• 제목/요약/키워드: Sensitivity Problem

검색결과 1,067건 처리시간 0.025초

Role of the HPV DNA Test in Follow-up of Treated Cervical Intraepithelial Neoplasia in Bangladesh

  • Nessa, Ashrafun;Rashid, Mohammad Harun Ur;Jahan, Munira;Ferdous, Noor-E;Nahar, Pervin Akhter Shamsun;Chowdhury, Afroza
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권19호
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    • pp.8063-8067
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    • 2014
  • Background: Cervical cancer is a major public health problem in Bangladesh. Persistence of high risk human papillomavirus (HRHPV) influences the progression of the disease, with an important role in followup for cervical intraepithelial neoplasia (CIN). Objective: To establish application of high risk HPV DNA test in the follow-up of women after treatment of CIN. Materials and Methods: This cross-sectional and hospital based study was carried out among 145 CIN treated women during the previous six months to three years at the colposcopy clinic of Bangabandhu Sheikh Mujib Medical University, Dhaka, between January 2011 and June 2012. Pap smear and HPV samples were collected and colposcopy was performed to find out the persistence of the disease. Cervical samples obtained were tested for HPV DNA using the Hybrid Capture II (HC-II) test. A cervical biopsy was collected whenever necessary. The results were compared to assess the efficacy of different methods during follow up such as Pap smear, HPV test and colposcopy. Results: Mean age of the recruited women (n=145) was 33.6 (${\pm}7.6$), mean age of marriage was 16.8 (${\pm}2.9$) and mean age of 1st delivery was 18.8 (${\pm}3.5$) years. More than half had high grade CIN before treatment and 115 (79.3%) women were managed by LEEP and 20.7% were managed by cold coagulation. Among the 145 treated women, 139 were negative for HPV DNA and six of them (4.1%) were HPV positive. Sensitivity of Pap smear (40.0) and HPV DNA test (40.0) was poor, but specificity was quite satisfactory (>93.0) for all the tests. Conclusions: The high risk HPV DNA test can be an effective method of identifying residual disease. It can be added to colposcopy and this should be applied to all treated women attending for their first or second post-treatment follow-up visit at 6 months to one year, irrespective of the grade of treated CIN.

전문대학생(專門大學生)의 정신건강(精神健康)과 사회적(社會的) 지지(支持)와의 관련성(關聯性) (Relationship between Mental health and Social Support of Junior College Students)

  • 김성영;차병준;박재용;감신
    • 한국학교보건학회지
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    • 제8권2호
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    • pp.277-291
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    • 1995
  • The study was designed to grasp the mental health of junior college students and identify the relation between mental health and social support. The subjects for this study were 781 sophomores attending T junior college in Taegu. The data were collected through questionnaire during the period from september 10,1993 to september 24, 1993. The results of this can be summarized as follows: In mental health the average mark was 1.94 on the basis of 5 marks. Those whose mark was more than 75% (low) had Depression(8.7%),Obsessive compulsive reaction(5.2%) Anxiety(3.6%). In social support, the average mark was 3.03 on the basis of 4 marks, which showed comparatively high support; relationship with friends was 75.4%, companionship was 75.4%, and mutual understanding was 72.3%. Many students got more than 75% in total marks. In the state of mental health, there was a significant difference depending on sex, total income, the character and the attitude toward his parents. There is also an unusual difference in social support depending on the major subjects, the character, the problem at present and the attitude toward his parents. In mental health, both male and female students got higher marks in Depression, Obsessive compulsive reaction than in any other item. In social support level all students had a high support in the relationship with friends and mutual understanding. Those who are affectionate to and dependent on their parents had a tendency to have better mental health. The simple correlation modules between social support mark and mental health one was -0.5555 and the partial correlation modules of controlling sex, age, growth place was -0.5557. There was little difference between them. In mental health items Interpersonal sensitivity was highest correlated with social support and Somatinization was lowest correlated. There was a significant correlation between mental health and social support: the higher social support were, the better mental health was. In conclusion, the study showed that the relationship between the social support and the mental health level revealed a significant correlation. In social support Expressive support (companionship support, mutual understanding support) showed a higher degree of support than instrumental support(monetary support, demand support). Therefore, in the guidance of students, it is necessary to expand expressive support considering these respects. Further multidimensional study is needed on how to improve the mental health of junior students through the social support.

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표본 추계학적 동적계획법을 사용한 한강수계 저수지 운영시스템 개발 (Reservoir Operating System Using Sampling Stochastic Dynamic Programming for the Han River Basin)

  • 음형일;박명기
    • 한국수자원학회논문집
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    • 제43권1호
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    • pp.67-79
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    • 2010
  • 한국수자원공사는 낙동강 및 금강수계에 대해 실시간 물관리 시스템을 개발하여 수계 내 다목적 댐의 효율적인 운영을 도모하였다. 본 연구에서는 이를 확장하여 최적화 기법인 표본 추계학적 동적계획법을 사용하여 한강수계 다목적댐의 효율적인 월말 목표저수량을 산정하고 이를 통해 실시간 물관리시스템의 효율을 극대화하고자 수행되었다. 수계 내 댐중 저수용량과 용수공급 측면에서 중요도가 높은 소양강댐, 충주댐, 화천댐 등 3개 댐만을 대상으로 모형을 개발하였으며 저수량 상태변수의 민감도 분석 결과를 통해 저수량 상태변수 개수를 설정하였다. 본 연구를 통해 제시된 최적화모형을 통한 운영률과 한국수자원공사의 운영목표수위에 의한 저수지 운영방식과 비교를 실시한 결과 연평균 37.22 MCM의 수계 내 요구용수 부족량 감소효과와 더불어 발전량 측면에서도 연간 171 GWh가 증가하는 것을 확인하였다. 또한 이수기 저수지 운영계획 시스템을 실제 적용한 결과 2007년~2008년 이수기 동안 전력생산, 수질개선 등을 위한 추가적인 용수공급이 가능하다는 것을 확인하였다. 이러한 실제 적용사례를 통해 SSDP 모형과 이수기 저수지운영 시스템의 그 유용성을 타진할 수 있었으며 다른 수계로 확장을 실시한다면 보다 합리적인 저수지 운영계획이 가능할 것으로 기대한다.

건강신념 및 효능기대증진 프로그램이 류마티스 관절염환자의 골다공증 예방행위에 미치는 영향 (The Effect of the Health Belief and Efficacy Expectation Promoting Program on Osteoporosis Preventive Health Behavior in Women with Rheumatoid Arthritis)

  • 이은남
    • 근관절건강학회지
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    • 제5권2호
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    • pp.174-190
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    • 1998
  • Osteoporosis has been known as a common complication of rheumatoid arthritis and a major preventable health problem. Lots of studios have demonstrated that changes in life style can help delay or prevent osteoporosis. Therefore nursing intervention related osteoporosis prevention have consisted of education programs aimed at changing dietary and exercise habit. However knowledge gained from education haven't always leaded to behavior change. Therefore it is important to consider other psychological variables in effecting behavior change. Numerous research have found self efficacy and health belief to be an important factor in individual decision making behavior. The purpose of the study was to develop health belief and efficacy expectation promoting program based on Health Belief Model & Self Efficacy Model and to investigate its effects in women with rheumatoid arthritis. For this purpose, one group pretest-post design was used. The subject of the study were 16 women with rheumatoid arthritis in Pusan city and data collection was carried out from April, 1997 to May, 1998. The intervention program was consisted of educating on osteoporosis and enhancing and reinforcing self efficacy by verbal persuasion during the period of 4 weeks. The instruments were used to collect data in this study were Osteoporosis Health Belief Scale, Osteoporosis Self Efficacy Scale, and Osteoporosis Preventive Behavior Scale. Data was analyzed by Wilcoxon signed rank test using SPSS $PC^+$ program. The results are as follows : 1) The behavior should be increased after intervention was supported(Z=-3.5162, p=.0004, diet : Z=-3.2942, p=.0010, exercise). 2) The sub-hypothesis that perceived sensitivity should be increased after intervention was supported (Z=-2.3854, p=.0171). 3) The sub-hypothesis that perceived severity should be increased after intervention was rejected(Z=-1.4327, p=.1520). 4) The sub-hypothesis that perceived benefit should be increased after intervention was supported(Z=-2.6410, p=.0083). 5) The sub-hypothesis that perceived barrier should be decreased after intervention was supported (Z=-2.4138, p=.0158). 6) The sub-hypothesis that efficacy expectation should be increased after intervention was supported(Z=-3.5162, p=.0004). As a conclusion, it was found that health belief and self efficacy promoting program was an effective nursing intervention for preventing osteoporosis of rheumatoid arthritis.

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성별에 따른 대학 내 성희롱에 관한 실태 및 인지도 분석 (Actual Condition and Sensitivity Analysis of Sexual Harassment in Campus by Gender)

  • 박옥임;김정숙;강희순
    • 한국지역사회생활과학회지
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    • 제15권3호
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    • pp.137-148
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    • 2004
  • The purpose of this study is to prevent and review counter-action for the sexual harassment in campus by revealing current state of sexual harassment in campus relatively weak in sexual discrimination with regard to sexual harassment emerged as social problem serious in our nation. The targets of study were students and assistants in three schools located at $Kwangju\cdot{Chonnam}$ area, a questionnaire made by pre-researcher was applied to student vs. assistant with regard to sexual consciousness and recognition, and current state of sexual harassment, with analysis of material processed through statistical analysis using SPSSWIN 10.0 for verification of $$\chi$^2$ for identification of difference vs. family and student vs. assistant. The result of this research with regard to sexual harassment is under following: Firstly, the recognition of concept of sexual harassment was proved to be aware of be more than half a responders above average, lack of recognition showed significant number requiring establishment of concept of sexual harassment, the responders stated that they could do it alone should be treated in the counseling room in school. Secondly, 28.7% of students and assistants answered that they have suffered from sexual harassment now and. before, even a great number of males have experienced such sexual harassment. In case of female assistants, more than half of them suffered from sexual harassment suggesting us significant level of sexual harassment to female assistants. A depth of sexual harassment to assistants should be investigated in a further way by preparing for and establishing concrete preventive actions and researches, mostly suffered by males; In this respect, a preventive training of sexual harassment should be deemed to be provided to males. Thirdly, as a result of investigation of sex education and preventive action against sexual harassment in college, most of elementary, junior, junior high school hardly provide no or inefficient sexual harassment, and they responded that the campus needs its education. As a way to educate campus with sexual harassment efficiently, a special lecture or regular class might be designed for systematic education or sexual harassment through schools counseling room might be effective emphasizing upon role of the room according to opinions of responders. The college is required to install such offices or centers as can exclusively manage and take charge of sex education program operation, legal system of anti-sexual harassment, or personnel arrangement for such activities in school by reflecting such result into school for appropriate and efficient education of or counseling to sex.

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말기 암 환자에서 감염에 대한 항생제 사용 - 대한가정의학회 완화의학연구회 세미나에 기초한 - (Antibiotics Use in Infected Patients with Terminal Stage of Cancer - Based on Seminar of Korean Family Medicine Palliative Medicine Research Group -)

  • 정휘수;김대영;송경포;대한가정의학회 완화의학연구회;서상연
    • Journal of Hospice and Palliative Care
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    • 제10권1호
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    • pp.43-47
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    • 2007
  • 말기 암 환자에서 감염에 대한 항생제 사용은 의학적 문제에 대해 해결해야 하는 의무와 임종을 앞둔 시점에 생명 연장으로 인한 환자의 고통증가에 대한 부담으로 명확하게 결정하기 어려운 문제이다. 대한가정의학회 완화의학연구회 세미나에서는 65세 남자환자로 직장암 말기에 악취를 동반한 광범위한 피부감염증으로 입원 후 국소 항생제 치료로 증상 호전 중 임종을 맞이한 증례를 토의하였고, 이를 통해 말기 암 환자에서 항생제 치료에 대한 문헌고찰과 토론 후 다음과 같이 의견을 제시하고자 한다. 항생제 치료 목적에 있어 증상조절을 고려해야 하며, 특히 요로계 감염이 있는 경우는 증상조절을 위해 항생제를 사용한다. 또한 감수성 검사를 통해 적절한 항생제를 처방해야 한다. 무엇보다도 우선적으로 고려되어야 할 점은 환자입장에서 무엇이 가장 득이 되는지를 생각하고, 항생제 사용에 대해 환자와 가족들의 의견을 존중하여 판단하며, 환자나 가족이 적극적으로 치료를 요구하는 경우에는 치료로 인한 득실에 대해 환자와 토의를 한 후 사용한다.

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근로자 건강진단시 간기능 이상자의 정밀검사항목 개선을 위한 조사연구 (A Baseline Study on the Choice of Optimal Screening Test Items among Workers with Abnormal Liver Function Tests on Workers' Periodic Health Examination)

  • 정해관;임현술;김규회
    • Journal of Preventive Medicine and Public Health
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    • 제27권4호
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    • pp.747-761
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    • 1994
  • Workers' periodic health examination is the main tools used to manage the health problems of most workers in Korea. The most common health problem found in workers' periodic health examination is liver disorder. Liver disorder is also one of the most common health problems in general population and one of the leading causes of mortality in adult population. Regulation proposed by government (No. 207, Ministry of Labor, 1992) defines the criteria for selection of workers with the liver dysfunction for further evaluative examination and the examination items used for diagnosis of the workers with liver dysfunction. This study was designed to evaluate the proficiency of each examination items presently defined in Regulation and propose the optimal examination items for detection of the liver disorders found by workers' periodic health examination. Study subjects are 186 workers with abnormal liver function tests in screening examination of workers' periodic health examination. Questionnaire survey including past history of liver disorder, drinking history, height and weight was done. Physical examination by physician, routine test items defined by Regulation (SGOT, SGPT, $\gamma$-GTP, protein, albumin, total and direct bilirubin, alkaline phosphatase, $\alpha$-feto protein, HBsAg and anti-HBs), anti-HCV antibody test and liver ultrasonography were done. Results are as follows; 1. Result of evaluative examination utilizing only the items defined in Regulation was; There were 75 workers with suspected live. disorder(40.3%), 63 with no liver dysfunction (33.9%), 13 with suspected hepatitis B(7.0%), 10 workers with hepatitis B(5.4%), 10 workers with hepatitis B carrier state(5.4%), 10 with alcoholic liver disorders(5.4%), 5 with fatty liver(2.7%). When alternative diagnostic criteria applying additional examination items (drinking history, body mass index, anti-HCV antibody and ultrasonography) diagnosability of liver disorder was increased. When all four items were included, final results were; 23 workers (17.8%) with hepatitis B (10 carriers, 13 suspects and 10 hepatitis B), 10 (5.4%) with hepatitis C(4 carriers, 5 suspects and 1 hepatitis C), 13(7.0%) with alcoholic liver disorder, 45(24.2%) with fatty liver (40 suspects, 5 fatty liver), 410%) with suspected liver disorders and 44 (23.7%) with normal liver. 2. Of examination items defined by Regulation, only SGOT, SGPT, $\gamma$-GTP and HBsAg were significantly different in abnormal rate and mean value, and all other laboratory findings did not showed significant difference between two groups. Drinking history, body mass index and anti-HCV antibody test which are the items that authors included in this study, also showed significant difference between two groups. Utilization of body mass index (BMI) for abnormal liver function group in diagnosis of fatty liver had high specificity (97.6%) but sensitivity (22.3%) was low. Therefore we suggest that SGOT, SGPT, $\gamma$-GTP, HBsAg, alcohol drinking history, BMI and anti-HCV Ab were useful for diagnosis of liver disorders among worker's periodic health examination.

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Kastle-Meyer(KM) test의 위양성 반응과 시약 적용 방법에 관한 연구 (A study on the false-positive reaction of Kastle-Meyer(KM) test and the application of KM reagent)

  • 김채린;김창용;김민영;유제설
    • 한국융합학회논문지
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    • 제11권10호
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    • pp.139-146
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    • 2020
  • Kastle-Meyer (KM) test는 현장에서 잠재혈흔을 확인하는 예비검사 방법으로, 다른 방법에 비해 감도가 뛰어난 반면, 혈액이 존재하지 않는 곳에서도 위양성 반응이 나타날 수 있다. 본 연구에서는 이러한 KM test의 위양성 반응의 문제를 해결하기 위해 새로운 적용 방법을 제시하고자 하였다. 새로운 KM test 적용 방법의 효과와 위양성의 식별 가능성을 확인하기 위해 기존의 두 가지 KM test 적용 방법과 반응 시간 및 양상을 비교하였다. 실험 결과, 실험에 사용된 KM test 적용 방법 간의 감도에는 유의한 차이가 없었으며, 희석비율이 5000:1 이하인 혈액에서는 즉시 양성반응이 나타나 위양성과 구분하기 용이했다. 하지만 혈액의 희석비율이 높아질수록 양성 반응의 발현 시간이 늦어지면서 위양성과 구분하기 어려웠고, 새로운 KM test 적용 방법은 반응의 양상을 통해 이를 보완할 수 있었다. 따라서 본 연구는 KM test가 현장에서 보다 정확하게 사용될 수 있도록 새로운 적용 방법을 제시하였다.

키값 동기된 혼돈계를 이용한 IoT의 보안채널 설계 (IoT Security Channel Design Using a Chaotic System Synchronized by Key Value)

  • 임거수
    • 한국전자통신학회논문지
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    • 제15권5호
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    • pp.981-986
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    • 2020
  • 사물인터넷은 장소나 시간에 제약 없이 센서와 통신 기능이 내장된 사물이 사람과 사물에 상호 작용이 가능하도록 구성된 사물 공간 연결망을 말한다. IoT는 인간의 편의를 위한 서비스 목적으로 개발된 연결망이지만 현재는 전력전송, 에너지관리, 공장자동화와 같은 산업 전반에 그 사용범위가 확대되고 있는 상태이다. 그러나 IoT의 통신프로토콜인 MQTT는 푸시 기술 기반의 경량 메시지 전송 프로토콜로 보안에 취약함을 갖고 있고 이것은 개인정보 침해나 산업정보 유출 같은 위험성이 내재되어 있다고 할 수 있다. 우리는 이런 문제점을 해결하기 위해 경량 메시지전송 MQTT 프로토콜에 서로 다른 혼돈계가 임의의 값으로 동기화되는 특성을 이용하여 보안 채널을 생성하는 동기화 MQTT 보안 채널을 설계하였다. 우리가 설계한 통신 채널은 혼돈 신호의 난수 유사성, 초기치 민감성, 신호의 재생산성과 같은 특성을 이용한 방법으로 잡음 채널에 정보를 전송하는 방법이라고 할 수 있다. 우리가 제시한 킷값으로 동기화된 암호화 방법은 경량 메시지 전송 프로토콜에 최적화된 방법으로 IoT의 MQTT에 적용된다면 보안 채널 생성에 효과적이라고 할 수 있다.

상박위(上膊圍)에 의(依)한 성장기(成長期) 아동(兒童)에 영양상태(營養狀態)의 판정(判定)에 관(關)한 연구(硏究) (A Study on the Nutritional Assessment of Early Childhood Using Mid-Upper-Arm Circumference)

  • 채범석;남롱강;정영진
    • Journal of Nutrition and Health
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    • 제8권4호
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    • pp.9-14
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    • 1975
  • Growth retardation and a variable degree of body disproportion are recognized features of malnutrition, and mild and moderate protein-calorie malnutrition(PCM). Among the various body measurements suggested to assess the prevalence of all grades of PCM as judged by growth retardation and by body disproportion, the 'mid-upper-arm circumference'-abbreviated to 'arm-circumference' has been suggested as a potential useful simple field index for the assessment of PCM showing that the measurement would give composite information simultaneously on three important effects on PCM-deficit in the muscle protein reservoirs, availability of calorie stores in the form of subcutaneous fat, and growth failure. And this is selected because of its easy accessibility, and less involvement with clinical edema. This study is conducted to make a comparison between the percentage of Korean weight for age standards and the percentage of mid-upper-arm circumference for age standards of 175 preschool children aged $3{\sim}72$ months who are selected among the low-income residents in Seoul. In this study, a comparison is made between the results obtained by expressing the observed weight of the child as a percentage of Korean standard, referred to as 'weight-for-age' and the observed arm-circumference expressed as a percentage of the age-specific arm standard of Jelliffe, referred to as 'arm-for-age'. All the measurements were taken following the techniques described by Jelliffe. The left mid upper arm was measured using a glass-fibre tape and the Fairbanks Morse beam balance was used for weighing. 80% level of weight for age Korean standard and 85% level of arm for are Jelliffe standard were used as an upper borderline limit for PCM. Comparing the 80% weight-for-age and the 85% arm-for-age standard as an upper limit for PCM, for children aged $3{\sim}72$ months, results in 84.6% agreement with the sensitivity of 86.4% and its specificity of 83.5%. If arm circumference alone had been measured and judgement made on this basis, then only 5.1% of the children would have been 'wrongly' classified. And there is a moderately close correlation between arm circumference and weight for age as the data in Table 4 shows. The problem therefore lies in the standard for arm circumference in normal children and in determining what is the lower limit of normal. Once this is clearly difined, one can rely more confidently on arm circumference measurements alone for the nutritional assessment of early childhood.

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