• 한국정밀공학회지
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• 제32권8호
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• pp.755-760
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• 2015

For proper wound healing, dermal contraction and remodeling are critical; during the natural healing process, differentiated fibroblasts called "myofibroblasts" typically undertake these functions. For severe wounds, however, a critical mass of dermal matrix and fibroblasts are lost, making self-regeneration impossible. To overcome this impairment, synthetic wound patches with embedded functional cells can be used to promote healing. In this study, we developed a polydioxanone (PDO)-based cell-embedded sheet on which dermal fibroblasts were cultured and induced for differentiation into myofibroblasts, whereby the following combinatorial physicochemical stimuli were also applied: aligned topology, electric field (EF), and growth factor. The results show that both the aligned topology and EF synergistically enhanced the expression of alpha smooth-muscle actin (${\alpha}$-SMA), a key myofibroblast marker. Our proof-of-concept (POC) experiments demonstrated the potential applicability of a myofibroblast-embedded PDO sheet as a wound patch.

• KIEAE Journal
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• 제13권2호
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• pp.131-139
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• 2013

The aim of this dissertation is establishing internal indicator list for achieving policy goal of Carbon Neutrality Green City. First of all, it started to construct the basic system of planning indicator based on through comprehension of current studies such as advanced researches, government guidelines and green building certifications. And then it was set up final indicator list through inspecting FGI (Focus Group Interview), Verification of suitability, and Analysis of importance). As a result of this research, the planning indicator divided three steps and there were classified four fields in the top-level; Green Land and Ecology, Green Energy, Green Resource and Transportation, Green Living and Institution. According to the data, it deducted four items (ratio of green land, site plan, heat island and management of climate, base of nature ecology) and twelve index in the field of green land and ecology, three item(energy conservation and self-supporting, energy efficiency, new regeneration energy) and twelve index in the field of green energy and regeneration, five items(water resources utilize and circulation, other resource reduction and circulation, public transportation, green transportation plan) and fifteen index. Totally, Planning Indicators of forty nine were deducted. Therefore, there was the result of importance analysis that the indicators of plan and maintain management as the side of space for carbon neutrality were more appreciated than carbon reduction of individual building.

• 한국주거학회논문집
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• 제14권6호
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• pp.15-22
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• 2003

The regeneration of built-up areas is considered as one of the necessary measures for the effectiveness of urban growth management. In this vein, this study explores how to limit the number of people who leaves the built-up areas and to restore the area with the resident. For this, a residential area of the built-up area is analyzed in terms of why people in that area are moving out of the area and who fills in it after all. This study founds that narrow roads in a residential area and the changes in land use from residential purposes to commercial are major forces that push the people in the built-up area. In addition, the lack of welfare facilities, the pavement of roads, and pedestrian roads. education. crime. the lack of interaction between neighbors, and the quality of housing are all emerged contributing the loss of people in the built-up areas. It is recommended that all the factors here should be restored in an appropriate way. Another finding is that those who fill in the built-up area are largely over 50, self-employed, comparably wealthy, and having their own families. Hence, it is advised that the built-up area would be rearranged in order to attract those type of people in there.

• 대한건축학회논문집:계획계
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• 제34권9호
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• pp.43-54
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• 2018

Recently, residents' community center is trying to combine with various program and facilities as the residents self-government program's development. This is due to the reduction of administrative tasks, the computerization of programs, the importance of community participation activities, the activation of community, and the increase of welfare projects. Therefore, previous studies on program complexity have been actively carried out. Nevertheless, spaces and programs studies of considering regional characteristics are lacking. Therefore, the community centers' program and spaces need to change. Therefore, this study propose an improvement direction through analyzing the situation of the residents' community center. For this study, the precedent research and institutional limitations are examined. In addition, this study selected and analyzed the 15 local community center. Thirdly, interviews were conducted with users and officials of the 5 residents' community centers on major changes. Finally, This study suggests direction of program improvement and architectural design direction. As a result of this study, integrated management measures with overlapping agencies should be sought. Surplus space will have to be rearranged into a new program through prior examination. Above all, the proposed remodeling guidelines require user requirements to be reflected and designed with the residents.

• 교육시설 논문지
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• 제28권2호
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• pp.3-10
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• 2021

Community-based design is also becoming important in Korea recently. However, the existing design methods of the "conformity" method had the problem of excluding the participation of residents. Therefore, the "decision-making" method, in which residents participate in the design themselves, is drawing attention. Development of specific methods is important for residents to actively participate in "decision making." The theory of "Design Games" has long been studied as a method of community-based design in many countries. The old downtown areas of Jeju Special Self-Governing Province are increasing in number of buildings abandoned due to aging and declining. Abandoned buildings are causing many social problems. A decision-making method has been developed in Jeju for the regeneration design of abandoned buildings. This study conducted a design workshop involving residents on abandoned buildings in the old city center of Jeju City. The possibility and task of decision-making method were analyzed. As a result, participating residents were actively involved in decision-making. It also helped residents understand and learn about the attractions of the neighborhood. Meanwhile, there were also difficulties in communicating among some participants. This is a structural problem with this method. Studies have also shown that it is important for residents themselves to try to understand the neighborhood.

• Journal of Periodontal and Implant Science
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• 제37권3호
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• pp.479-488
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• 2007

In spite of the attention given to the study of mesenchymal stem cells derived periodontal ligament (PDL), there is a lack of information about canine PDL cells. In this study, we characterized canine PDL cells to clarify their stem cell properties, including self renewal, proliferate rate, stem cell markers and multipotency. PDL cells were obtained from extracted premolars of canines, following a colony forming assay and proliferation rate of sub-confluent cultures of cells for self-renewal, immunostaining for STRO-1 and CD146/MUC18 and a differentiation assay for multipotency. Canine PDL cells formed single-cells colonies and 25% of the PDL cells displayed positive staining for BrdU. The cells expressed the mesenchymal stem-cell markers, STRO-1 and CD146/MUC18. Under defined culture conditions, the cells differentiated into osteoblasts and adipocytes, but the cells didn't differentiated into chondrocytes. The findings of this study indicated that the canine PDL cells possess crucial stem cells properties, such as self-renewal and multipotency, and express the mesenchymal stem cell markers on their surface. The isolation and characterization of canine PDL cells makes it feasible to pursue preclinical models of periodontal regeneration in canine.

• Journal of Periodontal and Implant Science
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• 제46권1호
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• pp.10-21
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• 2016

Purpose: This study evaluated the predictive performance of a combination of self-report questionnaires, salivary hemoglobin levels, and age as a non-invasive screening method for periodontitis. Methods: The periodontitis status of 202 adults was examined using salivary hemoglobin levels, responses to 10 questions on a self-report questionnaire, and the Community Periodontal Index (CPI). The ability of those two variables and the combination thereof with age to predict the presence of CPI scores of 3-4 and 4 was assessed using logistic regression and receiver operating characteristic (ROC) curve analysis. Results: CPI scores of 3-4 and 4 were present among 79.7% and 46.5% of the sample, respectively. The area under the ROC curves (AUROCs) of salivary hemoglobin levels for predicting prevalence of CPI scores of 3-4 and 4 were 0.63 and 0.67, respectively (with sensitivity values of 71% and 60% and specificity values of 56% and 72%, respectively). Two distinct sets of five questions were associated with CPI scores of 3-4 and 4, with AUROCs of 0.73 and 0.71, sensitivity values of 76% and 66%, and specificity values of 63% and 69%. The combined model incorporating both variables and age showed the best predictive performance, with AUROCs of 0.78 and 0.76, sensitivity values of 71% and 65%, and specificity values of 68% and 77% for CPI scores of 3-4 and 4, respectively. Conclusions: The combination of salivary hemoglobin levels and self-report questionnaires was shown to be a valuable screening method for detecting periodontitis.

• 한국산림과학회지
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• 제105권1호
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• pp.42-47
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• 2016

천연활엽수림의 천연갱신 가능성을 파악하고자, 당단풍나무의 개화 결실, 종자낙하, 종자활력을 강원도 평창군 중왕산 지역에서 2009년부터 2015년까지 조사하였다. 당단풍나무 꽃은 산방화서에 양성화와 웅성화가 달렸으며, 화서 내에서 성형태간 개화시기가 달랐다. 양성화가 먼저 개화하는 개체에서는 암술이 수분되어 자라기 시작한 꽃에서는 수술은 더 이상 성숙하지 않고 소실되었으며, 웅성화가 먼저 개화하는 수술이 발달한 꽃에는 암술은 흔적으로만 존재하였다. 다른 개체에서의 화분이 꿀벌, 애꽃벌류 및 꽃등에류에 의하여 수분이 이루어지는 이형자웅이숙(heterodichogamy)의 성 형태로 자가수분을 회피하는 기작을 가지고 있었다. 종자 낙하량은 310~234,840 ea/ha의 범위로 평균은 70,780 ea/ha이었다. 종자생산에 있어 연년변동이 심하며, 최대치가 최소치의 760배 가량이었다. 당단풍나무의 연년종자생산은 정규분포하는 것이라 사료된다. 성숙한 종자 중에서 피해 또는 부후종자가 59.3%로 가장 많았고, 건전종자가 23.9%, 미발육 종자 9.2%, 쭉정이종자 7.6% 등으로 나타났다. 건전종자 생산량을 좌우하는 요인은 개화기인 5월 중,하순에 화분매개충의 활동과 어린 자방이 자라는 시기에 흡즙성 해충의 밀도와 활동성이 가장 중요한 요인이라 사료된다. 당단풍나무의 천연갱신은 종자풍년 이듬해에 발아와 생장에 유리한 조건을 갖춘 갭에서 이루어질 것으로 사료된다. 낙엽활엽수의 천연갱신을 이해하기 위해서 개화결실 특성과 비산 전후 종자 피식 문제에 대한 장기간의 연구가 필요할 것이라 사료된다.

• 한국산림과학회지
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• 제103권2호
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• pp.153-158
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• 2014

천연활엽수림의 천연갱신 가능성을 파악하고자, 부게꽃나무(Acer ukurunduense Trautv. & C.A. Mey.)의 개화 결실, 종자낙하, 종자활력을 강원도 평창군 중왕산 지역에서 2009년부터 2013년까지 조사하였다. 부게꽃나무 꽃은 총 상화서(드물게 원추화서)에 양성화와 웅성화가 많이 달렸으며, 꽃의 배열은 화서마다 서로 달랐다. 화서 내에서 성형태간 개화시기가 달랐다. 양성화로 암술이 수분되어 자라기 시작한 꽃에서는 수술은 더 이상 성숙하지 않고 소실되었으며, 수술이 발달한 꽃에는 암술은 흔적으로만 존재하였다. 부게꽃나무는 꿀벌, 깜둥이창나방, 하늘소류, 애꽃벌류, 대모각다귀류 등이 수분하며, 자가수분을 회피하는 기작을 가지고 있다고 사료된다. 화서당 꽃의 수는 6월 8일에 189개였다가, 6월 21에는 과수당 시과?의 수는 41.2개였으며, 9월 5일에는 과수당 33.4개로 줄어들었다. 시과낙하량은 670~17,930 ea/ha의 범위로 평균은 6,720 ea/ha이었다. 건전배를 가진 것이 43.2%로 가장 많았고, 다음으로 피해 부후인 것이 41.8%, 미발육 10.2%, 쭉정이배 4.8%로 나타났다. 건전종자 생산량을 좌우하는 요인은 개화기인 6월 초순에 화분매개충의 활동과 어린 자방이 자라는 6월 초 중순 흡즙성 해충의 밀도와 활동성이 가장 중요한 요인이라 사료된다. 부게꽃나무의 천연갱신은 종자다산해에 발아와 생장에 유리한 조건을 갖춘 갭에서 이루어질 것으로 사료된다. 단풍나무류의 천연갱신을 이해하기 위해서 종자결실과 비산전 후 종자피식 문제에 대한 장기간의 연구가 필요할 것이라 사료된다.

• 한국산림과학회지
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• 제99권1호
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• pp.153-162
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• 2010

본 연구는 경기도 용인 지역 전나무(Abies holophylla Maxim.) 임분의 구조를 분석하고, 이 지역 전나무 임분의 지속가능성을 알아보기 위하여 수행되었다. 용인시의 정수리, 대대리, 호동 지역 전나무 임분에서 매목조사를 실시하고, 관목층의 구조와 치수의 발생을 조사하였다. 산림 관리나 작업이 이루어지지 않았던 정수리와 대대리 임분에서 전나무는 중요도 40%로 임분을 우점하고 있었으며, 연속적인 연령과 직경분포를 보이고 있었다. 반면 호동 지역 임분은 간벌과 택벌 등의 산림 작업이 이루어졌던 지역으로 전나무가 흉고직경 10-45 cm 범위에 분포하나 대부분 25-30 cm 직경급에 몰려 있고, 단일수관층을 가지고 있었다. 전나무의 연령과 흉고직경의 상관 관계는 유의한 것으로 나타나긴 하였으나 높지 않았고($R^2$=0.2, P=0.03), 비슷한 연령대라도 다양한 흉고직경 값을 가졌다. 정수리 임분의 연속적인 직경 분포와 다층수관구조는 전나무가 조림 후 지속적으로 갱신이 이루어져 왔음을 보여주었다. 전나무의 치수는 ha당 2000-33000본까지 발생하였으나, 2-5 cm 직경급의 전나무는 ha당 70-150본 정도로 치수 단계에서 유령목으로 자라나는 동안의 생존율은 낮았다. 지속적인 천연갱신과 연간 약 0.6 cm의 직경생장율은 조사 지역의 환경이 전나무 서식에 비교적 적합한 지역임을 나타낸다. 또한 전나무 임분은 향후에도 지속적으로 유지될 것으로 보여 내음성 수종인 전나무를 대상으로 한 택벌림 경영의 가능성을 제시해주고 있다.