• 품질경영학회지
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• 제40권4호
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• pp.431-440
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• 2012

Purpose: In this paper we propose modified Notz designs which are useful to experimenters who want to adopt the sequential experimentation strategy and to estimate second-order regression model with as few experimental points as possible. Methods: We first present the design matrices and design points in two or three dimensional spaces for such small sized second-order designs as small composite, hybrid, and Notz designs. Modified Notz designs are proposed and compared with some response surface designs in terms of the total number of experimental points, the estimation capability criteria such as D- and A-optimality. Results: When sequential experimentation is necessary, the modified Notz designs are recommendable. Conclusion: The result of this paper will be beneficial to experimenters who need to do experiments more efficiently, especially for those who want to reduce the time of experimentation as much as possible to develop cutting-edge products.

• 품질경영학회지
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• 제49권1호
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• pp.31-45
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• 2021

Purpose: A noncentral composite design method is to be developed to explore farther region for the first factorial design. A general guideline for sequential experimentation is provided. Methods: (1) A non-overlapping noncentral composite design (NNCD) is developed, in which the second factorial design shares one design point that indicates the best response value in the first factorial design. (2) Four composite designs are compared in terms of the four design evaluation criteria, which are D-, A, G, and I-optimality. (3) A follow-up design strategy is suggested based on the interaction effect, direction of improvement, number of factors. Results: (1) NNCD and model building method are presented, which is useful for exploring farther region from first factorial design block. (2) The performances of the four composite designs are compared. (3) A follow-up design strategy is suggested. Conclusion: (1) NNCD will be useful to explore farther region for the first factorial design. (2) A follow-up design strategy can be beneficial to the experimental practitioners for product and process design and improvement.

• Communications for Statistical Applications and Methods
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• 제9권3호
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• pp.619-627
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• 2002

It is unpractical for the optimal design theory based on the given model and assumption to be applied to the real-world experimentation. Particularly, when the experimenter feels it necessary to consider multiple objectives in experimentation, its modified version of optimality criteria is indeed desired. The constrained optimal design is one of many methods developed in this context. But when the number of constraints exceeds two, there always exists a problem in specifying the lower limit for the efficiencies of the constraints because the “infeasible solution” issue arises very quickly. In this paper, we developed a sequential approach to tackle this problem assuming that all the constraints can be ranked in terms of importance. This approach has been applied to the polynomial regression model.

• 대한산업공학회지
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• 제27권4호
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• pp.352-365
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• 2001

Two-level factorial designs are popular in industry due to their simplicity, efficiency, graphical interpretation, and flexibility in sequential experimentation. However, experimenters are often frustrated when they have factors with more than two levels. There have been some works on design of experiments with two- and four-level factors, which mostly deal with qualitative four-level factors. This paper discusses differences between qualitative and quantitative four-level factors. Optimal designs are provided for some designs with four-level quantitative and two-level factors.

• 품질경영학회지
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• 제47권3호
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• pp.631-639
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• 2019

Purpose: In this paper we present a case study of applying quick and easy experimental design approach to develop a Halogen free flame retardant material for cellular phone charger cable. Methods: We employ sequential experimentation of mixture design, verification design, and factorial design. A quick and easy approach is adopted based on data investigation and graphical method instead of strict statistical analysis, which helped enhancing smooth communication with the engineers and speeding up the development process. Results: Flame retardant material in pellet type produced from the optimal condition is transported to the customer and tested, to pass the customer retardancy criteria. Conclusion: The quick and easy experimental design approach is considered to be useful in this case study.

• 한국실내디자인학회논문집
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• 제19권5호
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• pp.226-233
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• 2010

This study is to analyze and determine the emotional design on domestic rec-education space, in order to propose a way to design children rec-education space. A study is on reviewing needs and verify categories of emotional design through interior design of rec-education space, A study procedure will begin with theoretical proofing of children rec-education and move on to needs of emotional design in interior design and types of analysis for it. With this procedure, we will project adequate way for emotional characteristics in rec-education space and will analyze types of it from interior design of rec-education space in nine different domestic brands. With this background, we like to present methods and reveal characteristics of it. The conclusion on this study is described as followed. First, children rec-education space has positively carried types of emotional characteristics: experimental, continuity, and symbolism. Second, Some precondition; application through types of pattern, experimentation on light in space, continuity on linear interior space composition, symbolism in abstract implementation, and physical control over designed subject, has low effectiveness on creating emotional space by applying such scale matters. Third, the actual interior design subject matters and supporting facilities' textural accommodation is inadequately built for their majority, children, whether it is direct or indirect for contact. Forth, Even though to carry emotional space needs some kinds of story telling and prerequisite sequential space composition, there are lack of applicable space compositions. For this reason, it needs on going study in emotional space for children rec-education space. Last, there are needs for researching a depth understanding and presenting different characteristics of emotional interior design by brands.

• Tuberculosis and Respiratory Diseases
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• 제46권1호
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• pp.75-81
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• 1999

연구배경: 최근 상어 간유(squalene)에 의한 지방성 폐렴이 다수 보고되고 있으나 이에 대한 동물 실험이 미흡한 상태로 저자들은 토끼에서 상어 간유 흡인 후 나타나는 폐 반응을 HRCT와 병리학적 검사를 통해 알아보았다. 방 법: 14 마리의 백색 토끼를 대상으로 스쿠알렌을 흡인 시킨 후 12마리의 토끼를 4마리씩 각각 1주, 2주, 4주에 HRCT와 병리 소견을 관찰하였고, 나머지 2마리는 각각 흡인된 스쿠알렌 양을 달리하여 6주째에 관찰하였다, 결 과: 총 14마리중 l마리는 주입 즉시 즉사 하였으며 나머지 13 마리중 HRCT상 6마리에서 폐렴이 발생하였고, 1 주째에 기관지 공기 조영상을 동반한 광범위한 폐렴이 발생하였다가 4주째에는 폐용적 감소, 6 주째에는 기관지 확장소견이 동반되었다. 병리소견상 주로 기관지 주위에 심한 염증 소견을 보였고 1주째부터 격막비후 소견이 관찰되었고 2주째에 폐포내 대식세포수가 가장 많았으며 6주째에 섬유모세포의 증식이 관찰되었다. 곁 론: 스쿠알렌 흡인 후 폐렴이 발생하였으며, 이는 2-3주에 가장 심한 염증 소견을 보여, 이후 서서히 호전됨을 동물실험을 통해 증명하였으며, HRCT에서도 조직학적 소견과 유사한 소견을 관찰할 수 있었다.