• 제목/요약/키워드: Separation time

검색결과 1,798건 처리시간 0.024초

암 환아 부모의 경험에 대한 질적 연구 (The Experience of Parents Whose Child is Dying with Cancer)

  • 조영숙;김수지
    • 대한간호학회지
    • /
    • 제22권4호
    • /
    • pp.491-505
    • /
    • 1992
  • The purpose of this research was to understand the structure of the lived experience of parents of a child terminally ill with cancer The research question was “What is the structure of the experience of parents of a child terminally ill with cancer\ulcorner” The sample consisted of 17 parents of children admitted to the cancer units of two university hospitals in Seoul. The unstructured interviews were carried out from October 10, 1991 through January 10, 1992. They were audio-recorded and analysed using Van Kaam's method. Parents ascribed the cause of the cancer to the mother's emotional imbalance during pregnancy, the mother's stress, failure to observe religious rites, food, the parent's sin, misfortune and pollution. The theme clusters were tension, fear and depression experienced during pregnancy, stress that children suffer from abusive parents, failure to observe religious activites, bad luck, and sins committed during a previous life. When the child suffered a recurrence of cancer, the parents experienced negative emotions, nervousness, sorrow. depression and death. The theme clusters were feelings of despair, helplessness, regret, guilt, insecurity, emptyness and apathy. The long struggle with cancer resulted in the loss of economic security, loss of psychological and physical well being, and social withdrawal. The theme clusters were the economic burden of medical cost, giving up treatment, debt, limited medical insurance coverage and blood transfusion. The loss of psychological well being included stress, lack of support systems, inability to carry out responsibilities, lack of trust of the medical ten family breakdown, inappropriate expression of emotion and not disclosing the diagnosis to the child. Physically the parents suffered fatigue, insomnia, loss of appetite, loss of weight, dizzness, headache, psychosomatic symptoms, and increased consumption of liquor and cigarettes. Social withdrawal was manifested by taking time off from work to look after the child, decrease of outside social activities and feelings of isolation. Influences on family life were spousal conflicts, negative response of siblings, separation of the family members and economic hardship. The theme clusters were blaming a spouse for the cause of the illness and disagreements, maladjustment, lonliness, hostility and depression of siblings. The high price of medical care over the long period was a major factor influencing the life of the family. Positive experiences during the child's long illness were the strengthening of support systems and religious beliefs and financial help from social organizations. The support of one's spouse primarily helped to overcome the stress of the long illness. In addition, support was received from parents of other children with cancer and from nurses and religious leaders. The nurse, by providing empathetic support, should be a person with whom parents can express their feelings and share their experiences.

  • PDF

EuroQoL-5 Dimension 한국 가중치 모형의 적용 연구 (A Study on the Application of the Korean Valuation Weights for EuroQoL-5 Dimension)

  • 이영훈;최진수;이정애;류소연;신민호;김진희
    • 보건교육건강증진학회지
    • /
    • 제26권1호
    • /
    • pp.1-13
    • /
    • 2009
  • Objectives: This study was conducted to estimate the health-related quality of life (HRQOL) using EuroQoL-5 Dimension (EQ-5D) and to identify its related factors among urban-dwelling adults. Methods: The data for this study were obtained from 1,134 subjects aged $20\sim91$, who participated in 'Survey on the health status and demand for health' in two cities of Korea (Dong-gu, Gwangju and Suncheon-si, Jeollanamdo). The HRQOL was measured using the EQ-5D instrument and EQ-5D index scores were calculated by two Korean valuation study model using time trade-off method. Results: The mean EQ-5D index scores for all subjects were $0.865{\pm}0.218$ (model A), and $0.921{\pm}0.170$ (model B). The EQ-5D index score was significantly different according to demographic and socioeconomic characteristics (gender, age, marital status, education, occupation, income, and health security system), self-rated health condition, health-related psychological assessments (enough sleep, fatigue rate, stress rate, and degree of satisfaction on the residence). The results of multiple linear regression showed that age, marital status, income, coverage of medical insurance, self-rated health condition, and fatigue rate were significantly related common statistical factors of HRQOL in two Korean valuation study model. Conclusion: Among the adults residing in urban environment, the HRQOL was significantly lower on the subjects with following conditions: higher age, being alone without a spouse as a result of death, divorce or separation, low income, medical aid program, poor self-rated health condition, and chronic fatigue. In order to improve the urban adults' quality of life, healthcare policy and health promotion program must be developed with considerations to factors related to the HRQOL.

문헌자료 고찰을 통한 우리나라 약국서비스 시행 현황 (Pharmaceutical Care Services of Community Pharmacies in Korea Through the Review of Literature)

  • 손현순;김효정;박혜경;한나영;오정미;지은희
    • 한국임상약학회지
    • /
    • 제25권1호
    • /
    • pp.18-26
    • /
    • 2015
  • Background: The recent change in pharmaceutical education system following the paradigm shift to patient-oriented pharmacy service requires an in-depth discussion to reorganize a future direction and establish a basis for maximizing social values of community pharmacy service. Objective: This study was conducted to review the current status of community pharmacy service provision in Korea based on published literatures. Methods: The electronic databases of National Digital Science Library and Electronic National Assembly Library were used to search the journal articles and dissertation papers. A search term "community pharmacy" was used and the published period was limited to papers published after year 2001, when the legal separation of prescribing and dispensing was implemented. Relevant study reports were also searched manually. Information about pharmacy service provision and study outcomes were retrieved from the selected papers, and classified by predefined individual service scope. Results: A total 33 papers reporting services provided by community pharmacies were selected (journal article 11, dissertation paper 17, and study report 5). Pharmacy services identified in these papers could be classified into prescription dispensing service, pharmaceutical care service, self medication service, other products service, and health promotion service. Twenty papers reported prescription dispensing services, three papers reported pharmaceutical care service, and only two papers reported health promotion service. Current community pharmacy services are highly dependent on prescription drugs while expanded services such as pharmaceutical care and health promotion are peripheral. Most prevalent research topic was medication counseling service (18 papers), reflecting that community pharmacists generally consider it to be the most important and fundamental service. Overall, current pharmacy services are very limited and focus on prescription dispensing service. Conclusion: At this point of time requiring expansion and quality improvement of community pharmacy services, we suggest further lively discussion to strengthen pharmacist's functional identity and set conditions for providing socially expected services.

HPLC-DAD를 이용한 평위산 중의 Hesperidin 및 Glycyrrhizin의 동시분석법 확립 (Simultaneous Determination of Hesperidin and Glycyrrhizin in Pyungwi-san by HPLC/DAD)

  • 이미경;최옥경;박진호;조정희;김도훈;백주현;김효진;이기용;김상두;김영중;성상현
    • 생약학회지
    • /
    • 제39권3호
    • /
    • pp.199-202
    • /
    • 2008
  • A high performance liquid chromatographic (HPLC) method for the simultaneous determination of hesperidin and glycyrrhizin was established for the quality control of traditional herbal medicinal preparation, Pyungwi-san (PWS). Separation and quantification were successfully achieved with a Waters XTerra RP18 column ($5{\mu}m$, 4.6 mm I.D. ${\times}$ 150 mm) by gradient elution of a mixture of acetonitrile and water containing 0.03% phosphoric acid (pH 2.03) at a flow rate of 1.0 ml/min. The diode-array UV/vis detector (DAD) was used for the detection and the wavelength for quantification was set at 230 nm. The presence of hesperidin and glycyrrhizin in this extract was ascertained by retention time, spiking with each authentic standard and UV spectrum. All four compounds showed good linearity $(r^2>0.995)$ in a relatively wide concentration ranges. The R.S.D. for intra-day and inter-day precision was less than 7.0% and the limits of detection (LOD) were less than 60 ng. The mean recovery of each compound was 99.0-105.6% with R.S.D. values less than 4.0%. This method was successfully applied to the determination of contents of hesperidin and glycyrrhizin in three commercial products of PWS. These results suggest that the developed HPLC method is simple, effective and could be readily utilized as a quality control method for commercial PWS products.

생태계 탄소순환 이해를 위한 국내 토양호흡 연구의 고찰 (Discussion of Soil Respiration for Understanding Ecosystem Carbon Cycle in Korea)

  • 이재호;이준석;전영문;채남이;이재석
    • 생태와환경
    • /
    • 제46권2호
    • /
    • pp.310-318
    • /
    • 2013
  • 육상생태계의 토양에는 대기의 약 2배에 해당하는 많은 양의 탄소를 가지고 있으며, 기후변화에 의한 기온 상승으로 대기로의 방출에 매우 취약한 상황에 놓여 있다. 한반도의 육상 생태계 토양탄소 수지의 변화예측을 위해 필연적으로 요구되는 다양한 생태계의 토양호흡 자료 수집을 위해 이용되는 방법론, 기기, 기기들 간의 오차, 시공간적인 불균일성, 결측 자료에 대한 보충 (gap filling), 발생원 별 구분 등에 대한 현 상황을 정리하고 그를 바탕으로 국내 토양호흡 연구의 문제점과 과제에 대해 고찰하였다. 결론적으로 국내의 토양호흡 연구는 기기 간 또는 방법들 간의 오차 보정이나 노력들이 매우 빈약하게 행해져 왔기 때문에 과거 및 현재 축적되는 자료의 품질은 거의 보정되지 않은 상태로 볼 수 있다. 이러한 문제점들이 해소되지 않고 지금까지와 같은 방식으로 토양호흡 자료가 축적된다면 그 활용성은 매우 낮을 수 밖에 없다. 또한 장기적인 자료 축적, 토양호흡 조절 메커니즘에 관한 조절 실험, 다양한 생태계, 토성, 토심 등에 대한 자료 역시 장래의 토양권 탄소 동태 변화를 모델 수단으로 예측하는 데에는 매우 중요한 요소이므로 토양호흡 자료 수집과 함께 수집되어야 할 것이다. 더불어 장기적인 측면에서 이러한 문제들이 연구자 간에 깊숙이 인식되어 보다 양질의 자료가 생산되도록 노력할 필요가 있다.

임하호 유입지천에 서식하는 어류에 미치는 탁수의 영향 (Effect of Turbid Water on Fishes in the Streams of Imha Reservoir)

  • 유삼환;김정숙;신명자;이종은;서을원
    • 생명과학회지
    • /
    • 제19권10호
    • /
    • pp.1410-1416
    • /
    • 2009
  • 본 연구는 탁수가 어류에 미치는 영향을 분석하기 위하여 임하호 유입지천인 탁수수계(영양군 화매천)와 비탁수수계(청송군 신흥천)의 수질, 토양성분 및 어류의 조직 생리적 변화를 조사하였다. 임하호 유입지천의 수질은 탁수수계에서 pH, DO, SS 및 탁도가 높았으며, 토양성분은 vermiculite (V), illite (I)와 같은 점토광물이 높은 것으로 보아 점토광물이 강우시 쉽게 유출되어 탁수에 영향을 줄 것으로 생각된다. 탁수수계에 서식하는 어류는 이차새변의 간격이 일정하지 않고, 상피세포의 분리와 부종 및 곤봉 형태가 관찰되었다. 또한 아가미 표면이 매끄럽지 못하며 다량의 이물질이 존재하였고, 신장 조직에서는 보우먼주머니 안의 사구체 크기가 수축되어 보우만 공간이 넓은 형태를 나타냈다. 이러한 조직학적 변화가 장기간 지속될 경우 어류의 2차 병변의 원인이 될 수 있으며, 더 나아가 어류의 건강상에 영향을 줄 것으로 사료된다. 항산화효소의 활성은 탁수수계에서 높은 활성을 보이며, GR은 항산화효소의 활성중 가장 낮은 활성을 나타냈다. 또한 탁수수계의 근육과 신장조직에서는 SOD, CAT, GPX, GST가 비탁수수계 보다 높은 활성을 보였다. 이는 활성산소가 많이 발생하는 탁수수계의 어류 체내에서는 유해한 라디칼을 제거하기 위해 항산화효소의 활성이 증가한 것으로 생각된다.

군 지연 및 충실도를 이용한 IR-UWB용 테이퍼 슬롯 안테나 방사패턴 분석 (Analysis of IR-UWB Tapered Slot Antenna Radiation Pattern using the Group delay and Fidelity)

  • 김근용;고영목;박경진;강은균;이대우;박종현;나극환
    • 전자공학회논문지
    • /
    • 제50권8호
    • /
    • pp.308-315
    • /
    • 2013
  • 본 논문에서는 IR-UWB를 위한 테이퍼 슬롯 안테나를 Ansoft인 HFFS을 사용하여 설계 및 제작 하였고 안테나의 군 지연 및 충실도를 사용하여 광대역 안테나의 빔 폭에 대해 연구를 제안하였다. 이를 위해 Network Analyzer에서 획득한 데이터를 Chirp Z-transform을 사용하여 시간영역에서의 분석을 하였고 시뮬레이션은 CST microwave studio를 이용하여 이를 확인 하였다. 안테나의 방사패턴의 분석은 두 안테나를 0.5 미터 간격으로 이격시킨 후 송신 안테나를 고정 후 수신 안테나를 $10^{\circ}$ 간격으로 $360^{\circ}$ 회전하여 각각의 충실도를 획득하여 안테나의 성능 분석하였다. 분석한 결과 ${\pm}40^{\circ}$ 미만일 경우 90%이상의 양호한 충실도를 얻었고 ${\pm}40^{\circ}$ 이상은 90%이하의 낮은 결과를 얻었다. 이러한 충실도를 이용한 방사패턴을 사용함으로 광대역 안테나의 빔 폭을 보다 정확한 분석을 할 수 있다.

Autocrine Regulation of Gonadotropin-releasing Hormone (GnRH) Operates at Multiple Control levels of GnRH Gene Expression in GT1-1 Neuronal Cells

  • Jin Han;Sehyung Cho;Woong Sun;Kyungjin Kim
    • Animal cells and systems
    • /
    • 제2권4호
    • /
    • pp.483-488
    • /
    • 1998
  • We previously found that a potent gonadotropin-releasing hormone (GnRH) agonist, buserelin, decreases GnRH promoter activity together with GnRH mRNA level, providing evidence for an autoregulatory mechanism operating at the level of GnRH gene transcription in immortalized GT1-1 neuronal cells. To examine whether agonist-induced decrease in GnRH mRNA level requires the continuous presence of buserelin, we performed a pulse-chase experiment of buserelin treatment. Short-term exposure (15 min) of GT1-1 neuronal cells to buserelin ($10{\mu}M$) was able to decrease GnRH mRNA levels when determined 24 h later. When GT1-1 cells were treated with buserelin ( $10{\mu}M$) for 30 min and then incubated for 1, 3, 6, 12, 24, and 48 h after buserelin removal, a significant decrease in GnRH mRNA levels was observed after the 12 h incubation period. These data indicate that inhibitory signaling upon buserelin treatment may occur rapidly, but requires a long time (at least 12 h) to significantly decrease the GnRH mRNA level. To examine the possible involvement of de novo synthesis and/or mRNA stability in buserelin-induced decrease in GnRH gene expression, actinomycin D ($5{\mu}m/ml$), a potent RNA synthesis blocker, was co-treated with buserelin. Actinomycin D alone failed to alter basal GnRH mRNA Revel, but blocked the buserelin-induced decrease in GnRH mRNA level at 12 h of post-treatment. These data suggest that buserelin may exert its inhibitory action by altering the stability of GnRH mRNA. Moreover, a polvsomal RNA separation by sucrose gradient centrifugation demonstrated that buserelin decreased the translational efficiency of the transcribed GnRH mRNA. Taken together, these results clearly indicate that GnRH agonist buserelin acts as an inhibitory signal at multiple levels such as transcription mRNA stability, and translation.

  • PDF

일라이트 분체 내에 함유된 산화철 제거에 옥살산과 L-아스코르브산이 미치는 영향 (Effects of Oxalic and L-ascorbic acids on Iron Removal form Iron-bearing Illite)

  • 이원표;강일모;문희수
    • 자원환경지질
    • /
    • 제40권2호
    • /
    • pp.141-151
    • /
    • 2007
  • 충북 영동지역에서 산출되는 일라이트를 대상으로 철 성분을 제거하는 실험을 수행하였다. 이는 일라이트 광석에 들어있는 철 성분을 제거하여 백색도를 향상시킴으로써 광석의 활용 가능성을 높여 주는데 있다. 철 성분의 제거 효율성을 평가하기 위해 무기산(황산, 염산), 유기산(L-아스코르브산, 옥살산), 혼합산(무기산+유기산)을 사용하였다. 실험결과 0.15 M L-아스코르브산을 0.5 N 황산에 첨가한 혼합산과의 탈철 반응을 수행한 경우, 60분 반응 시 1.5 wt%의 산화철 성분을 제거하여 가장 높은 효율을 나타내었다. 0.5N황산을 단독으로 사용한 경우에는 60분 반응 시 제거된 산화철이 0.68%에 불과하다. 황산만을 이용하여 1.5wt %의 산화철을 제거하기 위해서는 5N의 반응농도와 150분의 반응시간이 요구되었다. 따라서 친환경적이고, 인체친화적인 L-아스코르브산의 탈철반응이 반응농토와 반응시간에 있어서도 효율적임을 관찰하였다. 산화철 제거 후 일라이트는 백색도가 42%에서 75%로, 색도가 10YR 8/4에서 5Y, 8/1로 향상되어 CBD 처리와 같은 수준으로 증가하였다. 일라이트 입자를 교결하고 있던 산화철이 제거되어 입도가 소폭 감소하였으나 광물학적/물리 화학적 특성은 변화가 관찰되지 않았다.

입상 활성탄에 대한 비스마르크 브라운 R 염료의 흡착평형, 동력학 및 열역학 파라미터에 관한 연구 (Adsorption Equilibrium, Kinetics and Thermodynamic Parameters Studies of Bismarck Brown R Dye Adsorption on Granular Activated Carbon)

  • 이종집
    • 공업화학
    • /
    • 제24권3호
    • /
    • pp.327-332
    • /
    • 2013
  • 입상 활성탄에 대한 bismarck brown R의 흡착평형, 동력학 및 열역학 파라미터들을 회분식 실험을 통해 살펴보았다. 조작변수로서 초기농도, 접촉시간과 흡착온도의 영향을 조사하였다. 흡착평형자료는 선형회귀법을 사용하여 Langmuir와 Freundlich 흡착등온식에 대한 적합성을 평가하였다. 흡착평형은 Freundlich 흡착등온식이 더 잘 맞았으며, 계산된 분리계수(1/n) 값으로부터 입상 활성탄이 bismarck brown R을 효과적으로 처리할 수 있다는 것을 알 수 있었다. 동력학적 실험으로부터, 흡착공정은 유사이차반응속도식에 잘 맞으며, 속도상수($k_2$) 값은 온도가 증가할수록 증가하였다. 활성화에너지, 엔탈피, 엔트로피 및 Gibbs 자유에너지변화와 같은 열역학 파라미터들은 흡착공정의 특성을 평가하기 위하여 298~318 K의 온도 범위에서 조사하였다. 활성화 에너지의 계산값은 100 mg/L에서 8.73 kJ/mol로 입상 활성탄에 대한 bismarck brown R의 흡착이 물리적 공정임을 나타냈다. Gibbs 자유에너지변화의 음수값(${\Delta}G$ = -2.59~-4.92 kJ/mol)과 엔탈피변화의 양수값(${\Delta}H$ = +26.34 kJ/mol)은 흡착공정이 자발적이며 흡열과정으로 일어난다는 것을 나타냈다.