• Title/Summary/Keyword: Semi-batch Systems

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Optimization of a semi-batch esterification reactor (반회분 에스테르화 반응기의 최적화)

  • 이융효;박선원
    • 제어로봇시스템학회:학술대회논문집
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    • 1993.10a
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    • pp.582-588
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    • 1993
  • A scheme of dynamic optimization for batch reactor his been developed and applied to a semi-batch esterification reactor. To obtain optimal operating conditions for the given semi-batch reactor system with complex reaction kinetic and process constraints, a general nonlinear programming solver and finite element techniques have been introduced. The optimization results for the complex reactor system have been compared with those of Kumar et al. [1984] to show better optimization performance. The proposed optimizing scheme has been applied to the free end time problem to obtain the realistic operating condition. The results can supply valuable information for economic operation of the given batch esterification reactor.

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Optimal Learning Control Combined with Quality Inferential Control for Batch and Semi-batch Processes

  • Chin, In-Sik;Lee, Kwang-Soon;Park, Jinhoon;Lee, Jay H.
    • 제어로봇시스템학회:학술대회논문집
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    • 1999.10a
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    • pp.57-60
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    • 1999
  • An optimal control technique designed for simultaneous tracking and quality control for batch processes. The proposed technique is designed by transforming quadratic-criterion based iterative learning control(Q-ILC) into linear quadratic control problem. For real-time quality inferential control, the quality is modeled by linear combination of control input around target qualify and then the relationship between quality and control input can be transformed into time-varying linear state space model. With this state space model, the real-time quality inferential control can be incorporated to LQ control Problem. As a consequence, both the quality variable as well as other controlled variables can progressively reduce their control error as the batch number increases while rejecting real-time disturbances, and finally reach the best achievable states dictated by a quadratic criterion even in case that there is significant model error Also the computational burden is much reduced since the most computation is calculated in off-line. The Proposed control technique is applied to a semi-batch reactor model where series-parallelreactions take place.

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Production of Pyruvate Dehydrogenase Complex-E2 Specific Human Monoclonal Antibody in Fed-batch Culture Systems with High Cell Density Recombinant Escherichia coli (고농도 재조합 대장균의 Fed-batch 배양 시스템을 이용한 Pyruvate Dehydrogenase Complex-E2 특이성 인간 모노클론 항체의 생산)

  • 이미숙;전주미;차상훈;정연호
    • KSBB Journal
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    • v.15 no.5
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    • pp.489-496
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    • 2000
  • Several culture systems including batch, two-stage CSTR, semi-fed batch, and two-stage cyclic fed-batch were investigated for the efficient production of the Fab fraction of PDC-E2 specific human monoclonal antibody using high cell density recombinant E. coli. A two-phase batch system and a two-stage continuous system were examined to overcome plasmid instability problems, by separating the growth and the production stages. The cell density and productivity of the two-stage continuous culture was better than that of the two-phase batch fermentation. In the two-stage continuous culture system with DO-stat, the cell growth and the productivity were superior to those of the system without the DO control. Also, almost total plasmid stability was maintained in the two-stage continuous culture system. Modified M9 medium was selected as an optimum feeding medium for the fed-batch process, and the optimum C/N ratio determined to be 2:3. The optimum feeding rate was $0.6g/\ell/hr$ for a constant feeding strategy in semi-fed batch system. When the feeding medium was fed by pulsing, it was observed that more frequent pulsing resulted in improved cell growth. The linear feeding method was the most efficient of the various feeding methods tested. Finally, high cell density culture using a two-stage cyclic fed batch system with pH-stat was tried because the linear feeding method showed limitations in terms of obtaining high cell densities, and a cell density of $54 g/\ell$ was achieved. It was concluded that the two-stage cyclic fed batch system was the most efficient system for high cell density culture of the systems tested. However, productivity improvements were lower than expected due to the extremely high accumulations of acetate, although the low levels of residual glucose were maintained.

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Sentiment Orientation Using Deep Learning Sequential and Bidirectional Models

  • Alyamani, Hasan J.
    • International Journal of Computer Science & Network Security
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    • v.21 no.11
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    • pp.23-30
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    • 2021
  • Sentiment Analysis has become very important field of research because posting of reviews is becoming a trend. Supervised, unsupervised and semi supervised machine learning methods done lot of work to mine this data. Feature engineering is complex and technical part of machine learning. Deep learning is a new trend, where this laborious work can be done automatically. Many researchers have done many works on Deep learning Convolutional Neural Network (CNN) and Long Shor Term Memory (LSTM) Neural Network. These requires high processing speed and memory. Here author suggested two models simple & bidirectional deep leaning, which can work on text data with normal processing speed. At end both models are compared and found bidirectional model is best, because simple model achieve 50% accuracy and bidirectional deep learning model achieve 99% accuracy on trained data while 78% accuracy on test data. But this is based on 10-epochs and 40-batch size. This accuracy can also be increased by making different attempts on epochs and batch size.

Identification and Multivariable Iterative Learning Control of an RTP Process for Maximum Uniformity of Wafer Temperature

  • Cho, Moon-Ki;Lee, Yong-Hee;Joo, Sang-Rae;Lee, Kwang-S.
    • 제어로봇시스템학회:학술대회논문집
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    • 2003.10a
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    • pp.2606-2611
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    • 2003
  • Comprehensive study on the control system design for a RTP process has been conducted. The purpose of the control system is to maintain maximum temperature uniformity across the silicon wafer achieving precise tracking for various reference trajectories. The study has been carried out in two stages: thermal balance modeling on the basis of a semi-empirical radiation model, and optimal iterative learning controller design on the basis of a linear state space model. First, we found through steady state radiation modeling that the fourth power of wafer temperatures, lamp powers, and the fourth power of chamber wall temperature are related by an emissivity-independent linear equation. Next, for control of the MIMO system, a state space modeland LQG-based two-stage batch control technique was derived and employed to reduce the heavy computational demand in the original two-stage batch control technique. By accommodating the first result, a linear state space model for the controller design was identified between the lamp powers and the fourth power of wafer temperatures as inputs and outputs, respectively. The control system was applied to an experimental RTP equipment. As a consequence, great uniformity improvement could be attained over the entire time horizon compared to the original multi-loop PID control. In addition, controller implementation was standardized and facilitated by completely eliminating the tedious and lengthy control tuning trial.

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Biological Fixation of $CO_2$ by Chlorella sp. HA-1 in a Semi-Continuous and Series Reactor System

  • LEE JAE-YOUNG;KWON TAE-SOON;BAEK KITAE;YANG JI-WON
    • Journal of Microbiology and Biotechnology
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    • v.15 no.3
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    • pp.461-465
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    • 2005
  • Characteristics of biological $CO_2$ fixation by Chlorella sp. HA-1 were investigated in a semi-continuous and series reactor system using an internally illuminated photobioreactor to overcome shortcomings of physicochemical technologies such as adsorption and membrane separation. High $CO_2$ fixation rate was achieved in the semi-continuous reactor system, in which the dilution ratios of the culture medium were controlled. The average $CO_2$ fixation rate was maintained almost constantly when the dilution ratio increased by 0.1 increment from the initial value of 0.5. The total removal efficiency of $CO_2$ was enhanced by employing a series reactor system. The average $CO_2$ fixation rate increased until 4.013 g $CO_2\;day^{-1}$ in a series operation of four reactors, compared to 0.986 g $CO_2\;day^{-1}$ in a batch operation mode. The total $CO_2$ fixation rate was proportional to the number of reactors used in the series reactor system. In the series reactor system of semi-continuous operation, a large amount of $CO_2$ was removed continuously for 30 days. These results showed that the present reactor systems are efficient and economically feasible for a biological $CO_2$ fixation.

Optimal Design of Generalized Process-storage Network Applicable To Polymer Processes (고분자 공정에 적용할 수 있는 일반화된 공정-저장조 망구조 최적설계)

  • Yi, Gyeongbeom;Lee, Euy-Soo
    • Korean Chemical Engineering Research
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    • v.45 no.3
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    • pp.249-257
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    • 2007
  • The periodic square wave (PSW) model was successfully applied to the optimal design of a batch-storage network. The network structure can cover any type of batch production, distribution and inventory system, including recycle streams. Here we extend the coverage of the PSW model to multitasking semi-continuous processes as well as pure continuous and batch processes. In previous solutions obtained using the PSW model, the feedstock composition and product yield were treated as known constants. This constraint is relaxed in the present work, which treats the feedstock composition and product yield as free variables to be optimized. This modification makes it possible to deal with the pooling problem commonly encountered in oil refinery processes. Despite the greater complexity that arises when the feedstock composition and product yield are free variables, the PSW model still gives analytic lot sizing equations. The ability of the proposed method to determine the optimal plant design is demonstrated through the example of a high density polyethylene (HDPE) plant. Based on the analytical optimality results, we propose a practical process optimality measure that can be used for any kind of process. This measure facilitates direct comparison of the performance of multiple processes, and hence is a useful tool for diagnosing the status of process systems. The result that the cost of a process is proportional to the square root of average flow rate is similar to the well-known six-tenths factor rule in plant design.

Alcoholic Fermentation of Traditional Kanjang by Semi-pilot Scale Bioreactor Systems (Semi-pilot plant 규모 bioreactor를 이용한 재래식 간장의 알코올발효)

  • Kwon, Kwang-Il;Lee, Jong-Gu;Choi, Jong-Dong;Chung, Hyun-Chae;Ryu, Mun-Kyun;Im, Moo-Hyeog;Kim, Ki-Ju;Choi, Yong-Hoon;Kim, Young-Ji;Choi, Cheong;Choi, Kwang-Soo
    • Korean Journal of Food Science and Technology
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    • v.35 no.1
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    • pp.103-110
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    • 2003
  • Stable production of fermented kanjang containing 1.8% (v/v) ethanol was obtained within four days using traditional kanjang containing 4% added glucose in packed-bed bioreactor systems filled with immobilized Zygosaccharomyces rouxii and Candida versatilis on porous alumina ceramic bead carrier at $28{\pm}0.5^{\circ}C$ and aeration rate of 0.05 vvm. Specific rates of alcohol production for Z. rouxii and C. versatilis were 0.0033 and 0.0031/day, respectively, and those of glucose consumption were both -0.0087/day in the batch type of alcoholic fermentation. In semi-continuous alcoholic fermentation at a dilution rate of 0.25/day, specific rates of alcohol production for Z. rouxii and C. versatilis were 0.0045 and 0.0029/day, and those of glucose consumption were -0.01 and -0.008/day, respectively, using identical bioreactor system. Similar specific rates of alcohol production were observed both in the batch or semi-continuous process and in the continuous one at the dilution rate of 0.25/day. Sensory characteristics of all alcoholic-fermented kanjang by Z. rouxii, C. versatilis, and a mixture of both yeasts (2:1, w/w) were shown to be significantly superior to those of home-made kanjang as revealed through organoleptic evaluation tests (p<0.05).

An Analysis of Characteristics for the Non-catalytic Esterification of Palm Fatty Acid Distillate (PFAD) (팜지방산 디스틸레이트의 무촉매 에스테르화 반응특성 연구)

  • Hong, Seok Won;Cho, Hyun Jun;Yeo, Yeong-Koo
    • Korean Chemical Engineering Research
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    • v.52 no.3
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    • pp.395-401
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    • 2014
  • In this work, the reaction characteristics for the non-catalytic esterification of palm fatty acid distillate were analyzed. The esterification reaction was assumed as the pseudo homogeneous $2^{nd}$ order reversible reaction and 'reaction effectiveness factor (${\eta}$)' was used to take accounts into evaporation and reaction of water and methanol, which take place simultaneously in the liquid phase. The nonlinear programming was used to derive appropriate kinetic parameters, the reaction rate constant and mass transfer coefficient, minimizing the error between experimental data and the numerical values. Based on these parameters, the apparent activation energy was calculated to be 43.98 kJ/mol.