Korean Journal of Veterinary Research (대한수의학회지)
- Volume 35 Issue 4
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- Pages.713-727
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- 1995
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Effect of combination treatment of vitamin E and insulin in streptozotocin-treated rats and BB rats II. Effect on the fatty acid composition of phospholipid
BB 랫드 및 streptozotocin이 투여된 랫드에서 vitamin E와 insulin 병합 투여 영향 II. 인지질의 지방산 조성에 미치는 영향
- Kim, Soon-tae (Kyungsangbook Do Veterinary Service Laboratory) ;
- Huh, Rhin-sou (College of Veterinary Medicine, Kyungpook National University)
- Received : 1995.06.12
- Published : 1995.10.30
Abstract
The present study was investigated fatty acid composition of the phospholipid in the RBC membrane, liver and microsomal fraction after vitamin E and/or insulin treatment to evaluate the effect of vitamin E on the oxidative stress in STZ-treated rat and BB rat. Results obtained through the experiments were summarized as follows; 1. Effect of vitamin E and/or insulin treatment in STZ-treated rat 1) In the insulin treated group and the combination treated groups of vitamin E with insulin, body weights were increased compared to STZ-treated rat(STZ control group). Especially it was more significantly increased in the combination treated group of high dose vitamin E with insulin. 2) The composition of fatty acids of the phospholipid in RBC membrane, liver and microsomal fractions was shown a decreased C16:1, C18:1, C20:4 and an increased C16:0, C18:0, C18:2 in STZ control group compared to normal control group. In RBC membrane, liver and microsomal fractions after vitamin E with insulin treatment in STZ-treated rat, effect on the composition of fatty acids of the phospholipid was shown the result of a decreased C16:0, C18:0, C18:2 and an increased C16:1, C18:1, C20:4. 3) Hemolysis rate of the RBC to