• Title/Summary/Keyword: Scale Effects

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Early Result of Surgical Resection after Pre-Operative Concurrent chemoradiotherapy for N2-Positive Stage IIIA NSCLC (N2 종격동 림프절 전이가 있는 제 III A 병기 비소세포폐암에 있어 수술전 동시화학방사선요법 후 폐적출술의 조기 성적)

  • 차대원;김진국;심영목;김관민;박근칠;안용찬
    • Journal of Chest Surgery
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    • v.33 no.8
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    • pp.662-668
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    • 2000
  • Background: Many recent results of clinical trials show that pre-operative concurrent chemoradiotherapy and surgical resection could increase the survival of N2 positive stage IIIA non-small cell lung cancer. This study was performed to assess the feasibility, toxicity, and affect rates of concurrent chemoradiotherapy and surgical resection in N2 positive stage IIIA non-small cell lung cancer. Material and Method: Thirty-one patients who underwent preoperative concurrent chemoradiotherapy for N2 positive stage IIIA non-small-cell lung cancer from May 1997 to April 1999 were entered into the study. Mean age was 61 yrs(43∼70 yrs), There were 24 men and 7 women. The confirmation of N2 disease were achieved through mediastinoscopic biopsy(24) and CT scans(7). Induction was achieved by two cycles of cisplatin and etoposide(EP) plus concurrent chest radiotherapy to 45 Gy. Resections were done at 3 weeks after the complection of preoperative concurrent chemoradiotherapy. Resections were performed in 23 patients, excluding 5 refusals and 3 distant metastasis. Result: All patients were compled the thoracic radiotherapy except one who had distant metastasis. Twenty three patients were completed the planned 2 cycles of EP chemotherapy, and 8 patients were received only 1 cycle for severe side effects(6), refusal(1), and distant metastasis(1). There was one postoperative mortality, and the cause of death was ARDS. Three patients who had neutropenic fever and one patient who had radiation pneumonitis were required admission and treatment. Esophagitis was the most common acute side effect, but relatively well-tolerated in most patients. The complection rate of concurrent chemoradiotherapy was 74%, resection rate was 71%, pathologic complete remission rate was 13.6%, and pathologic down-staging rate was 68%. Conclusion: Morbidity related to each treatment was acceptable and many of the patients have benefited down staging of its disease. Further prospective, preferably randomized, clinical trials of larger scale may be warranted to confirm the actual benefit of preoperative concurrent chemoradiotherapy and surgical resection in N2-positive stage IIIA non-small cell lung cancer.

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An Assessment of Environmental Characteristics Associated with the Level of Endotoxin Concentration in Hospital Lobbies (일부 종합 병원 로비의 공기 중 엔도톡신 농도에 미치는 환경 요인 평가)

  • Lee, Kyeong-Min;Yeom, Jeongkwan;Lee, Wonjae;Ryu, Seung-Hun;Park, Dongjin;Park, Dong-Uk
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.24 no.3
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    • pp.310-320
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    • 2014
  • Backgrounds: Endotoxin, which found in the outer membrane of the gram-negative bacteria cell wall, makes up almost all of the lipopolysaccharide(LPS). When people are exposed to endotoxin,it can result in diverse health effects such as an airway irritation and inflammation, fever, malaise, bronchitis, allergic asthma, toxic pneumonitis, hypersensitivity lung disease. Cases among the elderly, children or pregnant can occur more frequently than a healthy adult if they are repeatedly exposed to the existing endotoxin. Therefore, we investigated and assessed the environmental characteristics associated with the airborne endotoxin concentration level in six hospital lobbies. Method: Endotoxin from indoor air in six hospital lobbies was measured by an area sampling method and analyzed according to American Society for Testing and Materials International(ASTM international) E2144-01. Total suspended particulate(TSP), carbon dioxide($CO_2$), temperature and humidity were also measured by using direct reading measurements or airborne sampling equipment at the same time. Environmental characteristics were appropriately divided into two or three groups for a statistics analysis. One-way analysis variable(one-way ANOVA) was used to examine a difference of the endotoxin concentration, depending on the environmental characteristics. In addition, only variables with p-value(p<0.25) were eventually designed to the best model by using multiple regression analysis. Results: The correlation analysis result indicated that TSP(p=0.003) and $CO_2$(p<0.0001) levels were significantly associated with endotoxin concentration levels. In contrast, temperature(p<0.068) and humidity(p<0.365) were not associated with endotoxin concentration. Levels of endotoxin concentration were statistically different among the environmental characteristics of Service time(p=0.01), Establishment of hospital(p<0.001), Scale of hospital(p=0.01), Day average people using hospital(p=0.03), Cleaning time of lobby(p=0.05), Season(p<0.001), and Cleaning of ventilation system(p<0.001) according to ANOVA. Finally, the best model(Adjusted R-square=72%) that we designed through a multiple regression test included environmental characteristics related to Service time, Area of lobby, Season, Cleaning of ventilation system, and Temperature. Conclusions: According to this study, our result showed a normal level of endotoxin concentration in the hospital lobbies and found environmental management methods to reduce the level of endotoxin concentration to a minimum. Consequently, this study recognized to be requirement for the management of ventilation systems and an indoor temperature in order to reduce the level of endotoxin concentration in the hospital lobbies.

Study on Factors that Induce Musculoskeletal Symptoms in Care Workers Who Offer Visiting Home-Help Services (방문요양 요양보호사의 근골격계 통증 유발요인에 관한 연구)

  • Kim, Deokju
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.27 no.4
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    • pp.352-360
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    • 2017
  • Objectives: This study aimed to determine the effects on musculoskeletal symptoms of both social demographic features and detailed characteristics of each task category of care workers who offer visiting home-help services. And to establish the measures that can reduce musculoskeletal symptoms among care workers. Methods: This study was conducted among 192 care workers from welfare centers C and K located in city P. After participants completed the task burden checklist regarding the scale of musculoskeletal symptoms and the details of their duties, the data collected were analyzed using the SPSS 21.0 program. Results: According to the degree of observable musculoskeletal symptoms in care workers, the highest figures were observed for back and shoulder pain. Based on the results of assessing the effect of detailed task category characteristics on musculoskeletal symptoms, "helping patients eat, helping patients move, helping patients bath, and changing body positions" were found to have an effect from the physical care category, "providing physical therapy assistance, treating bedsores" from the health care category, and "cleaning and doing laundry" from the facility management category. Conclusions: Due to the high proportion of patients requiring burdensome physical labor from care workers such as moving patients who have trouble doing so on their own, helping them change positions, and so on, it is highly likely that pain will occur in the low back, which carries most of the physical weight. So, education on human epidemiological positions that can reduce overload on areas prone to pain such as the low back and shoulders is essential. Proper equipment and personnel support must be provided for dangerous tasks. Further, multidimensional social support is required consistently.

Work Characteristics and Health Status of Shift Workers based on the Results of the Fifth Korean Working Conditions Survey (교대근로자의 업무특성과 건강상태에 대한 연구: 제5차 근로환경조사를 중심으로)

  • Baek, Kyunghee;Ha, Kwonchul
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.29 no.4
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    • pp.550-561
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    • 2019
  • Objectives: The purpose of this study is to provide basic data for the improvement of the working environment for health prevention and related countermeasures for shift workers. This study was conducted based on the Fifth Korean Working Conditions Survey (KWCS), which analyzed the health effects of shift work forces and compared them with preceding studies. Methods: By analyzing secondary rates using raw data from the 5th KWCS, 4,870 (9.7%) of the 50,184 total study subjects were divided into shift work and 45,314 (90.3%) non-shift work groups based on the response to shift status. Variables that could affect work health issues were identified and corrected. A cross-analysis was conducted to examine demographic characteristics (gender, age, and education level) of the workers and occupation characteristics (monthly net earnings, employment type, occupation, working period up to now, workplace scale, type of work system, and weekly working hours). In order to find the work health issue ratio between the shift and non-shift work groups, logistic regression was analyzed and the association with health problems according to shift type by gender was looked at through cross-analysis. Results: According to the surveys conducted from the 1st KWCS (2006) to the 5th KWCS (2017), the proportion of shift workers continued to increase. Also, muscular pains in the lower limbs (hips, legs, knees, feet, etc.) (OR=1.135, 95%CI 1.031-1.251), headaches, eyestrain (OR=1.580, 95% CI 1.428-1.748), anxiety (OR=1.715, 95% CI 1.402-2.099), difficulty falling asleep (OR=1.391), and other problems (OR=7.392) were reported. In addition, back pain, muscular pains in shoulders, neck and/or upper limbs, muscular pains in lower limbs (hips, legs, knees, feet, etc.), headaches, eyestrain, depression, anxiety, overall fatigue resulted in significant results for both male and female shift workers. Depression and anxiety were higher in female shift/circulation compared to males. Conclusions: The social nets for the health and safety of shift workers should be explored in a variety of ways, including management and supervision of shift sites, attempts to reorganize and improve the shift system, development of workers' health recovery programs, promotion, systematic treatment, and compensation systems.

Evaluating the Performance of APEX-Paddy Model using the Monitoring Data of Paddy Fields in Iksan, South Korea (국내 논필지 모니터링 자료를 이용한 APEX-Paddy 모델 적용성 평가)

  • Kamruzzaman, Mohammad;Cho, Jaepil;Choi, Soon-Kun;Song, Jung-Hun;Song, Inhong;Hwang, Syewoon
    • Journal of The Korean Society of Agricultural Engineers
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    • v.62 no.1
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    • pp.1-16
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    • 2020
  • The APEX model has been developed for assessing agricultural management efforts and their effects on soil and water at the field scale as well as more complex multi-subarea landscapes, whole farms, and watersheds. Recently, a key component of APEX application, named APEX-Paddy, has been modified for simulating water quality by considering paddy rice management practices. In this study, the performance of the APEX-Paddy model was evaluated using field data at Iksan experimental paddy sites in Korea. The discharge and pollutant load data during 2013 and 2014 were used to both manually and automatically calibrate the model. The APEX auto-calibration tool (APEX-CUTE 4.1) was used for model calibration and sensitivity analysis. Results indicate that APEX-Paddy reasonably performs in predicting runoff discharge rate and nitrogen yield. However, sediment and phosphorus yield is not correctly predicted due to the limitation of model schemes. With APEX-Paddy, the performance in reproducing the discharge and nitrogen yield is found to be a satisfactory level after manual calibration. The manually calibrated model performed better than the automatically calibrated model in nearly all comparisons. For runoff, manual calibration reduced PBIAS while R2 and NSE values of the automatically calibrated model were the same as the manual calibration. For T-N, NSE and PBIAS were reduced when using manual calibration, whereas R2 value was the same as manual calibration. The limitation of the APEX-Paddy model for predicting sediment, as well as the phosphorous yield, was discussed in this study.

Preliminary study on geochemical elements concentration changes in coral skeleton from Chuuk, Micronesia (마이크로네시아 축 경산호 골격의 지화학 원소 농도에 대한 예비연구)

  • Hyun, Sang-Min;Park, Heung-Sik;Kim, Su-Hyun;Kim, Han-Jun;Jang, Suk
    • The Korean Journal of Quaternary Research
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    • v.22 no.1
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    • pp.1-12
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    • 2008
  • We investigated metal concentrations and oceanic environment changes that have occurred over the past several years by studying the hard coral Porites lutea, which inhabits tropical and subtropical areas. Soft X-radiographs clearly showed distinctive annual bands within 71 mm coral sample, which reflect changes in the oceanic environment over this period. There were large fluctuations in the major and minor element concentrations. Considering the physicochemical partition coefficient, some elements accumulated in the aragonite matrix in a mechanical manner, while others were affected by environmental factors. The concentrations of some heavy metals varied over a wide range, implying local environmental effects. The variation of Sr/Ca and Mg/Ca in coral skeleton clearly showed large-scale fluctuation over the specific intervals, implying environmental changes during this period. The concentrations of heavy metals also show high fluctuations, and roughly accord with Mg/Ca variation. In addition, Cu and Zn seem to show cyclicity-like peaks, coincide with Mg/Ca variation over the specific intervals. Such variation might be related to local pollution and oceanographic changes. More detailed investigation is necessary, including the pretreatment of coral skeleton sediment.

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A Discourse Analysis of Attempts to Strengthen Global Image through the 2011 World Athletics Championships (스포츠 관광을 통한 대구의 세계화 - 2011 대구세계육상선수권대회의 문화지리학적 분석 -)

  • Ethan, Yorgason
    • Journal of the Korean association of regional geographers
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    • v.19 no.3
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    • pp.454-475
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    • 2013
  • In 2011, Daegu hosted the International Association of Athletics Federation Championships and attempted to use this event strengthen its global profile. Organizers hoped Daegu 2011 would strengthen knowledge about Daegu internationally and help the city overcome recent economic stagnation by bolstering tourism and investment on the global scale. Written from the perspective of a foreigner living in Korea, this interpretive article uses mixed-method cultural geographic analysis to evaluate the momentum Daegu 2011 produced in these directions. The article draws on a tripartite "territorialisation" approach to mega-event tourism's production of space, focusing on representational efforts during the approach to the championships and the event itself. Promotional materials receive particular attention. Interviews with international tourists during 2011 strengthen conclusions drawn from analysis of promotional materials. After reviewing relevant conceptual literature, Daegu's history, and the background of Daegu 2011, the article devotes three subsections to analysis. The first uses critical discourse analysis of a key promotional video to argue that Daegu's self-promotions betrayed insecurity about the city's place within the global tourism market. A second analysis subbsection finds that additional promotional materials did not fully overcome that problem. These materials also produced an overload of Daegu images and aspirations. The third subsection further develops these arguments, pointing to a partial mismatch between images emphasized by promotions and experiences available in the tourism landscape. This subsection also argues that while Daegu 2011 undoubtedly produced positive effects for the city, key challenges remain if Daegu will be placed on the map of globally acknowledged cities.

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Studies on the Thermal and Rheological Properties of Polypropylene/Starch-MB Blends (폴리프로필렌/옥수수전분 블렌드의 열적 유변학적특성 연구)

  • Kim, Youn Cheol;Lee, Chang-Young
    • Applied Chemistry for Engineering
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    • v.18 no.6
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    • pp.557-561
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    • 2007
  • Polypropylene (PP)/corn starch master batch (starch-MB) blends with different PP compositions of 40, 50, 60, and 80 wt% were prepared by melt compounding at $200^{\circ}C$, using lab scale Brabender mixer. The chemical structures and thermal properties of the PP/starch-MB blends were investigated by FT-IR, differential scanning calorimetry (DSC), and thermogravimetric analyzer (TGA). The chemical structure was confirmed by the existence of hydroxy group. There was no district change in melting temperature and melting enthalpy, and TGA curve indicated a decrease in degradation temperature with starch-MB content. The porosity change of blend was measured by scanning electron microscope (SEM), the degree of porosity on the blend surface increased with the starch-MB content. The rheological properties indicated an increase in complex viscosity, shear thinning tendency and elasticity with the starch-MB concentration. These effects were confirmed by an oscillatory viscometer at $200^{\circ}C$. From these results, it is found that 40 wt% is the optimum starch-MB concentration. The fiber was fabricated from PP60/MB40 with 40 wt% starch-MB and the porosity and tensile properties were investigated.

Effects of Egg White Manufacturing Conditions on the Physicochemical and Sensory Properties of Angel Food Cakes (난백분말 제조 조건에 따른 엔젤 푸드 케이크의 특성 변화)

  • Yang, Hae-Young;Kim, Min-Young;Kim, Jeong-Yeon;Shim, Jae-Yong;Imm, Jee-Young;Park, Ki-Hwan
    • Korean Journal of Food Science and Technology
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    • v.41 no.2
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    • pp.167-172
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    • 2009
  • The principal objective of this study was to determine the optimum manufacturing conditions of egg white with high foaming property for the production of angel food cakes. The egg whites were desugarized and powdered at predetermined pHs and drying temperatures. The physicochemical properties of the produced cakes were measured and sensory evaluations were conducted on a 9-point scale. The volume and textural properties of cakes produced from spray-dried egg whites did not differ from those of the cakes prepared from the control egg whites. The pH of batter and the specific gravity of foam and batter with egg white powder at pH 6.74/66.5$^{\circ}C$ did not differ from those of the control, whereas the one prepared with commercial powder lost the characteristics of cake to a significant degree. The overall acceptance scores of egg white powder of pH 6.74/66.5$^{\circ}C$ and commercial powder were 6.25 and 2.33 as compared to the control (6.42). These results indicate that the egg white powder that was desugarized, pH-adjusted to 6.74, and dried at 66.5$^{\circ}C$ might be utilized to prepare angel food cakes with the desirable physicochemical and sensory attributes.

The Effect of Middle Schoolers' Oral Health Awareness on Oral Health Condition and Oral Health Behavior (중학생들의 구강보건인식이 구강건강상태와 구강건강행위에 미치는 영향)

  • Cho, Eun-Suk
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.10
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    • pp.5020-5028
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    • 2013
  • The purpose of this study is to investigate the effects of awareness of oral health on oral health status and oral health behavior with subjects of students in the middle school which is the important period when lifetime set of teeth is completed with eruption of the second molar tooth and complete set of permanent teeth, and provide the basic data for development of oral health program for adolescents. We examined oral condition and conducted the survey about students' awareness of oral health and behavior in the middle school located in JeonJu. As the results of oral examination, dental caries and malocclusion were higher in female students and periodontal disease was higher in male students (p < 0.038). There was no significant difference in awareness of oral health between male and female students. However, M = 4.08 out of 5 point scale, which was high. For oral health behaviors, female students (M = 4.508) was higher than male students (M = 4.257) in the question of 'I visit the dental office when my gums are bleeding'. Female students (M = 4.547) was higher than male students (M = 4.333) in the question of 'I use the dental floss after brushing my teeth'(p<0.05). Awareness of oral health gave the significant effect on the oral health behavior at 95 % confidence level. Therefore, the education for oral health behavior is required to improve oral health and studies are needed to present the development of program for awareness and knowledge of oral health affecting behavior.