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Association of XRCC3 Thr241Met Polymorphisms and Gliomas Risk: Evidence from a Meta-analysis

  • Liang, Hong-Jie;Yan, Yu-Lan;Liu, Zhi-Ming;Chen, Xu;Peng, Qi-Liu;Wang, Jian;Mo, Cui-Ju;Sui, Jing-Zhe;Wu, Jun-Rong;Zhai, Li-Min;Yang, Shi;Li, Tai-Jie;Li, Ruo-Lin;Li, Shan;Qin, Xue
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.7
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    • pp.4243-4247
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    • 2013
  • The relationship between the X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and gliomas remains inclusive or controversial. For better understanding of the effect of XRCC3 Thr241Met polymorphism on glioma risk, a meta-analysis was performed. All eligible studies were identified through a search of PubMed, Elsevier Science Direct, Excerpta Medica Database (Embase) and Chinese Biomedical Literature Database (CBM) before May 2013. The association between the XRCC3 Thr241Met polymorphism and gliomas risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of nine case-control studies including 3,533 cases and 4,696 controls were eventually collected. Overall, we found that XRCC3 Thr241Met polymorphism was significantly associated with the risk of gliomas (T vs. C: OR=1.10, 95%CI=1.01-1.20, P=0.034; TT vs. CC: OR=1.30, 95%CI=1.03-1.65, P=0.027; TT vs. TC/CC: OR=1.29, 95%CI=1.01-1.64, P=0.039). In the subgroup analysis based on ethnicity, the significant association was found in Asian under four models (T vs. C: OR=1.17, 95%CI=1.07-1.28, P=0.00; TT vs. CC: OR=1.79, 95%CI=1.36-2.36, P=0.00; TT vs. TC/CC: OR=1.75, 95%CI=1.32-2.32, P=0.00; TT/TC vs. CC: OR=1.11,95% CI=1.02-1.20). This meta-analysis suggested that the XRCC3 Thr241Met polymorphism is a risk factor for gliomas, especially for Asians. Considering the limited sample size and ethnicities included in the meta-analysis, further large scale and well-designed studies are needed to confirm our results.

B-cell Lymphoma 2 rs17757541 C>G Polymorphism was Associated with an Increased Risk of Gastric Cardiac Adenocarcinoma in a Chinese Population

  • Li, Qiong;Yin, Jun;Wang, Xu;Wang, Li-Ming;Shi, Yi-Jun;Zheng, Liang;Tang, Wei-Feng;Ding, Guo-Wen;Liu, Chao;Liu, Rui-Ping;Gu, Hai-Yong;Sun, Jia-Ming;Chen, Suo-Cheng
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.7
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    • pp.4301-4306
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    • 2013
  • Aim: Apoptosis has been considered as a fundamental component in cancer pathogenesis, and related genetic factors might play an important role in gastric cardiac adenocarcinoma (GCA) genesis. Methods: We conducted a hospital based case.control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): BCL2 rs17757541 C>G, BCL2 rs12454712 T>C, FAS rs2234767 G>A, FASL/FASLG rs763110 C>T, ERBB2 rs1136201 A>G and VEGFR2/KDR rs11941492 C>T on the development of GCA. A total of 243 GCA cases and 476 controls were recruited for the study and genotypes were determined using a custom-by-design 48-Plex SNPscan$^{TM}$ Kit. Results: The BCL2 rs17757541 C>G polymorphism was associated with increased risk of GCA. However, there was no significant associations with the other five SNPs. Stratified analyses indicated a significantly increased risk of GCA associated with the BCL2 rs17757541 C>G polymorphism among males, older patients and those with a history of smoking or drinking. Conclusion: These findings indicated that the functional polymorphism BCL2 rs17757541 C>G might contribute to GCA susceptibility. However, our results were limited by small sample size. Future larger studies are required to confirm our current findings.

A Study on the Export Potential of Bangladesh's Ready-Made Garments (중력모형을 이용한 방글라데시 의류 유망 수출시장 추정)

  • Hossain, Sumon;Oh, Keunyeob
    • Management & Information Systems Review
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    • v.37 no.2
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    • pp.87-108
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    • 2018
  • This article explores the international trade flow of Bangladesh's ready-made garments (RMG). We first suggest the brief history and an international structure of trade among countries by using the trade volume. Then we implemented a gravity model regression with the sample of 38 major partner countries in order to investigate the potential export market for the RMG industry. The fixed effect and random effect model for the panel data during the period of 1990 to 2011 are estimated. Our result shows that Bangladesh's RMG exports are affected positively by the size of economy, inflation, exchange rate, foreign direct investment(FDI) and trade openness. On the other hand, the distance between trading partners are related negatively with the trade volume. We used the estimated coefficients from the panel regression in order to predict RMG export potential of Bangladesh. This might show which country is the promising export market for Bangladesh RMG industry. We found that Bangladesh has the highest potential of RMG export with Japan and USA, which seem to have considerable room for export growth if trade barriers and constraints are removed. We added some policy implications for encouraging the RMG export of Bangladesh by using the results from the analysis.

Annealing Effects on Al0.2CoFe1.8O4 Ferrite Film and Powder (Sol Gel 방법으로 제조한 Al0.2CoFe1.8O4 분말과 박막의 열처리 효과)

  • Chae, Kwang-Pyo;Lee, Jae-Gwang;Kweon, Hyuck-Su;Kim, Jung-Hoon;Lee, Young-Bae
    • Journal of the Korean Magnetics Society
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    • v.15 no.3
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    • pp.186-190
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    • 2005
  • The $Al_{0.2}CoFe_{1.8}O_4$ ferrite films and powders were prepared by the sol-gel method. The crystallographic and magnetic properties of the samples were examined with annealing temperature by X-ray diffraction, $M\ddot{o}ssbauer$ spetroscopy and vibrating sample magnetometry. The powder samples showed the presence of spinel structure at annealing temperatures above 673 K, while the film samples indicated the spinel structure above 873 K, also the particle size increased with rising annealing temperatures. The $M\ddot{o}ssbauer$ spectra of $Al_{0.2}CoFe_{1.8}O_4$ powder annealed above 873 K could be fitted as the superposition of two Zeeman sextets due to ferrimagnetic phase. And the spectra of annealed at 673 K exhibited the superposition of ferrimanetic and paramagnetic phase and those of annealed at 473 K showed only a paramagnetic phase. The magnetic behaviour of powders appeared that the coercivity increased until annealed at 673 K but decreased above this temperature. The coercivity of the film samples decreased from 1.084 kOe at 873 K to 0.540 kOe at 1073 K with increasing annealing temperatures.

Mossbauer study of $CoCr_xFe_{2-x}O_4$ (Mossbauer 분광법에 의한 $CoCr_xFe_{2-x}O_4$의 연구)

  • 채광표;이혁진;이재광;이성호;이영배
    • Journal of the Korean Magnetics Society
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    • v.10 no.2
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    • pp.74-80
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    • 2000
  • CoCr$_{x}$ Fe$_{2-x}$O$_4$(0.0$\leq$x$\leq$1.0) ferrites have been fabricated by sol-gel method. The crystallographic and magnetic properties of the samples were investigated by means of x-ray diffraction, scanning electron microscophy, Mossbauer spectroscopy and vibrating sample magnetometry. The structure of all the samples is cubic spinel type and the lattice constant decrease with increasing Cr content. The substituted Cr ions were located only in the B-site. The particle size also decreases with increasing Cr content. The Mossbauer spectra consist of two sextets due to Fe$^{3+}$ions at A- and B sites for 0.0$\leq$x$\leq$0.6, while, a paramagnetic doublet appears for 0.8$\leq$x$\leq$1.0. The magnetic hyperfine field decreases with increasing Cr content. The relaxation spectra was shown at 0.8$\leq$x$\leq$1.0 in CoCr$_{x}$ Fe$_{2-x}$O$_4$. The coercivity decreases drastically, while, the saturation magnetization decreases linearly with increasing x.ing x.

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Prospective Study for Korean Red Ginseng Extract as an Immune Modulator following a Curative Surgery in Patients with Advanced Colon Cancer

  • Boo, Yoon-Jung;Park, Joong-Min;Kim, Jin;Suh, Sung-Ock
    • Journal of Ginseng Research
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    • v.31 no.1
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    • pp.54-59
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    • 2007
  • In this paper, we present evidence that the Korean red ginseng extract shows the immunomodulatory activities during postoperative chemotherapy after curative surgery in patients with advanced colon cancer. We measured the circulating interleukin-2 (IL-2), interleukin-8 (IL-8)and interleukin-10 (IL-10) as a immune modulator to evaluate the effect of Korean red ginseng. The mean preoperative value of IL-2 was similar in the non-RG group and the RG group (5.72 pg/ml versus 6.87 pg/ml, p>0.05). The mean value of IL-2 was compared with IL-2 from healthy control group, there was no significant difference (14.89 pg/ml versus 14.22 pg/ml, p>0.05). The mean preoperative value of IL-8 was higher in the non-RG group comparing with the RG group (30.92 pg/ml versus 36.25 pg/ml, p < 0.05). At postoperative 3 month, the mean values of IL-8 from non-RG and RG group down to 24.56 pg/ml and 21.46 pg/ml respectively. The IL-8 of RG group at 3 month showed no difference with that of HC group(21.46 pg/ml versus 16.31 pg/ml, p>0.05). The preoperative mean value of IL-10 of non-RG, RG and HC group was 11.56 pg/ml, 10.8 pg/ml, and 3.68 pg/ml respectively. At postoperative 3 month, the mean values of IL-10 from non-RG and RG group down to 8.45 pg/ml and 5.04 pg/ml respectively. In spite of decreasing IL-10 levels of both cancer Patients group with time, there was still significant difference with that of HC group (non-RG versus HC group, p=0.00, RC versus HC group, p=0.04). The results of this study suggest that the red ginseng extract may have some immunomodulatory properties associated with IL-2, IL-8 and IL-10 activity in patients with advanced colorectal cancer during postoperative chemotherapy. We think to need the further studies and a larger sample size to fully evaluate the antitumor effect of ginseng and need to establish this mechanism of action as well as identify the active components associated with antitumor activity and immunomodulation in patients with advanced colorectal cancer.

Characteristics of Microwave-Assisted Extraction for Grape Seed Components with Different Solvents (추출용매에 따른 포도씨 성분의 마이크로웨이브 추출 특성)

  • Lee Eun-Jin;Kwon Joong-Ho
    • Food Science and Preservation
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    • v.13 no.2
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    • pp.216-222
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    • 2006
  • Microwave energy (2450 MHz) was applied to extract health-effective component (HEC) from grape seed. Three different solvents approved for grape seed extract such as water, ethanol and acetone, were confirmed in their microwave-heating properties and by which extraction efficiencies were determined. Microwave-assisted extraction (MAE) was performed under different parameters; microwave power : (0, 50, 100 and 150), time : (1, 3, 5, 7, and 9 min), the sample to solvent ratio : (1:20, 1:10, 1:5 and 1:2.5), and particle size(whole, 20, 40 and 60 mesh) and the subsequent extracts were used for determining their physicochemical properties, such as total yield : (TY), total phenolics : (TP), catechin content : (CC), electron donating ability : (EDA), and browning color. The heating properties of solvent demonstrated the optimal ranges of microwave and time as 100 W and 2 to 6 min. The TY and HFC content were higher with increasing powers in water and ethanol solvent, while HFC content were lower in acetone at over 100 W. The longer of extraction time up to 5 min, the higher extraction efficiency. Based upon the overall MAE efficiency and solvent recovery, it was found optimal to use 10 times volume of ethanol for 10 mesh of seed particle at 100 W.

Classifications of Skin Colors on Korean Elderly Women and their Preference Colors (한국노인 여성의 피부색 분류와 선호색에 관한 연구)

  • 김구자;정혜원
    • Journal of the Korean Society of Clothing and Textiles
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    • v.26 no.2
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    • pp.303-314
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    • 2002
  • The colors of apparel have become an important element to be used strategically in order to give differentiated character at the level of fiber and fabric production. The colors of apparel have a close relationship with the skin colors of consumers and their preference colors. This study was carried out to classify the skin colors of Korean elderly women into several similar skin colors and to analyse their preference colors. Sample size was 471 Korean elderly women. With color spectrometer, JX-777, we measured 4 points of the body; cheek with removing cosmetics off, forehead, rear neck and arm on the interior part near elbow. All subjects had been shown with 40 color chips and answered the preference colors of apparel and the preference colors. Data weirs analysed to classify skin colors using K-means Cluster Analysis and Duncan test. Independent variables for Cluster Analysis were 12 variables out of L value, a value and b value of 4 points. In doing so, we used SPSS WIN 10 statistical package. Findings were as follows: 1) The skin colors of the Korean elderly women were composed of skin colors of YR, R, and Y. 2) 355 subjects were classified into 4 kinds of skin color groups. 3) The average face color of type 1 was 6.7YR 5.1/4.3 and 56 observations out of 355 subjects were composed of Type 1 and of Type 2 was 6.1YR 6.1/4.5 and 166 observations out of 355 and of 3 Type 6. YR 4.8/4.2 and 75 observations out of 355 and of Type was 6.17 YR 5.7/4.7 and 58 observations out of 355. 4) The average skin color of Type 1 was 7.0YR 5.9/4.4 and of Type 2 was 7.2YR 6.3/4.2 and of Type 3 was 7.0YR 6.2/4.2 and of Type 4 was 7.6YR 5.4/4.2 respectively. 5) The mean values of 12 variables between the 4 classified face color and skin color groups showed significantly different except H value of skin color. 6) All 4 groups showed that the most preference color of apparel and the most preference color were 2.5R 5/14 respectively.

Expressions of Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptor Gene in the Rat Uterus (흰쥐 자궁에서 Pituitary Adenylate Cyclase-Activating Polypeptide와 수용체 유전자의 발현)

  • 이성호
    • Development and Reproduction
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    • v.2 no.1
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    • pp.21-27
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    • 1998
  • The present study was performed to analyze the gene expressions of pituitary adenylate cyclase-activating polypeptide(PACAP) and its receptor in the rat uterus, a candidate for novel extrahypothalamic source and target. The PACAP cDNA fragments corresponding to the common exon region which is found in both the rat hypothalamus and testis were produced from all tissue samples including the rat uterus by reverse transcriptionpolymerase chain reaction (RT-PCR). No PCR product was amplified from the rat hypothalamic, pituitary, ovarian and uterine samples when the 5' primer corresponding to the testis-specific exon 1 region was used, while the predicted size of product was detected from the testis sample. RT-PCR using the uterine RNA and specific primers for the PACAP receptor yielded products with predicted sizes. Transcripts for the rat uterine PACAP receptor were identified as type I isoforms with hip-hop and hip- or hop-type inserts. After pregnant mare's serum gonadotropin (15 IU) treatment of immature rats (day 25), the level of PACAP mRNA was increased in 24 h and 48 h group, and was declined to the lowest in 72 h group. The present study shows the presence of transcripts for PACAP and its receptor isoform in the rat uterus. These finding ssuggest that the uterine PACAP ight act as a novel autocrine and/or paracrine factor via its specific receptors on the reglulation of rat uterine function and physiology during the reproductive cycle.

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Studies on the Separation of Immunoglobulin and Immunological Response from Korean Native Cattle (한우초유중 Ig의 분리 ${\cdot}$ 정제 및 면역 반응에 관한 연구)

  • Baick, Seung-Cheon;Kim, Yong-Hwi;Shin, Je-Ho;Yu, Je-Hyeon
    • Journal of Dairy Science and Biotechnology
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    • v.15 no.1
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    • pp.1-9
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    • 1997
  • This study was conducted to efficiently separate the Ig from Korean native cattle colostrum and to utilize them as an immunogen for the production of antibodies aginst rabbit. The results obtained were as follows : 1. About 84% of Ig G could be separated from Korean native cattle colostrum by·gel filtration using Superose 12 column on HPLC. The separation profile of Korean native cattle colostral immunoglobulin was similar that of Holstein colostral Ig. 2. Separation of Korean native cattle colostral Ig by anion exchange chromatography using Mono Q column on HPLC was poor resolution chromatographic pattern. 3. Hi-Trap Protein G column showed better results than the Protein A Sepharose CL-4B column in the Ig G binding capacity from Korean native cattle colostral Ig. 4. Protein G Sepharose Fast Flow system resulted in higher Ig g binding capacity as the industrial size scale-up approach. 5. Sufficient titer reaction of antibody to Korean native cattle colostral Ig G was confirmed by ELISA.

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