model is trained in all classes by applying the over-sampling method. The classification model was implemented using Gradient boosting, 1D Convolutional Neural Networks, and LSTM algorithm, and gradient boosting model showed the best performance among classification models with 99.975% accuracy.

• Journal of Gastric Cancer
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• v.19 no.1
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• pp.111-120
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• 2019

Background: Billroth I anastomosis is one of the most common reconstruction methods after distal gastrectomy for gastric cancer. Intracorporeal Billroth I (ICBI) anastomosis and extracorporeal Billroth I (ECBI) anastomosis are widely used in laparoscopic surgery. Here we compared ICBI and ECBI outcomes at a major gastric cancer center. Methods: We retrospectively analyzed data from 2,284 gastric cancer patients who underwent laparoscopic distal gastrectomy between 2009 and 2017. We divided the subjects into ECBI (n=1,681) and ICBI (n=603) groups, compared the patients' clinical characteristics and surgical and short-term outcomes, and performed risk factor analyses of postoperative complication development. Results: The ICBI group experienced shorter operation times, less blood loss, and shorter hospital stays than the ECBI group. There were no clinically significant intergroup differences in diet initiation. Changes in white blood cell counts and C-reactive protein levels were similar between groups. Grade II-IV surgical complication rates were 2.7% and 4.0% in the ECBI and ICBI groups, respectively, with no significant intergroup differences. Male sex and a body mass index (BMI) ${\geq}30$ were independent risk factors for surgical complication development. In the ECBI group, patients with a BMI ${\geq}30$ experienced a significantly higher surgical complication rate than those with a lower BMI, while no such difference was observed in the ICBI group. Conclusion: The surgical safety of ICBI was similar to that of ECBI. Although the chosen anastomotic technique was not a risk factor for surgical complications, ECBI was more vulnerable to surgical complications than ICBI in patients with a high BMI (${\geq}30$).

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3423-3440
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• 2023

In this work, a multivariate time-series machine learning meta-model is developed to predict the transient response of a typical nuclear power plant (NPP) undergoing a steam generator tube rupture (SGTR). The model employs Recurrent Neural Networks (RNNs), including the Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), and a hybrid CNN-LSTM model. To address the uncertainty inherent in such predictions, a Bayesian Neural Network (BNN) was implemented. The models were trained using a database generated by the Best Estimate Plus Uncertainty (BEPU) methodology; coupling the thermal hydraulics code, RELAP5/SCDAP/MOD3.4 to the statistical tool, DAKOTA, to predict the variation in system response under various operational and phenomenological uncertainties. The RNN models successfully captures the underlying characteristics of the data with reasonable accuracy, and the BNN-LSTM approach offers an additional layer of insight into the level of uncertainty associated with the predictions. The results demonstrate that LSTM outperforms GRU, while the hybrid CNN-LSTM model is computationally the most efficient. This study aims to gain a better understanding of the capabilities and limitations of machine learning models in the context of nuclear safety. By expanding the application of ML models to more severe accident scenarios, where operators are under extreme stress and prone to errors, ML models can provide valuable support and act as expert systems to assist in decision-making while minimizing the chances of human error.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.2
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• pp.263-272
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• 2022

As a result of climate change, the heatwave and urban heat island phenomena have become more common, and the frequency of heatwaves is expected to increase by two to six times by the year 2050. In particular, the heat sensation index felt by workers at construction sites during a heatwave is very high, and the sensation index becomes even higher if the urban heat island phenomenon is considered. The construction site environment and the situations of construction workers vulnerable to heat are not improving, and it is now imperative to respond effectively to reduce such damage. In this study, satellite imagery, land surface temperatures (LST), and long short-term memory (LSTM) were applied to analyze areas above 33 ℃, with the most vulnerable areas with increased synergistic damage from heat waves and the urban heat island phenomena then predicted. It is expected that the prediction results will ensure the safety of construction workers and will serve as the basis for a construction site early-warning system.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.3
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• pp.715-722
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• 2009

The aim of this study was to investigate the safety of short-term use of Korean herbal medicine (KHM; prescribed herbal medicine by doctors of traditional Korean medicine) on liver function. Three hundred eighty four outpatients who took KHM for various conditions were enrolled for multi-center, prospective observational study. Of them 237 patients completed questionnaire and were checked liver function (aspartic aminotransferase;AST, alanine aminotransferase;ALT, alkaline phosphatase;ALP, total bilirubin;t-Bil, direct bilirubin;d-Bil, gamma glutamyltranspeptidase;GGT, protein and albumin) before and after taking KHM (duration; 21.4${\pm}$10.0 days), and data were analysed statistically. Of the 213 patients showing normal liver function test (LFT) at baseline, 209 (98.1%) remained within the normal range at the second test while 3 (1.4%) revealed slight increase of LFT. Only one subject had raised LFT regarding level of liver injury without perceived symptoms. Twenty-four of 237 patients were abnormal at baseline, and 16 at the second testing. Of the patients taking KHM, only 4 changed from normal to abnormal while 12 from abnormal to normal in their LFT. There were no significant increase in LFT level between the first and second test, except in the t-Bil level, however, the change of t-Bil was small and within normal range. The current study showed that the use of KHM did not increase the frequency of abnormal LFTs, at least in the short term.

• Journal of the Geological Society of Korea
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• v.54 no.5
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• pp.557-566
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• 2018

Pohang earthquake (Main shock magnitude = 5.4) occurred in Southeastern region of South Korea in November 15, 2017. Groundwater levels of 6 monitoring wells with 5 minutes interval measurements located in that region and stream water levels of 4 stations located along the Hyeongsan-gang stream are used for the analysis of earthquake induced effects. Four groundwater monitoring wells show a short-term decrease of groundwater level after a main shock and one well does an increase and the maximum change is about 42.0 cm. Especially, groundwater levels at two monitoring wells near the epicenter are consistently maintained after a decrease. There is little relationship between earthquake magnitude or a distance to epicenter and changing amount of groundwater level and it may be due to the inhomogeneity of geologic material and unconsolidated sediments distribution. The changes in permeability of fractured zone and groundwater levels occasionally cause changes in stream flow rate, and water level of the Hyeongsan-gang stream in the study area decreases just after the earthquake and increases again up to the normal level and next shows an more gentle decreasing slope. Total increasing flow rates at S1 (upstream site) and S4 (downstream site) stations are about $12,096m^3$ and $116,640m^3$, respectively, during the increasing period.

• Journal of the Korean housing association
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• v.19 no.4
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• pp.79-87
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• 2008

Snoezelen, multi-sensory stimulation, provides stimulation through the visual, aural, tactile, olfactory, gustatory and proprioceptive senses. Its aim is to be a relaxing, feeling of safety, novelty and stimulation with no expectations for performance. Agitated behavior of people with dementia causes significant problems and distress for cares. The objective of this research study was to test the effects of Snoezelen room on physical and verbal agitated behaviors of people with dementia. Four patients participated five sessions in Snoezelen room of 'F' dementia care facility in Sweden. Assessment instrument was basically used Cohen-Mansfield Agitation Inventory-Short Form to be rated by caregivers on a 5-point frequency scale. Pre-trial and post-trial assessments were carried out during $27^{th}$ Aug.-$27^{th}$ Sept. 2007. Result shows that Snoezelen room has some short-term positive effect on agitated behavior even though there was a considerable variation individuals responded. This result adds to the increasing evidence that Snoezelen could be a therapeutic environment for the elderly with dementia. Further research study, with larger number of participation, and a control group is required to establish more scientific evidence of Snoezelen effects on health outcome.