• 대한기관식도과학회지
• /
• 제11권1호
• /
• pp.37-41
• /
• 2005

Deep neck infections mean infection in the potential spaces and facial planes of the neck, either abscess formation or cellulitis. Deep neck infections are caused by dental, salivary gland, pharyngeal and tonsillar infections. Sometimes, deep neck infection may be caused by tuberculosis in case of immunodefiecient patients. Acquired immunodeficiency syndrome(AIDS) is a disease associated with defective cell-mediated immunity after infected with human immunodeficiency virus(HIV). The chance of opportunistic infection in patients of AIDS increases as the level of immunodeficienty progresses. Human immunodeficiency virus infection is the most single significant risk factor for progression of pulmonary tuberculosis to extrapulmonary sites. In patients infected with HIV, the rate of extrapulomonary tuberculosis rises upto $60\%$. We report a case of a 47 year old male patient with AIDS associated with deep neck infection by tuberculosis.

• 대한약침학회지
• /
• 제11권4호
• /
• pp.95-99
• /
• 2008

Objective Sjogren's Syndrome is a chronic inflamatory disorder characterized by lymphocytic infiltration of lacrimal and salivary gland. It may be associated with renal disease such as tubulonephritis or glomerulonephritis. Proteinuria is a kidney disorder resulting in an abnormally high amount of protein in the urine. When the glomeruli are damaged, proteins of various sizes pass through them and are excreted in the urine. This report is a case of proteinuria with Sjogren's Syndrome. Methods The patient was diagnosed as kidney yang deficiency syndrome and treated with Woogyu-eum, Sa-am acupuncture therapy and bee venom acupuncture therapy. Visual Analog Scale was used to estimate the clinical symptoms. Results Clinical symptoms and proteinuria were improved without steroid therapy. Conclusion Therefore, we concluded that oriental medical therapy may be useful to treat proteinuria with Sjogren's Syndrome.

• Imaging Science in Dentistry
• /
• 제51권2호
• /
• pp.209-216
• /
• 2021

Sjögren syndrome is a chronic autoimmune inflammatory disease characterized by lymphocytic infiltration of exocrine glands, predominantly the parotid and lacrimal glands, thereby resulting in oral and ocular dryness. It has been reported to occur most frequently in women between 40 and 50 years of age. Sjögren syndrome has an insidious onset, is slowly progressive, and presents a wide range of clinical manifestations, leading to delays or challenges in the diagnosis. Early diagnosis of this condition is essential to prevent the associated complications that affect patients' quality of life. This report presents 3 cases of Sjögren syndrome in female patients aged between 40 and 75 years who presented with complaints of persistent dry mouth and burning sensation. The cases highlight the diagnostic value of 3-dimensional cone-beam computed tomographic sialography in the detection of salivary gland pathologies at an early stage.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제41권
• /
• pp.39.1-39.6
• /
• 2019

Background: Radioiodine therapy has been widely used for thyroid disease patients, but hyposalivation and xerostomia may occur in 10~30% of patients. Sialocentesis is a procedure that removes inflammatory substances in the salivary duct and expands the duct for the secretion and delivery of saliva. In this study, thyroid disease patients treated with radioactive iodine were selected among the patients with xerostomia who visited the hospital, and the effect of sialocentesis was compared and analyzed. And then, comparison between the radioiodine therapy-experienced group and the non-radioiodine therapy-experienced group was conducted. Results: In this study, we studied xerostomia patients who underwent radioiodine therapy due to thyroid diseases and who underwent sialocentesis at the Korea University Anam Hospital. Sialocentesis is conducted by one surgeon. The study also compares the clinical symptoms before and after the surgery. After the procedure, the discomfort due to xerostomia was reduced, and the symptom was improved effectively. Conclusions: The results of this study showed that sialocentesis has a clinical effect in the treatment of xerostomia, which is a side effect of radioiodine therapy. In addition, the possibility of further clinical application of sialocentesis in the future is found.

• Tuberculosis and Respiratory Diseases
• /
• 제79권3호
• /
• pp.184-187
• /
• 2016

Since IgG4-related pancreatitis was first reported in 2001, IgG4-related disease has been identified in other organs such as salivary gland, gallbladder, thyroid, retroperitoneum and kidney; but lung invasion is rare. A 63-year-old man presented with hemoptysis at the pulmonary clinic and chest computed tomography revealed about 4.1 cm irregular shaped mass with spiculated margin at the left upper lobe. Despite no elevation of serum IgG4 level, he was finally diagnosed as IgG4-related lung disease by transthoracic needle biopsy. After treatment with oral glucocorticoids, hemoptysis disappeared and the size of lung mass was decreased.

• Journal of Oral Medicine and Pain
• /
• 제33권3호
• /
• pp.247-256
• /
• 2008

일상생활에서 우리는 항상 스트레스에 노출되어 있으며, 스트레스에 대한 반응은 우리 삶의 질과 건강에 중요한 영향을 미친다. 특히 정서적으로 중요한 구강안면영역에도 다양한 스트레스성 질환이 존재한다. 그러나 스트레스와 질병에 관한 오랜 연구에도 불구하고 스트레스성 구강안면질환의 병인은 아직 명확하지 않다. 이에 저자는 최근 임상의학에서 관심이 집중되어지고 있는 스트레스와 질병에 대한 분자생물학적 접근의 일환으로 스트레스성 구강안면질환의 병인을 규명하고자 본 연구에 임하였다. 즉, 스트레스 단백질로 알려진 clusterin이 스트레스의 생리적 반응으로서 세포보호작용 결과 발현된다는 사실에 기초하여, 스트레스 부여 후 타액선 조직 내에서의 그 발현변화를 추적하였다. Sprague-Dawley계 웅성 백서(200-230g/bw)를 구속 스트레스 부여군(구속장치에 구속한 후 0, 3, 5일에 희생) 및 정상군으로 나누고, 각각 악하선을 적출하였으며, 면역조직화학법 및 Northern Blot을 이용하여 Clusterin의 변화를 관찰하였다. 그 결과는 다음과 같다. 1. 구속 스트레스 부여군의 clusterin 단백질은 실험 즉일군에서 증가되었고, 그 이후에는 감소되었다. 2. 구속 스트레스 부여 3일군과 5일군에서 핵붕괴 및 핵농축 등의 핵변화를 동반한 apoptosis가 유도되었다. 3. 구속 스트레스 부여 결과, 선포세포가 도관세포보다 일찍 세포사하였다. 4. 구속 스트레스 부여군의 clusterin mRNA는 실험 즉일군에서만 미약하게 관찰되었다. 즉, 타액선 조직은 스트레스 단백질인 clusterin을 생산하여 세포를 보호함으로써 스트레스 상황에 적응하지만, 생리적 적응한계를 넘는 스트레스에 노출될 때에는 조직이 apoptosis됨이 확인되었다. 따라서, 본 연구결과는 구강건조증등 스트레스성 타액선관련 증상 및 질환의 병리적 기전에 대한 규명에 도움이 되리라고 생각하며, 또한 clusterin은 향후 생체에 가해진 스트레스에 대한 표식자(marker)로 사용될 수 있을 것으로 사료된다.

• 한국산학기술학회논문지
• /
• 제18권7호
• /
• pp.565-568
• /
• 2017

쇼그렌 증후군은 입안 건조와 호중성백혈구 감소증을 주로 보이는 자가면역질환이다. 일반적으로 쇼그렌 증후군은 중추신경계를 잘 침범하지 않는 것으로 알려져 있다. 하지만 드물게, 쇼그렌 증후군에서 미세혈관병성 변성이 생기고, 이로 인해 소혈관에 영향을 미치기도 한다. 34세의 여자 환자가 왼쪽 위사분맹 및 왼쪽 팔다리의 저린 증상이 있어 내원하였다. 뇌자기공명영상에서 오른쪽 후대뇌동맥 영역의 급성 뇌경색 소견이 확인되었다. 혈액학적 검사는 항핵항체 (FANA2+) 및 항DNA항체 (anti-SS-A (RO)) 양성이었다. 그리고 침샘 섬광조영술에서 타액 분비양이 현저히 저하되었다. 따라서 환자는 쇼그렌 증후군으로 진단할 수 있었다. 본 환자의 경우처럼 쇼그렌 증후군에서 대혈관을 침범하는 것은 매우 드문 일이다. 또한 쇼그렌 증후군 환자가 저혈소판증을 보였을 경우, 항혈소판 제재를 쓰는 것이 어려울 수 있다. 이 연구는 대혈관 침범 및 저혈소판증을 보인 쇼그렌 증후군 환자에서 항혈소판 제재 및 하이드록시클로로퀸을 통한 성공적인 치료와, 이와 관련된 임상 양상 및 병태생리를 보고한 사례연구이다.

• 대한소아치과학회지
• /
• 제43권1호
• /
• pp.79-84
• /
• 2016

Myoepithelioma는 타액선에 발생하는 드문 질환이다. Myoepithelioma는 소아 및 청소년보다 성인에서 호발한다. 구개부의 종창을 주소로 8세 여환이 본원으로 내원하였다. 환아의 나이와 상대적으로 큰 종양의 크기를 고려하여, 전신 마취 하에 구개부 점막 조직을 보존하는 보존적인 외과적 절제술이 시행되었다. 수술 부위의 치유가 적절히 일어났으며, 40개월의 관찰기간 동안 재발되지 않았다. 주변의 구개부 조직을 보존하는 최소 침습적 제거술은 소아에서 발생되는 myoepithelioma의 치료시 유용할 것으로 사료되었다.

• 대한두경부종양학회지
• /
• 제18권2호
• /
• pp.157-162
• /
• 2002

Background and Objectives: Adenoid cystic carcinoma (ACC) is a unique tumor characterized by frequent and delayed distant metastasis (DM) with uncommon regional lymph node metastasis. We evaluated the factors affecting DM of ACC and survival after appearance of DM. Materials and Methods: Medical records, radiographs and pathologic slides were reviewed for 94 patients from 1979 through 2001. Results: DM of ACC occurred in 46 patients, and developed more frequently in patients with tumors of the solid histologic subtype than in patients with tubular or cribriform subtypes. DM occurred less frequently in the sinonasal tract, and development of DM was not affected by tumor stage. Disease-specific 5- and 10-year survival rates were 88% and 72% for patients without DM, respectively and 76% and 48% for those with DM(p=0.02). Regarding the site of DM and its impact on outcomes, 30 patients had lung metastasis alone, 5 patients bone metastasis alone and 6 patients developed both lung and bone metastasis. Median survivals after appearance of DM among patients with isolated lung metastases and those with bone metastases with or without lung involvement were 54 and 21 months, respectively (p=0.04). Conclusions: Development of DM in ACC is predicted by solid histologic subtype, and major salivary gland or oral/pharyngeal rather than sinonasal primary site. Those patients with bone involvement with our without lung metastases had worse outcomes than those with pulmonary metastasis only.

• Archives of Plastic Surgery
• /
• 제35권3호
• /
• pp.321-324
• /
• 2008

Purpose: Lymphoma originated from mucosa associated lymphoid tissue(MALT) is most common in gastrointestinal system, and rarely found in salivary gland, thyroid, bronchus or orbit. We experienced a case of MALT lymphoma which was originated from conjunctiva and involving lower eyelid without metastasis. Methods: A 40-year-old man suffered palpable mass on right lower eyelid without pain. Orbital computed tomographic and ultrasonographic findings showed a conical mass($1.9{\times}1.2{\times}0.9cm$ size) inside lower eyelid. The mass was completely excised under local anesthesia and histopathological examination was followed. Results: Microscopic finding showed a multiple follicular colonization. In the follicle, small lymphocytes and plasma cells differentiated to centrocyte-like cell, monocyte B cell, plasma cell were diffusely infiltrated. Immunophenotyping was preformed on fixed section. The majority of the small cells were immunoreactive for the B cell marker CD20. Based on the typical histological findings supported by immunostaining, the mass was defined as MALT lymphoma. After excision, SPECT, abdominal CT was carried out and there were no evidence of extraorbital disease. Conclusion: Biopsy and pathological examination should be performed in patients who complain palpable mass on lower eyelid because of possibility of MALT lymphoma. Although MALT lymphoma is rarely metastasized, it is necessary to evaluate the extraorbital involvement using SPECT or other radiologic exams. For detecting extraorbital involvement, periodic follow-up examination is need.