• YAKHAK HOEJI
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• v.54 no.4
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• pp.252-257
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• 2010

The aim of this study was to investigate the effect of resveratrol on the pharmacokinetics of nifedipine in rats. The pharmacokinetic parameters of nifedipine were measured after the oral administration of nifenipine (6 mg/kg) in the presence or absence of resveratrol (0.5, 2.5 and 10 mg/kg, respectively). The effect of resveratrol on the P-glycoprotein (Pgp), CYP 3A4 activity was also evaluated. Resveratrol inhibited CYP3A4 enzyme activity in a concentration-dependent manner with 50% inhibition concentration ($IC_{50}$) of 0.94 ${\mu}M$. In addition, resveratrol significantly enhanced the cellular accumulation of rhodamine 123 in MCF-7/ADR cells overexpressing P-gp. Compared to the control groups, the presence of 2.5 mg/kg and 10 mg/kg of resveratrol significantly (p<0.05, p<0.01) increased the area under the plasma concentrationtime curve (AUC) of nifedipine by 49~75%, and the peak concentration ($C_{max}$) of nifedipine by 48~66%. The absolute bioavailability (AB%) of nifedipine was significantly (p<0.05) increased by 22.9-34.8% compared to the control (19.8%). The terminal half-life ($T_{1/2}$) of nifedipine was significantly (p<0.05) increased compared to the control. While there was no significant change in the time to reach the peak plasma concentration ($T_{max}$) of nifedipine in the presence of resveratrol. It might be suggested that resveratrol altered disposition of nifedipine by inhibition of both the CYP3A and P-glycoprotein efflux pump in the small intestine of rats. In conclusion, the presence of resveratrol significantly enhanced the oral bioavailability of nifedipine, suggesting that concurrent use of resveratrol or resveratrol-containing dietary supplenment with nifedipine should require close monitoring for potential drug interation.

• YAKHAK HOEJI
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• v.56 no.2
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• pp.126-135
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• 2012

Purpose: To develop therapeutic duplication criteria for the drugs used for respiratory diseases. Method: Therapeutic duplication was defined as "more than 2 drug ingredient-usage in which each has the same therapeutic effect and combination therapy does not confer additional therapeutic benefit". Respiratory system drugs approved in Korea were examined for the study. The WHO's Anatomical Therapeutic Chemical Classification System was used for grouping of the corresponding drug ingredients. The principles and recommendations on combination usage or multiple drug regimens were reviewed by using the clinical practice guidelines, textbooks, product labelings, and clinical articles. Clinical expert group consultation was performed and expert opinions were incorporated into the final criteria. Results: Nine hundred sixty two drug products with Korean Food and Drug Administration classification codes of 141, 149, 222, and 229 were evaluated, of which 87 active ingredients were composed. The drug ingredients were classified into 12 groups (antihistamines, oral nasal decongestants, leukotriene receptor antagonists, inhaled anticholinergics, inhaled corticosteroids, oral ${\beta}2$-agonists, long-acting ${\beta}2$-agonists, short-acting ${\beta}2$-agonists, xanthines, antiallergics, mucolytics and cough suppressants). The use of more than 2 drug ingredients including the same group was therapeutic duplication, and thus combination should be recommended not to be used. Conclusion: Twelve drug groups were identified as therapeutic duplication criteria. Combination therapy within each group should not be used otherwise therapeutic benefits outweigh potential risks.

• International Journal of Highway Engineering
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• v.13 no.4
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• pp.151-158
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• 2011

Tunnel sections on the expressway are different from rest of sections on the expressway in terms of velocity, the number of passing cars, and vehicle density which, in particular, affect drivers' behavior before and after drivers pass through the tunnel. However, literature review reveals that former studies are too focused on quantitative indicator to consider qualitative aspects. Thus, this study tried to find out qualitative factors affecting speed reduction in tunnel sections based on questionnaire surveys and its analysis in tunnel sections selected by taking consideration of diverse conditions. Analysis showed that factors concerning tunnel configuration (lane width, shoulder width, and tunnel length) related to very long tunnels increasingly popular recently had some effects on reduced speed inside of tunnels. It appeared that visual environment such as visibility of tunnel entrance had an impact in speed reduction and vehicle speed tended to change according to lighting illumination level inside of tunnels. It is expected that continual investment would be made in technological development related to expressway tunnel design and service improvement based on this study.

• KSCI Review
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• v.14 no.2
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• pp.255-262
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• 2006

A Malicious code is used to SMiShing disguised as finance mobile Vishing, using Phishing, Pharming mail, VoIP service etc. to capture of personal information. A Malicious code deletes in Anti-Virus Spyware removal programs. or to cure use. By the way, the Malicious cord which is parasitic as use a DLL Injection technique, and operate are Isass.exe, winlogon.exe. csrss.exe of the window operating system. Be connected to the process that you shall be certainly performed of an exe back, and a treatment does not work. A user forces voluntarily a process, and rebooting occurs, or a blue screen occurs, and Compulsory end, operating system everyone does. Propose a treatment way like a bird curing a bad voice code to use a DLL Injection technique to occur in these fatal results. Click KILL DLL since insert voluntarily an end function to Thread for a new treatment, and Injection did again the Thread which finish an action of DLL, and an end function has as control Thread, and delete. The cornerstone that the treatment way that experimented on at these papers and a plan to solve will become a researcher or the revolutionary dimension that faced of a computer virus, and strengthen economic financial company meeting Ubiquitous Security will become.

• Informatization Policy
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• v.22 no.3
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• pp.3-15
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• 2015

This study aims to examine the recent trend of domestic researches on the Internet of Things(IoT) which has drawn a lot of attention in the field of ICT. This meta-analysis analyzes 101 studies published in academic journals from 2010, focusing on research topics, methods and the fields of study. The results show that the research topics of most used studies were related to the technological and industrial issues, and especially in the technical field, the major topic was suggesting new IoT technology. The most research method was testing research followed by the literature review. Even though engineers are holding the mainstream of the IoT technology, some experts in the field of social science release their articles nowadays. These results indicate that the IoT has a great ripple effect both technologically and socioculturally, and researches need to be vitalized in the fields of industry, service, policy and institution as well as technological fields. In addition, the research for the future should extend methodological diversity and take more convergence approaches in a variety of fields.

• The Journal of the Korea Contents Association
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• v.15 no.1
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• pp.152-158
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• 2015

The Korean Government said that it issued advance notice of the amendment of medical act article 34 on Oct. 29 of last year. Another issue at the heart of controversy in 2009 was telemedicine between doctors and patients for the purpose of helping those in the dead zone of medicine and supporting medical service industry. It failed, however, to enact legislation due to the strong opposition from medical profession as well as the apprehension about abuse of medical treatment and the rise of medical expenses. To amend and legislate a law, it is needed in advance to examine and analyze the rationality, propriety and feasibility of it. In particular, when it comes to amending a medical act, the validity should be acknowledged only when the right to life and health of the people is protected. Medical act article 34 is in the state of drift because of stiff resistance from medical and civic groups. This study purpose of analyze and to explain the amendment of recent proposition of Medical Act Article 34 and to suggest possible improvement methods.

• The Journal of the Korea Contents Association
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• v.14 no.3
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• pp.401-413
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• 2014

The principal objective of this study is to examine the relationship between the emotional intelligence and customer orientation in airline service context. Moreover, this study was designed to test the moderating effect of social support to provide fundamental and practical data for airline industry. In this study, 2 hypotheses based on literature reviews were employed. A questionnaire was also developed based on previous studies. A convenience sample of 233 flight attendants was surveyed and a total of 214 usable questionnaires were analyzed. Then the data and hypotheses were examined using multiple regression analysis using SPSS 18.0. The results are as follows. Firstly, emotional intelligence was divided into 'self-emotional appraisal', 'other's emotional appraisal', 'regulation of emotion' and 'use of emotion' according to the literature review. Analysis showed that emotional intelligence has partial effect on customer orientation accordingly. Secondly, social support has partial moderating effects between emotional intelligence and customer orientation. Continuous and systematic training program which build up team work should be conducted to administer 'emotional intelligence'.

• Journal of Korean Academy of Nursing
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• v.41 no.6
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• pp.780-787
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• 2011

Purpose: This study was conducted to examine activities of daily living (ADL) of older adults admitted to Korean long-term care hospitals (LTCHs), and to explore the patient and organizational factors that have an impact on the ADL of this population. Methods: A secondary analysis of the Korean minimum data set (K-MDS) of patients (N=14,369) and of the profiles of LTCHs (N=358) from the Health Insurance Review and Assessment Service was done between January and July 2008. The outcome variable was ADL score 6 months after baseline assessment. Multi-level linear regression was employed to explore the patient and organizational factors that affected ADL scores. Results: Of the patients, 45.4% had a baseline ADL score of between 31 and 40, with a score of 40 indicating that the patient was entirely dependent for all items. None of the organizational characteristics were significantly associated with effects on the ADLs of older adults who had been in a LTHC for at least 6 months. However, patient characteristics, such as age, baseline ADL, frequency of physical therapy, urinary incontinence, fecal incontinence, pressure ulcers, and having a tube or catheter, were significantly associated with ADL 6 months after baseline. Conclusion: In order to maintain and improve the ADL of older adults in LTCHs, we should develop strategies to prevent urinary and fecal incontinence, pressure ulcers, unnecessary tubes or catheters, providing adequate physical therapy. Additional studies should include more detailed information regarding nursing staff, including RN hours for direct care, education level and turnover.

• Korean Journal of Child Studies
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• v.3
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• pp.83-96
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• 1982

TV has a very strong influence on various aspects of children's life and development. In view of this influence, various problems related to the content and production of TV programs for early - childhood deserve a careful study. Recognizant of this significance, this study aims to suggest the direction in which the production of TV programs for early childhood in Korea will steer by defining the concept of TV programs for early childhood and by analyzing the current status and trends of producting TV program for early childhood at abroad. In this study, attempts were made to suggest some strategies for the production of TV programs for early childhood based on an expansive literature review. 1. The running time of TV programs for early-childhood ages of 4-5 year old is suggested to be 15 minutes. 2. In the process of producing the programs, a group of professionals including in-service teachers, researchers specializing in child development, psychology and sociology, idea-creators, script writers, media experts, producers, and monitors should provide concerted efforts throughout the process. 3. The running time of TV programs for early-childhood should be less than 20 minutes and therefore should have simple learning objectives. 4. The contents of programs should be organized in such a way as to enable children to view themselves as well as the environment in more positive ways and to fester desirable values and beliefs in them based on various constructive activities and plays. 5. The programs should adopt various techniques including repetition, to ensure the maximum learning effect in full consideration of children's interest. 6. The programs should be continuously revised and supplemented based on the evaluation of the programs, children's responses and monitor's feedbacks.

• International Commerce and Information Review
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• v.6 no.3
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• pp.63-79
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• 2004

Peer-to-peer(P2P) has potential strength and possible factors which enable it to develop toward a new business by supplementing the limitation of the existing central server-type network. In various business sectors, various attempts have already been made to apply P2P. The computing power which was possible to be formed through peer-to-peer networking will become a powerful tools for expanding toward new business area depending the utilization methods by sector. Although the technology-centric P2P concept is a major interest now, its development direction will head toward service-centric P2P concept for satisfying desires of end-users(individual peers) for reliable contents and improving their purchasing convenience. But the solution requisites should be solved for the efficient application of P2P to business such as the establishment of and supplement for the industrial standard and legal system for P2P, the enhancement of peers recognition of P2P. Presently e-commerce using P2P is being implemented by a few enterprises locally by means of B2C. But if many enterprises enter this type of e-commerce, and the standardization of peer programmes, goods and documents is made, it will be able to be extended to B2B. Also it seems that it can be utilized in international transactions as well as in domestic transactions. So there is much room for the application of P2P to be extended further. Also there has been presented the necessity for related industries to support their work with theories and for academic studies to be made actively to set the direction of its development. It is hoped that multi-angled and in-depth studies on the utilization of P2P and various attempts to application of it to business be made on the basis of this study. For the development of P2P, continuous study and attempts are needed. The field of P2Ps application is very large and it will become a powerful tool, depending upon its application methods.