• The Journal of Korea Robotics Society
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• v.15 no.4
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• pp.309-315
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• 2020

This study shows a control strategy that acquires both precision and manipulation sensitivity of remote center motion with manual traction for a surgical assistant robot. Remote center motion is an essential function of a laparoscopic surgical robot. The robot has to keep the position of the insertion port in a three-dimensional space, and general laparoscopic surgery needs 4-DoF (degree-of-freedom) motions such as pan, tilt, spin, and forward/backward. The proposed robot consists of a 6-axis collaborative robot and a 2-DoF end-effector. A 6-axis collaborative robot performs the cone-shaped trajectory with pan and tilt motion of an end-effector maintaining the position of remote center. An end-effector deals with the remaining 2-DoF movement. The most intuitive way a surgeon manipulates a robot is through direct teaching. Since the accuracy of maintaining the remote center position is important, direct teaching is implemented based on position control in this study. A force/torque sensor which is attached to between robot and end-effector estimates the surgeon's intention and generates the command of motion. The predefined remote center position and the pan and tilt angles generated from direct teaching are input as a command for position control. The command generation algorithm determines the direct teaching sensitivity. Required torque for direct teaching and accuracy of remote center motion are analyzed by experiments of panning and tilting motion.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.10a
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• pp.221-224
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• 2012

This paper presents a CMOS interface circuit for MEMS acceleration sensor. It consists of a capacitance to voltage converter(CVC), a second-order switched-capacitor (SC) integrator and comparator. A bandgap reference(BGR) has been designed to supply a stable bias to the circuit and a ${\Sigma}{\Delta}$ Modulator with chopper - stabilization(CHS) has also been designed for more suppression of the low frequency noise and offset. As a result, the output of this ${\Sigma}{\Delta}$ Modulator increases about 10% duty cycle when the input voltage amplitude increases 100mV and the sensitivity is x, y-axis 0.45v/g, z-axis 0.28V/g. This work is designed and implemented in a 0.35um CMOS technology with a supply voltage of 3.3V and a sampling frequency of 3MHz sampling frequency. The size of the designed chip including PADs is $0.96mm{\times}0.85mm$.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.34 no.6
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• pp.83-91
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• 2006

An advanced method of Relaxed Static Stability (RSS) is utilized for improving the aerodynamic performance of modern version supersonic jet fighter aircraft. The flight control system utilizes RSS criteria in longitudinal axis to achieve performance enhancements and improve stability. The flight control law of T-50 advanced trainer employs RSS concept in order to improve the aerodynamic performance and guarantee aircraft stability. The longitudinal center of gravity(X-c.g) varies as a function of external stores, fuel state and gear position. Shifts in X-c.g relate directly to longitudinal static margin in aircraft stability. This paper deals the maximum aft X-c.g for critical aircraft loadings and checks static margin limits using sensitivity such as damping, natural frequency, gain and phase margin. And nonlinear analysis was conducted for such as short period input. And also, this paper shows the T-50 aircraft stability based on the result of high angle of attack flight such as upright and inverted departure.

• BMB Reports
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• v.52 no.3
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• pp.208-213
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• 2019

Chemoresistance is the primary obstacle in the treatment of locally advanced and metastatic nasopharyngeal carcinoma (NPC). Recent evidence suggests that the transcription factor forkhead box M1 (FoxM1) is involved in chemoresistance. Our group previously confirmed that FoxM1 is overexpressed in NPC. In this study, we investigated the role of FoxM1 in cisplatin resistance of the cell lines 5-8F and HONE-1 and explored its possible mechanism. Our results showed that FoxM1 and NBS1 were both overexpressed in NPC tissues based on data from the GSE cohort (GSE12452). Then, we measured FoxM1 levels in NPC cells and found FoxM1 was overexpressed in NPC cell lines and could be stimulated by cisplatin. MTT and clonogenic assays, flow cytometry, ${\gamma}H2AX$ immunofluorescence, qRT-PCR, and western blotting revealed that downregulation of FoxM1 sensitized NPC cells to cisplatin and reduced the repair of cisplatin-induced DNA double-strand breaks via inhibition of the MRN (MRE11-RAD50-NBS1)-ATM axis, which might be related to the ability of FoxM1 to regulate NBS1. Subsequently, we demonstrated that enhanced sensitivity of FoxM1 knockdown cells could be reduced by overexpression of NBS1. Taken together, our data demonstrate that downregulation of FoxM1 could improve the sensitivity of NPC cells to cisplatin through inhibition of MRN-ATM-mediated DNA repair, which could be related to FoxM1-dependent regulation of NBS1.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.11
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• pp.1649-1654
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• 2021

In this paper, we introduce a regularization of long short-term memory (LSTM) based fall detection system using TensorFlow that can detect falls that can occur in the elderly. Fall detection uses data from a 3-axis acceleration sensor attached to the body of an elderly person and learns about a total of 7 behavior patterns, each of which is a pattern that occurs in daily life, and the remaining 3 are patterns for falls. During training, a normalization process is performed to effectively reduce the loss function, and the normalization performs a maximum-minimum normalization for data and a L2 regularization for the loss function. The optimal regularization conditions of LSTM using several falling parameters obtained from the 3-axis accelerometer is explained. When normalization and regularization rate λ for sum vector magnitude (SVM) are 127 and 0.00015, respectively, the best sensitivity, specificity, and accuracy are 98.4, 94.8, and 96.9%, respectively.

• Science of Emotion and Sensibility
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• v.12 no.1
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• pp.1-10
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• 2009

The purpose of this study is to find out the relationship between the design factor and the sensitivity in web site. The classification of sensitivity-types consists of the research of books and the survey, and the language specialist's review and the analysis of factor. The research of the Image Scale accomplished through the analysis of the result of sensitivity-types. The major findings of the analysis are summarized as follows. The webpage sensitivity-types are classified into the 7 types, namely 'refreshment', 'calm', 'refinement', 'strongness', 'youth', 'uniqueness', 'futurity'. As a result of analyzing of similarity between the adjectives by multiple standards, the web site Image Scale space consists of the axis between 'heavy-light' and 'soft-hard'. As a result of the research of relationship between the web site design factor and the emotion, the color and the layout influenced into 'soft-hard' much, and the light and the color influenced into 'heavy-light' much.

• Molecules and Cells
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• v.38 no.8
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• pp.705-714
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• 2015

We investigated the role of HDAC3 in anti-cancer drug-resistance. The expression of HDAC3 was decreased in cancer cell lines resistant to anti-cancer drugs such as celastrol and taxol. HDAC3 conferred sensitivity to these anti-cancer drugs. HDAC3 activity was necessary for conferring sensitivity to these anti-cancer drugs. The down-regulation of HDAC3 increased the expression of MDR1 and conferred resistance to anti-cancer drugs. The expression of tubulin ${\beta}3$ was increased in drug-resistant cancer cell lines. ChIP assays showed the binding of HDAC3 to the promoter sequences of tubulin ${\beta}3$ and HDAC6. HDAC6 showed an interaction with tubulin ${\beta}3$. HDAC3 had a negative regulatory role in the expression of tubulin ${\beta}3$ and HDAC6. The down-regulation of HDAC6 decreased the expression of MDR1 and tubulin ${\beta}3$, but did not affect HDAC3 expression. The down-regulation of HDAC6 conferred sensitivity to taxol. The down-regulation of tubulin ${\beta}3$ did not affect the expression of HDAC6 or MDR1. The down-regulation of tubulin ${\beta}3$ conferred sensitivity to anti-cancer drugs. Our results showed that tubulin ${\beta}3$ serves as a downstream target of HDAC3 and mediates resistance to microtubule-targeting drugs. Thus, the HDAC3-HDAC6-Tubulin ${\beta}$ axis can be employed for the development of anti-cancer drugs.

• The Korean Journal of Pain
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• v.37 no.4
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• pp.320-331
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• 2024

Background: MicroRNA (miRNA) plays a crucial role in neuropathic pain (NP) by targeting mRNAs. This study aims to analyze the regulatory function and mechanism of miR-382-5p/dual specificity phosphatase-1 (DUSP1) axis in NP. Methods: We utilized rats with chronic constriction injury (CCI) of the sciatic nerve as the NP model. The levels of miR-382-5p and DUSP1 were reduced by intrathecal injection of lentiviral interference vectors targeting miR-382-5p and DUSP1. The mRNA levels of miR-382-5p and DUSP1 in the dorsal root ganglions (DRGs) were measured by RT-qPCR assay. The pain behavior was evaluated by mechanical nociceptive sensitivity and thermal nociceptive sensitivity. The expression levels of interleukin-6 (IL)-6, IL-1β, and tumor necrosis factor-α in the DRGs were analyzed by ELISA assay. The targeting relationship between miR-382-5p and DUSP1 was verified by DLR assay and RIP assay. Results: Compared to the Sham group, the CCI rats exhibited higher levels of miR-382-5p and lower levels of DUSP1. Overexpression of miR-382-5p significantly decreased DUSP1 levels. Reducing miR-382-5p levels can lower the mechanical nociceptive sensitivity and thermal nociceptive sensitivity of CCI rats and inhibit the over-activation of pro-inflammatory factors. Reduced miR-382-5p levels decreased NP in CCI rats. DUSP1 is the target of miR-382-5p, and down-regulation of DUSP1 reverses the inhibitory effect of reduced miR-382-5p levels on NP. Conclusions: Down-regulation of miR-382-5p inhibits the over-activation of pro-inflammatory factors by targeting and regulating the expression of DUPS1, thereby alleviating NP.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.9
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• pp.925-932
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• 2014

If a rotor possesses a high gyroscopic coupling or the running speed is high, the dynamical changes in the rotor become prominent. When active magnetic bearings are used to support such rotors, it is necessary for the bearing controller to take these dynamical changes into consideration. Independent-axis controllers, which are the most commonly used, modulate the bearing force solely based on the sensor output of the same axis. However, this type of controller has difficulties in overcoming the dynamical changes. On the other hand, mixed-axis controllers transform the sensor output into components corresponding to the vibrational modes. A separate controller can then be designed for each vibrational mode. In this way, the controller can be designed based on the dynamics of the rotor. In this paper, we describe a design process for a mixed-axis controller that uses a detailed mathematical model of the system. The performance of the controller is evaluated based on the ISO sensitivity requirements and unbalance response, while considering the change in the system dynamics due to the running speed.

• Journal of the Korean Society of Marine Environment & Safety
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• v.20 no.1
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• pp.42-48
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• 2014

Seasickness not only makes persons on board vessels to vomit but also causes vertigo, headache, sleepiness, fatigue, lethargy and other discomforts. This ailment leads to disturbance of biorhythm and decline of perception which would eventually cause reduction of situational awareness among ship's operators that leads to marine accident. This study is about the sensitivity of people onboard ships to seasickness and focused on deck or navigation officer cadets(apprentice officers) and engine officer cadets(apprentice engineers) who have no previous experiences on board. It is conducted by using motion sensor that can measure ship's X, Y, Z-axis motions and through the questionnaire survey, and evaluated each students' degree of seasickness symptoms. Through this study, in same circumstance, we have known that there are different degrees of motion sickness for wheel house worker and engine room worker, It also confirmed that seasickness have high relationship with degree of hull motion and also, with cycle of hull motion. In addition, we have confirmed that Z-axis hull movement has higher relationship with seasickness than X-axis and Y-axis hull movements. This study aims to initiate additional researches about X-axis and Y-axis of the ship's motion which it expects to greatly enhance safety of wheelhouse and engine room personnel, ship's livability and comfortable sailing.