• Parasites, Hosts and Diseases
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• v.62 no.1
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• pp.42-52
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• 2024

Antimalarial drugs are an urgently need and crucial tool in the campaign against malaria, which can threaten public health. In this study, we examined the cytotoxicity of the 9 antimalarial compounds chemically synthesized using SKM13-2HCl. Except for SKM13-2HCl, the 5 newly synthesized compounds had a 50% cytotoxic concentration (CC₅₀) >100 μM, indicating that they would be less cytotoxic than SKM13-2HCl. Among the 5 compounds, only SAM13-2HCl outperformed SKM13-2HCl for antimalarial activity, showing a 3- and 1.3-fold greater selective index (SI) (CC₅₀/IC₅₀) than SKM13-2HCl in vitro against both chloroquine-sensitive (3D7) and chloroquine -resistant (K1) Plasmodium falciparum strains, respectively. Thus, the presence of morpholine amide may help to effectively suppress human-infectious P. falciparum parasites. However, the antimalarial activity of SAM13-2HCl was inferior to that of the SKM13-2HCl template compound in the P. berghei NK65-infected mouse model, possibly because SAM13-2HCl had a lower polarity and less efficient pharmacokinetics than SKM13-2HCl. SAM13-2HCl was more toxic in the rodent model. Consequently, SAM13-2HCl containing morpholine was selected from screening a combination of pharmacologically significant structures as being the most effective in vitro against human-infectious P. falciparum but was less efficient in vivo in a P. berghei-infected animal model when compared with SKM13-2HCl. Therefore, SAM13-2HCl containing morpholine could be considered a promising compound to treat chloroquine-resistant P. falciparum infections, although further optimization is crucial to maintain antimalarial activity while reducing toxicity in animals.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.409-414
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• 2005

In the literatures, the FFT-based SAM has been well applied to the computation of the steady-state responses of discrete dynamic systems. In this paper, a fast fourier transforms (FFT)-based spectral analysis method (SAM) is proposed fur the dynamic analysis of spectral element models subjected to the non-zero initial conditions. However, the FFT-based SAM has not yet been developed for the continuous systems represented by the spectral element model.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.25 no.8
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• pp.821-827
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• 2014

Many researches on the usage of shared spectrum have continuously been carried out to solve the recent frequency shortage problem and to use efficiently the spectrum without interference. Also, exponential mobile data growth and the solutions needed to address this challenge are parallel key objectives addressed in many countries. Spectrum policy innovation to meet this challenge is the ASA/LSA (Authorized Shared Access/Licensed Shared Access), which is the best access model to employ the small cell technology to meet this mobile traffic growth. Because 3.5 GHz bands is considered as the ASA/LSA frequency, in this paper, we propose the SAM(Spectrum Access Model) in 3~4 GHz bands to estimate the available ASA/LSA bands and to open more free spectrum. These results are utilized as the data to develop the SAM for the small cell and the open frequency in future.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.04a
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• pp.835-838
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• 2010

본 논문에서는 공공기관의 효율적인 보안 진단을 위하여 금융 위험평가 시스템에 사용되는 통계적 CAEL 모델을 적용하여 보안평가 모델(SAM)을 설계하였다. SAM은 통계적 CAEL 모델을 기반으로 조직과 관련된 보안변수와 보안지표를 평가요소로 하여 요소별 평가등급 선정 방식과 최종 종합평점 산출 방법으로 보안평가 결과값을 도출한다. SAM은 조직의 보안수준 결과에 중요하게 영향을 미칠 수 있는 모든 요소들을 평가대상으로 하고 정량적인 방법인 보안평가 모델을 활용하여 결과를 산출한다. SAM은 조직의 규모, 특성 등에 따라 보안변수를 변경할 수 있으며, 각 보안 지표별 통계적 자료 값을 수집하여 요구되는 변수만 입력하면 되기 때문에 사용 용이성도 우수하다.

• Journal of Korea Water Resources Association
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• v.33 no.S1
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• pp.297-303
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• 2000

• Journal of Korean Society of Water and Wastewater
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• v.30 no.5
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• pp.561-569
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• 2016

In this paper a concept of the paradigm shift in the operations of Water and Wastewater systems regarding the production and usage of water was introduced. Based on this concept the interrelationships between the water quality in the upper basin of NakDong River relative to Busan and the degree of satisfaction of the customers on the water supply service in Busan were modeled using the System Dynamics modeling methodology. SamRangJin basin area was determined as the upper basin of Busan after analyzing the relationships between the water quality of MoolGeum water intake point and water quality data of various mid- and upper water intake points along NakDong River. The amount of contaminants generated in SamRangJin basin was modeled using the Gross Regional Domestic Product in the area and the treated amount was calculated using the efficiency of wastewater treatment and the degree of improvement of environmental condition per investment. The water quality at MoolGeum water intake point was modeled to take the effects of the remaining amount of contaminants after treatment and the non-point source contaminants in SamRangJin basin. Using the developed System Dynamics model the effects of the investment for the improvement of environmental condition in SamRangJin basin were compared to the case of alternate water source development for Busan in terms of the degree of satisfaction of the customers on the water supply service in Busan.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.728-733
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• 2009

지금까지의 하천 설계는 하천의 유량, 유사량, 하상토 입도분포, 강턱의 입자 또는 하도 표면의 특성, 하곡의 경사 등을 고려하여 안정한 횡단면을 결정하기 위한 목적으로 발전되어 왔다. 하지만, 하천 복원에 있어서 이동 하상의 안정 하도 및 하천을 설계하는 작업은 수리학적, 하천 형태학적, 그리고 유사 수리학적 측면에서 매우 복잡한 문제들을 포함하고 있으며 더 나아가 다양한 생태서식처 및 환경을 제공할 수 있는 측면까지도 고려하도록 요구되어 지고 있다. 자연하천 복원 설계시 가장 선행되어야 할 작업은 복원하고자 하는 현재의 하천 및 하도의 안정성에 대한 평가이며 이러한 과정에서 평형 하천의 개념을 반드시 고려해야 한다. 안정하도 및 평형하천 형태를 계산하는 방법들이 여러 연구자들에 의해 제안되어 왔고 여러 해석적 방법들 중 Copeland의 방법은 실제로 충적하천에서의 안정 하도 평가 및 설계에 가장 많이 이용되고 있으며 미공병단에 의해 개발된 SAM(Stable Channel Analysis Model) 모형에서 채택하고 있는 해석적 방법 중 하나이다. 본 연구에서는 Copeland의 해석적 안정하도 분석 방법을 기본 모듈로 채택하고 있는 미공병단에서 개발한 SAM(Stable Channel Analysis Model)의 기본적인 특성과 활용도에 대해서 알아보고 이를 남한강 제1지류인 청미천의 구하도 복원 예정 구간에 적용시켜 현재하도의 안정성을 평가하였다. 분석 결과, 안정하도 경사는 현재 하도 경사보다 완만한 것으로 나타났으나 SAM에서 예측하고 있는 청미천의 안정 하폭은 현재 하도의 하폭보다 훨씬 작은 것으로 나타났다. 이는 현재 청미천의 복원 구간에서 사주가 많이 발생하는 이유를 뒷받침 하는 결과라고 할 수 있다. 안정수심은 현재 하도의 수심보다 깊은 것으로 계산되었다. SAM을 이용한 계산 결과들은 현재하도의 안정성 평가뿐만 아니라 복원 구간의 안정하도 설계를 위한 기초자료로 활용될 것이다.

• KIISE Transactions on Computing Practices
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• v.20 no.12
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• pp.664-669
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• 2014

As the prevalence of cloud computing increases, various cloud service types have emerged, such as IaaS, PaaS, and SaaS. The growth and diversification of these cloud services has also resulted in the development of technology for cloud service brokers (CSBs), which serve as intermediate cloud services that can assist cloud tenants (users) in deploying services that fit their requirements. In order to broker cloud services, CSBs require the specification of structural models in order to facilitate the analysis and search for cloud services. In this study, we propose a variability-based service analysis model (SAM) that can be used to describe various cloud services. This model is based on the concept of variability in the software product line and represents the commonality and variability of cloud services by binding variants to each variation point that exists in the specification, quality, and pricing of the services. We also propose a virtual cloud bank architecture as a CSB that serves as an intermediate to provides tenants with appropriate cloud services based on the SAM.

• Journal of the Korean Electrochemical Society
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• v.16 no.4
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• pp.217-224
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• 2013

In this paper, we have investigated the characteristics of cyclic voltammetry of a self-assembled mono-layer(SAM) electrode which was modified by 3-Mercaptopropionic acid (3-MPA) on gold nanoparticle(AuNP)-deposited electrode. Also, the transport phenomena of electrons and ions around the electrode have been analyzed. The governing equation and its boundary conditions by adopting the semi-infinite diffusion model were formulated for the mass-transfer dominant system. In order to obtain the numerical solutions of cyclic voltammetry(CV) on SAM electrodes, MATLAB program was implemented by applying the explicit finite difference method. Resulting CV program for the SAM-modified electrode was verified in good agreements with the experimental CV results for the 3-MPA on AuNP electrode.

• Journal of Oriental Neuropsychiatry
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• v.21 no.1
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• pp.109-124
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• 2010

Objectives: This experiment was designed to investigate the effect of the InSamYangYoung-tang(Renshenyangrongtang) extract on $A{\beta}$-induced AD model. Methods: The effects of the InSamYangYoung-tang(Renshenyangrongtang) extract on neural damages of cultured PC12 cells induced by $A{\beta}$ were investigated. The effects of the InSamYangYoung-tang(Renshenyangrongtang) extract on neural damages of hippocampal and cortical neurons in the mouse induced by $\beta$-amyloid were investigated. Results: 1. $A{\beta}$ treatment into neuronal cells activated cell death pathway when analyzed by MTT assay and by histological analysis. Then InSamYangYoung-tang(Renshenyangrongtang) treatment improved cell survival to a similar level as in normal group. 2. $A{\beta}$ treatment increased caspase 3 protein levels but decreased phospho-Erk1/2 in neuronal cells. InSamYangYoung-tang(Renshenyangrongtang) treatment reversed the production levels of two proteins close to those in normal group. 3. $A{\beta}$ treatment induced the atrophy of neuronal cells in terms of neuronal processes and cell body shrinkage, but InSamYangYoung-tang(Renshenyangrongtang) greatly improved their morphology. 4. Neuroprotective activity, as observed in InSamYangYoung-tang(Renshenyangrongtang)-treated groups, was similarly observed in cells treated with galantamine which was used as a positive control. Moreover, overall recovery pattern by InSamYangYoung-tang(Renshenyangrongtang) was similar between cultured PC12 cells and in vivo hippocampal and cerebral cortical neurons in the mouse brain. Conclusions: This experiment shows that the InSamYangYoung-tang(Renshenyangrongtang) may play a protective role in neural tissues damaged by cytotoxic substances. Since neuronal damage seen in degenerative brains such as AD are largely unknown, the current data may provide possible insight into therapeutic strategies for AD treatments. InSamYangYoung-tang(Renshenyangrongtang) might be effective for the treatment of AD. Investigation into the clinical use of the InSamYangYoung-tang(Renshenyangrongtang) for AD is suggested for future research.