• Journal of Periodontal and Implant Science
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• 제38권2호
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• pp.125-134
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• 2008

Purpose: Bone morphogenetic protein (BMP) is a potent differentiating agent for cells of the osteoblastic lineage. It has been used in the oral cavity under a variety of indications and with different carriers. However, the optimal carrier for each indication is not known. This study evaluated the bone regenerative effect of rhBMP-2 delivered with different carrier systems. Materials and Methods: 8 mm critical-sized rat calvarial defects were used in 60 male Sprague-Dawley rats. The animals were divided into 6 groups containing 10 animals each. Two groups were controls that had no treatment and absorbable collagen membrane only. 4 groups were experimentals that contained rhBMP-2 only and applied with absorbable collagen sponge($Collatape^{(R)}$), $MBCP^{(R)}$, Bio-$Oss^{(R)}$ each. The histological and histometric parameters were used to evaluate the defects after 2- or 8-week healing period. The shape and total augmented area were stable in all groups over the healing time. Results: New bone formation was significantly greater in the rhBMP-2 with carrier group than control group. rhBMP-2/ACS was the highest in bone density but gained less new bone area than rhBMP-2/$MBCP^{(R)}$ and rhBMP-2/Bio-$Oss^{(R)}$. The bone density after 8 weeks was greater than that after 2 weeks in all groups. However, rhBMP-2 alone failed to show the statistically significant difference in new bone area and bone density compared to control group. Also $MBCP^{(R)}$ and Bio-$Oss^{(R)}$ particles remained after 8 weeks healing period. Conclusion: These results suggest that rhBMP-2 with carrier system is an excellent inductive agent for bone formation and we can use it as the predictable bone tissue engieering technique. Future study will likely focus on the kinetics of BMP release and development of carriers that is ideal for it.

• Journal of Periodontal and Implant Science
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• 제38권1호
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• pp.51-58
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• 2008

Purpose: In dental clinical fields, various periodontal membranes are currently used for periodontal regeneration. The periodontal membranes are categorized into two basic types: resorbable and non-resorbable. According to the case, clinician select which membrane is used. Comparing different membranes that are generally used in clinic is meaningful. For this purpose, this study evaluates histological effects of various membranes in canine one wall intrabony defect models and it suggest a valuation basis about study model. Material and Method: The membranes were non-resorbable TefGen $Plus^{(R)}$, resorbable Gore Resolut $XT^{(R)}$ and resorbable $Osteoguide^{(R)}$. One wall intrabony defects were surgically created at the second and the mesial aspect of the fourth mandibular premolars in either right or left jaw quadrants in two dogs. The animals were euthanized 8 weeks post-surgery when block sections of the defect sites were collected and prepared for histological evaluation. Results: 1. While infiltration of inflammatory cells were observed in control, TefGen $Plus^{(R)}$ and Gore Resolut $XT^{(R)}$, it was not observed in $Osteoguide^{(R)}$. 2. TefGen $Plus^{(R)}$ had higher integrity than others and $Osteoguide^{(R)}$ was absorbed with folding shape. Gore Resolut $XT^{(R)}$ was divided everal parts during resorbtion and it was also absorbed from inside. 3. Quantity of new bone and new cementum was not abundant in all membranes. 4. For histologic evaluation of membranes we should consider infiltration of inflammatory, migration of junctional epithelium, integrity of membrane, quantity of new bone and new cementum, connective tissue formation and aspect of resorption. Conclusion: This histologic evaluation suggests that $Osteoguide^{(R)}$ provides periodontal regenerative environment with less inflammatory state. It is meangful that this study model suggests a valuation basis about other study model.

• Corrosion Science and Technology
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• 제4권4호
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• pp.155-163
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• 2005

Heavy duty coating are required to have minimum durable period of 15 years under average usage environment because these paints are coated with purpose of anti-corrosion, antifouling, plastering etc. Onto steel structures constructed upon land and sea and other ferrous structures of electric power generation plants, electricity transmission towers, large structures of various plants, etc. Therefore we tried to estimate heavy duty coating longevity through reliability evaluation method and used combined cyclic anti-conrrosion test method composed of drying, moisturizing and salt spray as for accelerated life test to estimate longevity. Accelerated life test hours to heavy duty coating of first grade (with longevity not less than 15 years) specification may be obtained from troubleless test hours $t_n=\frac{B_p}{n^{1/\beta}}\left[\frac{1n(1-CL)}{1n(1-p)} \right]^{1/\beta}=19.671$ (yr) where shape parameter $\beta=1.1$, confidence level CL=80 %, warranty life $B_{10}=15$ yr and sampling size n=10 (2 sets). Because acceleration factor {AF} found by accelerated test is 41.7, accelerated life test hours required may be represented about 4,132 hr so that if this amount of hours is converted to number of cycles(6 hr/cycle) of complex cycle corrosion resistance test then the amount is tantamount about 690 cycles. That means if there does not occur trouble failure (with defect factor sum not more than 20) during when there is performed 690 cycles of combined cyclic anti-corrosion test to heavy duty coating specimen then it signifies that there can be warranted longevity $B_{10}$ of 15 yr under condition of confidence level CL=80 %.

• 대한화학회지
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• 제29권2호
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• pp.80-87
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• 1985

상온에서 ${\gamma}$-선 조사에 의해 생긴 황산암모늄$((NH_4)_2SO_4)$단결정 내의 방사선 손상은 몇개의 상자성 중심을 형성한다. X-band 전자스핀 공명분석기(EPR spectrometer)로 전자스핀공명 스펙트럼을 얻었고 피크의 세기가 가장 큰 g = 2.0036인 Gauss 형의 등방성 피크는 $SO_3^-$가 피크임을 알았다. 직교하는 세축 a,b,c로 그 단결정을 회전시키면서 ESR 스펙트럼을 얻어 각도 의존성을 보았다. $g^-$값은 등방성 피크와 무등방성 피크의 상대적 위치로 부터 구하였고 각 상자성종들의 $g^-$값의 3${\times}$3 matrix 원소들을 대각화하여 특성 주 $g^-$값과 방향여현을 얻었다. 이 특성 주 $g^-$값과 방향여현으로 분석한 결과 황산암모늄 단결정내에는 무등방성 피크에 해당하는 $SO_4^-,\;SO_2^-$ 및 전자 과잉중심들의 상자성 결함이 존재함을 확인 하였다.

• 한국정밀공학회지
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• 제29권12호
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• pp.1272-1278
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• 2012

The micro barrier rip array structures have been applied in a variety of areas including as privacy films, micro heat sinks, touch panel and optical waveguide. The increased aspect ratio (AR) of barrier rip array structures is required in order to increase the efficiency and performance of these products. There are several problems such as burr, defect of surface roughness and deformation and breakage of barrier rip structure with machining high-aspect ratio micro barrier rip array structure using orthogonal cutting method. It is essential to develop technological methods to solve these problems. The optimum machining conditions for machining micro barrier rip array structures having high-aspect ratio were determined according to lengths ($200{\mu}m$ and $600{\mu}m$) and shape angles ($2.89^{\circ}$ and $0^{\circ}$) of diamond tool, overlapped cutting depths ($5{\mu}m$ and $10{\mu}m$), feed rates (100 mm/s) and three machining processes. Based on the optimum machining conditions, micro barrier rib array structures having aspect ratio 30 was machined in this study.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.170.1-170.1
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• 2016

$Bi_2Te_3$ has long been studied for its excellent thermoelectric characteristics. Recently, this material has been known as a topological insulator (TI). The surface states within the bulk band gap of a TI, which are protected by the time reversal symmetry, contribute to the conduction at the surface, while the bulk is in insulating state. In contrast to the bulk defects tuning the chemical potential to the Dirac energy, the native defects near the surface are expected not to change the shape of the Fermi surface and the related spin structure. Using scanning tunneling microscopy (STM), we have systematically characterized surface or near surface defects in p- and n- doped $Bi_2Te_3$, and identified their structure by first principles calculations. In addition, bias-polarity dependences of STM images revealed the electron donor/acceptor nature of each defect. A detailed theoretical study of the surface states near the Dirac energy reveals the robustness of the Dirac point, which verifies the effectiveness of the disturbance on the backscattering from various kinds of defects.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제38권
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• pp.11.1-11.8
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• 2016

Background: Silk cocoon is composed of multiple layers. The natural silk cocoon containing all layers was cut as a rectangular shape as defined as total group. The inner and outermost layers were removed from the total group and the remained mat was defined as the middle group. The objectives of this study was to compare the total group with the middle group as a barrier membrane for the guided bone regeneration. Methods: The effects of these materials on the cellular proliferation and alkaline phosphatase (ALP) expression of MG63 cells were explored. For comparing bone regeneration ability, bilateral bone defects were created in calvarial areas in ten adult New Zealand white rabbits. The defects were covered with silk membranes of the middle group, with silk membrane of the total group used as the control on the contralateral side. The defects were allowed to heal for 4 and 8 weeks. Micro-computerized tomography (${\mu}CT$) and histological examination were performed. Results: The middle group exhibited a higher MTT value 48 and 72 h after treatment compared to the total group. ALP expression was also higher in the middle group. The results of ${\mu}CT$ and histologic examination showed that new bone formation was significantly higher in the middle group compared to the total group 8 weeks postoperatively (P < 0.05). Conclusions: In conclusion, the middle layer of the silk cocoon supports guided bone regeneration better than unprocessed silk cocoon.

• Archives of Plastic Surgery
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• 제34권6호
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• pp.748-752
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• 2007

Purpose: The goal of palatoplasty is focused on two points. One is to close the palatal defect completely, and the other to create a velopharyngeal system for normal speech. While established methods such as pushback palatoplasty or double opposing Z palatoplasty are used in wide cleft palate repair, sequelae such as maxillary hypoplasia or oronasal fistula may result. Therefore, when palatoplasty with buccinator myomucosal flap is used in the case of wide cleft palates, maxillary hypoplasia and oronasal fistula is reduced and optimal results are obtained. Methods: From October 2005 to December 2006, four children with wide complete cleft palate underwent unilateral buccinator myomucosal flap and intravelar veloplaty. Mean age at cleft repair was 15 months, and mean cleft size was 2.15 cm. The patients underwent intravelar veloplasty and palatoplasty was done using unilateral buccinator myomucosal flap. Results: The patients, after mean 10 months of follow-up observation, showed no signs of oronasal fistula resulting from flap tension. The shape and color similar to normal oral mucosa was obtained, and velopharyngeal function was acquired. Conclusion: When intravelar veloplasty and palatoplasty with unilateral buccinator myomucosal flap is done on wide cleft palates, postoperative speech function is optimal, velopharyngeal incompetence is effectively corrected, and sequelae resulting from pushback palatoplasty and double opposing Z-plasty, such as maxillary hypoplasia and oronasal fistula, is reduced.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2011년도 제42회 하계학술대회
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• pp.2005-2006
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• 2011

작은 크기 다양한 입출력 포트 등의 많은 이점으로 PCB 회로기판에서 볼그리드배열(BGA) 방식의 기판이 사용되고 있다 하지만 BGA 기판 내부 기포는 기판의 성능을 떨어뜨리고 실패를 야기한다 자동적으로 X-ray 영상에서 기포를 검출하기 위해서 본 논문에서는 국부 영상 명암 변량 측정 방법을 이용한 새로운 덩어리 검출기를 제안한다 국부 영상 명암 변량의 활용은 영상의 밝기 기포의 모양, 기포의 위치 및 부품간의 간섭등에도 연산 결과에 영향이 적은 불변성을 가진다. 또한 박스 필터의 다양한 사이즈를 적용하여 다양한 크기의 영상을 분석하므로 결과적으로 제안한 덩어리 검출 필터는 기포의 다양한 크기에 도강력하다. 실험 결과는 제안한 기법이 정상 부위를 비정상 부위 로보이는 확률false-ratio)을 낮게 유지하면서 기포 검출률을96.104% 까지 높일 수있음을 보인다.

• 비파괴검사학회지
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• 제18권4호
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• pp.304-312
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• 1998

비파괴검사중의 하나인 초음파 탐상검사는 교량, 발전설비 및 석유화학플랜트 등의 각종 다양한 구조물들의 안전성 확보를 위한 내부결함 및 손상평가를 위하여 일반적으로 폭넓게 사용되고 있다. 초음파를 이용한 데 파괴 평가 기술은 각종 구조물에 존재하는 내부결함에 의한 산란신호를 통해 건전성을 평가하는 기법이므로 결함의 신뢰성 녹은 정량적 평가를 위해서는 결함으로부터의 초음파 산란산호특성에 대한 기본적 이해가 필수적이며 따라서 이를 위한 모델링 수치해석 연구가 요구된다. 본 연구에서는 동탄성 경계요소법을 이용하여 무한체내에 존재하는 다중기공 결함에 의한 초음파 수평횡파의 근거리 산란특성에 대하여 결함의 형상과 결함사이의 상호작용을 고려하여 해석하였다. 본 연구에서 얻어진 결과들은 결함검출 민감도의 개선 및 역변환 해석에 의한 정량적 비파괴 평가에 큰 도움을 줄 수 있다.