• Journal of Pharmaceutical Investigation
• /
• v.24 no.3
• /
• pp.139-144
• /
• 1994

The effect of some formulation variables on the release rate of famotidine, a $H_2$ receptor antagonist, from cellulose matrices containing hydroxypropylcellulose (HPC) in different ratios and types was investigated. The effects of tablet shape and compression pressure on dissolution rate of famotidine were studied. And the effect of the pH of dissolution media was also studied. Increase in the ratio of polymer to drug decreased the release rate of famotidine. Increase of the polymer viscosity also decreased the release rate. The release rate of famotidine was dependent on the pH of dissolution media. The release rate of drug was not much dependent on the compression pressure but dependent on the tablet shape and/or surface area. Consequently, the release rate of famotidine can be modified by changing the HPC contents, types of polymers with different viscosity grades or using appropriate fillers.

• Proceedings of the Korean Reliability Society Conference
• /
• 2004.07a
• /
• pp.129-137
• /
• 2004

This paper presents an accelerated life test for burnout of tungsten filament of incandescent lamp. From failure analyses of field samples, it is shown that their root causes are local heating or hot sports in the filament caused by tungsten evaporation and wire sag. Finite element analysis is performed to evaluate the effect of vibration and impact for burnout, but any points of stress concentration or structural weakness are not found in the sample. To estimate the burnout life of lamp, an accelerated life test is planned by using quality function deployment and fractional factorial design, where voltage, vibration, and temperature are selected as accelerating variables. We assumed that Weibull lifetime distribution and a generalized linear model of life-stress relationship hold through goodness of fit test and test for common shape parameter of the distribution. Using accelerated life testing software, we estimated the common shape parameter of Weibull distribution, life-stress relationship, and accelerating factor.

• The Transactions of the Korean Institute of Electrical Engineers
• /
• v.39 no.9
• /
• pp.964-975
• /
• 1990

This paper aims at the design of high voltage electrode contour under specified field condition. Defining the contour with B-Spline curve, the number of contour variables can be reduced and very smooth electrode can be obtained. For the analysis of the electric field, Surface Charge Method which has advantages in practical model has been used. As an initial contour, the rod-plane gap has been used since the difference between maximum and minimum field value is relatively large. Various field conditions including uniform field condition are given to the end of the rod electrode. Under uniform field condition, authors designed an electrode whose field-deviation was under 0.5%. Finally, the relation between the curvature and field of the electrode has been checked, which showed that B-Spline curve is appropriate for the shape function.

• 유체기계공업학회:학술대회논문집
• /
• 2004.12a
• /
• pp.578-582
• /
• 2004

This paper presents the response surface optimization method using three-dimensional Navier-Stokes Analysis to optimize the shape of a axial flow fan. Reynolds-averaged Navier-Stokes equations with k-$\epsilon$ turbulence model are discretized with finite volume approximations. Regression analysis is used for generating response surface, and it is validated by ANOVA. Five geometric variables, i.e., distribution of sweep angle at mean and tip, lean angle at mean and tip, and spanwise location of mean were employed to optimize the efficiency. The computational results are compared with experiment data. As a main result of the optimization, the efficiency was successfully improved.

• 유체기계공업학회:학술대회논문집
• /
• 2004.12a
• /
• pp.437-442
• /
• 2004

The optimization of a blade sweep for a transonic axial compressor rotor (NASA rotor 37) has been performed using a response surface method and a Reynolds-averaged Wavier-Stokes (RANS) flow simulation. Two shape variables of the rotor blade, which are used to define a blade sweep, are introduced to increase an adiabatic efficiency. Data points for response evaluations have been selected by D-optimal design, and linear programming method has been used for an optimization on a response surface. The result shows that the adiabatic efficiency is increased to about 1 percent compared to that of the reference shape of the rotor blade. Relatively high increasement of the adiabatic efficiency is obtained between 20 and 60 percent span. In the present study, backward swept blade is more effective to increase the adiabatic efficiency In the axial compressor rotor.

• 유체기계공업학회:학술대회논문집
• /
• 2004.12a
• /
• pp.285-288
• /
• 2004

This study presents a numerical procedure to optimize the shape of dimple surface to enhance turbulent heat transfer in rectangular channel. The response surface based optimization method is used as an optimization technique with Reynolds-averaged Wavier-Stokes analysis of fluid flow and heat transfer with shear stress transport (SST) turbulence model. The dimple depth-to -dimple print diameter ratio, channel height- to- dimple print diameter ratio. and dimple print diameter-to-pitch ratio are chosen as design variables. The objective function is defined as a linear combination of heat transfer coefficient and friction drag coefficient with a weighting factor. Full factorial method is used to determine the training points as a mean of design of experiment.

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2007.10a
• /
• pp.46-49
• /
• 2007

The purpose of this study is to develop the optimum shape of blank for the crank throw of large marine engine in order to reduce manufacturing cost and forging defects. The effects of the curvature radius and the height of wing part of blank selected as design variables on the defects and machining margin of final products after forging process were investigated using FEA. Based on the results, the optimum shape for the blank of the crank throw was proposed and verified by experiment.

• Journal of the Society of Naval Architects of Korea
• /
• v.52 no.3
• /
• pp.171-179
• /
• 2015

Usually, in case of wind turbines on land, there are a lot of constraints for installation such as the insufficient installation space and noise pollution. On March 11, 2011, a nuclear leakage accident occurred due to the tsunami caused by the earthquake in Japan and then there have been a rapidly growing interest in floating offshore wind turbines. In this study, an optimization of the substructure of a semi-submersible type floating offshore wind turbine was made. Design variables were set and design alternatives were fixed. UOU-FAST was used for motion analysis in combined environmental conditions of waves and wind. Response Amplitude Operators(RAOs) were compared between the design alternatives.

• Proceedings of the KSR Conference
• /
• 2002.10b
• /
• pp.876-883
• /
• 2002

Electric vehicle body has to be subjected to uniform load and requires auxiliary equipment such as air pipe and electric wire pipe. Especially, the cross beam supports the weight of passenger and electrical equipments. a lightweight vehicle body is salutary to save operating costs and fuel consumption. Therefore this study is to perform the size and the shape optimization of crossbeam fur electric vehicle using the method of topology optimization to introduce the concept of homogenization based on optimality criteria method which is efficient for the problem having the number of design variables and a few boundary condition. this provides the method to determine the optimum position and shape of circular hole in the cross beam and then can achieve the optimal design to reduce weight.

• Journal of Magnetics
• /
• v.20 no.2
• /
• pp.193-200
• /
• 2015

Direct-acting solenoid valves are used in the automotive industry due to their simple structure and quick response in controlling the flow of fluid. We performed an optimization study of response time in order to improve the dynamic performance of a direct-acting solenoid valve. For the optimal design process, we used the commercial optimization software PIAnO, which provides various tools for efficient optimization including design of experiments (DOE), approximation techniques, and a design optimization algorithm. 35 sampling points of computational experiments are performed to find the optimum values of the design variables. In all cases, ANSYS Maxwell electromagnetic analysis software was used to model the electromagnetic dynamics. An approximate model generated from the electromagnetic analysis was estimated and used for the optimization. The best optimization model was selected using the verified approximation model called the Kriging model, and an optimization algorithm called the progressive quadratic response surface method (PQRSM).