• 한국자기공명학회논문지
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• 제25권1호
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• pp.1-7
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• 2021

Employing of 13C stable-isotopes in NMR metabolomics can give unique splitting patterns and coupling constants information originated from 13C-13C coupling interaction that provide an important structural information regarding the cellular metabolic process. But it has been known that an undesirable signal distortion in 2D heteronuclear correlation study, due to 13C-13C interaction, hampers an analysis of the coupling information. Recently, we proposed J-scaled distortion-free heteronuclear single-quantum coherence (HSQC) sequence which provides a distortion-free 13C-13C coupling information with a selective resolution enhancement of JCC splitting. In this paper, we dicuss theoretical aspect and practical feature of J-scaled HSQC pulse sequence. The conceptual explanation of orgin of the signal distortion by 13C-13C coupling interaction and design of J-scaled HSQC through exemplified results are provided in brief.

• Bulletin of the Korean Chemical Society
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• 제15권3호
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• pp.228-236
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• 1994

The effect of the vibration mode coupling induced by the vibration-rotation interaction on total energy was investigated for the states with zero total angular momentum(J=0) in a quasilinear symmetric triatomic molecule of $AB_2$ type using a model potential function with a slight potential barrier to linearity. It is found that the coupling energy becomes larger for the levels of bend and asymmetric stretch modes and smaller for symmetric stretch mode as the excitation of the vibrational modes occurs. The results for the real molecule of $CH_2^+$, which is quasilinear, generally agree with the results for the model potential function in that common mode selective dependence of coupling energy is exhibited in both cases. The differences between the results for the model and real potential function in H-C-H system are analyzed and explained in terms of heavy mixing of the symmetric stretch and bend mode in excited vibrational states of the real molecule of $CH_2^+$. It is shown that the vibrational mode coupling in the potential energy function is primarily responsible for the broken nodal structure and chaotic behavior in highly excited levels of $CH_2^+$ for J= 0.

• 한국전자통신학회논문지
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• 제12권4호
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• pp.561-568
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• 2017

저밀도 파장분할다중화 기술을 광 집적 소자에 효율적으로 활용하기 위하여 광섬유와 평면기판 내 광 도파로 사이의 파장 선택적 광 결합기 구조가 효율적인 수단으로 고려될 수 있다. 본 논문에서는 공기 도랑 격자를 지닌 실리콘 도파로와 단일 모드 광섬유 간 결합을 고려하였다. 격자의 깊이에 따른 결합 효율의 경향성과 그 한계점을 조사하였다. 이를 위해 결합 모드 이론에 기반을 둔 모델링을 통하여 설계된 결합기 구조의 결합효율을 예측하고, 유한요소법을 이용한 시뮬레이션 결과와 정량적으로 비교 분석 하였다.

• Bulletin of the Korean Chemical Society
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• 제35권10호
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• pp.3081-3084
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• 2014

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.30-30
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• 2003

Without a definitive resolution of stoichiometry of cardiac Na$^{+}$-Ca$^{2+}$exchange (NCX), we cannot proceed to any quantitative analysis of exchange function as well as cardiac excitation-contraction coupling. The stoichiometry of cardiac NCX, however, is presently in doubt because reversal potentials determined by various groups range between those expected for a 3-to-1 and a 4-to-1 flux coupling. For a new perspective on this problem, we have used ion-selective microelectrodes to quantify directly exchanger-mediated fluxes of $Ca^{2+}$and Na$^{+}$in giant membrane patches. $Ca^{2+}$- and Na$^{+}$-selective microelectrodes, fabricated from quartz capillaries, are placed inside of the patch pipettes to detect extracellular ion transients associated with exchange activity. Ion changes are monitored at various distances from the membrane, and the absolute ion fluxes through NCX are determined via simulations of ion diffusion and compared with standard ion fluxes (Ca$^{2+}$ fluxes mediated by $Ca^{2+}$ ionophore, and Na$^{+}$ fluxes through gramicidin channels and Na$^{+}$/K$^{+}$pumps). Both guinea pig myocytes and NCX1-expressing BHK cells were employed, and for both systems the calculated stoichiometries for inward and outward exchange currents range between 3.2- and 3.4-to-1. The coupling ratios do not change significantly when currents are varied by changing cytoplasmic [Ca$^{2+}$] or by adding cytoplasmic Na$^{+}$. The exchanger reversal potentials, measured in both systems under several ionic conditions, range from 3.1- to 3.3-to-1. Taken together, a clear discrepancy from a NCX stoichiometry of 3-to-1 was obtained. Further definitive experiments are required to acquire a fixed number, and the present working hypothesis is that NCX current has an extra current via ‘conduction mode’.ent via ‘conduction mode’.

• Archives of Pharmacal Research
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• 제27권1호
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• pp.25-30
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• 2004

Combinatorial homoserine lactone mixtures and individual products were obtained from the methionine-functionalized resin in solid-phase synthesis. The four-step process consisting of a coupling step of an N-Fmoc-L-methionine, deprotection of N-Fmoc group, N-coupling with a carboxylic acid, and cleavage reaction through a polymer supported strategy is described. Gas chromatography-mass selective detector (GC-MSD) techniques provide the most powerful methods for identifying both the combinatorial mixtures and individual products.

• Bulletin of the Korean Chemical Society
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• 제34권1호
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• pp.42-48
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• 2013

Potassium N-heterobiaryltrifluoroborates were successfully prepared via a selective Cu-catalyzed C-N coupling reaction. The $BF_3K$ moiety was well tolerated under the reaction conditions involving CuI and dimethyl-ethylenediamine (DMEDA) in the presence of DMSO. The Pd-catalyzed Suzuki-Miyaura cross couplings of potassium N-heterobiaryltrifluoroborates with bromoarenes were studied to prepare the N-heterotriaryl compounds. Moreover, homocoupling, iodination, and hydroxylation of potassium N-heterobiaryltrifluoroborates provided the corresponding products in high yields.

• Bulletin of the Korean Chemical Society
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• 제32권spc8호
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• pp.2911-2915
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• 2011

Efficient synthetic method for the preparation of ethyl 2-aryl-2,3-alkadienoates through Pd-catalyzed selective allenyl cross-coupling reactions of aryl iodides with organoindiums generated in situ from indium and ethyl 4-bromo-2-alkynoate was developed. The cyclization reaction of ethyl 2-aryl-2,3-alkadienoates catalyzed by $AuCl_3$ and AgOTf in the presence of AcOH or TfOH produced various ${\alpha}$-aryl ${\gamma}$-butenolides or ${\gamma}$-substituted ${\alpha}$-aryl ${\gamma}$-butenolides.

• 한국광학회지
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• 제13권3호
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• pp.228-234
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• 2002

금속박막이 포함된 측면 연마 광섬유 결합기의 편광 선택적 결합 특성에 관한 이론적 연구 결과를 보고한다. 직교 모드이론을 이용하여 다양한 구조 조건에서 소자의 결합 특성을 분석하였다. 금속 박막의 두께가 증가함에 따라 TE 모드사이의 결합의 세기는 급격히 약해지는 반면에 TM 모드의 결합의 세기는 커짐을 보였다. 높은 편광 소멸비와 낮은 삽입 손실을 가지는 편광 분리기의 설계 조건을 제시하였다.

• Journal of the Optical Society of Korea
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• 제19권6호
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• pp.673-678
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• 2015

Terahertz dual-band frequency selective surface filters made by perforating two different rectangular holes in molybdenum have been designed, fabricated and measured. Physical mechanisms of the dual-band resonant responses are clarified by three differently configured filters and the electric field distribution diagrams. The design process is straightforward and simple according to the physical concept and some formulas. Due to the weak coupling between the two neighboring rectangle holes with different sizes in the unit cell, good dual-band frequency selectivity performance can be easily achieved both in the lower and higher bands by tuning dimensions of the two rectangular holes. Three samples are fabricated, and their dual-band characteristics have been demonstrated by a THz time-domain spectroscopy system. Different from most commonly used metal-dielectric structure or metal-dielectric-metal sandwiched filters, the designed dual-band filters have advantages of easy fabrication and low cost, the encouraging results afforded by these filters could find their applications in dual-band sensors, THz communication systems and other emerging THz technologies.