• Title/Summary/Keyword: Scale constant

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Scale-up of Recombinant Hirudin Production from Saccharomyces cerevisiae

  • Kim, Chul-Ho;K. Jagannadha Rao;Youn, Duk-Joong;Rhee, Sang-Ki
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.8 no.5
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    • pp.303-305
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    • 2003
  • Scale-up of hirudin production from Saccharomyces cerevisiae from bench-scale to pilot-scale was carried out based on constant volumetric oxygen transfer coefficient (K$\sub$L/a). Fed-batch mode of cultivation using step-wise feeding strategy of galactose was employed for the production of hirudin in a 30-L and a 300-L pilot-scale fermentor. The final hirudin concentrations were achieved 390 mg/L and 286.1 mg/L, and the volumetric productivities were 80.4% and 90.7% with the 30-L and 300-L fermentors, respectively, compared to the productivity of the 5-L bench-scale fermentor.

Laboratory Simulation of Corrosion Damage in Reinforced Concrete

  • Altoubat, S.;Maalej, M.;Shaikh, F.U.A.
    • International Journal of Concrete Structures and Materials
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    • v.10 no.3
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    • pp.383-391
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    • 2016
  • This paper reports the results of an experimental program involving several small-scale columns which were constructed to simulate corrosion damage in the field using two accelerated corrosion techniques namely, constant voltage and constant current. A total of six columns were cast for this experiment. For one pair of regular RC columns, corrosion was accelerated using constant voltage and for another pair, corrosion was accelerated using constant current. The remaining pair of regular RC columns was used as control. In the experiment, all the columns were subjected to cyclic wetting and drying using sodium chloride (NaCl) solution. The currents were monitored on an hourly interval and cracks were visually checked throughout the test program. After the specimens had suffered sufficient percentage steel loss, all the columns including the control were tested to failure in compression. The test results generated show that accelerated corrosion using impressed constant current produces more corrosion damage than that using constant voltage. The results suggest that the constant current approach can be better used to simulate corrosion damage of reinforced concrete structures and to assess the effectiveness of various materials, repair strategies and admixtures to resist corrosion damage.

A Kinetic Study for Exopolysaccharide Production in Submerged Mycelial Culture of an Entomopathogenic Fungus Paecilomyces tenuipes C240 (동충하초 Paecilomyces tenuipes C240의 균사체 배양에 의한 세포외 다당체 생산의 동력학적 연구)

  • Xu Chung Ping;Yun Jong Won
    • Journal of Life Science
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    • v.15 no.1 s.68
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    • pp.15-20
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    • 2005
  • The unstructured model was tested to describe mycelial growth, exopolysaccharide formation, and substrate consumption in submerged mycelial culture of Paeeiliomyees tenuipes C240. The Logistic equation for mycelial growth, the Luedeking-Piret equation for exopolysaccharide formation, and Luedeking­Piret-like equations for glucose consumptions were successfully incorporated into the model. The value of the key kinetic constants were: maximum specific growth rate ${\mu}m,\;0.7281\;h^{-1};$ growth­associated constant for exopolysaccharide production $(\alpha),\;0.1743g(g\;cells)^{-1}$; non-growth associated constant for exopolysaccharide production $(\beta),\;0.0019g(g\;cells)^{-1}\;;$ maintenance coefficient $(m_s),\;0.0572g\;(g\;cells)^{-1}$. When compared with batch experimental data, the model successfully provided a reasonable description for each parameter during the entire growth phase. The model showed that the production of exopolysaccharide in P. tenuipes C240 was growth-associated. The model tested in the present study can be applied to the design, scale-up, and control of fermentation process for other kinds of basidiomycetes or ascomycetes.

Estimation of Aggregate Matching Function in Korea (한국의 구인·구직 매칭함수 추정)

  • Lee, Daechang
    • Journal of Labour Economics
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    • v.38 no.1
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    • pp.1-30
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    • 2015
  • The aggregate matching function is estimated to explain dynamics among job seekers, vacancies and new hires in Korea. Due to measurement errors inherent in vacancies data, I introduce a latent variable for job openings and use the instrumental variables to correct its endogeneity. Matching efficiency is also estimated using some explanatory variables like job seekers' characteristics and public employment services. The result shows that Korea's matching function also exhibits a constant returns to scale.

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The CORDIC Circuit of Redundant Signed Binary Number (Redundant Signed Binary Number에 의한 CORDIC 회로)

  • 김승열;김용대;한선경;유영갑
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.40 no.6
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    • pp.1-8
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    • 2003
  • A novel CORDIC circuit is presented based on a redundant number system eliminating global carry Propagation. The number format employs a new recoding scheme similar to the Booth receding resolving carry problems in addition. A pipelined architecture is introduced having a constant scale factor in its computation of trigonometric functions. The operational time of the circuit is constant independent of the number of operand digits.

Nanomachining on Single Crystal Silicon Wafer by Ultra Short Pulse Electrochemical Oxidation based on Non-contact Scanning Probe Lithography (비접촉 SPL기법을 이용한 단결정 실리콘 웨이퍼 표면의 극초단파 펄스 전기화학 초정밀 나노가공)

  • Lee, Jeong-Min;Kim, Sun-Ho;Kim, Tack-Hyun;Park, Jeong-Woo
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.20 no.4
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    • pp.395-400
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    • 2011
  • Scanning Probe Lithography is a method to localized oxidation on single crystal silicon wafer surface. This study demonstrates nanometer scale non contact lithography process on (100) silicon (p-type) wafer surface using AFM(Atomic force microscope) apparatuses and pulse controlling methods. AFM-based experimental apparatuses are connected the DC pulse generator that supplies ultra short pulses between conductive tip and single crystal silicon wafer surface maintaining constant humidity during processes. Then ultra short pulse durations are controlled according to various experimental conditions. Non contact lithography of using ultra short pulse induces electrochemical reaction between micro-scale tip and silicon wafer surface. Various growths of oxides can be created by ultra short pulse non contact lithography modification according to various pulse durations and applied constant humidity environment.

Acoustic Performance Enhancement in PVDF Speakers by Using Buckled Nanospring Carbon Nanotubes

  • Ham, Sora;Lee, Yun Jae;Kim, Jung-Hyuk;Kim, Sung-Ryong;Choi, Won Kook
    • Journal of Sensor Science and Technology
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    • v.28 no.6
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    • pp.360-365
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    • 2019
  • A polyvinylidene fluoride (PVDF)-based film speaker is successfully fabricated with enhanced bass sound by incorporating buckled nanospring carbon nanotubes (NS-CNTs) as fillers. Various concentrations up to 1-7 wt% of uniformly dispersed buckled NS-CNTs are loaded to increase the beta (β)-phase fraction, crystallinity, and dielectric constant of the speaker, and this results in the bass part enhancement of about 19 dB full scale (dBFS) at 7 wt% filler loading of the piezoelectric film speaker.

Theoretical Calculation of Parabolic Rate Constant for High-Temperature Oxidation of Metals (금속의 고온 산화동안 포물선 속도상수의 이론적 계산)

  • Kim, Insoo;Cho, Weol Dong
    • Journal of the Korean Society for Heat Treatment
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    • v.14 no.5
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    • pp.282-285
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    • 2001
  • Based on the mass balance of anion and cation fluxes, the parabolic rate constant ($K_p$) of oxide grown during the high-temperature oxidation of metal is theoretically calculated. It is assumed that the diffusion of oxygen anion and metal cation through oxide scale obeys the Fick's 1st law, the growth of oxide is controlled by the diffusion of ions, electrical potential gradient as driving force for diffusion of ions is ignored, and oxidation occurs within an existing oxide layer. Then, the parabolic rate constant can be expressed by $K_p=[2{\rho}_{MmOn}{M^2}_{MmOn}(mD_oC_o{^e}+nD_MC_M{^e})/nm]$.

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An Analysis on Economies of Scale for Tuna Distant Longline Fishery Using a Translog Cost Function (트랜스로그 비용함수를 이용한 참치연승어업 규모의 경제성 분석)

  • Cho, Hoon-Seok;Nam, Jong-Oh
    • The Journal of Fisheries Business Administration
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    • v.51 no.3
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    • pp.17-31
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    • 2020
  • The purpose of this study is to identify economic situation on scale of tuna distant longline fishery by analyzing its economies of scale using the cost function. To analyze its economics of scale, the deep-sea fishing statistics were used from 2012 to 2016. In detail, the number of panels for estimating the cost function was 68 tuna distant longline vessels from 2012 to 2016, and the total number of observations over the five years were 340. As a final model, the two-way fixed effect model based on the translog cost function was adopted through the F test, the Breusch-Pagan test and the Hausman test. As a result of the analysis, it was found that tuna distant longline fishery between 2012 and 2014 was diseconomies of scale, the fishery between 2015 and 2016 was economies of scale. However, the economic indicators of the scale from 2012 to 2016 were almost close to zero, indicating that the constant returns to scale, the optimal scale, were reached. Therefore, in the situation where the amount of fishery resources in the world continues to decrease, it is necessary to prepare a method to obtain economic benefits through scale maintenance and reduction rather than indiscriminate scale expansion.