• Journal of Periodontal and Implant Science
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• 제36권2호
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• pp.289-303
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• 2006

This study was performed to evaluate the effect of bone graft materials including demineralized freeze-dried bone, freeze-dried bone, deproteinized bovine bone on space-making capacity and bone formation in guided bone regeneration with titanium reinforced ePTFE membrane(TR-ePTFE). Adult male rabbits(mean BW 2kg) were used in this study. Intramarrow penetration defects were surgically created with round bur on calvaria of rabbits. TR-ePTFE membrane was adapted to calvarial defect and bone graft materials were placed. Animals were sacrificed at 2, 8, 12 weeks after surgery. Non-decalcified specimens were processed for histologic analysis and prepared with Villaneuva bone stain. The results of this study were as follows: 1. TR-ePTFE membrane was biocompatible and capable of maintaining the space-making. 2. Tissue integration was not good at TR-ePTFE membrane. Fixation was not enough. so, wound stabilization was not good. 3. In animals using deproteinized bovine bone, demineralized freeze-dried bone, bone formation was little. 4. In animals using freeze-dried bone, bone formation was better. Within the above results, bone formation may be inhibited when wound stabilizafion was not good.

• 센서학회지
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• 제20권4호
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• pp.272-278
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• 2011

Recently, the performance of binaural hearing aids is rapidly improved with the technology advancement of wireless communication, digital signal processing, and integrated circuit design. However, the previous hearing aids developer platforms can't be applied to binaural hearing aids developing, because it has no consideration for wireless communication and binaural hearing control. Also, the previous developer platforms are not easy to use for the algorithm development, because programming languages are limited. In this paper, we designed and implemented the open platform board for binaural hearing aids developing. The designed board can be programmed by general programming language and can be used wireless communication module. In order to verify the designed open platform board, we used the volume control algorithm using two open platform board. As a result of experiment, we verified the performance of designed and implemented open platform board that was successfully operated the binaural hearing control and the wireless communication.

• 한국식품과학회지
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• 제48권5호
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• pp.515-520
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• 2016

본 연구에서는 꽃송이버섯 자실체와 기부의 항산화 활성, 베타글루칸 함량 및 면역 활성을 비교하였다. DPPH 라디컬제거능 실험결과 꽃송이버섯 기부의 항산화 활성이 자실체에 비해 약 2.3배 높은 활성을 보였다. 건조 중량 기준 꽃송이버섯 추출물의 베타글루칸 함량 또한 기부가 23.7 g/100 g로 자실체의 함량 13.8 g/100 g보다 유의하게 높은 것으로 측정되었다. 면역 저하에 대한 꽃송이버섯 추출물의 투여는 $TNF-{\alpha}$, IL-2, IL-10, IgE 함량에서 유의미한 결과를 도출하였지만, 자실체와 기부의 효과는 유의적인 차이가 없었다. 혈액 내의 백혈구 함량 및 비장의 무게는 꽃송이버섯 자실체보다 꽃송이버섯 기부 추출물을 경구 투여한 실험군에서 효과적이었다.

• 한국전통의학지
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• 제15권1호
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• pp.77-82
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• 2006

Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95. the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.

• 대한피부과학회지
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• 제56권10호
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• pp.594-602
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• 2018

Background: Acute generalized exanthematous pustulosis (AGEP) is typically a medication-induced acute febrile eruption. Few large-scale studies have reported clinical data regarding AGEP in Korea. Objective: This study analyzed the clinical and histopathological features of AGEP in Koreans to identify recent trends in this context. Methods: This study retrospectively reviewed 31 patients with AGEP. Age, sex, clinical features, etiologies, laboratory findings, histopathological features, and treatment outcomes were obtained from patients' medical records and photographs. Results: The mean age of onset was 43.6 years, and the male : female ratio was 2.1 : 1. All patients showed non-follicular tiny pustules and erythema. Fever was reported in 13 patients and neutrophilia in 17 patients. Medications were considered the most common etiological contributors. Twenty patients showed drug-induced AGEP, and 11 of 20 patients showed antibiotic-induced AGEP. Serum C-reactive protein and lactate dehydrogenase levels increased in 93.8% and 77.8% of the patients, respectively. Histopathologically, all patients showed subcorneal or intraepidermal pustules, followed by exocytosis and neutrophilic dermal infiltrate. Twenty-five patients improved within a mean period of 7.5 days after the onset of the skin rash. The percentage of women in the drug-induced AGEP group was significantly higher than that in the non-drug-induced AGEP group. Conclusion: This report describes a large-scale study that analyzed the clinical and histopathological features of AGEP in Koreans and seems to accurately reflect the recent trends in this context. Clinically, it is important to note that the percentage of women in the drug-induced AGEP group was higher than that in groups showing other etiologies of AGEP.

• Journal of Gastric Cancer
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• 제20권4호
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• pp.421-430
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• 2020

Purpose: Currently, there is no clear evidence to support any specific treatment as a principal therapy for stage IV gastric cancer outlet obstruction (GCOO) patients. This study evaluated the outcomes of palliative gastrectomies and survival prognostic factors in patients with stage IV resectable GCOO. Materials and Methods: We retrospectively reviewed the medical records of 48 stage IV GCOO patients who underwent palliative gastrectomies between June 2010 and December 2019. Palliative gastrectomies were performed only in patients with resectable disease. Early surgical outcomes and prognostic factors were analyzed using univariate and multivariate analyses. Results: There were no specific risk factors for postoperative complications, except for being underweight. Severe postoperative complications developed in five patients, and most of the patients underwent interventional procedures and received broad-spectrum antibiotics for intra-abdominal abscesses. The multivariate survival analysis showed that palliative chemotherapy is a positive prognostic factor, while the specific type of hematogenous and lymphatic metastasis is a negative prognostic factor. Conclusions: We recommend that the treatment method for stage IV GCOO should be selected according to each patient's physical condition and tumor characteristics. In addition, we suggest that palliative gastrectomies can be performed in stage IV resectable GCOO patients without unfavorable prognostic factors (types of hematogenous and lymphatic metastases).

• Safety and Health at Work
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• 제12권1호
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• pp.102-107
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• 2021

Background: This study was conducted to identify the association between sleep duration and suicidal ideation among farmers in Korea. Methods: We used Safety for Agricultural Injuries of Farmers cohort data collected from September 2015 to June 2018, which was an agricultural survey on the health and behaviors of adult farmers in Jeju island, Korea. Results: A total of 964 participants were included in the analysis, and 3.7% of them were identified with having suicidal ideation. The frequencies of average daily sleep duration of <6 h (short sleep), 6-8 h (normal sleep), and >8 h (long sleep) were 24.4%, 70%, and 5.6%, respectively. Multivariate analyses revealed that short sleep duration was significantly associated with suicidal ideation compared with normal sleep duration (odds ratio = 2.49, 95% confidence interval = 1.07-5.77). Conclusion: Our findings suggest that short sleep duration in farmers result in higher suicidal ideation. Because individuals who have suicidal ideation often commit suicide, careful monitoring is required to prevent suicide in farmers with short sleep duration.

• 한국정보통신학회논문지
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• 제26권4호
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• pp.510-518
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• 2022

국가수준에서 시행되는 진단평가는 학교에서 학습부진이 있는 학생을 조기 발견하는 것이 매우 중요하다. 본연구는 부산교육종단의 2019년 중학교 1학년의 데이터를 입력하여 2020년 성취여부를 판별하는 인공지능 모델을 구축하고 분석하였다. 머신러닝 알고리즘으로 중학교 국어, 영어, 수학 기초학력을 예측하는 예측모형을 개발하고, 다음 학년 예측에도 78%, 82%, 83% 의 정확도를 보이는 것을 확인하였다. 또한, 중학교 과목별 성취예측 의사결정트리를 그려서 과정을 분석해보면서, 성취 예측에 영향을 미치는 특성들은 어떠한 것들이 있는지 살펴보았다.

• Archives of Plastic Surgery
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• 제51권1호
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• pp.62-66
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• 2024

Gestational gigantomastia is characterized by the rapid growth of breasts during pregnancy. The treatment method of gestational gigantomastia is unclear; if the medical treatment is ineffective, surgery is considered. However, sufficient research on which method is best to perform breast reconstruction for the gestational gigantomastia patient has not yet been conducted. Our patient was young and had aesthetic needs; thus, we did not recommend modified radical mastectomy. However, it was difficult for the patient to consider active reconstruction using an implant or autologous tissue because of the expected complications and economic problems. The patient had a thin body shape and very large breasts compared with the trunk. Therefore, breast volume was not significantly required after reconstruction. Additionally, we expected that a considerable portion of skin would remain after mastectomy as a tubular-shaped breast. It was expected that the Goldilocks technique would be sufficient to meet the patient's volume needs. Therefore, we proceeded with total mastectomy and reconstruction using the Goldilocks procedure. No complications were recorded after the operation; most of the patient's discomfort was resolved, and the shape and size of the breasts were satisfactory.

• Molecules and Cells
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• 제26권2호
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• pp.181-185
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• 2008

The effects of calcitonin gene-related peptide (CGRP) on pacemaker currents in cultured interstitial cells of Cajal (ICC) from the mouse small intestine were investigated using the whole-cell patch clamp technique at $30^{\circ}C$. Under voltage clamping at a holding potential of -70 mV, CGRP decreased the amplitude and frequency of pacemaker currents and activated outward resting currents. These effects were blocked by intracellular $GDP{\beta}S$, a G-protein inhibitor and glibenclamide, a specific ATP-sensitive $K^+$ channels blocker. During current clamping, CGRP hyperpolarized the membrane and this effect was antagonized by glibenclamide. Pretreatment with SQ-22536 (an adenylate cyclase inhibitor) or naproxen (a cyclooxygenase inhibitor) did not block the CGRP-induced effects, whereas pretreatment with ODQ (a guanylate cyclase inhibitor) or L-NAME (an inhibitor of nitric oxide synthase) did. In conclusion, CGRP inhibits pacemaker currents in ICC by generating nitric oxide via G-protein activation and so activating ATP-sensitive $K^+$ channels. Nitric oxide- and guanylate cyclase-dependent pathways are involved in these effects.