• The Korean Journal of Physiology and Pharmacology
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• v.15 no.5
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• pp.307-312
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• 2011

It has been rereported that axons which display 5-hydroxytryptamine (5-HT) immunoreactivity are abundant in the pancreas and the majority of serotonergic axons terminate within intrapancreatic ganglia, islet and acini. This histological result strongly suggests that intrapancreatic serotonergic nerves could affect to the pancreatic endocrine and exocrine secretion. Thus, this study was aimed to investigate whether intrapancreatic serotonergic nerves could affect pancreatic exocrine secretion and an action mechanism of the intrapancreatic serotonergic nerves. The rats were anesthetized with a single injection of urethane. The median line and the abdominal aorta was carefully dissected and cannulated with PE-50 tubing just above the celiac artery, and then tightly ligated just below the superior mesenteric artery. The pancreatic duct was also cannulated with Tygon microbore tubing. With the addition of serotonin, pancreatic volume flow and amylase output were significantly inhibited electrical field stimulation (EFS). On the other hand, pancreatic volume flow and amylase output were significantly elevated in EFS with the addition of spiperone. EFS application, however, pancreatic volume flow and amylase output had no significant change in cholecystokinin (CCK) alone when serotonin was applied under a 5.6 mM glucose background. Pancreatic volume flow and amylase output under 18 mM glucose background were significantly elevated in CCK plus serotonin than in CCK alone. These data suggest that intrapancreatic serotonergic nerves play an inhibitory role in pancreatic exocrine secretion and an important role in the insulin action or release.

• Journal of Nutrition and Health
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• v.39 no.2
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• pp.133-144
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• 2006

The purpose of this study was to evaluate the nutritional status and to identify related factors in elderly hemodialysis patients. Sixty-four patients who were registered in Asan Medical Center, Seoul, Korea, participated in the study. The data was collected between September and December, 2003. General characteristics were obtained with the use of an interviewer-administered questionnaire. Anthropometric and biochemical data, 3-day dietary records and dietary habits were also obtained. The results of this study were analyzed with t-test or $X^2$-test using SPSS package program. The percentage of elderly hemodialysis patients who were undergoing mild to severe malnutrition (MN group) and were normal nutrition (NN group) by subjective global assessment (SGA) criteria were 46.9% and 53.1 %, respectively. Appetite (p < 0.05) and dietary cholesterol intakes (p < 0.05) were significantly lower in MN group than the NN group. Body mass index (BMI, p < 0.001), lean body mass (LBM, p < 0.05), triceps skinfold thickness (TSF, p < 0.01), mid ann circumference (MAC, p < 0.01) and mid ann muscle circumference (MAMC, p < 0.05) were also lower in the MN group than the NN group. There were also significant differences in blood urea nitrogen (BUN, p < 0.05), creatinine (p < 0.05), prealbumin (p < 0.001) and C-reactive protein (CRP, p < 0.05). SGA was negatively correlated with serum BUN, creatinine and pre albumin, dry weight, BMI, LBM, total body water, TSF, MAC and MAMC, and positively correlated with age. In stepwise multiple regression analysis, SGA was related to BMI, CRP, age and BUN. In conclusion, almost half of the subjects were in malnourished status and had lower values in anthropometric and biochemical data. Our results suggest that SGA is a simple and adequate method for assessing the nutritional status in elderly hemodialysis patients and adequate dietary guidelines based on individual nutritional status are needed in the patients.

• International Journal of Advanced Culture Technology
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• v.9 no.3
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• pp.174-180
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• 2021

The necessity of this study is as follows. A decrease in the number of newborns, an increase in the youth unemployment rate, and a decrease in the employment rate are having a fatal impact on universities. To help increase the employment rate of universities, we intend to utilize Big Data of university public information. Big data refers to the process of collecting and analyzing data, and includes all business processes of finding data, reprocessing information in an easy-to-understand manner, and selling information to people and institutions. Big data technology can be divided into technologies for storing, refining, analyzing, and predicting big data. The purpose of this study is to find the vision and special department of a university with a high employment rate by using big data technology. As a result of the study, big data was collected from 227 universities on www.academyinfo.go.kr site, We selected 130 meaningful universities and selected 25 universities with high employment rates and 25 universities with low employment rates. In conclusion, the university with a high employment rate can first be said to have a student-centered vision and university specialization. The reason is that, for universities with a high employment rate, the vision was to foster talents and specialize, whereas for universities with a low employment rate, regional bases took precedence. Second, universities with a high employment rate have a high interest in specialized departments. This is because, as a result of checking the presence or absence of a characterization plan, universities with a high employment rate were twice as high (21/7). Third, universities with high employment rates promote social needs and characterization. This is because the characteristic departments of universities with high employment rates are in the order of future technology and nursing and health, while universities with low employment rates promoted school-centered specialization in future technology and culture, tourism and art. In summary, universities with high employment rates showed high interest in student-centered vision and development of special departments for social needs.

• Journal of the Korea Convergence Society
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• v.9 no.11
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• pp.561-567
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• 2018

The study was investigate the effect of family stress and job stress on depression in middle man. A questionnaire was completed by 127 C & K city middle aged mans from july 1 to August 20 2018. The data were analyzed by SPSS/WIN 21.0 program, descriptive statistics, ANOVA, t-test, and Pearson correlation coefficient calculation and multiple regression analysis. Differences in family stress job stress depression according to general characteristics of middle-aged men showed significant difference in economic status and old age instability. The variables affecting depression are job stress(${\beta}=0.288$, p<.001), aging anxiety(${\beta}=0.142$, p<.001), economic status(${\beta}=0.035$, p<.001), family stress(${\beta}=0.016$, p<.001). As a way to reduce family stress and job stress, it is necessary to deal with health care and family conflict such as exercise hobby life relaxation.

• Korea Journal of Hospital Management
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• v.23 no.4
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• pp.81-86
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• 2018

Purposes: The purpose of this study is to argue that the taxation system for non-for-profit medical institution in Korea should be revised and that the basic direction should be to expand tax exemption like the US. Methods: We analyzed the US context of taxation policy for non-for-profit medical institutions and compared the US and Korean situation. Findings: In the United States, for-profit or non-for-profit medical institutions eternities are the most important criteria for hospital classification. Basically, full tax-exemption has been applied for non-for-profit medical institutions. The reason why many hospitals maintain their status as non-for-profit are following. First, the American society places great importance on the social responsibility and role of non-for-profit hospitals. Second, maintaining the status of non-for profit medical institutions is financially beneficial while maintaining good social reputation. The most powerful financial incentives are tax deductions and tax deductions for donations. Practical Implications: How will the taxation system for medical institutions in Korea be reformed in the future? First, if Korean government do not allow for-profit medical institutions, Korean government should consider implementing a full tax exemption system suitable for non-profit medical institutions like the US. Second, there are many variation in taxation for non-for-profit medical institution according to their legal positions. Therefore, current taxation system should be revised. Third, the reorganization of such taxation system should be in a direction that can finally encourage community benefit activities of medical institutions of nonprofit hospitals.

• Biomedical Science Letters
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• v.24 no.4
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• pp.357-364
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• 2018

Manganese (Mn) is used as main materials in various chemical processes of industry, but it suggested that Mn brings about its toxicant by fume or dust through respiratory system and skin barrier. Mn toxicant induces the loss of mental health and life quality by cerebrovascular and skin diseases. Nevertheless, it lefts much unknown on the mechanism and the effectively therapeutic methods about Mn toxicant. Therefore, this study was evaluated the cytotoxicity induced by manganese dioxide ($MnO_2$) in cultured NIH3T3 fibroblasts, and also, the correlation between $MnO_2$-induced cytotoxicity and oxidative stress was examined. While, the effect of Eclipta prostrata L. (EP) extract belong to Compositae was assessed against $MnO_2$-induced cytotoxicity in the view of antioxidative effect for searching the natural resources mitigating or preventing the $MnO_2$-induced cytotoxicity. In this study, $MnO_2$-induced cytotoxicity was revealed as mid-toxic by Borenfreud and Puerner's toxic criteria, and catalase (CAT), an antioxidant prevented $MnO_2$-induced cytotoxicity by the remarkable increase of cell viability in these cultures. While, in the protective effect of EP extract on $MnO_2$-induced cytotoxicity, EP extract effectively prevented the cytotoxicity induced by $MnO_2$ via antioxidative effects such as xanthine oxidase (XO) inhibitory ability and DPPH-radical scavenging ability. From the above results, EP extract showed the effective prevention against $MnO_2$-induced cytotoxicity correlated with oxidative stress by antioxidative effects. Conclusively, this study may be useful to research or development the alternatively therapeutic agent from natural resources like EP extract for the treatment of diseases resulted in oxidative stress.

• Nutrition Research and Practice
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• v.13 no.5
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• pp.399-409
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• 2019

BACKGROUND/OBJECTIVES: This study was designed to provide scientific evidence on the effectiveness of worksite-based dietary intervention to reduce obesity among overweight/obese employees. MATERIALS/METHODS: Electronic search was performed using Ovid Medline, Embase, Cochrane Library, and CINAHL databases. The keywords used were "obesity," "nutrition therapy," and "worksite." The internal validity of the randomized controlled trials (RCTs) was assessed using the Cochrane's Risk of Bias. Meta-analysis of selected studies was performed using Review Manager 5.3. RESULTS: A total of seven RCTs with 2,854 participants were identified. The effectiveness of dietary interventions was analyzed in terms of changes in weight, body mass index (BMI), total cholesterol, and blood pressure. The results showed that weight decreased with weighted mean difference (WMD) of -4.37 (95% confidence interval (CI): -6.54 to -2.20), but the effectiveness was statistically significant only in short-term programs < 6 months (P = 0.001). BMI also decreased with WMD of -1.26 (95% CI: -1.98 to -0.55), but the effectiveness was statistically significant only in short-term programs < 6 months (P = 0.001). Total cholesterol decreased with WMD of -5.57 (95% CI: -9.07 to -2.07) mg/dL, demonstrating significant effectiveness (P = 0.002). Both systolic (WMD: -4.90 mmHg) and diastolic (WMD: -2.88 mmHg) blood pressure decreased, demonstrating effectiveness, but with no statistical significance. CONCLUSIONS: The worksite-based dietary interventions for overweight/obese employees showed modest short-term effects. These interventions can be considered successful because weight loss was below approximately 5-10 kg of the initial body weight, which is the threshold for the management of obesity recommended by the Scottish Intercollegiate Guideline Network (SIGN).

• Nutrition Research and Practice
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• v.13 no.3
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• pp.263-267
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• 2019

BACKGROUD/OBJECTIVES: Obesity is globally a major public health issue. Evidence suggests that elevated ferritin levels are associated with obesity, dyslipidemia, insulin resistance, and metabolic syndrome. This study was undertaken to examine the relationship between the serum ferritin level and depression in Korean male adults with respect to classification of the prevailing obesity. SUBJECTS/METHODS: This was a case-control study; subjects were classified into obese group (${\geq}25.0kg/m^2$, 28 subjects) and normal group ($18.5-22.9kg/m^2$, 27 subjects). A survey was conducted to assess the depression levels as per the guidelines suggested by the Center program for Epidemiological Studies-Depression (CES-D). Blood was collected from each group for assessing biomarkers, and isolated plasma was evaluated for fasting glucose, insulin, quantitative insulin sensitivity check index, and ferritin levels. Data were analyzed, and groups were compared with respect to Body Mass Index (BMI), depression scale and biomarkers. RESULTS: The average depression score of the obesity group was 16.86, which was higher than the normal group (12.56). Subjects scoring more than 16 points comprised 53.6% of the population in the obese group, which was more than double that in the normal group, as assessed by the CES-D program. Furthermore, the serum ferritin level of the obesity group was 207.12 ng/mL, which was higher than that of the normal group (132.66 ng/mL). Lastly, the BMI appeared to be significantly correlated with both depression (r = 0.320, P = 0.017) and elevated ferritin levels (r = 0.352, P = 0.008). CONCLUSION: This study provides evidence of existing correlation between ferritin and depression with obesity.

• Journal of Digital Convergence
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• v.17 no.5
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• pp.267-277
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• 2019

The purpose of this study was to investigate the level of parenting traumatic experiences, parenting stress and posttraumatic growth related characteristics in middle aged women and identify relationships among the variables. The subjects were 197 middle aged women who experienced adolescent parenting stress. The data was collected from September 20, 2018 to September 30, 2018. Collected data were analyzed using descriptive statistics, independent samples t-test, One-way ANOVA, Pearson correlation coefficient with SPSS/WIN 28.0. Parenting stress of adolescent was relatively high, but posttraumatic stress was low. There were significant negative correlations for posttraumatic growth with parenting traumatic. These results are expected to be important data for the development and application of the intervention program to reduce the stress of parenting and posttraumatic growth in the middle aged women.

• Journal of Digital Convergence
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• v.20 no.5
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• pp.537-546
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• 2022

The purpose of this study is to investigate the relationship of grit with well-being and self-efficacy. Grit was considered as a two-factor variable with consistency of interest and perseverance of effort. For the empirical analysis, data were collected from the sample of 237 nurses working at general hospitals. Collected data were analyzed using SPSS 26 to test the hypothetical relationships. It was suggested that two factors of grit would be possible associated with well-being. However, the results of this study showed that the consistency of interest part of grit had non-significant effect on well-being, Perseverance of effort part of grit had indirect effect on well-being through fully mediation effect of self-efficacy. This study confirmed that grit, some how, positively related to well-being and variables such as, self-efficacy, could be a important variable to bridge grit to well-being. Further studies were suggested to perform studies on more about grit's two factors and unexplored external variables between grit and well-being of nursing professionals.