• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.1-7
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• 2010

Since the introduction of the biopharmaceutics classification system (BCS) in 1995, it has viewed as an effective tool to categorize drugs in terms of prediction for bioavailability (BA) and bioequivalence (BE). The BCS consist of four drug categories: class I (highly soluble and highly permeable), class II (low soluble and highly permeable), class III (highly soluble and low permeable) and class IV (low soluble and low permeable), and almost all drugs belong to one of these categories. Likewise, classifying drugs into four categories according to their solubility and permeability is simple and relatively not controversial, and thus the FDA adopted the BCS as a science-based approach in establishing a series of regulatory guidance for the industry. Actually, many pharmaceutical companies have gained a lot of benefits, which directly connect to cost loss and failure decrease in the early stage of drug development. Recently, instead of solubility, using dissolution characteristics (e.g. intrinsic dissolution rate) have provided an improvement in the classification in correlating more closely with in vivo drug dissolution rather than solubility by itself. Furthermore, a newly modified-version of BCS, biopharmaceutics drug disposition classification system (BDDCS), which classify drugs into four categories according to solubility and metabolism, has been introduced and gained much attention as a new insight in respect with the drug classification. This report gives a brief overview of the BCS and its implication, and also introduces the recent new trend of drug classification.

• Journal of Korean Society of Rural Planning
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• v.20 no.2
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• pp.127-137
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• 2014

Self-sufficiency rate of food in South Korea is almost at the lowest level among OECD countries, and the decrease tend of farmland is expected to be continued. In this situation, the government has been revised the target self-sufficiency rate of food, and carried forward various policies in order to achieve it. One of those policies is the restoration business of idle farmland which is planned to carry forward after 2015. This study set up indicators evaluating effective use of idle farmland, and tried to apply in the field before carrying forward restoration business. The result of this study may be summarized as follows. First of all, it reset an evaluation indicator that was based on the evaluation indicator developed in order to set application directions of idle farmland. Next, it selected 30 idle farmlands with reset evaluation indicator among 11,635 which were inspected nationwide in 2012. Before applying indicator, it measured the condition of recycling such as accessibility of farmland, condition of irrigation and drainage system, land state, and surroundings by field investigation. Then, it calculated composite score in each target area through applying indicators, and verified the indicator by comparing calculated result with the one which was decided from field investigation. Finally, it carried out field investigation, correct and upgrade some problems of the standard of score calculation that was found during applying previously set evaluation indicator to target area, and established the final standard of calculation for evaluation indicator.

• Journal of Korean Society of Steel Construction
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• v.25 no.5
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• pp.579-585
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• 2013

Shear buckling stresses of steel pipes due to the lateral forces have been analyzed via parametric analysis. Detailed FEM models are prepared, and steel types, thickness, radii and length of steel pipes are selected as parameters. STK400, STK490 and SM570 are used and the thickness of pipe is 2mm and 40mm. The radii(R) and lengths(L) are determined based on the values satisfying the following relationship as R/t=20~400 and L/R=1~3. The shear buckling stresses decrease for all types of considered steels as R/t increase from 20 to 200. High strength steels are more sensitive to R/t, and also have an bigger effect on shear buckling stresses than low strength steels. It is found that shear buckling stresses decrease as L/R increases, showing that the steel pipes become weak as the length of the steel pipe increases.

• International Journal of Industrial Entomology and Biomaterials
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• v.31 no.2
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• pp.79-84
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• 2015

A new cecropin-like antimicrobial peptide (Px-CLP) gene was isolated from the immunechallenged larvae of the swallowtail butterfly, Papilio xuthus, by employing annealing control primer (ACP)-based GeneFishing PCR. The full-length cDNA of Px-CLP is 310 nucleotides encoding a 70 amino acid precursor that contains a putative 22-residue signal peptide, a 4-residue propeptide, a presumed 37-residue mature peptide, and an uncommon 7-residue acidic pro-region at the C-terminus. The deduced amino acid sequence of Px-CLP showed significant identities with other Lepidopteran cecropin D type peptides. RT-PCR revealed that the Px-CLP transcript was detected at significant level after injection with bacterial lipopolysaccharide (LPS). The peptides with or without C-terminal acidic sequence region were synthesized on-solid phage and submitted to antibacterial activity assay. The synthetic 37-mer peptide (Px-CLPa), which removed C-terminal acidic sequence region, was showed exclusively antibacterial activity against E. coli ML35; meanwhile, a 44-mer peptide (Px-CLPb) with C-terminal acidic peptide region was not active. This result suggests that Px-CLP is produced as a larger precursor containing a C-terminal pro-region that is subsequently removed by C-terminal modification.

• Radiation Oncology Journal
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• v.12 no.3
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• pp.369-376
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• 1994

This is a retrospective analysis of 64 patients who was treated with postoperative radiation therapy after radical hysterectomy and bilateral pelvic lymphadenectomy (53 patients) or total abdominal hysterectomy(11 patients) for uterine cervix cancer between May 1980 and September 1991 at the Department of Radiation Oncology, Kyung Hee University Hospital. Most patients were FIGO IB (31 Patients) and IIA (25 patients), and median period of follow-up was 5.1 years. Of these patients,24 received adjuvant whole pelvis irradiation of 6000 cGy and 40 received 5000-5500 cGy whole pelvis irradiation and/or intracavitary radiation (7 Patients). The actuarial overall and relapse free 5 year survival rate were $71.0\%$, $68.3\%$ respectively. The survival rates by stage were $79.1\%$ in stage I, and $61.2\%$ in stage II. Treatment failure was noted in 18 of 64 patients ($28.1\%$), Iocoregional failure in 8 ($12.5\%$), distant metastasis in 8 ($12.5\%$), paraaortic node metastasis in 1 and one patient and concurrent locoregional and distant metastasis. The univariate analysis of prognostic factors affecting to overall survival rate represented lymph node status, the number and site of metastatic lymph node, parametrial invasion, the thichness of cervical wall invasion, and size of cancer mass. Histology, vessel invasion, endometrial extension, hemoglobin level. resection margin status, age, radiation dose were not significant prognostic factors. Complication relating to operation and postoperative radiation were variable according to radiation therapy method: 6000 cGy RT group 8/24($33.3\%$), 5000-5500 cGy+ICR 3/7 ($42.9\%$), 5000-5500 cGy external RT only group 3/33 ($9.1\%$). In conclusion, the results suggest that postoperative radiotherapy is necessary in high risk patients for locoregional control and improving survival rate, and higher dose does not improve results but only increases complication.

• Journal of Sensor Science and Technology
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• v.29 no.5
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• pp.360-364
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• 2020

In this study, the colorimetric sensor, polyester (PET) fabric dyed with lead (II) acetate (Pb(C₂H₃O₂)₂), was fabricated and characterized for the detection of the hydrogen sulfide (H₂S). The surface morphology of the fabric was determined using scanning electron microscope and energy-dispersive X-ray spectroscopy. The optical properties of the fabric were evaluated by measuring the variation in the blue value of an RGB sensor. The fabric showed a significant color change, high linearity (R² : 0.98256), and fast response time (< 1.0 s) when exposed to H₂S. This is because the sensor is highly porous and permeable to the gas. The fabric can not only be used as a hydrogen sulfide sensor but also be used to detect and prevent H₂S influx using sticky tape on pipelines.

• Korean Journal of Psychosomatic Medicine
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• v.4 no.1
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• pp.3-12
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• 1996

Objects : This study was attempted to evaluate the body image and the self concept in high risk adolescents for eating disorders. Methods 589 middle school students were investigated with EAT(Eating Attitude Test) and BITE(Bulimic Investigatory Test Edinburgh) and Schematic Figures(Child/Adolescent Version) and Piers-Harris Self-Concept Scale. According to the score of EAT and BITE, three high risk groups(high EAT group, high BITE group, high EAT & BITE group) were identified. Three groups were examined in terms of sex, weight, self concept and body image. Each group was EAT group, BITE group, EAT & BITE group Results: The results of the study were as follows : 1) EAT & BITE group showed greatest body image distortion. 2) BITE group and EAT & BITE group showed lower score in self concept scale. 3) The majority of EAT group were boys, BITE group and EAT & BITE group were mostly girls. 4) All three high risk groups, especially Bin group, revealed overweight compared with normal control group. Conclusions : High BITE group and high EAT & BITE group could be considered as significantly high risk groups for eating disorders, showing overweight, severe body image distortion, and poor self concept. EAT score alone seemed not to discriminate high risk adolescents for eating disorders.

• Journal of the Korean Society for Advanced Composite Structures
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• v.6 no.2
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• pp.52-62
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• 2015

This study aims at developing a new seismic resistant method by using precast concrete wall panels for existing low-rise, reinforced concrete beam-column buildings such as school buildings. Three quasi-static hysteresis loading tests were performed on one unreinforced beam-column specimen and two reinforced specimens with U-type precast wall panels. Top shear connection of the PC panel was required to show the composite strength of RC column and PC wall panel. However, the strength of the connection did not influence directly on the ultimate loading capacities of the specimens in the positive loading because the loaded RC column push the side of PC wall panel and it moved horizontally before the shear connector receive the concentrated shear force in the positive loading process. Under the positive loading sequence(push loading), the reinforced concrete column and PC panel showed flexural strength which is larger than 97% of the composite section because of the rigid binding at the top of precast panel. Similar load-deformation relationship and ultimated horizontal load capacities were shown in the test of PR1-LA and PR1-LP specimens because they have same section dimension and detail at the flexural critical section. An average of 4.7 times increase in the positive maximum loading(average 967kN) and 2.7 times increase in the negative maximum loading(average 592.5kN) had resulted from the test of seismic resistant specimens with anchored and welded steel plate connections than that of unreinforced beam-column specimen. The maximum drift ratios were also shown between 1.0% and 1.4%.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.3
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• pp.558-564
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• 2016

The network interference gives positive and negative effects to security and QoS simultaneously by disturbing the decoding of receiver and eavesdropper. The transmission of artificial noise enables to indirectly control these contradicting effects. This paper proposed the secrecy enhancement technique via artificial noise with protected zones of transmitter and receiver and investigated its gain by using stochastic geometry. For given arbitrary artificial noise power ratio, we first analyzed connection outage probability and secrecy outage probability for four different scenarios (separated, overlapped, included secrecy protected zones- type A, B) according to distance and size of protected zones of the transmitter and receiver. We then derive the secrecy transmission rate and find the optimal artificial noise power ratio to maximize it. Finally, with numerical examples, we investigate the effects of the system parameters such as size of protected zones of transmitter and receiver on the optimal artificial noise power ratio.

• The korean journal of orthodontics
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• v.46 no.6
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• pp.372-378
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• 2016

Objective: The purpose of the present study was to evaluate the postoperative three-dimensional (3D) changes in the proximal segments after mandibular setback sagittal split ramus osteotomy and to compare the changes between the conventional mini-plate fixation and semi-rigid sliding plate fixation. Methods: Cone-beam computed tomography (CBCT) images were used to evaluate the postoperative 3D changes in the proximal segments during the healing process. CBCT images were superimposed using the symphysis and the lower anterior mandible as references. Results: There were no statistically significant differences between the conventional mini-plate and semi-rigid sliding plate groups (p > 0.05). With respect to the distribution of changes greater than 2 mm in the landmarks, the right condylion, right coronoid process, and left condylion showed ratios of 55.6%, 50.0%, and 44.4%, respectively, in the semi-rigid sliding plate group; however, none of the landmarks showed ratios greater than 30% in the conventional mini-plate group. Conclusions: There were no statistically significant differences in postoperative changes in the segments between the conventional mini-plate and semi-rigid sliding plate groups. Nevertheless, while selecting the type of fixation technique, clinicians should consider that landmarks with greater than 2 mm changes were higher in the semi-rigid sliding plate group than in the conventional mini-plate group.