• Plant Resources
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• 제3권1호
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• pp.93-97
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• 2000

As indicated by Chinese letters “沙赫” (sha-ji) is the ripe fruit of Seabuckthron(Hippophae rhamnoides Linneus) family Flaeagnaceae is one of ancient natural medicine used by the Tibetan and Mongolian nationallites with ancient methods to treat desease. It is an effectiv Traditional Tibetan medicine. Bud only now are they beginning to be understood in the world of modern medicine. Hippophae was written in the book of Traditional Tibetan Medicine - “Somalaza” (8th century), “Sibuyidian” (1840) and “Jingzhubencao” (Qing Dynasty). The “Sibuyidien” was trnslated in to the Russian and published at 1903 in the Russian. Then the Russian bigan to study on Hippophae and they have achieved great successes. The Chinese scientists began to study on the chemical constituent and medical action with modern technique at 1952. With more than 40 years painstaking eport they have conceived and used a wide variety of experimental screening systems, achieved successes. Finally they with one's own tests has keen verified that the crude drug being various kind of bioactive substance could inhibits tumor, increase immunity, wipe out free radical, prevent disease of cardiovascular system, have anti-radiation, anti-inflammeutory effects. At 1977 the Hippophae rhamnoides was written in Chinase Pharmacopoeia.

• Nuclear Engineering and Technology
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• 제53권3호
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• pp.851-859
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• 2021

Small PWR can be used for power generation and heating. Considering that small PWR has the characteristics of flexible operating conditions and complex operating environment, the controller designed based on single power level is difficult to achieve the ideal control of small PWR in the whole range of core power range. To solve this problem, a flexible switching controller based on fuzzy controller and LQG/LTR controller is designed. Firstly, a core fuzzy multi-model suitable for full power range is established. Then, T-S fuzzy rules are designed to realize the flexible switching between fuzzy controller and LQG/LTR controller. Finally, based on the core power feedback principle, the core flexible switching control system of small PWR is established and simulated. The results show that the flexible switching controller can effectively control the core power of small PWR and the control effect has the advantages of both fuzzy controller and LQG/LTR controller.

• Archives of Pharmacal Research
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• 제27권7호
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• pp.757-762
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• 2004

The protective adaptive response to electrophiles and reactive oxygen species is mediated by the induction of phase II detoxifying genes including glutathione S-transferases (GSTs). NF-E2-related factor-2 (Nrf2) phosphorylation by protein kinase C (PKC) is a critical event for its nuclear translocation in response to oxidative stress. Previously, we have shown that peroxynitrite plays a role in activation of Nrf2 and Nrf2 binding to the antioxidant response element (ARE) via the pathway of phosphatidylinositol 3-kinase (PI3-kinase) and that nitric oxide synthase in hepatocytes is required for GSTA2 induction. In view of the importance of PKC and Pl3-kinase in Nrf2-mediated GST induction, we investigated the role of these kinases in peroxynitrite formation for GSTA2 induction by oxidative stress and determined the relationship between PKC and PI3-kinase. Although PKC activation by phorbol 12-myristate-13-acetate (PMA) did not increase the extents of constitutive and inducible GSTA2 expression, either PKC depletion by PMA or PKC inhibition by staurosporine significantly inhibited GSTA2 induction by tert-butylhydroquinone (t-SHa) a prooxidant chemical. Therefore, the basal PKC activity is req- uisite for GSTA2 induction. 3-Morpholinosydnonimine (SIN-1), which decomposes and yields peroxynitrite, induced GSTA2, which was not inhibited by PKC depletion, but slightly enhanced by PKC activation, suggesting that PKC promotes peroxynitrite formation for Nrf2-mediated GSTA2 induction. Treatment of cells with S-nitroso-N-acetyl-penicillamine (SNAP), an exogenous NO donor, in combination with t-BHQ may produce peroxynitrite. GSTA2 induction by SNAP ＋ t-BHQ was not decreased by PKC depletion, but rather enhanced by PKC activation, showing that the activity of PKC might be required for peroxynitrite formation. LY294002 a P13-kinase inhibitor blocked GSTA2 induction by t-BHQ, which was reversed by PMA-induced PKC activation. These results provide evidence that PKC may playa role in formation of peroxynitrite that activates Nrf2 for GSTA2 induction and that PKC may serve an activator for GSTA2 induction downstream of PI3-kinase.

• 전기전자학회논문지
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• 제14권1호
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• pp.8-16
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• 2010

본 논문에서는 CCD 이미지 처리를 위한 최대 15MS/s의 속도의 중저속 아날로그-프론트 엔드(analog-front end, AFE)에서 사용될 수 있는 연속근사 ADC(Successive Approximation ADC, SA-ADC)의 설계를 제안한다. 파이프라인 ADC와 달리 SA-ADC는 동작주파수의 변화에 따른 전력소모의 스케일링(scaling) 효과가 크므로 저속에서 중속에 이르는 넓은 범위의 가변 데이터 처리 속도의 응용에 매우 효과적이다. 제안하는 설계는 입력 신호의 샘플링 동작을 내부 DAC(sub-DAC)로부터 따로 분리한 후, 커패시터 커플링을 통해 차동 결합함으로써 신호경로에 이르는 부하를 크게 줄이는 "차동 커패시터 커플링 기법"의 도입, 연속근사의 기법적 측면에서 signed 구조를 활용하여 데이터 변환주기 이전에 홀드된 입력신호로부터 미리 MSB(sign bit)를 결정함으로써 1사이클의 변환주기를 절약하고 내부 DAC의 하드웨어를 1비트 줄이는 구조와 같은 특징을 갖고 있다. 본 설계는 3.3V $0.35{\mu}m$ CMOS 공정으로써 설계하고 Spectre 시뮬레이션을 이용하여 그 특성을 분석함으로써 CCD 아날로그 프론트-엔드에 적용될 수 있음을 입증하였다.

• Journal of Microbiology and Biotechnology
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• 제26권11호
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• pp.1908-1917
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• 2016

Wild strain L-6 was subjected to combined mutagenesis, including UV irradiation, atmospheric and room temperature plasma, and ion beam implantation, to increase the yield of 1,3-dihydroxyacetone (DHA). With application of a high-throughput screening method, mutant Gluconobacter oxydans I-2-239 with a DHA productivity of 103.5 g/l in flask-shake fermentation was finally obtained with the starting glycerol concentration of 120 g/l, which was 115.7% higher than the wild strain. The cultivation time also decreased from 54 h to 36 h. Compared with the wild strain, a dramatic increase in enzyme activity was observed for the mutant strain, although the increase in biomass was limited. DNA and amino acid sequence alignment revealed 11 nucleotide substitutions and 10 amino acid substitutions between the sldAB of strains L-6 and I-2-239. Simulation of the 3-D structure and prediction of active site residues and PQQ binding site residues suggested that these mutations were mainly related to PQQ binding, which was speculated to be favorable for the catalyzing capacity of glycerol dehydrogenase. RT-qPCR assay indicated that the transcription levels of sldA and sldB in the mutant strain were respectively 4.8-fold and 5.4-fold higher than that in the wild strain, suggesting another possible reason for the increased DHA productivity of the mutant strain.

• 대한전자공학회논문지SD
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• 제41권10호
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• pp.69-75
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• 2004

본 논문에서는 온도 및 전원전압에 덜 민감한 기준전압을 위해 온-칩 필터를 사용하는 8b 220 MS/s 230 rnW 3단 파이프라인 CMOS A/D 변환기 (ADC) 회로를 제안한다. 제안하는 RC 저대역 필터는 기존의 큰 값을 가진 칩 외부의 바이패스 캐패시터를 사용하지 않고도 고속 동작 시 발생하는 여러 가지 잡음을 효과적으로 감쇄시키고 큰 R, C 부하에서도 기준전압의 정착시간을 줄인다. 시제품 ADC는 0.25 um CMOS 공정을 이용하여 설계 및 제작되었고, 입/출력단의 패드를 제외한 코어 면적은 2.25 ㎟ 이며 측정된 DNL 및 INL은 각각 -0.35～+0.43, LSB, -0.82～+0.71 LSB 수준을 보여준다. 또한, SNDR은 200 MS/s, 220 MS/s 샘플링 주파수에서 입력 주파수가 수 MHz에서 110 MHz까지 증가할 때 각각 43 dB 및 41 dB로 유지되었고, 입력주파수가 500 MHz 까지 증가할 때는 입력주파수가 110 MHz의 경우에 비해 3 dB 정도만 감소되었다.

• 대한한방소아과학회지
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• 제29권4호
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• pp.67-76
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• 2015

Objectives The purpose of this review is to investigate the domestic and foreign studies of pediatric Chuna treatment and propose the directions of future studies and clinical applications. Methods We searched for the study at RISS, KISS, DBPIA, Pubmed, CNKI by keywords, '추나', 'Osteopathic', 'Chiropractic', 'Manipulation', '推拿', '導引', '按摩', After 2010. Results 1. Selected 3 domestic studies were categorized as 1 survey study and 2 case reports. Selected 41 foreign studies from Pubmed were categorized as 15 systemic reviews, 8 survey studies, 12 case reports and 6 control studies. Selected 82 foreign studies from CNKI were categorized as 10 systemic reviews, 22 case reports and 50 control studies. 2. 2 clinical domestic studies researched on idiopathic Scoliosis. The foreign clinical studies from Pubmed are 18 cases, and those studies were categorized into Premature baby care (3), Infant colic (2), ADHD (2), Congenital talipes equinovarus (1), Somatic dysfuntion (1), Nonsynostotic occipital plagiocephaly (1), Conversion disorder (1), Lower back pain (1), Chronic bilateral dorsal foot pain and stiffness (1), plantar fasciitis (1), Migraine headaches (1), Cyclic vomiting syndrome (1), Acute otitis media (1) and Cerebral palsy (1). The other 72 foreign clinical studies were from CNKI, and they studied 39 different diseases. Systematically, they studied about digestive diseases (25), respiratory diseases (20), fever (6), musculoskeletal diseases (5), nervous system diseases (5), dermatology diseases (2) and other disease states. The Chuna treatment was used in variety of studies. 3. 2 clinical domestic studies adopted techniques of Osteopathy Chuna. The foreign clinical studies from Pubmed adopted techniques of Osteopathic manipulation (10) and Chiropractic manipulation (8). The other foreign clinical studies from CNKI adopted techniques of Acupressure (69), Abdominal manipulation (23), Spinal manipulation (21), Thoracic manipulation (11), Traction manipulation (2), Muscular manipulation (2), Squeezing Sha manipulation (1), Spine correction (1), Joint manipulation (1) and Fascia manipulation (1). Conclusions In addition to musculoskeletal disorders, variety of pediatric diseases could be treated with Chuna treatment instead of acupuncture.

• International Journal of Naval Architecture and Ocean Engineering
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• 제2권3호
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• pp.155-170
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• 2010

Availability of economic and efficient energy resources is crucial to a nation's development. Because of their low cost and advancement in drilling and exploration technologies, oil and gas based energy systems are the most widely used energy source throughout the world. The inexpensive oil and gas based energy systems are used for everything, i.e., from transportation of goods and people to the harvesting of crops for food. As the energy demand continues to rise, there is strong need for inexpensive energy solutions. An offshore platform is a large structure that is used to house workers and machinery needed to drill wells in the ocean bed, extract oil and/or natural gas, process the produced fluids, and ship or pipe them to shore. Depending on the circumstances, the offshore platform can be fixed (to the ocean floor) or can consist of an artificial island or can float. Semi-submersibles are used for various purposes in offshore and marine engineering, e.g. crane vessels, drilling vessels, tourist vessels, production platforms and accommodation facilities, etc. The challenges of deepwater drilling have further motivated the researchers to design optimum choices for semi-submersibles for a chosen operating depth. In our series of eight papers, we discuss the design and production aspects of all the types of offshore platforms. In the present part I, we present an introduction and critical analysis of semi-submersibles.

• JSTS:Journal of Semiconductor Technology and Science
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• 제16권1호
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• pp.70-79
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• 2016

This paper proposes a low-power range-scaled 14b 30 MS/s pipeline-SAR composite ADC for high-performance CIS applications. The SAR ADC is employed in the first stage to alleviate a sampling-time mismatch as observed in the conventional SHA-free architecture. A range-scaling technique processes a wide input range of 3.0VP-P without thick-gate-oxide transistors under a 1.8 V supply voltage. The first- and second-stage MDACs share a single amplifier to reduce power consumption and chip area. Moreover, two separate reference voltage drivers for the first-stage SAR ADC and the remaining pipeline stages reduce a reference voltage disturbance caused by the high-speed switching noise from the SAR ADC. The measured DNL and INL of the prototype ADC in a $0.18{\mu}m$ CMOS are within 0.88 LSB and 3.28 LSB, respectively. The ADC shows a maximum SNDR of 65.4 dB and SFDR of 78.9 dB at 30 MS/s, respectively. The ADC with an active die area of $1.43mm^2$ consumes 20.5 mW at a 1.8 V supply voltage and 30 MS/s, which corresponds to a figure-of-merit (FOM) of 0.45 pJ/conversion-step.

• Computers and Concrete
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• 제14권3호
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• pp.299-313
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• 2014

Effects of polypropylene (PP) fibers, steel fibers (SF) and hybrid on the properties of highstrength fiber reinforced self-consolidating concrete (HSFR-SCC) under different volume contents are investigated in this study. Comprehensive laboratory tests were conducted in order to evaluate both fresh and hardened properties of HSFR-SCC. Test results indicated that the fiber types and fiber contents greatly influenced concrete workability but it is possible to achieve self consolidating properties while adding the fiber types in concrete mixtures. Compressive strength, dynamic modulus of elasticity, and rigidity of concrete were affected by the addition as well as volume fraction of PP fibers. However, the properties of concrete were improved by the incorporation of SF. Splitting tensile and flexural strengths of concrete became increasingly less influenced by the inclusion of PP fibers and increasingly more influenced by the addition of SF. Besides, the inclusion of PP fibers resulted in the better efficiency in the improvement of toughness than SF. Furthermore, the inclusion of fibers did not have significant effect on the durability of the concrete. Results of electrical resistivity, chloride ion penetration and ultrasonic pulse velocity tests confirmed that HSFR-SCC had enough endurance against deterioration, lower chloride ion penetrability and minimum reinforcement corrosion rate.