• Journal of Acupuncture Research
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• v.19 no.1
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• pp.92-100
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• 2002

Objective : I planned to write this paper to use more Dong-Si acupunture treatment clinically by comparing Dong-Si acupunture with common acupunture for lumbago. Methods : This study was carried out on 56 patients with lumbago who were hospitalized in Dongshin Univ. Oriental Hospital from 1st, April, 2001 to 31st, Octover, 2001. Group A of 28 patients were taken both common acupunture and Dong-Si acupunture. And Group B of 28 patients were only taken common acupunture. And after 10 days of admission, I checked and compared VAS(Visual Analogue Scale) and improvement index out of these two groups. Results : In improvement index, Group A is $0.3932{\pm}0.1073$ and Group B is $0.2793{\pm}0.1080$. So Group A is thought to be significant(P=0.000). In VAS(Visual Analogue Scale), Group A is $6.9286{\pm}1.4889$ and Group B is $5.0000{\pm}1.4142$. So Group A is also thought to be significant(P=0.0000). Conclusion : The group with both Dong-Si acupunture and common acupunture treatment is more effective than the group with common acupunture treatment.

• Journal of Acupuncture Research
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• v.25 no.1
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• pp.25-55
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• 2008

Objectives : The aim of the present study was to observe the effect of Astragali Radix Herbal-Acupuncture Solution(AR-HAS) at $ST_{36}$(jok-samni, $Z\acute{u}s\bar{a}n$ Li) on collagen- II -induced arthritis(CIA) in mice. Methods : DBA/1J mice were immunized with bovine type II collagen(CII) on days 0 and 21 to induce arthritis. The mice were divided into 5 groups : normal group(no CIA), control group(CIA+no treatment), needle prick group(CIA+single prick with an injection needle), saline group(CIA+saline injection) and ARHA group(CIA+ R-HA treatment). The needle prick, saline injection, and AR-HA groups were injected on the right $ST_{36}$(jok-samni) of mice for 9 weeks, 3 times a week, beginning 4 weeks after the booster immunization. Results : 1. The incidence of arthritis, AI(arthritis index), and joint edema decreased in the AR-HA group. 2. Weight gain, hypertrophy of the spleen, adhesion of the tissues, and transformation of the joint were restrained in the AR-HA group. 3. The concentrations of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, $IFN-{\gamma}$ in CIA mouse serum and $IFN-{\gamma}$, IL-10 in the CIA mouse spleen cell culture decreased significantly at $ST_{36}$ in the AR-HA group. 4. Total cell counts increased significantly, and the ratio of $CD3e^+$ to $CD45R^+$, $CD4^+$ to $CD8^+$, and $CD4^+$ to $CD25^+$ cells decreased significantly at $ST_{36}$ in the CIA mouse spleen cell culture of the AR-HA group. 5. Total cell counts decreased significantly, and $CD4^+/CD25^+$ and $CD45R^+/CD69^+$ decreased significantly at $ST_{36}$ in the CIA mouse lymph nodes of the AR-HA group. 6. $CD3e^+/CD69^+$ and $CD11b^+/Gr-1^+$ cells decreased significantly at $ST_{36}$ in the CIA mouse joints of the AR-HA group. 7. The histological examination showed that cartilage destruction and synoviocyte proliferation decreased in the CIA mouse joints of the AR-HA group, and collagen fiber was expressed similar to that seen in the normal group. Conclusions : Our experiments show that at $ST_{36}$, an anti-inflammatory mechanism of AR-HA controls synovial cell proliferation and protects against cartilage destruction in rheumatoid arthritis.

• Herbal Formula Science
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• v.28 no.4
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• pp.385-406
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• 2020

Objectives : To study the use of Cinnamomum cassia among the 394 prescriptions listed in Donguibogam Methods : After selecting a total of 394 prescriptions, 284 prescriptions with Cinnamon Cassia as the protagonist were analyzed and summarized in the table. In particular, the investigation was conducted by comparing the Cinnamomi Ramulus and Cinnamomi Cortex. Results : The Cinnamomum cassia is used in 52 fields of treatment such as common cold & flu diseases, abscess and stroke, etc. Prescriptions containing Cinnamomi Ramulus were most commonly used for cold disease. And prescriptions containing Cinnamomi Cortex were most commonly used for wind diseases. Prescriptions that utilize Cinnamomum cassia are used in the treatment of feeling of cold, numbness, low back pain, cough and so on. Prescriptions containing Cinnamomi Ramulus mainly treat cold disease. And prescriptions containing Cinnamomi Cortex treat mainly abdominal pain and diarrhea. 14 prescriptions of the same name are included with Cinnamomum cassia. The other unclassified Cinnamomum cassia is considered suitable for use with Cinnamomi Cortex. Cinnamomum cassia is only used as a raw material. Conclusions : According to the classification of Cinnamomum cassia, further study of prescription utilization is needed.

• Toxicological Research
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• v.34 no.2
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• pp.163-172
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• 2018

Air pollution is increasing, along with consumption of fossil fuels such as coal and diesel gas. Air pollutants are known to be a major cause of respiratory-related illness and death, however, there are few reports on the genotoxic characterization of diverse air pollutants in Korea. In this study, we investigated the mutagenic activity of various particles such as diesel exhaust particles (DEP), combustion of rice straw (RSC), pine stem (PSC), and coal (CC), tunnel dust (TD), and road side dust (RD). Ultra-fine particles (UFPs) were collected by the glass fiber filter pad. Then, we performed a chemical analysis to see each of the component features of each particulate matter. The mutagenicity of various UFPs was determined by the Ames test with four Salmonella typhimurium strains with or without metabolic activation. The optimal concentrations of UFPs were selected based on result of a concentration decision test. Moreover, in order to compare relative mutagenicity among UFPs, we selected and tested DEP as mutation reference. DEP, RSC, and PSC induced concentration-dependent increases in revertant colony numbers with TA98, TA100, and TA1537 strains in the absence and presence of metabolic activation. DEP showed the highest specific activity among the particulate matters. In this study, we conclude that DEP, RSC, PSC, and TD displayed varying degrees of mutagenicity, and these results suggest that the mutagenicity of these air pollutants is associated with the presence of polycyclic aromatic hydrocarbons (PAHs) in these particulate matters.

• Journal of Korean Society for Atmospheric Environment
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• v.33 no.6
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• pp.533-543
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• 2017

As the public interest in environmental issues increased, the "Act On The Integrated Control Of Pollutant-Discharging Facility" was enacted. Through the integrated environmental pollution prevention act in which 19 industries with large environmental impacts are sequentially applied, pollutants can be managed in a medium-integrated manner and integrated permission of the business unit is possible and BAT can be applied to enable a scientific and proactive environmental management system. In order to facilitate the implementation of integrated environmental pollution prevention act with these advantages, the BAT BREF should be published, modified and revised every 5 years considering the level of scientific development. This study reviewed the issues to be considered in applying BAT and the types of BAT and focused on presenting improvements and development direction when revising and supplementing the standards in the future based on these contents. For this purpose, when revising the standards, it will be necessary to reflect on the domestic situation, to expand the TWG(Technical Working Group) of small-scale workplace experts, and to exchange opinions with business places that have similar processes for each waste type through a systematic total inspection. In addition to these methods, by establishing a resident participation system through information disclosure, it is expected to be used as a guideline for environmental management of business places not subject to integrated permission of less than 3 types as well as those subject to integrated permission.

• Journal of Microbiology and Biotechnology
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• v.25 no.3
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• pp.393-398
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• 2015

Aptamers are composed of single-stranded oilgonucleotides that can selectively bind desired molecules. It has been reported that RNA or DNA could act as not only a genetic messenger but also a catalyst in metabolic pathways. RNA aptamers (average sizes 40-50 bp) are smaller than antibodies and have strong binding capacities to target molecules, similar to antigenantibody interactions. Once an aptamer was selected, it can be readily produced in large quantities at low cost. The objectives of this study are to screen and develop aptamers specific to oral pathogens such as Porphyromonas gingivalis, Treponema denticola, and Streptococcus mutans. The bacterial cell pellet was fixed with formaldehyde as a target molecule for the screening of aptamers. The SELEX method was used for the screening of aptamers and a modified western blot analysis was used to verify their specificities. Through SELEX, 40 kinds of aptamers were selected and the specificity of the aptamers to the bacterial cells was confirmed by modified western blot analysis. Through the SELEX method, 40 aptamers that specifically bind to oral pathogens were screened and isolated. The aptamers showed possibility as effective candidates for the detection agents of oral infections.

• The Journal of Internal Korean Medicine
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• v.33 no.2
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• pp.197-208
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• 2012

Objectives : Gleditsiae Spina has the effects of expelling toxins, draining pus, invigorating blood and resolving abscesses. Some clinicians apply the herb for patients suffering from cancer. However, its anti-cancer activities are not well understood. In the present study, anti-tumor agents from Gleditsiae Spina were purified. Methods : The viability of the PC-3 cell line was determined using MTT assay, and the induction of apoptosis by Gleditsiae Spina extract in PC-3 cells was measured by Annexin-V/propidium iodide double staining assay detected by flow cytometry. TLC and HPLC analysis were used to separate and identify the anti-cancer agents. Results : Treatment of the extract resulted in significant decreased cell viability of PC-3 cells in a dose- and time-dependent manner. Dose-dependent apoptotic cell death was also measured by flow cytometry analysis. The anti-cancer agents were successfully separated and identified by using TLC and HPLC analysis and the most potential agent among them was separated from EtOAC fraction. Conclusions : These results might be applied in developing new drugs from natural resources like Korean traditional medicine, and also support the clinical usefulness of herbal medicine.

• Korean journal of food and cookery science
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• v.30 no.2
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• pp.146-152
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• 2014

This study surveyed consumers' sensory liking ratings of 3 types of developed brown rice products (brown rice nut waffles, Kimchi and tuna rice ball, sweet red-bean paste rice ball) and analyzed the drivers for liking or disliking the brown rice products. Each brown rice product had a brown rice to brown rice powder ratio of either: 100:0; 80:20; or 50:50. Forty consumers evaluated the acceptance of brown rice products on a 9-point hedonic scale and gave comments regarding liking or disliking each product. The results of the preference investigation analysis showed subjectivity depending on the brown rice product and the respondents' genders and ages. For brown rice nut waffles was affected by gender, age, and brown rice powder mixing ratio (p < 0.05). The variables "liking the aroma"; "liking the delicate flavor"; "liking the chewiness"; "liking the moistness"; "liking the softness"; "liking the harmony"; "liking the aftertaste" and "overall acceptability" did not differ significantly with the Kimchi and tuna rice ball. For the sweet red-bean paste rice ball product, the rates of liking the chewiness, stickiness, moistness, and softness of the 0% brown rice powder mix were all higher (p < 0.05) than were the rates of liking those same qualities in the 50% brown rice powder mix. Among all brown rice products, there were high correlations between the overall acceptability, liking the saltiness, liking the aroma, and liking the harmony. A preference investigation analysis showed that the brown rice product fillings were key factors to the products' overall acceptability.

• Journal of the Korean Society of Physical Medicine
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• v.8 no.2
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• pp.271-280
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• 2013

PURPOSE: This study was conducted in chronic hemiplegic patients to examine the effect of the training of the ipsilateral arm that is identical to the model performing movements and the training of the contralateral arm on the function of the arm. METHODS: The subjects were participated total 2 patients(the subject 1 with left hemiplegia and the subject 2 with right hemiplegia). The study was conducted for 4 weeks. The action observation training were repeated 10 times in 10 days during intervention period. The evaluation of the arm function such as BBT, MFT and MAL in the each subject were examined 5 times in the baseline period, 10 times during the intervention period and 5 times during the baseline regression period. RESULTS: The results of the evaluation in each subject were presented as mean values and video graphs. The arm function of the 2 subjects were improved during the intervention period in comparison with the baseline period, and the improvement was maintained even during the regression baseline period. In addition, there were large variation ratio of BBT and MAL (AOU, QOM) in comparison with subject 1. CONCLUSION: According to the results, the action observation training was more effective in improving upper limb function of stroke patients who imitate the performed behavior of paralyed parts on the same side.

• Journal of Korean Society on Water Environment
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• v.34 no.3
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• pp.339-345
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• 2018

The integrated environmental permit system is currently in operation online. It carries out various functions of postmanagement such as the submission of annual reports containing operations management data onto integrated management workplaces, the operation and management of emission facilities and prevention facilities, and the disclosure of information on the integrated permission. On the other hand, the integrated environmental permit system needs to perform various roles in order to stably manage and smoothly perform the permitting work. It is necessary to utilize this system to establish policies by using diverse operations management data onto integrated management workplaces collected in the integrated environmental permit system. This system can also play a role in improving the post-management system and user convenience after the permission review and approval processes. The integrated environmental permit system can be effectively used to set up the BAT-AEL because it collects all of the cross-media data and identifies the overall status of the workplace. In order to establish a post management system after the approval, it is necessary to provide performance management and performance evaluation functions as conditions of the permit after approval. In addition, a variety of support functions should be provided to enable the permission authority and the environmental expert examination agency to facilitate the review of permits. It will be necessary to provide an evaluation system and a proactive diagnostic function to determine whether permission conditions and permit emission standards will change in the future. Also, it is important to adopt an information exchange platform that can be used to collect the status data onto the workplaces; the platform can also be used as an information exchange site for technical working groups (TWG), and for collecting field experts' opinions.