• Title/Summary/Keyword: Sensitivity test

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A Study of Analytical Sensitivity on TDM Test Kit in Clinical Chemistry (약물검사 키트의 분석 민감도에 대한 연구)

  • Chang, Sang Wu;Kim, Nam Yong;Lee, Hee Gyung;Kim, Hyun Jung;Lee, Yun Jung;Jin, Ok Bae;Kim, Mi Gyung
    • Korean Journal of Clinical Laboratory Science
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    • v.36 no.2
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    • pp.127-130
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    • 2004
  • Analytical sensitivity on TDM test is the lowest concentration that can be distinguished from background noise. The aim of study was to evaluate analytical sensitivity that is also referred to as the lower limit of detection(LLD) about difference between zero calibrator and isotonic saline sample. We tested for 10 days with zero calibrators and 0.85% saline samples while running trilevel control samples under control. Raw data divided by two groups calculated mean and standard deviation from two sample populations and analytical sensitivity by ${\bar{X}}+2SD$. In comparison with isotonic saline samples and zero calibrators, there were significant differences in phenytoin, phenobarbital and vancomycin, etc. Especially analytical sensitivity on phenytoin is at the same level as the upper limit of analytical measurement range with $40{\mu}g/mL$. We think the cause of this is matrix interference. In conclusion, we were sure that standard protocol for analytical sensitivity as lower limit of analytical measurement range on TDM test must be measured with zero standard rather than an isotonic saline sample and type 1 reagent DW for reducing matrix effects within interactions between different materials in a mixture.

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Brand Sensitivity and Public Self-Consciousness among Fashion Consumers (패션 소비자들의 브랜드 민감성과 공적 자기의식에 관한 연구)

  • Lee, Seung-Hee
    • Journal of Fashion Business
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    • v.14 no.4
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    • pp.102-110
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    • 2010
  • The purposes of this study were to examine the relationship between brand sensitivity and public self-consciousness, and the effects of gender and age on brand sensitivity and public self-consciousness. The subject used for this study were three hundred and thirty-five college students (118 male students and 217 female students). For data analysis, descriptive statistics, Cronbach's alpha, multiple regression, and t-test were used. As the results, first, there were the significant differences between male students and female students on brand sensitivity and public self-consciousness. Female students had higher scores on brand sensitivity and public self-consciousness than male students as expected. Second, there were the significant differences between younger college students and older college students on brand sensitivity and public self-consciousness. Older college students had higher scores on brand sensitivity and public self-consciousness than younger college students. Finally, public self-consciousness influenced on brand sensitivity the most significantly, followed by age variable. Based on these results, brand management marketing strategy of fashion products would be provided.

Potential of Marine Ciliate Mesodinium rubrum as a Standard Test Species for Marine Ecotoxicological Study (해양생태독성 평가용 표준시험생물로서 섬모충류 Mesodinium rubrum에 대한 연구)

  • An, Kyoung-Ho;Park, Gyung-Soo;Lee, Seung-Min
    • Journal of Environmental Science International
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    • v.20 no.9
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    • pp.1087-1093
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    • 2011
  • The mixotrophic marine ciliate Mesodinium rubrum possesses a highly modified algal endosymbiont as a nutrition source for the species. Accordingly, we assumed that the species can reflect the ecotoxicity on marine producer (as phytoplankton) and consumer (as zooplankton) both. A series of experiments were conducted to identify the potential of the species as a standard test species for marine ecotoxicological study. The comparison of species sensitivity on reference toxic materials was made using potassium dichromate for phytoplankton and copper chloride for zooplankton. The ciliate revealed the highest sensitivity on both reference materials among the seven test species including phytoplankton, benthic copepod and rotifer species. The toxicity end point of the species was 72hr-$EC_{50}$=1.52 mg/L (as potassium dichromate) estimated by population growth inhibition (PGI), which is more sensitive than the most sensitive phytoplankton Skeletonema costatum (72hr-$EC_{50}$=3.05 mg/L). As comparison to rotifer, it also revealed higher sensitivity on copper chloride; 72hr-$EC_{50}$=0.38 mg/L for ciliate and 48hr-$EC_{50}$=0.48 mg/L for rotifer. Also, the elutriate toxicity test of various ocean disposal wastes were conducted to identify the potential of ciliate toxicity test application using industrial waste sludges. The toxicity of leather processing waste sludge was highest on the ciliate, followed by dyeing waste sludge and dye production waste sludge as an increasing order of toxicity. 72h-$EC_{50}$ of ciliate PGI test was 1.83% and that of S. costatum 3.84% for leather waste sludge which showed highest toxicity. The toxicity test results also revealed that the highest sensitivity was observed on ciliate species on ocean disposed sludge wastes. Also, ciliate toxicity test well discriminated the degree of toxicity between sludge sources; 72h-$EC_{50}$ values were 1.83% for leather processing waste sludge, 16.75% for dye production waste sludge and 27.75% for textile production waste sludge. Even the laboratory culture methods of the species were not generally established yet, the species has high potential as the standard test species for marine toxicity test in terms of the dual reflection of phyto- and zooplankton toxicity from single test, sensitivity and test replicability.

The Diagnostic Usefulness of Endoscopic Findings and Detection Rates of CLO and HpKit Test for Helicobacter pylori Infection in Children (소아의 Helicobacter pylori 감염에 있어서 위내시경 소견의 진단적 의의와 CLO 및 HpKit 검사의 검출률)

  • Lee, Seung Yeon;Yoo, Ji Hyung;Chung, Ki Sup
    • Clinical and Experimental Pediatrics
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    • v.45 no.4
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    • pp.482-488
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    • 2002
  • Purpose : We performed this study to evaluate the diagnostic usefulness of endoscopic finding of nodular gastritis, CLO and HpKit test for H. pylori infection in children. Methods : Gastroduodenal endoscopy and mucosal biopsy were performed on 212 children who visited our hospital between Jul. 1999 and May 2000 due to abdominal pain. We performed CLO and HpKit test for H. pylori with the time interval of 15, 30 minutes, 1, 2, 3, 24, 48, 72, 96, 120 and 144 hours. Histological examination of H. pylori was made by H-E or Alcian yellow stain with biopsy specimens. Sensitivity, specificity, positive predictive and negative predictive value of nodular gastritis, CLO and HpKit test were calculated from the analysis of above data. Results : Sensitivity and specificity of 3 hour-CLO test was 68.4% and 100% respectively. Sensitivity and specificity of 3 hour-HpKit test was 65.8% and 100% respectively. No significant difference in sensitivity and specificity was found between in 3 hour-CLO and HpKit test(P>0.05). Sensitivity of CLO test increased as time lapsed, but corresponding specificity did not decrease as time lapsed(sensitivity and specificity at 144 hours : 89.5% and 94.8% respectively). However, sensitivity of HpKit test increased as time lapsed, but specificity markedly decreased. Sensitivity and specificity of the nodular gastritis was 78.9% and 93.7% respectively. Conclusion : Both CLO and HpKit test have relatively low sensitivity and specificity for the detection of H. pylori in 3 hours of testing in children. The endoscopic finding of nodular gastritis is another good standard in the diagnosis of H. pylori infection in children.

Developing and Utilizing of a Social Workers' Ethical Sensitivity Test(SWEST) (사회복지사 윤리적 민감성 검사도구(SWEST) 개발 및 활용에 관한 연구)

  • Choi, Myung-Min
    • Korean Journal of Social Welfare
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    • v.60 no.2
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    • pp.5-28
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    • 2008
  • This study tried to develop an test tool of social workers' ethical sensitivity(SWEST) on base of realization about the importance of ethical sensitivity of social worker who are required more ethicalities than the other professionals. Nevertheless, there has been no tool that can measure ethical sensitivity of social workers in our country up to now. Through analysis of existing ethical sensitivity tests in other professions, a paper and pencil method about unstructured question with cases including ethical issues and structured scoring system was chosen as an appropriate method for the SWEST. This study progressed in order : 1st collecting cases, 2nd composing cases, 3rd consulting cases, 4th pilot study, 5th making scoring standards, 6th determining case examples and scoring standards. With the result, the tool consists of 3 case examples with ethical issues : 1) self-determination and confidentiality, 2) equality and double relationship, 3) informed consent and conflict interest. And ethical sensitivities of social work major students and social workers were measured with the SWEST, to see practical utility of this test. The agreement degrees between two independent raters were above 90%. And respondent's ethical sensitivity displayed the most definite difference according to taking or not taking a course 'Social work values and ethics'. Through these results, it can be drawn that the SWEST is reliable and valid to test relevant differences in Korean social workers' ethical sensitivity. The SWEST is expected to activate studying, educating, and practicing ethics in social work.

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Improvement of Sensitivity to In-plane Strain/Deformation Measurement by Micro-ESPI Technique (마이크로 ESPI 기법에 의한 면내 변형 측정 민감도 향상)

  • Kim D.I.;Huh Y.H.;Kee C.D.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.06a
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    • pp.1442-1445
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    • 2005
  • Several test methods, including micro strain/deformation measurement techniques, have been studied to more reliably measure the micro properties in micro/nano materials. Therefore, in this study, the continuous measurement of in-plane tensile strain in micro-sized specimens of thin film materials was introduced using the micro-ESPI technique. TiN and Au thin films 1 and $0.47\;\mu{m}$ thick, respectively, were deposited on the silicon wafer and fabricated into the micro-sized tensile specimens using the electromachining process. The micro-tensile loading system and micro-ESPI system were developed to measure the tensile strain during micro-tensile test. The micro-tensile stress-strain for these materials was determined using the algorithm for continuous strain measurement. Furthermore, algorithm for enhancing the sensitivity to measurement of in-plane tensile strain was suggested. According to the algorithm for enhancement of sensitivity, micro-tensile strain data between interfringe were calculated. It is shown that the algorithm for enhancement of the sensitivity suggested in this study makes the sensitivity to the in-plane tensile strain increase.

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A study on the strain rate sensitivity according to the temperature for steel sheets of an auto-body (차체용 강판의 온도에 따른 변형률 속도 민감도 연구)

  • Lee H. J.;Song J. H.;Cho S. S.;Kim S. B.;Huh H.;Park S. H.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2005.10a
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    • pp.148-151
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    • 2005
  • This paper is concerned with the thermo-mechanical behavior and temperature dependent strain rate sensitivity of steel sheet for an auto-body. In order to Identify the temperature dependent strain rate sensitivity of SPRC35R and SPRC45E, uniaxial tension tests are performed with the variation of the strain rates from 0.001/sec to 200/sec, and the variation of environmental temperatures from $-40^{\circ}C\;to\;200^{\circ}C$. The thermo-mechanical response at the quasi-static state is obtained with the static tensile test and at the intermediate strain rate is from the high speed tensile test. The experimental results show that the strain rate sensitivity increases at low temperature and it decreases at high temperature. It means that as the strain rate getting increasing, the variation of flow stress is more sensitive on the temperature. The results also indicates that the material properties of SPRC35R is more depend on the changes of strain rates and temperature than those of SPRC45E.

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A Study on the Strain-Rate Sensitivity According to the Temperature for Steel Sheets of an Auto-Body (차체용 강판의 온도에 따른 변형률속도 민감도 연구)

  • Lee, H.J.;Song, J.H.;Cho, S.S.;Park, S.H.;Huh, H.
    • Transactions of Materials Processing
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    • v.15 no.2 s.83
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    • pp.132-137
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    • 2006
  • This paper is concerned with the thermo-mechanical behavior including temperature dependent strain-rate sensitivity of steel sheet for an auto-body. In order to identify the temperature dependent strain-rate sensitivity of SPRC35R and SPRC45E, uniaxial tension tests are performed with the variation of the strain-rates from 0.001 /sec to 200 /sec at environmental temperatures varied from $-40^{\circ}C\;to\;200^{\circ}C$. The thermo-mechanical response at the quasi-static state is obtained with the static tensile test and at the intermediate strain-rate is from the high speed tensile test. Experimental results show that the strain-rate sensitivity increases at low temperature. It represents that as the strain-rate increases, the variation of flow stress becomes sensitive on the temperature. The results indicate that the flow stress of SPRC35R is more dependent on the changes of strain-rate and temperature than those of SPRC45E.

A Characteristics of RF Sensitivity for a Firing Fuse (기폭용 퓨즈의 RF 감도 특성)

  • 간종만;권준혁
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.15 no.6
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    • pp.573-578
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    • 2004
  • EED consists of bridgewire, explosive charge, lead pins and metal case. If a firing signal is injected to EED, the explosive charge in EED is initiated by heating of bridgewire. Electromagnetic waves radiated from high power transmitters or radars can also cause unexpected firing of EED. Therefore, EMC design and test requirements for EED in military specifications are established and applied. This report describes the characteristics of RF sensitivity fur a firing fuse which is used fur EMC test instead of a real EED installed in aircraft. RF firing level of the fuse was predicted using transmission line(TL) theory. n sensitivity and RF sensitivity specified in military specifications were measured.

Verification of Reduced Order Modeling based Uncertainty/Sensitivity Estimator (ROMUSE)

  • Khuwaileh, Bassam;Williams, Brian;Turinsky, Paul;Hartanto, Donny
    • Nuclear Engineering and Technology
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    • v.51 no.4
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    • pp.968-976
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    • 2019
  • This paper presents a number of verification case studies for a recently developed sensitivity/uncertainty code package. The code package, ROMUSE (Reduced Order Modeling based Uncertainty/Sensitivity Estimator) is an effort to provide an analysis tool to be used in conjunction with reactor core simulators, in particular the Virtual Environment for Reactor Applications (VERA) core simulator. ROMUSE has been written in C++ and is currently capable of performing various types of parameter perturbations and associated sensitivity analysis, uncertainty quantification, surrogate model construction and subspace analysis. The current version 2.0 has the capability to interface with the Design Analysis Kit for Optimization and Terascale Applications (DAKOTA) code, which gives ROMUSE access to the various algorithms implemented within DAKOTA, most importantly model calibration. The verification study is performed via two basic problems and two reactor physics models. The first problem is used to verify the ROMUSE single physics gradient-based range finding algorithm capability using an abstract quadratic model. The second problem is the Brusselator problem, which is a coupled problem representative of multi-physics problems. This problem is used to test the capability of constructing surrogates via ROMUSE-DAKOTA. Finally, light water reactor pin cell and sodium-cooled fast reactor fuel assembly problems are simulated via SCALE 6.1 to test ROMUSE capability for uncertainty quantification and sensitivity analysis purposes.