• 통합자연과학논문집
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• 제5권4호
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• pp.216-219
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• 2012

Structure-based drug design possibly benefit from in silico methods that precisely predict the binding affinity of small molecules to target macromolecules. There are many limitations arise from the difficulty of predicting the binding affinity of a small molecule to a biological target with the current scoring functions. There is thus a strong interest in novel methodologies based on MD simulations that claim predictions of greater accuracy than current scoring functions, helpful for a regular use designed for drug discovery in the pharmaceutical industry. Herein, we report a short review on free energy calculations using MMPBSA method a useful method in structure based drug discovery.

• 음성과학
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• 제10권3호
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• pp.225-239
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• 2003

In this paper, we develop a keyword spotting system using vocabulary-independent speech recognition technique, and investigate several non-keyword modeling and post-processing methods to improve its performance. In order to model non-keyword speech segments, monophone clustering and Gaussian Mixture Model (GMM) are considered. We employ likelihood ratio scoring method for the post-processing schemes to verify the recognition results, and filler models, anti-subword models and N-best decoding results are considered as an alternative hypothesis for likelihood ratio scoring. We also examine different methods to construct anti-subword models. We evaluate the performance of our system on the automatic telephone exchange service task. The results show that GMM-based non-keyword modeling yields better performance than that using monophone clustering. According to the post-processing experiment, the method using anti-keyword model based on Kullback-Leibler distance and N-best decoding method show better performance than other methods, and we could reduce more than 50% of keyword recognition errors with keyword rejection rate of 5%.

• Asian-Australasian Journal of Animal Sciences
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• 제11권5호
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• pp.491-497
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• 1998

Four types of serum supplements viz. estrus cow serum (ECS), estrus buffalo serum (EBS), pro-estrus buffalo serum (PrBS) and post-estrus buffalo serum (PtBS), added to TCM-199, were evaluated for in vitro maturation and fertilization of buffalo follicular oocytes. The oocytes were recovered from buffalo ovaries after slaughter, using either aspiration or scoring (multiple incisions) method. The recovered oocytes were categorized as A, B and C based on their cumulus investment and ooplasm homogeneity and cultured in four media. The in vitro matured oocytes were inseminated with $1{\times}10^6$ spermatozoa washed in 2.9% sodium citrate solution. The scoring method yielded greater number of morphologically good oocytes than the aspiration method (3.85 vs 1.76 per ovary, p < 0.01). The maturation rates of three categories of oocytes did not differ from one another. The maturation rates of 80.00, 82.08, 78.77 and 66.23%, while the fertilization rates of 54.54, 55.38, 52.80 and 36.76% were recorded for media containing ECS, EBS, PrBS, and PtBS, respectively. The medium containing PtBS gave lower maturation, as well as fertilization, rates than the other three media (p < 0.05). Thus, the scoring method was better than the aspiration method for the recovery of follicular oocytes. The oocytes categorized A, B and C had similar maturation capabilities. The TCM-199 containing buffalo/cow serum collected at pro-estrus or estrus appeared better for in vitro maturation and fertilization of buffalo follicular oocytes than that containing serum collected at post estrus.

• 한국전자통신학회논문지
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• 제16권5호
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• pp.899-908
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• 2021

현대의 무기체계는 복잡한 체계로 구성되어 있기 때문에 성능개량 요소의 우선 순위를 도출하는 것은 상당한 어려움이 있다. 또한, 이해관계자들의 의견을 고려한 정량적 성능개량 요소 우선순위 선정 방법론에 대한 연구도 미흡한 실정이다. 본 연구에서는 K1계열 전차와 K2전차의 성능개량 요소 우선순위를 정량적으로 도출하기 위해 전차 개발 경험을 보유한 전문가들을 대상으로 설문을 수행하고 AHP, 평점법, TOPSIS 기법을 이용하여 서문 데이터를 분석하고 분석 결과로 우선순위를 정량적으로 도출하였다. 본 연구의 결과는 향후 무기체계 개발 및 성능개량 단계에서 이해관계자들의 의사결정 지표로 활용될 것으로 기대된다.

• International Journal of Quality Innovation
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• 제1권1호
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• pp.75-80
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• 2000

Objective evaluation is necessary for the company to know the level of its TQM activity and to improve it. This article proposes self-evaluation model for TQM activity through comparison study of the examination viewpoints for the Deming Prize with criteria of the Malcolm Baldridge National Quality Award. Proposed self-valuation model consists of three evaluation categories i.e. management system, management performance and survey/audit system. Evaluation on these categories is done for process and performance by using scoring method. This self-evaluation model is useful for checking the progress of TQM and make company recognize the strength and weakness of its TQM activity, namely, positioning analysis.

• Journal of Cardiovascular Imaging
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• 제31권1호
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• pp.1-17
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• 2023

The Coronary Artery Calcium Data and Reporting System (CAC-DRS) is a standardized reporting method for calcium scoring on computed tomography. CAC-DRS is applied on a per-patient basis and represents the total calcium score with the number of vessels involved. There are 4 risk categories ranging from CAC-DRS 0 to CAC-DRS 3. CAC-DRS also provides risk prediction and treatment recommendations for each category. The main strengths of CAC-DRS include a detailed and meaningful representation of CAC, improved communication between physicians, risk stratification, appropriate treatment recommendations, and uniform data collection, which provides a framework for education and research. The major limitations of CAC-DRS include a few missing components, an overly simple visual approach without any standard reference, and treatment recommendations lacking a basis in clinical trials. This consistent yet straightforward method has the potential to systemize CAC scoring in both gated and non-gated scans.

• 대한수의학회지
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• 제55권1호
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• pp.47-52
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• 2015

The purpose of this study was to determine if contrast media would enhance visualization of the endocardium for assessment of left ventricle (LV) function. In addition, differences between pre- and post-contrast evaluation for the cardiac output measurements including the modified Simpson's method and automated contour tracking (ACT) method were examined. Ten clinically healthy adult beagle dogs (three males and seven females) between 2~3 years old and weighing 6.6~10.8 kg were used. Echocardiographic examinations were performed to compare pre- and post-contrast LV endocardium visualization using a segmental scoring method. Two different methods for measuring cardiac output were also compared. LV visualization was significantly enhanced in post-contrast echocardiography (p < 0.01). Significant differences between pre- and post-contrast measurements for the modified Simpson's method (p < 0.05) were also observed. No significant difference was found for the ACT method. Contrast echocardiography provides better LV chamber opacification and significantly improves wall segment visualization. Furthermore, contrast echocardiography for measuring cardiac output is helpful for the modified Simpson's method.

• 한국지구과학회:학술대회논문집
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• 한국지구과학회 2004년도 춘계학술발표회 논문집
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• pp.18-19
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• 2004

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제4권1호
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• pp.45-56
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• 2015

본 연구에서는 문맥 정보를 함께 고려해야만 인식할 수 있는 단어 오류에 대하여 오류 인식 방법과 수정 후보 생성 방법을 제안한다. 이 문제는 기존의 영어권에서 이미 많이 다룬 연구 주제이다. 본 연구에서는 영어 자동채점 시스템에서 사용하도록 특화된 방법을 제안한다. 문맥 정보를 고려한 단어 오류 검사에서는 자주 혼동되어 사용되는 단어집합(confusion set)을 활용한다. 비영어권 사용자의 작문 특성을 반영하기 위해 기존의 영어권에서 구축한 혼동집합 이외에 자동으로 혼동집합을 구축하여 실험해 보았다. 또한 품사 중의성으로 인해 기존의 구문오류 검사기가 다루지 못하는 오류를 정의하고 오류 인식과 오류수정 후보를 생성하는 방법을 제안한다. 실제 한국어가 모국어이면서 초/중급 작문 수준의 수험생들이 작성한 영어 문장에 대해 평가해 본 결과, 약 70.48%의 f1 값을 얻어 기존의 영어권 결과에 비해 뒤지지 않는 성능을 보였다.

• 한국산업보건학회지
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• 제32권3호
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• pp.253-267
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• 2022

Objectives: This study was performed to check whether the CRS (Chemical Ranking and Scoring) system is appropriate as a method to determine substances as candidates for substances subject to permission and to apply this system to the selection of candidates for substances subject to permission. Methods: A risk score was obtained by multiplying the hazard score and the exposure score and then ranking them. The hazard sub-indicators are carcinogenicity, germ cell mutagenicity, reproductive toxicity, specific target organ toxicity-repeated exposure, respiratory sensitization and endocrine disrupting chemicals. Exposure sub-indicators are persistence, bioaccumulation and emission volume. Sensitivity analysis was performed for missing values. Correlation analysis and multivariable linear regression analysis were performed among hazard, exposure and risk in order to confirm that CRS was an appropriate method. Results: As a result of the sensitivity analysis on missing values, it was confirmed that the effect on the risk ranking was not sensitive. Correlation and regression analysis confirmed that exposure had a greater effect on risk than hazard. Conclusions: The CRS system, which derives a risk score using a hazard and exposure score, is judged to be appropriate as a method for the selection of preliminary of candidates for substances subject to permission. Benzene, cadmium, nickel, and cobalt were selected as priority candidates for substances subject to permission.