• 한국임상수의학회지
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• 제6권1호
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• pp.209-216
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• 1989

In order to investigate sedative action of detomidine and its effect on physical signs, hematological and blood chemical components, 15 Holstein cattle were used. The dosage of detomidine was 25 ${\mu}$g/kg and 50 ${\mu}$g/kg. Blood was collected before injection, 30, 60 and 120 min. after injection. Induction time of sedation in a cattle given with 25 ${\mu}$g/kg and 50 ${\mu}$g/kg of detomidine was 10.6${\pm}$2.8. 7.6${\pm}$1.0min. respectively and maintenance time was 70.4${\pm}$8.3, 86.5${\pm}$9.9, respectively. After injection of detomidine, body temperature was slightly increased, heart rate and respiratory rate were slightly decreased. The levels of red blood cell, hemoglobin, packed cell volume and white blood cell were not changed by detomidine. Blood glucose level following detomidine was markedly increased but total protein, serum glutamic oxaloacetic transminase, alkaline phosphatase, lactic dehydrogenase, blood urea nitrogen and creatinine were not changed. This results indicated that detomidine was useful sedative in bovine practice.

• 한국임상수의학회지
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• 제14권2호
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• pp.151-160
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• 1997

This study was performed to assess clinical signs, sedative and physiologic effects of a combination of fentanyl, azaperone and xylazine (F-A-X). The experiments were divided into four groups; xylazine 0.1mg/kg (X 0.1), F-A-X 0.05 MG/KG (F-A-X 0.05), F-A-X 0.1 MG/KG (F-A-X 0.1) and F-A-X 0.2mg/kg (F-A-X 0.2). Heart rates were decreased in all groups. Respiratory rates were decreased in other groups, but increased in F-A-X 0.2. Body temperatures were in normal ranges. After administration of F-A-X, most of cattle were recumbency and did not respond to needle prick. Duration of sedation was prolonged with increasing dosages. F-A-X did not induce sufficient analgesia for dehorning. Side effects were salivation and urination in all, but they were much less in F-A-X groups than those in X 0.1. Intermittent apnea and bloat were observed in F-A-X 0.2. Serum chemistry values were in normal ranges exvept for hyperglycemia invreased thorough experimental time. Based on above results, it may be concluded that F-A-X is effective preanesthetic with low dosage of 0.05~0.1 mg/kg being useful for immobilization or manipulation without tissue incision in cattle.

• 생약학회지
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• 제12권4호
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• pp.190-194
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• 1981

It was prevously shown that 'Kamisamhwang-Tang' had been examined for effects of the anticonvulsion, antipyretic, analgesic and sedative. To investigate the effect on cardiovascular system and antibacterial activities, pharmacological studies have been carried out with each extract. The results of this investigation were summarized as follows: 1) 'Kamisamhwang-Tang' depressed central convulsion induced by strychnine, picrotoxine and caffeine in mice. 2) Antipyretic, analgesic and sedative action were observed. 3) Hypotensive effect was observed in rabbits. 4) Antibacterial activities was observed.

• 동의신경정신과학회지
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• 제1권1호
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• pp.39-48
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• 1990

Baikgeumhoan is well known for cure of epilepsy. In order to investigate the anticonvulsion, analgesic action and sedative effect of Baikgeumhoan pharmacological studies have been carried out with Baikgeumhoan. Baikgeumhoan is composed of two drugs; Rhizoma curcumae and Alumen. The results were as follows ; 1. Anticonvulsion effect against the convulsion induced by picrotoxin in Mice was significantly recognized. 2. Analgesic action estimated by the acetic acid stimulating meehod was shown in Mice. 3. Sedative effect was shown in Mice. Considering the above experimental results, it is suggested that the effects of Baikgeumhoan based on the Oriental medicinal references were similary consistant with actual experimental results.

• 약학회지
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• 제15권2호
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• pp.53-63
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• 1971

A water-soluble basic extract was obtained from Zizyphi spinosi semen and tested on its sedative and psychotropic activities. In a 2.2m $\times$ 2.2m $\times$ 0.8m open-field, the effect of the extract on unlearned emotional responses of mice was determined. Intraperitoneal injection of 5mg/kg, 10mg/kg, and 20mg/kg of the extract caused to show less often the frequency of ambulation, rearing and exploration and more the frequency of lying and sleeping than that of placebo control, meprobamate and chlordiazepoxide treated groups. In a standard shuttle box, the effect of the extract on learned emotional responses was determined. Intraperitoneal injection of 10mg/kg of the extract caused to show less conditioned response, secondary conditioned response and defecation than either placebo control or pre- and post-treated sessions with the extract throughout the acquisition and extinction of conditioned avoidance response. Intraperitoneal injection of 10mg/kg of the extract showed similar sedative actions with that of 1.25mg/kg of chlorpromazine. The extract shows major tranquilizer-like effect as chlorpromazine.

• 대한소아치과학회지
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• 제38권4호
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• pp.355-361
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• 2011

소아치과 분야에서 chloral hydrate와 hydroxyzine를 이용한 진정 요법은 가장 보편화된 방법이지만 진정 효과는 약물의 용량, 연령, 체중, 술 전 환아의 수면 시간, 술 전 공복유지 유무, 환아의 건강 상태에 따라 좌우 될 수 있다. 본 연구는 경험적으로 chloral hydrate 진정 요법 시행 전날 수면 시간이 짧을수록 진정 효과가 더 크다는 점에 착안하여 협조전 단계 환아에서 chloral hydrate/hydroxyzine을 이용한 진정 치료 시 치료 전 수면 시간과 진정 효과의 관계에 대해 알아보고자 시행 하였다. 한림대 소아치과에 내원한 환자 중 사전 조사에서 1일 평균 수면 시간이 비슷한 만 2-5세 아이들 37명을 대상으로 chloral hydrate/hydroxyzine 진정 요법 하 치료를 시행하였다. 치수 치료를 포함하여 수복치료를 요하는 아이들을 대상으로 하였으며 치수치료를 한 환자는 총 11명이었다. 진정 효과는 동일한 평가자에 의해 Houpt 등의 rating scal에 따라 점수를 산정하여 단순회귀 분석법으로 평가하였고 치수 치료 유무에 따라 진정 효과가 달라지는지 여부를 t-test로 평가하여 다음과 같은 결과를 얻었다. 1. Houpt 등의 rating scale 중 sleep, crying 항목은 전날 수면 시간에 따라 유의하지는 않지만 반비례 상관관계를 지닌다(p>0.05). 2. Movement, overall behavior는 전날 수면 시간에 따라 유의하게 반비례하는 상관관계를 나타냈다(p<0.05). 3. 치료 내용에 따른 진정 요법 효과의 차이는 보이지 않았다(p>0.05). 실험 결과 진정 전 수면 시간이 짧을수록 진정 효과가 높은 것으로 나타났다.

• 동의생리병리학회지
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• 제16권3호
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• pp.567-571
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• 2002

In order to prove the sedative, anticonvulsive effects of Incenses and to identify the effect of this medicine to cerebral glutamic acid and GABA density in experimental animal. we used Incense which was made of traditional herb medicines. We also examined what kind of material is to be involved in biosynthesis of these elements. In addition we experimented to find out synthesis of active GABA-T. Incenses were inhaled 8 hours a day for 4 weeks to mice. Finally we have following results. On the convulsion induced by pentylenetetrazole(PTZ), Incenses showed significant anticonvulsive effect. Density of glutamic acid in brain was significantly decreased. On the contrary, density of GABA was significantly increased. The Activity of GABA- T in brain was significantly reduced. The quantity of lipid peroxide in the brain was significantly decreased. Activity of xanthine oxidase and aldehyde oxidase were significantly reduced in brain. From the above results, we confirmed that Incenses decreased the density of glutamic acid, increased GABA density and decreased the activity of GABA- T in brain. For the convulsion which was induced by PTZ, Incenses showed significant anticonvulsive effect. With this we can recognize that Incenses had ability to control the quantity of lipid peroxide in brain. In the conclusion, Incenses has significant anticonvulsive effect, so I strongly recommend to prescribe Incenses to treat convulsive disorder like epilepsy.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2001년도 10주년 기념 국제학술 심포지움 및 추계학술대회
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• pp.90-90
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• 2001

• 생약학회지
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• 제19권2호
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• pp.141-151
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• 1988

The sedative, antipyretic, analgesic and anticonvulsive action, action on the isolated ileum in mice, retricting action on edema, action on blood pressure and respiration of Sipmidojuksan were evaluated. The results were as follows; sedative effects were recognized by the unbalanced effects of spontaneous momentum by wheel cage method, muscle relaxing action by rotor rod method and prolongation of sleeping hours. In mice, a significant antipyretic effect to endotoxin was recognized. Significant anagesic effects by acetic acid and Randall-Sellito method were recognized. Significant anticonvulsive effects to strychnine and picrotoxin were recognized. Spontaneous momentum of isolated ileum in mice was restricted, and relaxing effects on smooth muscle of digestive organ were noted by anti-acetylcholine, anti-barium chloride and anti-histamine effects. Significant antiedemic effects to carrageenin and histamine were recognized. Dilatation of blood vessels and decrease of blood pressure were noted.

• 생약학회지
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• 제16권1호
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• pp.18-25
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• 1985

Experimental studies were conducted to investigate for the effect of Tongkyu-tang on analgesic, antipyretic, sedative, anti-inflammatory, isolated ileum and anti-histamine actions. Tongkyu-Tang was composed of sixteen crude drugs including Astragali Radix, which has been used for the treatment of common cold, headache, rhinitis, nasal obstruction, rhincospasm, etc. The following results have been obtained; analgesic and antipyretic actions were obtained. Prolonged action against the hypnotic duration of pentobarbital were significantly noted in mice. Anti-inflammatory effects in the paw edema induced by 1% carrageenin and 1% dextran were significantly shown in rats. Spontaneous motilities of isolated ileum of mice were strongly suppressed, and contractions of isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Antihistamine actions were noted. Considering the above experimental results, it is suggested that effects of Tongkyu-tang based on the Oriental Medical References were similarly consistent with the actual experimental results.