• Journal of the Korean Society for Precision Engineering
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• v.21 no.3
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• pp.5-8
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• 2004

• Biomedical Science Letters
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• v.29 no.1
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• pp.1-10
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• 2023

Since its first identification in 1995, klotho (KL) has become the most promising gene to consider for suppressing aging and aging-related diseases. KL knockout mice exhibited similar phenotypes found in human with premature aging such as short lifespan, osteoporosis, arteriosclerosis and hearing loss. Genetically modified mice overexpressing KL prolonged lifespan more than 20%. Also, clinical reports have indicated decreased concentration of the circulating KL protein in blood, which is called soluble klotho (sKL), is closely related to development of senile diseases. The best way to discover significance of sKL on the development of the diseases might be comparison of sKL concentration between controls and patients. Here we analyzed published clinical reports identified sKL concentration in the cohorts. The sKL concentrations were displayed using heatmap for better comparison. In most of the senile diseases, disease progression was inversely related with sKL concentration. Hypertension was the only disease had no relationship, while schizophrenia was the only disease had direct proportion to the disease progression. Overall, sKL concentration in blood could be a marker to determine current severity of the senile diseases and even to estimate disease progression for the patients at the onset of their senile diseases.

• Journal of Korean Public Health Nursing
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• v.13 no.2
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• pp.1-11
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• 1999

The purpose of this study was to provide the elderly and their family kowledge about senile dementia and to get them to have positive attitude about senile dementia. The subjects were 204 elderly who lived in the whole country. The data were collected from Sep. to Dec., 1998, using a 36 items questionnaire and analyzed by SAS program for t-test, ANOVA. Scheffe test, Pearson Correlation Coefficients. The results were as follows: 1. The mean score of knowledge about senile dementia was $9.33\pm2.68$(range 0-15), The elderly who was unschooled, lived in Kyung Sang province, didn't have any hobby or interest, didn't access to informations about senile dementia got lower score than the others. 2. The examples of knowledge test items about senile dementia that the subjects above fifty percents answered uncorrectly were 'the patient of senile dementia doesn't die soon', 'senile dementia is uncurable disease', 'the symptoms of senile dementia is apparent in new and strange circumstances', 'the pood and lonely elderly is apt to have senile dementia'. 3. The mean score of attitude about senile dementia was $15.87\pm2.25$(range 0-20) and attitude about senile dementia was relatively positve. Attitude about senile dementia by general characteristic was not significantly different. 4. The examples of attitude test items about senile dementia to which the majority of subjects agreed were 'It is a pity to see the patient suffered from senile dementia', 'It is difficult to take care of senile dementia patient' and so on. 5. The correlation between kowledge and attitude about senile dementia was very low. Therefore this study suggests that it is crucial to educate the elderly and their family to induce positive attitude about senile dementia.

• Journal of Acupuncture Research
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• v.23 no.3
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• pp.117-127
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• 2006

Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease associated with aging in the human population. This disease is characterized by the following 4 structural changes : Atrophy of the Cortex, Parasympathetic, and other neural cells, the existence of Neurofibrillary tangles (NFTs), and the accumulation of Senile plaques. NFTs and Senile plaques is known to be the index of this disease. Senile plaques disturbs the neutro transmission and depletes of Acetylcholine. So, Recovery of Acetylcholine is the primal objective for treating Alzheimer's disease. So, Inhibiting the activity of Acetylcholine Esterase (AChE), which causes the hydrolysus of acetylcholine into choline and acetate, can be seen as a key role for treating Alzheimer's disease. Increasing body of evidence has been demonstrated that Bee Venom Acupuncture (BV) could compete with complex protein involving in multiple step of $NF-_{\kappa}B$ activation and exert the anti-inflammatory potential of combined inhibition of the prostanoid and nitric oxide synthesis systems by inhibition of IKK and $NF-_{\kappa}B$. BV dose-dependently attenuated Scopolamine-induced Acetylcholine esterase activities in cerebral cortex and hippocampus of the mice brain. This study therefore suggests that BV acupuncture method may be useful for prevention of development or progression of AD.

• Journal of agricultural medicine and community health
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• v.22 no.2
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• pp.265-276
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• 1997

The best way to care senile dementia patients is understanding the nature of disease. Care-givers can't understand the patients because the patients can't properly communicate with care-givers. Thus, care-givers are supposed to find out ways to understand them in the nature of disease. From this view, there seems no exception in essential attitude of care-givers toward the patients. Without positive understanding the nature of disease and respecting patient's rights as a human even though they are badly disorder in their word and behavior. There seems no expectation for thousands quality of care-giving.

• Molecular & Cellular Toxicology
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• v.5 no.2
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• pp.108-112
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• 2009

Alzheimer's disease(AD) is a neurodegenerative disorder characterized pathologically by senile plaques, neurofibrillary tangles, and synapse loss. Especially, extracellular beta-amyloid (Abeta) deposition is a major pathological hallmark of Alzheimer's disease (AD). In AD senile plaques, high level of iron and car-bonylated Abeta were detected. Iron has a Lewis acid property which can increase the electrophilicity of carbonyls, which may react catalytically with nucleophiles, such as amines. Hence, this study investigated whether or not iron could promote the carbonylation of amine with malondialdehyde (MDA) in the physiological condition. As the basic study, we examined that iron might promote the conjugation reaction between propylamine, monoamine molecule and MDA in the physiological condition. As the concentration of iron increased, the fluorescence intensity produced from the conjugation reaction increased in a dose-dependent manner. Instead of propylamine, we applied the same reaction condition to Abeta 1-40 peptide, one of major components founded in AD senile plaques for the conjugation reaction. As the result, the fluorescence intensity produced from the conjugation reaction between Abeta 1-40 peptide and MDA showed the similar trend to that of the reaction used with propylamine. This study suggests that iron can accelerate the conjugation reaction of MDA to Abeta 1-40 peptide and play an another important role in deterioration of AD brain.

• The Journal of Internal Korean Medicine
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• v.19 no.1
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• pp.185-201
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• 1998

The present experiment was desined to examine catecholamines, 5-hydroxytryptamine, amino acids, malondialdehyde(MDA) and free radical scavening activity, by administering Samultang extract of a variety of concentraction to senile brain The results were summarized as followings: 1. Samultang significantly increased noradrenaline in the cortex, striatum, hippocampus and hypothalamus of the brain tissue of senile rats, and even though Samultang increased noradrenaline also in other brain tissue, there was no significance. 2. Samultang had effects on dopamine changes in hypothalamus of the brain tissue of senile rats. 3. Samultang significantly increased 5-hydrotryptamine in pons-medulla oblongota and cerebellum, but decreased in hypothalamus. 4. Samultang increased amino acid in the brain tissue of senile rats. 5. Samultang significantly decresed lipid peroxide production in the brain tissue of senile rats. 6. Samultang significantly decresed MDA and free radical in the brain tissue of senile rats. According to the above results, Samultang is assumed to improve brain function by reacting on biochemical of the senile brain, and that Samultang can be used to treat regressive brain disease carrying symptoms of psychoactive disorders.

• Journal of Oriental Neuropsychiatry
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• v.8 no.2
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• pp.25-37
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• 1997

The present experiment was designed to examine catecholamines, 5-hydroxytryptamine, amino acids. malondialdehyde(MDA) and free radical scavenging activity, by administering Chilbokyeum extracts of a variety of concentration to senile brain rats. The results were summarized as followings ; 1. Chilbokyeum significantly increased noradrenalin in the hippocampus and hypothalamus of the brain tissue of senile rats, ad even though Chilbokyeum increased noradrenalin also in other brain tissue, there was no significance. 2. Chilbokyeum had no effects on dopamine changes in all brain tissue of senile rats.3. Chilbokyeum significantly increased 5-hydroxy-tryptamine in cerebellum, but decreased in other brain tissue.4. Chilbokyeum increased amino in the brain tissue of senile rats. 5. Chilbokyeum significantly decreased MDA and free radical in the brain tissue of senile rats. According to the above results, Chilbokyeum is assumed to improve brain function by reaction by reacting on biochemical of the senile brain, and that Chilbokyeum can be used to treat regressive brain disease carrying symptoms of psychoactive disorders.

• The Journal of Internal Korean Medicine
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• v.19 no.2
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• pp.107-124
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• 1998

The present experiment was desined to examine catecholamines, 5-hydroxytryptamine, amino acids, malondialdehyde(MDA) and free radical scavening activity, by administering Cheonmagudeungyeum extract of a variety of concentraction to senile brain The results were summarized as followings: 1. Cheonmagudeungyeum significantly increased noradrenaline in the hippocampus and hypothalamus of the brain tissue of senile rats, and even though Cheonmagudeungyeum increased noradrenaline also in other brain tissue, there was no significance. 2. Cheonmagudeungyeum had no effects on dopamine changes in all brain tissue of senile rats. 3. Cheonmagudeungyeum significantly increased 5-hydrotryptamine in cerebellum, but decreased in other brain tissue. 4. Cheonmagudeungyeum increased amino acid in the brain tissue of senile rats. 5. Cheonmagudeungyeum significantly decresed MDA and free radical in the brain tissue of senile rats. According to the above results, Cheonmagudeungyeum is assumed to improve brain function by reacting on biochemical of the senile brain, and that Cheonmagudeungyeum can be used to treat regressive brain disease carrying symptoms of psychoactive disorders.

• The Journal of Internal Korean Medicine
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• v.18 no.2
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• pp.94-111
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• 1997

The present experiment was designed to examine catecholamines, serotonine, amino acids, malondialdehyde and free radical scavenging activity, by administering Yukmijihwangtang extract of a variety of concentraction to senile brain. The results were summarized as followings: 1. Yukmijihwangtang significantly increased noradrenaline in the striatum, hypothalamus, midbrain and pons-medulla oblongota of the brain tissue of senile rats, and even though Yukmijihwangtang increased noradrenaline also in other brain tissue, there was no significance. 2. Yukmijihwangtang significantly increased dopamine in the striatum, hypothalamus and midbrain of the brain tissue of senile rats, and even though Yukmijihwangtang increased dopamine also in other brain tissue, there was no significance. 3. Yukmijihwangtang significantly increased serotonine in the pons- medulla oblongata and cerebellum of the brain tissue of senile rats, and even though Yukmijihwangtang increased serotonine also in the other brain tissue except hypothalamus and midbrain, there was no significance. 4. Yukmijihwangtang significantly increased amino acid in the brain tissue of senile rats. 5. Yukmijihwangtang significantly decresed malondialdehyde and free radical in the brain tissue of senile rats. According to the above results, Yukmijihwangtang is assumed to improve brain function by reacting on biochemical of the senile brain, and that Yukmijihwangtang can be used to treat regressive brain disease carrying symptoms of psychoactive disorders.