• Journal of Soil and Groundwater Environment
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• v.14 no.6
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• pp.53-64
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• 2009

Wetlands can remove organic contaminants, metals and radionuclides from wastewater through various biogeochemical mechanisms. In this study, a mathematical model was developed for simulating the fate and transport of chemical species in marsh wetland sediments. The proposed model is a one-dimensional vertical saturated model which is incorporated advection, hydrodynamic dispersion, biodegradation, oxidative/reductive chemical reactions and the effects from external environments such as the growth of plants and the fluctuation of water level due to periodic tides. The tidal effects causes periodic changes of porewater flow in the sediments and the evapotranspiration and oxygen supply by plant roots affect the porewater flow and redox condition on in the rhizosphere along with seasonal variation. A series of numerical experiments under hypothetical conditions were performed for simulating the temporal and spatial distribution of chemical species of interests using the proposed model. The fate and transport of a trace metal pollutant, chromium, in marsh sediments were also simulated. Results of numerical simulations show that plant roots and tides significantly affect the chemical profiles of different electron acceptors, their reduced species and trace metals in marsh sediments.

• Journal of the Korean Institute of Landscape Architecture
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• v.30 no.3
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• pp.12-24
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• 2002

The purpose of this paper is to decompose the effect of resources of natural parks(NP) on user's satisfaction to answer the research question: What are the causal effects of resources of natural parks on user\ulcorner After reviewing the literature, classification of resources of NP, various approaches and analysis methods employed, we constructed the conceptual framework and have formulated the hypothesis of this research. We had obtained data through a questionnaire, which surveyed 414 visitors at 6 of the 73 NP in Korea in 2001, based on a stratified sampling method. We have analyzed the data using descriptive statistical methods, Pearson's correlation analysis, and a path analysis method. We found that 1) While the indirect effect of topographical feature and valley(TFV), socio-cultural resources(SCR), and climate, sound, and scent(CSS) turned out to be 2.75, 1.20, and 2.00 times higher than that of wild animal and plant(WAP), the direct effect of TFV, SCR, and landscape turned out to be 2.95, 2.88, and 2.64 times higher than that of CSS, 2) The magnitude of causal effects of the three exogeneous variables of TFV, WAP, and SCR and two intervening variables of CSS and landscape on User's satisfaction turned out to be 0.403, 0.048, 0.323, 0.188, and 0.243, respectively, 3) Total direct effect of the exogeneous and intervening variables on user's satisfaction is 0.871, while that of indirect effect is 0.334, and 4) Causal effect of tangible resources is 1.80 times higher than that of intangible while total effect of tangible resources are 1.36 times higher than that of intangible. The research results suggest that 1) Criteria for designation and maintenances of NP and results of previous studies on resources turned out to be unreliable and distorted, 2) In the criteria of planning and maintenance of NP, intangible resources must be included, 3) Remedial directions to increase user's satisfaction should be focused on maintenance of TFV and landscape in NP, and 4) The approach and path analysis adopted by this research is valid and highly useful for other resource based recreation area. It is recommended that more empirical study on seasonal variation of resources in NP based user's preference be performed in the future.

• Clinical and Experimental Reproductive Medicine
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• v.31 no.3
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• pp.155-168
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• 2004

Objective: Melatonin, which is secreted by pineal gland play an important role in the regulation of ovarian function via seasonal rhythm and sleep in most mammals. It also has a role in the protection of cells by removing toxic oxygen free radicals brought about by metabolism. In the present study, effects of melatonin on the mouse oocyte maturation were examined using two different culture conditions provided with 5% or 21% oxygen concentration. Material and Method: Immature mouse oocytes were obtained from the ovarian follicles of $3{\sim}4$ weeks old ICR strain mice intraperitoneally injected with 5 I.U. PMSG 44 hour before. Under stereomicroscope, morphologically healthy oocytes with distinct germinal vesicle (GV) were liberated from the graafian follicles and collected using mouth-controlled micropipette. They were then cultured for 17 hour at $37^{circ}C$, 5% $CO_2$ and 21% $O_2$ (95% air) or 5% $CO_2$, 5% $O_2$ and 90% $N_2$. New modified Hank's balanced salt solution (New MHBS) was used as a culture medium throughout the experiments. Effects of melatonin were examined at a concentration of $0.0001{\mu}M$, $0.01{\mu}M$ or $1.0{\mu}M$. For the prevention of spontaneous maturation of immature oocytes during culture, dibutyryl cyclic AMP (dbcAMP) and/or hypoxanthine were included in the medium. Results: Under 21% oxygen condition, oocytes cultured in the presence of $0.01{\mu}M$ melatonin showed a significantly higher maturation rates, in terms of germinal vesicle breakdown (95.0% vs 89.0%) and polar body formation (88.1% vs 75.4%), compared to those cultured with $0.0001{\mu}M$ or $1.0{\mu}M$ melatonin. However, no difference was observed in oocytes cultured under 5% oxygen whether they were treated with melatonin or not. In the presence of $0.01{\mu}M$ melatonin, oocytes either cultured under 21% or 5% oxygen exhibited no difference in the polar body formation (85.6% vs 86.7%). However, in the absence of melatonin, oocytes cultured under 21% oxygen exhibited lower polar body formation (74.7%). When oocytes were cultured in the presence of dbcAMP alone or with varying concentrations of melatonin, those treated with both compounds always showed better maturation, i.e., germinal vesicle breakdown and polar body formation, compared to those cultured with dbcAMP alone. At the same concentration of melatonin, however, oocytes exposed to 21% oxygen showed poor maturation than those to 5% oxygen. Similar results were obtained from the experiments using hypoxanthine instead of dbcAMP. Conclusion: Based upon these results, it is suggested that melatonin could enhance the meiotic maturation of mouse oocytes under 21% oxygen concentration, and release oocytes from the meiotic arrest by dbcAMP or hypoxanthine regardless of the concentration of oxygen, probably via the removal of oxygen free radicals.

• Journal of Life Science
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• v.32 no.5
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• pp.375-390
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• 2022

Influenza viruses are zoonotic respiratory pathogens, and influenza infections have caused a substantial burden on public health systems and the livestock industry. Although currently approved seasonal influenza vaccines have shown potent protection efficacy against antigenically well-matched strains, there are considerable unmet needs for the efficient control of viral infections. Enormous efforts have been made to develop broadly protective universal influenza vaccines to tackle the huge levels of genetic diversity and variability of influenza viruses. In addition, antiviral drugs have been considered important interventions for the treatment of viral infections. The viral neuraminidase inhibitor oseltamivir is the most widely used antiviral medication to treat influenza A and influenza B viruses. However, unsatisfactory clinical outcomes resulting from side effects and the emergence of resistant variants have led to greater attention being paid to plants as a natural resource for anti-influenza drugs. In particular, the recent COVID-19 pandemic has underpinned the need for safe and effective antiviral drugs with a broad spectrum of antiviral activity to prevent the rapid spread of viruses among humans. This review outlines the results of the antiviral activities of various natural products isolated from plants against influenza viruses. Special focus is paid to the virucidal effects and the immune-enhancing effects of antiviral natural products, since the products have broad applications as inactivating agents for the preparation of inactivated vaccines and vaccine adjuvants.

• IMMUNE NETWORK
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• v.20 no.4
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• pp.32.1-32.15
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• 2020

Influenza virus is the major cause of seasonal and pandemic flu. Currently, oseltamivir, a potent and selective inhibitor of neuraminidase of influenza A and B viruses, is the drug of choice for treating patients with influenza virus infection. However, recent emergence of oseltamivir-resistant influenza viruses has limited its efficacy. Morin hydrate (3,5,7,2',4'-pentahydroxyflavone) is a flavonoid isolated from Morus alba L. It has antioxidant, anti-inflammatory, neuroprotective, and anticancer effects partly by the inhibition of the NF-κB signaling pathway. However, its effects on influenza virus have not been studied. We evaluated the antiviral activity of morin hydrate against influenza A/Puerto Rico/8/1934 (A/PR/8; H1N1) and oseltamivir-resistant A/PR/8 influenza viruses in vitro. To determine its mode of action, we carried out time course experiments, and time of addition, hemolysis inhibition, and hemagglutination assays. The effects of the co-administration of morin hydrate and oseltamivir were assessed using the murine model of A/PR/8 infection. We found that morin hydrate reduced hemagglutination by A/PR/8 in vitro. It alleviated the symptoms of A/PR/8-infection, and reduced the levels of pro-inflammatory cytokines and chemokines, such as TNF-α and CCL2, in infected mice. Co-administration of morin hydrate and oseltamivir phosphate reduced the virus titers and attenuated pulmonary inflammation. Our results suggest that morin hydrate exhibits antiviral activity by inhibiting the entry of the virus.

• Journal of the korean society of oceanography
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• v.34 no.1
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• pp.1-21
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• 1999

A two-layer quasi-geostrophic numerical model is used to investigate the temporal variability of the East Korea Warm Current (EKWC), especially the separation from the Korean coast and the generation of warm eddies. An attention is given on the active role of the nonlinear boundary layer process. For this, an idealized flat bottom model of the East Sea is forced with the annual mean wind curl and with the inflow-outflow specified at the Korea (Tsushima) and Tsugaru Straits. Two types of separation mechanisms are identified. The first one is influenced by the westward movement of the recirculating leg of the EKWC (externally driven separation),the second one is solely driven by the boundary layer dynamics (internally driven separation). However, these two processes are not independent, and usually coexist. It is hypothesized that 'internally driven separation' arises as the result of relative vorticity production at the wall, its subsequent advection via the EKWC, and its accumulation up to a critical level characterized by the separation of the boundary flow from the coast. It is found that the sharp southeastern corner of the Korean peninsula provides a favorable condition for the accumulation of relative vorticity. The separation of the EKWC usually accompanies the generation of a warm eddy with a diameter of about 120 km. The warm eddy has a typical layer-averaged velocity of 0.3 m/s and its lifespan is up to a year. In general, the characteristics of the simulated warm eddy are compatible with observations. A conclusion is therefore drawn that the variability of the EKWC is at least partially self-excited, not being influenced by any sources of perturbation in the forcing field, and that the likely source of the variability is the barotropic instability although the extent of contribution from the baroclinic instability remains unknown. The effects of the seasonal wind curl and inflow-outflow strength are also investigated.

• Journal of Korean Society of Steel Construction
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• v.10 no.3 s.36
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• pp.537-551
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• 1998

The intention of this paper is to provide realistic values of design thermal loads applicable to composite box girder bridges on the basis of the statistical analysis of long-term measured temperature data. For this purpose, temperatures were recorded at a newly constructed composite box girder bridge during about 20 months. Before analyzing the extreme values, major thermal loading parameters that characterize the temperature profile are defined, and a seasonal behavior of those is examined in detail. The limit distributions of the thermal loading parameters are then determined by the tail-equivalence method, and the thermal loading parameters corresponding to selected return period are calculated. Finally, the results are compared to the specifications suggested in a current design code for thermal loads, and it is concluded that the current design code is unsuitable for representing the self-equilibrated thermal stresses in composite bridges, and the horizontal temperature difference which is not suggested in current design code should be taken Into account in particular cases.

• 한국해양학회지
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• v.18 no.2
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• pp.169-179
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• 1983

Distribution of soft-bottom macrobenthos en Masan Bay was studied in terms of seasonal changes in species composition, abundance, and diversity from August, 1980 to May, 1981. Of the 65 species ot benthic macrofauna observed, polychaete was the most dominant taxonomic group with 34 species, which accounted for 72% of the total number of benthic animals. Species richness and numerical abundance seemed to decrease from the outer Bay stations to the innermost bay station, where certain zoological groups such as crustaceans and echinoderms were eliminated. Based on the ecological indices calculated, the inner basins of the Masan Bay apparently receive high input levels of organic material derived from land drainage, domestic wastes, and industrial complex installed in Masan city and nearby urban area. Particularly, at two inner bay stations of the Masan Bay, these levels seemed to approach the limit of the degradative capacity of the muddy bottom ecosystem, and have significantly affected the characteristics and distfibution of the benthic macrofauna.

• Journal of the Korean Society of Clothing and Textiles
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• v.29 no.3_4 s.141
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• pp.511-522
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• 2005

The purpose of this study is to analyze the organization of trading area and fashion trend in Gumi based on the observation of fashion brand stores which had been undertaken on a regular basis from July 2001 through July 2004. Gumi has over 1,000 stores located in main trading streets, about $25\%$ of which was fashion retail stores. In July 2004, $64.6\%$ of them was selling branded products, and the number of unisex casual wear stores was the greatest, followed by women's casual wear stores, sportswear stores, and children's wear stores. On the main streets of Gumi, casual attires as well as casual wear stores can be easily observed because the population of eumi is young compared to that of other regions. Among casual wear brands, especially sensory, or trendy casual wear brands such like BNX, A6, Coax, Koolhaas, EXR, and Smex came into Gumi area in large numbers since fall of 2002. From the observation data, dynamic and systemic effects of economic state, population, seasonal elements, product characteristics, etc. on the organizations of trading area were identified.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.33 no.1
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• pp.1-8
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• 2000

Benthic environments and composition of macrobenthic fauna around the marine fish culture cages were studied to clarify the effect of fish farming near Tongyong from August, 1995 to february, 1996. Sediment grain size and bottom dissolved oxygen under the fish cages were similar to that of a control site, but organic content was higher under the cages. Fewer species were found under the fish cages than under the control site, but conspicuously higher density was obtained under cages. Capitella capitals, Nebalia bipes were dominant infauna, and Asterina pertinifera and Astelias amurensis were dominant epifauna under the fish cage whereas Lumbrineris longifolia and Anphioplus sp. dominated in the control site. Diversity index showed seasonal variation under the fish cages, but showed little variation at the control site. The benthic fauna under the fish cages showed different community structures from the control site. As results, the fish culture cages affected the benthic environment and the community structure of benthic fauna by input of the organic content and biological effects such as dead shells.