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Recent Domestic and International Trends in Clinical Research of Herbal Medicine Treatment for Crohn's disease (크론병의 한약 치료에 대한 최근 국내외 임상연구 동향)

  • Lee, Shin Hee;Heo, Yu Jin;Cho, Yun Soo
    • The Journal of Pediatrics of Korean Medicine
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    • v.35 no.4
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    • pp.56-74
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    • 2021
  • Objectives The purpose of this study is to analyze the trend of herbal medicine treatment, treatment's effect and stability for Crohn's disease by reviewing clinical studies published over the past 5 years. Methods 22 articles which were published from 2017 to August, 2021 were obtained from the ScienceON, Research information sharing service (RISS), Koreanstudies Information Service System (KISS), Oriental medicine advanced searching integrated system (OASIS), China national knowledge infrastructure (CNKI), Pubmed. We analyzed the literature in regards to the treatment methods and results. Results There were 6 case reports, 1 controlled clinical trial, and 15 randomized controlled trial and in most cases, herbal medicines and Western medicines were administered in combination. The pathology of damp-heat due to spleen deficiency was the most common, and Sijunzi-tang and Shenling Baishu san were the most commonly used. As a result of the treatment, it was found that the combined administration of the herbal medicine and the Western medicine was more effective than the administration of the Western medicine alone. Conclusions Herbal treatment of Crohn's disease induced high cure rate safely than when only western treatment was applied. Future studies on safety and studies that can suggest specific guidelines for the combined administration of western and herbal medicines are needed.

An Analysis of the Trends of Korean Medicine Treatments for Trigger Finger (방아쇠 수지에 대한 한의학적 치료 연구 동향 분석)

  • Choi, Jae-Yong;Lee, Sang-Gun;Kim, Ho;Yoo, Sang-Joon;Kang, Dong-Hyeob;Lee, Do-Hoon;Choi, Ki-Won;Lee, Yu-Jin
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.4
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    • pp.65-74
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    • 2021
  • Objectives The purpose of this review is to analyze the trends of Korean medicine treatment for trigger finger. Methods Clinical papers using Korean medicine to treat trigger finger were searched in five online databases-Koreanstudies Information Service System, Oriental Medicine Advanced Searching Integrated System, ScienceON, Research Information Sharing Service, and PubMed. Nine studies were selected, and we analyzed their characteristics according to the author, year, number/gender/age of patients, duration of disease, duration of treatment, intervention method, measurement methods, and results. Results Seven case report studies, one prospective observational study, and one randomized controlled trials (RCTs) were selected in online databases, and there were no review studies. The most frequently used therapies were pharmacopuncture and acupuncture treatment. visual analogue scale, Quinnell's classification of triggering, was frequently used for measurement methods. All nine studies had therapeutic effects. Conclusions We reviewed studies of Korean medicine treatments for trigger finger, in this study. However, there are limitations that seven of the nine selected papers were case papers, and the number of papers was small. This paper suggests that a higher level of research and more studies on Korean medicine treatments of trigger finger need to be conducted.

A Study on the Trend and Meaning of Searching for Herbal Medicines in Online Portal Using Naver DataLab Search Trend Service (네이버 데이터랩 검색어 트렌드 서비스를 이용한 온라인 포털에서의 한약재 검색 트렌드와 의미에 대한 고찰)

  • Kim, Young-Sik;Lee, Seungho
    • The Korea Journal of Herbology
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    • v.36 no.5
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    • pp.1-14
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    • 2021
  • Objectives : From January 2020, when the first confirmed case of COVID-19 in Korea, the use of health information using the Internet is expected to increase. It is expected that there will be a significant change in the general public's interest in Korean herbal medicines for health care. Therefore, in this study, we tried to confirm the change in the search trend of Korean herbal medicines after the COVID-19 epidemic. Methods : Using the "Naver DataLab (http://datalab.naver.com)" service of a Korean portal site Naver, search volume was investigated with 606 Korean herbal medicines as keywords. The search period was from January 2020, right after the onset of COVID-19, to June 2021. The search results were sorted by the peak search volume and the total search volume. Results : 'Cheonsangap (천산갑, 穿山甲, Manitis Squama)' was the most searched Korean herbal medicine in the peak search volume and total search volume with least bias. Conclusions : The problem of supply and demand of Korean herbal medicines of high public interest was identified. Broadcasting and media exposure were the factors that had a big impact on the search volume for Korean herbal medicines. As it was confirmed that the search volume for Korean herbal medicines increased rapidly due to media exposure, it is necessary to provide correct information about Korean herbal medicines, improve public awareness, and manage stable supply and demand based on continuous search trend monitoring.

Development of the Rule-based Smart Tourism Chatbot using Neo4J graph database

  • Kim, Dong-Hyun;Im, Hyeon-Su;Hyeon, Jong-Heon;Jwa, Jeong-Woo
    • International Journal of Internet, Broadcasting and Communication
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    • v.13 no.2
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    • pp.179-186
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    • 2021
  • We have been developed the smart tourism app and the Instagram and YouTube contents to provide personalized tourism information and travel product information to individual tourists. In this paper, we develop a rule-based smart tourism chatbot with the khaiii (Kakao Hangul Analyzer III) morphological analyzer and Neo4J graph database. In the proposed chatbot system, we use a morpheme analyzer, a proper noun dictionary including tourist destination names, and a general noun dictionary including containing frequently used words in tourist information search to understand the intention of the user's question. The tourism knowledge base built using the Neo4J graph database provides adequate answers to tourists' questions. In this paper, the nodes of Neo4J are Area based on tourist destination address, Contents with property of tourist information, and Service including service attribute data frequently used for search. A Neo4J query is created based on the result of analyzing the intention of a tourist's question with the property of nodes and relationships in Neo4J database. An answer to the question is made by searching in the tourism knowledge base. In this paper, we create the tourism knowledge base using more than 1300 Jeju tourism information used in the smart tourism app. We plan to develop a multilingual smart tour chatbot using the named entity recognition (NER), intention classification using conditional random field(CRF), and transfer learning using the pretrained language models.

Clinical Effectiveness of Acupuncture Related to Improvement in Quality of Life and Problems after Percutaneous Coronary Intervention : A Systematic Review (관상동맥 중재술 후 문제점 및 삶의 질 개선에 관한 침 치료 효과 : 체계적 문헌 고찰)

  • Lee, Ji Sung;Park, Ui Hyun;Kwon, Jung-nam
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.33 no.2
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    • pp.82-88
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    • 2019
  • This systematic review evaluates the clinical effectiveness of acupuncture related to improvement in quality of life and problems after Percutaneous Coronary Intervention(PCI). We searched papers in many databases, including National Discovery for Science Leaders(NDSL), Koreanstudies Information Service System(KISS), Oriental Medicine Advanced Searching Integrated System(OASIS), Research Information Sharing Service(RISS), Public/Publisher MEDLINE(Pubmed), Embase, Cochranelibrary, Chinese Academic Journals(CAJ), Japan Science and Technology Agency(J-STAGE). Initially, 161 studies were found. Of these, 141 studies were excluded following abstract screening. After the remaining 20 papers were scanned, 5 RCTs were selected and analyzed. Among these 5 RCTs, HAMD(Hamilton Rating Scale for Depression) is significantly effective in 1 RCT. In 2 RCTs, LVEF(Left Ventricular Ejection Fraction) is significantly effective. In 2 RCTs, 6MWT(Six-Minute Walk Test) is significantly effective. The review of 5 studies suggests that acupuncture after PCI can be effective in many problems occured after PCI. However, This study couldn't conduct a meta-analysis due to the differences in interventions. Therefore, we hope that systematic reviews with meta-analysis will be published.

Review of Clinical Study over the Last 10 Years on Korean Medicine Treatment for Cancer: Focusing on Korean Database (한방 암 치료에 대한 최근 10년간 임상연구 고찰: 국내 데이터베이스를 중심으로)

  • Choi, Ji-Won;Nam, Yeon-Kyeong;Lee, Jung-Han;Woo, Hyeon-Jun
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.4
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    • pp.75-86
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    • 2021
  • Objectives This study aimed to analyze the research trends in clinical studies on the traditional Korean medicine used for cancer treatment between 2011 and 2020. Methods We searched 7 Korean web databases (Research Information Sharing Service [RISS], Oriental Medicine Advanced Searching Integrated System [OASIS], Koreanstudies Information Service System [KISS], Korean Medical database [KMBASE], DBpia, Korea Institute of Science and Technology Information [KISTI], and KoreaMed) and classified collected papers dated between 2011 and 2020 by the year of publication, publication journal, study design, type of cancer affecting the patients, interventions used, evaluation system used, and combination with conventional medicine. Results A total of 167 papers were collected. More than 10 papers were published annually. The papers were mainly published in the Journal of Korean Traditional Oncology (28.7%). The predominant type of the study was case study (67.7%). The main type of cancer was breast cancer, affecting 262 patients. Most of the studies reported using multiple traditional Korean medicine treatments (55.1%). Eighty-nine studies reported using clinical laboratory tests for evaluation. Most of the patients took conventional medicine simultaneously (608 patients). Conclusions Research related to Korean medicine for cancer patients is at a rudimentary level. Therefore, for further clarity, high evidence-based researches, including randomized controlled trials and cohort studies, should be conducted.

A Comparative Study of Mongolian and Korean Traditional Medicine (몽골과 한국 전통의학의 비교 연구)

  • Purevjav, Oyanga-Bileg;Ha, Won-Bae;Geum, Ji-Hye;Lee, Jung-Han
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.4
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    • pp.87-103
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    • 2021
  • Objectives The purpose of this study was to investigate the development process and describe the diagnosis methods, theories and treatments of Mongolian traditional medicine and Korean traditional medicine through literature records and prior studies. Methods Literature records and previous studies on traditional medicine of both countries were collected through various sites in Mongolia (Esan, Mongoliajol, Kok, Yumpu, Scribd, Science and Technology Foundation [STF]) and Korea (Koreanstudies Information Service System [KISS], Korea Institute of Science and Technology Information [KISTI], National Digital Science Library [NDSL], Research Information Sharing Service [RISS], Oriental Medicine Advanced Searching Integrated System [OASIS]). Also the English database was searched through PubMed. In the case of Mongolian traditional medicine, medical books published in Mongolia were mainly referenced and used for research. Results Studying the development process, basic concepts and the system of diagnosis and treatment of the two traditional medicine, several commonalities and differences were revealed. Conclusions This study showed that the scope of diagnosis methods between Mongolian and Korean traditional medicine were slightly different, and that the medical terminology for the diagnosis method had slightly different contents from each other. Although there were many similarities in treatments of Mongolian and Korean traditional medicine, the Chuna therapy is found in Korean traditional medicine only. The basic theories constituting traditional medicine were the same, but the five-element theory used by the two countries differs in the following two factors. Mongolia uses elements of air and space as the theory of five elements, while Korea uses elements of wood and iron.

Thread Embedding Therapy in Rheumatoid Arthritis: A Systematic Review of Animal Studies (매선요법의 류마티스 관절염 동물모델을 활용한 실험연구: 체계적 문헌고찰)

  • Jun, Purumea;Zhao, HuiYan;Kang, Suk-Yun;Han, Chang-Hyun
    • Korean Journal of Acupuncture
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    • v.38 no.3
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    • pp.122-132
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    • 2021
  • Objectives : This systematic review aims to assess the effectiveness of thread embedding therapy on animal model for rheumatoid arthritis. Methods : Search was conducted in the Cochrane library, MEDLINE (PubMed), EMBASE, the Chinese National Knowledge Infrastructure, Wan-Fang Database, Technology Journal Database, the Korean Studies Information Service System, the Oriental Medicine Advanced Searching Integrated System, the Research Information Sharing Service, the National Digital Science Library, the Korean Traditional Knowledge Portal and the Korea Citation Index. Data were extracted concerning animal model, intervention and rheumatoid arthritis indicator by two independent reviewers. Reporting quality was also evaluated by the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines 2.0. Results : One thousand thirty six studies were primarily selected. After screening, 10 studies met the inclusion criteria. 1 study was published 2005, 1 study was published 2010, 1 study was published 2012, 1 study was published 2015, 2 studies were published 2016, 3 studies were published 2017, 1 study was published 2018. The most frequently used acupoints were ST36 and BL23, and were used with an average frequency of 11.8 days. All of these thread embedding therapy studies were effective on behavioral, morphological, immunohistological and hematological indicators to treat of rheumatoid arthritis model. Conclusions : These results demonstrated the effectiveness of thread embedding therapy and suggested the putative mechanism. However, considering the small number of included studies, low reporting quality and differences in study design, further studies with rigorous designs and high reporting quality need to be conducted.

Systematic Review and Meta-analysis on Acupotomy for Piriformis Muscle Syndrome (이상근증후군의 도침치료에 대한 체계적 문헌고찰 및 메타 분석)

  • Park, Song-Mi;Jung, Sue-un;Park, Jung-Hyeon;Do, Hyun-jeong;Cho, Sung-Woo
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.2
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    • pp.25-40
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    • 2021
  • Objectives This study was conducted to analyze the effect of using acupotomy for piriformis muscle syndrome. Methods The databases used for the search were PubMed, Embase, Cochrane library, China National Knowledge Infrastructure (CNKI), Koreanstudies Information Service System (KISS), Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS), KMbase, and National Digital Science Library (NDSL). The literature was searched using a total of 9 domestic and foreign databases. randomized controlled trial using only acupotomy as an intervention was selected. The selected studies are analyzed the risk of bias through Cochrane risk of bias, and meta-analysis was performed using Revman. Results As a result of meta-analysis of 11 selected studies, acupotomy was more effective than nerve block and acupuncture. In terms of visual analog scale and immediate analgesic effect, acupotomy did not have statistically significant results compared to other treatment methods. meta-analysis of electro-acupuncture and acupotomy showed no significant results. Conclusions When acupotomy is applied as a treatment for piriformis muscle syndrome, it is more effective than nerve block and acupuncture. but most of the studies have been judged as 'unclear' in the risk of bias assessment. Due to characteristics of treatment group and control group's intervention, It is judged that the blinding of the participant was not properly implemented. Therefore, it is considered that high-quality studies are necessary to supplement the problems in the future.

Chuna Manual Therapy for Rhinitis: Systematic Review and Meta Analysis (비염에 대한 추나요법의 효과: 체계적 문헌 고찰과 메타분석)

  • Cho, Ju-chan;Park, In-hwa;Heo, In
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.16 no.1
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    • pp.35-42
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    • 2021
  • Objectives The objective of this study was to evaluate the effect of chuna manual therapy for rhinitis. Methods We performed a literature search using ten electronic databases (PubMed, Embase, Cochrane Library, Chinese Academic Journals(CAJ), Research Information Sharing Service(RISS), Dbpia, National Digital Science Library(NDSL), Koreanstudies Information Service System(KISS), Korean Medical database(KMbase), and Oriental Medicine Advanced Searching Integrated System(OASIS)) and two academic journals up to the end of April 2021. We included randomized controlled trials (RCTs) which appraised the effect of chuna manual therapy (CMT) in the treatment of rhinitis. The risk of bias was evaluated from the Cochrane Risk of Bias tool. Results 4 appropriate RCTs were included and analyzed. The efficacy rate of the CMT group was statistically higher compared to the control group treated with medicine[RR 1.14 (95%CI 1.06 1.22), P<0.01]. Conclusions Based on results, CMT could be effective in rhinitis. However, evidence were limited due to small number of studies, lack of well-designed RCT and regional bias. Further well-designed research should be required to obtain stronger evidence.