• Clinical and Experimental Pediatrics
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• 제56권4호
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• pp.165-175
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• 2013

Purpose: There was a global increase in the prevalence of oseltamivir-resistant influenza viruses during the 2007-2008 influenza season. This study was conducted to investigate the occurrence and characteristics of oseltamivir-resistant influenza viruses during the 2007-2008 and 2008-2009 influenza seasons among patients who were treated with oseltamivir (group A) and those that did not receive oseltamivir (group B). Methods: A prospective study was conducted on 321 pediatric patients who were hospitalized because of influenza during the 2007-2008 and 2008-2009 influenza seasons. Drug resistance tests were conducted on influenza viruses isolated from 91 patients. Results: There was no significant difference between the clinical characteristics of groups A and B during both seasons. Influenza A/H1N1, isolated from both groups A and B during the 2007-2008 and 2008-2009 periods, was not resistant to zanamivir. However, phenotypic analysis of the virus revealed a high oseltamivir $IC_{50}$ range and that H275Y substitution of the neuraminidase (NA) gene and partial variation of the hemagglutinin (HA) gene did not affect its antigenicity to the HA vaccine even though group A had a shorter hospitalization duration and fewer lower respiratory tract complications than group B. In addition, there was no significant difference in the clinical manifestations between oseltamivir-susceptible and oseltamivir-resistant strains of influenza A/H1N1. Conclusion: Establishment of guidelines to efficiently treat influenza with oseltamivir, a commonly used drug for treating influenza in Korean pediatric patients, and a treatment strategy with a new therapeutic agent is required.

• 한국도로학회논문집
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• 제17권2호
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• pp.55-62
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• 2015

Cracking is an inevitable fact of asphalt concrete pavements and plays a major role in pavement deterioration. Pavement cracking is one of the main factors determining the frequency and method of repair. Cracks can be treated with a number of preventative maintenance actions, including overlay surface treatments such as slurry sealing, crack sealing, or crack filling. Pavement cracks can show up as one or all of the following types: transverse, longitudinal, fatigue, block, reflective, edge, and slippage. Crack sealing is a frequently used pavement maintenance treatment because it significantly extends the pavement service life. However, crack sealant often fails prematurely due to a loss of adhesion. Because current test methods are mostly empirical and only provide a qualitative measure of the bond strength, they cannot accurately predict the adhesive failure of the sealant. This study introduces a laboratory test aimed at assessing the bonding of hot-poured crack sealant to the walls of pavement cracks. A pneumatic adhesion tensile testing instrument (PATTI) was adopted to measure the bonding strength of the hot-poured crack sealant as a function of the curing time and temperature. Based on a limited number of test results, the hot-poured crack sealants have very different bonding performances. Therefore, this test method can be proposed as part of a newly developed performance-based standard specification for hot-poured crack sealants for use in the future. PURPOSES : The purpose of this study was to evaluate both the adhesion and failure performance of a crack sealant as a function of its curing time and curing temperature. METHODS: A pneumatic adhesion tensile testing instrument (PATTI) was adopted to measure the adhesion performance of a crack sealant as a function of the curing time and curing temperature. RESULTS: With changes in the curing time, curing temperature, and sealant type, the bond strengths were found to be significantly different. Also, higher bond strengths were measured at lower temperatures. Different sealant types produced completely different bond strengths and failure behaviors. CONCLUSIONS: The bonding strength of an evaluated crack sealant was shown to differ depending on various factors. Two sealant types, which were composed of different raw materials, were shown to perform differently. The newly proposed test offers the possibility of evaluating and differentiating between different crack sealants. Based on alimited number of test results, this test method can be proposed as part of a newly developed performance-based standard specification for crack sealants or as part of a guideline for the selection of hot-poured crack sealant in the future.

• 대한수의학회지
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• 제35권4호
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• pp.699-712
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• 1995

The present study, to evaluate the effect of vitamin E on the oxidative stress in STZ-treated rat and BB rat, was investigated the biochemical enzyme activity in the serum, and malondialdehyde and carbonyl group in the RBC membrane, liver and microsomal fraction after vitamin E and/ or insulin treatment. Results obtained through the experiments were summarized as follows; 1. Effect of vitamin E and/or insulin treatment in STZ-treated rat 1) Lipid peroxidation level in RBC membrane, liver and microsomal fraction was significantly decreased in vi. tamin E and/or insulin treatment group, and especially more significantly decreased in vitamin E with insulin treated group. 2) Protein oxidation level in RBC membrane, liver and microsomal fraction was significantly decreased in vitamin E and/or insulin treatment group. And it was especially more significantly decreased in RBC membrane and liver of vitamin E with insulin treated group. 3) In the enzyme activity in the serum, the activity of AST and ALT was not altered in all experimental group. The increased ALP activity in STZ-treated group was significantly decreased in insulin treated group and vitamin E with insulin treated group. 4) Decreased level of albumin and creatinine after STZ treatment was significantly increased in vitamin E and/or insulin treated group. 5) Level of glucose, cholesterol and triacylglycerol in serum: Glucose level was not significantly different in vitamin E treated group compared to STZ control group. But it was significantly different in the insulin treated group and vitamin E with insulin treated group compared to STZ control group. The cholesterol content in the serum was significantly increased in STZ control group compared to normal control group. And except low dose vitamin E treatment group, it was significantly decreased in vitamin E and/or insulin treated group compared to STZ control group. The triacylglycerol content in the serum was significantly decreased in STZ control group and increased in high dose vitamin E treated group and vitamin E with insulin treated group. But it was not significantly different in low dose vitamin E treated group and insulin treated group compared to STZ control group. 2. Effect of vitamin E and/or insulin treatment in BB rat 1) Lipid peroxidation level in liver was decreased by vitamin E with insulin treatment compared to insulin treatment. But it was not different in microsomal fractions. 2) Protein oxidation level in liver and microsomal fraction was decreased by vitamin E with insulin treatment compared to insulin treatment only in microsomal fractions. These results suggest that the combination treatment of vitamin E and insulin could prevent the oxidative change of lipid and protein of the RBC membrane, liver and microsomal fraction in STZ-treated rats and BB rats.

• 대한수의학회지
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• 제35권4호
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• pp.713-727
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• 1995

The present study was investigated fatty acid composition of the phospholipid in the RBC membrane, liver and microsomal fraction after vitamin E and/or insulin treatment to evaluate the effect of vitamin E on the oxidative stress in STZ-treated rat and BB rat. Results obtained through the experiments were summarized as follows; 1. Effect of vitamin E and/or insulin treatment in STZ-treated rat 1) In the insulin treated group and the combination treated groups of vitamin E with insulin, body weights were increased compared to STZ-treated rat(STZ control group). Especially it was more significantly increased in the combination treated group of high dose vitamin E with insulin. 2) The composition of fatty acids of the phospholipid in RBC membrane, liver and microsomal fractions was shown a decreased C16:1, C18:1, C20:4 and an increased C16:0, C18:0, C18:2 in STZ control group compared to normal control group. In RBC membrane, liver and microsomal fractions after vitamin E with insulin treatment in STZ-treated rat, effect on the composition of fatty acids of the phospholipid was shown the result of a decreased C16:0, C18:0, C18:2 and an increased C16:1, C18:1, C20:4. 3) Hemolysis rate of the RBC to $H_2O_2$ was increased in the STZ control group and it was decreased below the hemolysis level of normal control group by vitamin E treatment. 2. Effect of vitamin E and/or insulin treatment in BB rat 4) Only in microsomal fraction, fatty acid composition was different between insulin treatment group and vitamin E with insulin treatment group. It was increased C16:0 and C18:1, and decreased C18:0 and C18:2 in vitamin E with insulin treatment group: But C20:4 was not different in two groups. These results suggest that the combination treatment of vitamin E and insulin could prevent the oxidative change of fatty acids in P-lipid of the RBC membrane, liver and microsomal fraction in STZ-treated rats and BB rats.

• 한국전자통신학회논문지
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• 제11권5호
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• pp.531-538
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• 2016

교통사고의 발생의 주요 원인의 대부분은 운전자의 법규 위반 행위이며, 특히 과속 및 불법유턴은 대형 사고로 이어질 잠재적 위험성을 내포한다. 사업용 차량의 경우 불법유턴 위험성에 대한 지각이 부족하고, 단속장비 및 감시 인력 또한 부족한 실정이다. 이에 본 논문에서는 사업용 운전자의 불법유턴 위반행위를 예방하고, 안전운행 습관을 유도하고자, 맵 연동기반 운행행태 판단 기술을 개발에 대해 소개한다. 이를 위해 전국 총 26만개 링크자료 중 23,782 건의 유턴 허용 정보와 14만 6천 건의 제한속도 정보를 수집하였다. 또한 운행행태 분석을 위해 판단알고리즘을 구축하였으며, 최종적으로 안드로이드 기반 애플리케이션을 개발하였다. 개발된 애플리케이션의 맵 매칭, 운행행태 판단 및 기타 데이터 산출의 정확도를 평가하기 위해 테스트를 수행하였으며, 분석결과 맵 매칭은 86%, 운행행태 판단 정확도는 83%로 평가되었다. 또한 정보출력 표출에 대한 정확도는 모두 100%로 평가되었다. 향후 과제로서는 기술의 정확도 향상을 위해 모니터링 시스템 설계가 필요할 것으로 판단되며, 개발된 기술을 활용할 수 있는 서비스 시나리오의 검토가 필요하다고 판단된다.

• 대한전자공학회논문지TC
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• 제38권10호
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• pp.1-9
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• 2001

ATM-PON(Passive Optical Network)에서 OLT(Optical Line Termination)가 ONU(Optical Network Unit)에게 동적으로 대역폭을 할당하기 위하여 MAC(Medium Access Control) 프로토콜이 필요하다. 이를 통하여 OLT는 ONU의 정보를 수집하고 각 ONU에게 효율적으로 승인을 제공한다. MAC 프로토콜의 두 가지 중요한 기능은 승인 요청 절차와 승인 분배 알고리즘이다. 후자는 TC(Transmission Convergence) 기능모듈에서 연산 량이 가장 많은 부분이며, 칩 면적에서 비교적 큰 부분을 차지하고, 전체 동작 속도를 제한하는 요소가 되기도 하며, 각 트래픽에 대한 서비스 품질을 보장할 수 있도록 설계되어야 한다. 본 논문에서는 MAC을 FPGA를 이용하여 구현하며, 이것은 활동중인 ONU의 수와 큐 길이 정보에 따라 동적으로 대역폭을 할당하며, 각 ONU의 셀 지연변이를 최소화하기 위하여 승인을 등 간격으로 배분한다. 동적인 대역할당을 위하여 MAC 스케쥴러의 구조는 프로그램 가능한 look-up 테이블을 가지고 있다. 또한 이 구조는 단순하면서도 적은 칩 면적과 적은 지연시간을 가지고 있다.

• 대한수의학회지
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• 제35권2호
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• pp.347-352
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• 1995

Closantel이 간질(Fasciola hepatica)에 감염된 소에 미치는 치료 효과를 알아보기 위하여 간질 및 쌍구흡충에 자연감염된 41두의 한우 암컷에 체중 kg당 closantel 5mg을 1회 경구투여하였다. 치료 후 2주째부터 일주일 간격으로 3회 실시한 분변검사에서 closantel로 치료한 군은 치료 후 2주째까지는 음성이었으나 치료 후 3주 및 4주째에는 3마리의 소의 분변에서 간질충란이 검출되어 97.7%의 음전율을 나타냈다. 치료군 41두 중 30두는 임신중이었으나 임신우로부터 또는 이들로 부터 태어난 송아지에서 아무런 부작용이나 이상증세가 관찰되지 않았다. 검사한 모든 소에서 쌍구흡충란이 검출되었으나 closantel 치료에 의하여 제거되지 않았다. 두번째 실험에서는 16두의 Holstein종 송아지에 실험적으로 300개의 간질 피낭유충을 인공감염시켰으며, 감염후 14주째에 이르러 모든 개체의 분변에서 간질 충란이 검출되었다. 이들에게 감염 후 18주에 체중 kg당 5mg의 closantel을 경구투여하였으며, 치료 후 2주째부터 1주일 간격으로 3회 실시된 충란검사에서 치료군의 모든 송아지가 100% 음전율을 나타냈다. 본 실험의 결과, 간질에 자연 또는 인공감염된 소에 체중 kg당 5mg의 closantel을 경구투여했을 경우, 97% 이상의 치료효과가 있음이 관찰되었다.

• 한국토양비료학회지
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• 제41권4호
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• pp.235-238
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• 2008

토양침식을 예측하는 WEPP(Water Erosion Prediction Project)모델은 연방 정부기관이 토양과 물 보전 및 환경을 계획하고 평가하는데 활용하고자 1985년 8월 차세대 물에 의한 토양침식을 예측하기 위해 만들어졌다. 미농무성 농업연구소에 의해 개발된 WEPP 모델은 경험적인 침식 예측을 위한 도구로써 침투, 유거수, 강우와 물에 의한 토양입자의 분리, 침전물의 이동, 퇴적, 작물의 생장 및 수확 후 잔여물의 분해 등을 포함한 토양 침식과 관련된 많은 중요한 물리적 과정을 모의한다. WEPP 모델은 모델을 구성하는 모듈의 입력자료와 모델을 시험하기 위해서 필요한 자료를 경작지, 초지, 산림 등 광대한 현장 실험 결과들로부터 얻었다. 미국내 여러 농업연구소와 협력 대학 등 수 많은 연구소의 큰 노력으로 모델을 만들 수 있었다. WEPP 모델은 경사지 혹은 작은 유역 규모에 적용이 가능하며, 물리적 모델이기 때문에 미국과 다른 여러 나라에서 중요한 자연자원을 효과적으로 평가할 수 있다. 최근 들어 DOS프로그램으로 만들어진 초기 WEPP모델을 윈도우 인터페이스와 GIS프로그램을 통합하여 향상시켰다. 또한, 바람과 물에 의한 침식을 통합 예측하는 시스템을 쉽게 이용할 수 있도록 구축 중에 있다.

• 한국식품영양학회지
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• 제25권1호
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• pp.57-63
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• 2012

This paper analyzes phenolic compounds, carbon isotopes, and sugar components of whiskys based on the maturation period. For this, the paper considers a total of 40 whiskys(mainly imports) distributed in Korea. It is important to analyze the presence phenolic compounds(e.g., furfural, syringaldehyde, vanillin, syringic acid, and vanillic acid) because these are found only in whiskys ripened in oak. The results indicate that the total content of phenolic compounds increased with the increase in the storage period regardless of the type of whisky. In terms of vanillin/syringaldehyde(V/S), Scotch whiskys had 0.4~0.5; American whiskies, 0.30~0.34; and Canadian whiskies, 0.31~0.33. In terms of Scotch whiskys, Macallan had 0.25~0.34, making it unique among Scotch whiskys. In terms of the ratio of carbon isotopes, there were clear differences between malt Scotch whiskys, blended Scotch grain whiskys, American whiskys, and Canadian whiskys: -23.4~ -24.3, -16.8~-21.0, -11.0~-11.5 and -9.5~13.9, respectively. In addition, malt Scotch whiskys contained 40~230 $mg/{\ell}$ of fructose; blended Scotch whiskys, 20~120 $mg/{\ell}$; American whiskys, 50~70 $mg/{\ell}$; and Canadian whiskys, 20~100 $mg/{\ell}$, demonstrating that the fructose content of single-malt whiskys was twice the average fructose content. On the other hand, malt Scotch whiskys contained 30~170 $mg/{\ell}$ of glucose; blended Scotch whiskys, 20~120 $mg/{\ell}$; American whiskys, 20~30 $mg/{\ell}$; and Canadian whiskys, 10~110 $mg/{\ell}$, demonstrating that the glucose content of single-malt whiskys exceeded the average glucose content. This study's results can be used as a database of classification for whiskys based on the fermentation of raw ingredients and the period of maturation for distinguishing between different types of whiskys. In addition, the results can facilitate the verification of genuine whiskys by allowing for the identification of different types of whiskys based on the period of maturation.

• 기본간호학회지
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• 제6권3호
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• pp.522-531
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• 1999

This research identifies the ingress to egress primary factors that causes a patient to receive delayed emergency medical care. This material was collected between February 1st to 28th, 1998. Research envolved 4,118 people who visited the college emergency medical center in Kyeongido Province, South Korea. Medical records were examined, using the retrospective method. to determine the length of stay and the main cause for waiting. Results are as follows : 1. The age group with the highest admission rate was 10 and under, approximately 1,394 (33.9%). Followed by an even distribution for ages between 11-50 at 10-15% for their respective ranges. The lowest admission rate was 50 years and above. 2. From the 4,118 records examined, 3,489 received outpatient treatment (84.7%); 601 were admitted for inpatient care (14.6%); 25 arrived dead on arrival (0.6%); and 4 people died at the hospital. 3. Between 7PM to 12AM, 42.9% were admitted to the EMC. The hours from 9PM to 11PM recorded the highest admission rate and 5AM to 8AM was the lowest From 8PM to 12AM, the most beds were occupied. 4. For most patients. the average length of stay was approximately 2.2 hours. By medical department, external medicine was the longest for 2.8 hours. Pediatrics was the shortest for 1.6 hours. The average waiting period for inpatient admission was 2.6 hours. Inpatient admission for pediatrics and external medicine was 3.4 hours and 2.2 hours respectively. 5. Theses are primary factors for delay at EMC: 1) pronged medical consultations to decide between inpatient versus outpatient treatment, and delaying to be inpatient, 2) when you call physicians they are delayed to come 3) Understaffing during peak or critical hours, 4) Excessive consulting with different medical departments, 5) some patients require longer monitoring periods, 6) medical records are delayed in transit between departments, 7) repeated laboratory tests make delay the result, 8) overcrowded emergency x-ray place causes delay taking x-ray and portable x-ray, 9) the distance between EMC and registration and cashier offices is too far. 10) hard to control patient's family members. The best way to reduce EMC waiting and staying time is by cooperation between departments, both medical and administrative. Each department must work beyond their job description or duty and help each other to provide the best medical service and satisfy the patient needs. The most important answer to shortened the EMC point from ingress to egress is to see things from a patient point of view and begin from there to find the solution.