• Title/Summary/Keyword: Safety measure

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Anti-oxidative and anti-inflammatory effects of Danpitang in RAW 264.7 cell (단피탕(丹皮湯) 추출물의 항산화 및 항염증 효과 연구)

  • Oh, Sol-La;Park, Hye-Su;Kim, Ee-Hwa;Kim, Yong-Min
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.32 no.3
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    • pp.37-47
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    • 2019
  • Objectives : The purpose of this study is to investigate the anti-oxidative and the anti-inflammatory effects of Danpitang(DPT) extract in RAW 264.7 macrophages. Methods : The macrophage cell line RAW 264.7 cells were used and MTT assay was performed to measure the cell viabilities at the various concentrations of DPT($50-400{\mu}g/m{\ell}$). Nitric oxide(NO) was measured in LPS-induced RAW 264.7 cells. Expressions of iNOS, COX-2, $TNF-{\alpha}$, $IL-1{\alpha}$, $IL-1{\beta}$ and IL-6 were also performed by real-time PCR. Protein expression of iNOS and COX-2 was confirmed by western blot. The anti-oxidant activities of DPT was measured by DPPH radical scavenging activity. Results : 1. There was no cytotoxicity in RAW 264.7 cells treated with DPT compared to the control. 2. DPT treated group significantly inhibited NO production compared to the LPS treated group. 3. DPT treated group significantly decreased mRNA expressions of iNOS, COX-2, $TNF-{\alpha}$, $IL-1{\alpha}$, $IL-1{\beta}$ and IL-6 compared to the LPS treated group. 4. To evaluate the safety of the products for the human body, Adverse events, SCORAD Index Assessment were conducted; There were no severe adverse events during this study. And SCORAD Index showed a statistically significant decrease in treatment group in baseline, 2 weeks and 4 weeks. Therefore, it is suggested that products, if used for certain period, should be safe for the human body. 5. DPT was found to have high DPPH free radical scavenging ability. Conclusions : According to the above results, DPT can be used as a therapy in various anti-inflammatory skin diseases.

A Study on Smart Soil Resistance Measuring Device for Safety Characterized Ground Design in Converged Information Technology (ICT 융합 환경에서의 안전 특성화 접지 설계를 위한 스마트 대지 저항 측정 기술에 관한 연구)

  • Kim, Hong-Yong;Shin, Seung-Jung
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.19 no.1
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    • pp.203-209
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    • 2019
  • In this work, a new land-specific resistance measuring device (GM) and a measuring probe (Grounding Rod) are connected to the WENNER quadrant as power-line communication (PLC). In groups of two (P1,P2) probes, five to ten probes are installed in series on the ground at intervals of 1m, 2m, 4m, 8m, and 16m, respectively. If the PLC signal from the GMD is detected by the receiver of the Probe 1 (P1) for measurement, the minute voltage and current for measurement flow from the PSD (power supply) attached to the probe to the ground, and then, through the soil between P1 and P2, enters the Probe 1 (P2). The resistance value is then measured by the principle of voltage drop due to ground resistance. Measure the earth resistance every T seconds up to 1 trillion and store the measured data on the Arduino Server mounted on the main equipment. Stored measurement data can be derived from formulas by Ohm's Law and from inherent resistance (here,). Data obtained in real time will be linked to CDGES programs installed on Main PC, enabling data analysis and real-time monitoring of the ground environment on land. In addition, a three-dimensional display is possible with 3D graph support by identifying seasonal characteristics such as temperature and humidity of land (soils). The limitations of the study will require specific application measures of Test Bed for commercial access to a model that has been developed and operated experimentally.

A Study on the Awareness of Visitors to King Mu Trekking Course Program of Iksan (익산 무왕길 탐방프로그램 이용자의 인식에 대한 연구)

  • Park, Yool-Jin
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.36 no.4
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    • pp.80-93
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    • 2018
  • The following results could be obtained from the research on awareness and satisfaction of the tourists who joined the program 'A Journey in Search of King Mu's Road'. With regard to awareness of the site tour program, tourists replied that they participated in the program mainly because of their interest in education for their children. They expressed great needs for the municipal government office to maintain walkways, signboards and guide maps as well as to reinforce safety facilities as a measure to increase satisfaction with the site tour on the part of visitors and tourists. In terms of satisfaction with operation and management of the site tour program, the contents of the program were highly appreciated while it turned out necessary to rediscover garden culture resources and to develop and operate an expanded internal tour course for tourists to look around inside the relics by utilizing the recently excavated Baekje historical resources. As a consequence, it might be expected possible to experience and educate the local history and garden culture thanks to the historical culture and environmental values that have been preserved in the Baekje cultural circles. Moreover, the importance of walking trips will be recognized for its effects to allow those who get tired from daily life to come into contact with nature, practice self-reflection and care for their health as well.

Susceptibility of Myzus persicae on Potato field and Riptortus clavatus on Soybean field to Insecticides treated by Multi-copter (농업용 멀티콥터를 활용한 감자의 복숭아혹진딧물과 콩의 톱다리개미허리노린재의 약제방제 효율)

  • Park, Bueyong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.1
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    • pp.231-236
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    • 2021
  • The Aphid, Myzus persicae, and the bean bug, Riptortus clavatus, are major insects in crops. This study examined the insecticide susceptibility and phytotoxicity of insecticides dispersed using an Unmanned Aerial Vehicle (UAV, multi-copter) against the insects. Sulfoxaflor suspension concentrate (SC, 16X) on potato fields and etofenprox, methoxyfenzide suspo-emulsion(SE, 8X) on soybean fields were dispersed after deploying water-sensitive paper within the field to measure the distribution pattern and coverage index of the falling insecticide. Both insecticides showed a controlled mortality of 76.4% against aphids and 97.5% and 94.4% against the 2nd nymphal, and 5th nymphal stage of the bugs, respectively. The droplet distribution was less than 0.5mm, and coverage analysis revealed an inside and outside coverage of 3.1 and 1.6, respectively. The surrounding area was affected by insecticide spraying using a multi-copter. This study is expected to help expand UAV control and use it safely in the future.

Removal of residual VOCs in a collection chamber using decompression for analysis of large volatile sample

  • Lee, In-Ho;Byun, Chang Kyu;Eum, Chul Hun;Kim, Taewook;Lee, Sam-Keun
    • Analytical Science and Technology
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    • v.34 no.1
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    • pp.23-35
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    • 2021
  • In order to measure the volatile organic compounds (VOCs) of a sample which is too large to use commercially available chamber, a stainless steel vacuum chamber (VC) (with an internal diameter of 205 mm and a height of 50 mm) was manufactured and the temperature of the chamber was controlled using an oven. After concentrating the volatiles of the sample in the chamber by helium gas, it was made possible to remove residual volatile substances present in the chamber under reduced pressure ((2 ± 1) × 10-2 mmHg). The chamber was connected to a purge & trap (P&T) using a 6 port valve to concentrate the VOCs, which were analyzed by gas chromatography-mass spectrometry (GC-MS) after thermal desorption (VC-P&T-GC-MS). Using toluene, the toluene recovery rate of this device was 85 ± 2 %, reproducibility was 5 ± 2 %, and the detection limit was 0.01 ng L-1. The method of removing VOCs remaining in the chamber with helium and the method of removing those with reduced pressure was compared using Korean drinking water regulation (KDWR) VOC Mix A (5 μL of 100 ㎍ mL-1) and butylated hydroxytoluene (BHT, 2 μL of 500 ㎍ mL-1). In case of using helium, which requires a large amount of gas and time, reduced pressure ((2 ± 1) × 10-2 mmHg) only during the GC-MS running time, could remove VOCs and BHT to less than 0.1 % of the original injection concentration. As a result of analyzing volatile substances using VC-P&T-GC-MS of six types of cell phone case, BHT was detected in four types and quantitatively analyzed. Maintaining the chamber at reduced pressure during the GC-MS analysis time eliminated memory effect and did not affect the next sample analysis. The volatile substances in a cell phone case were also analyzed by dynamic headspace (HT3) and GC-MS, and the results of the analysis were compared with those of VC-P&T-GC-MS. Considering the chamber volume and sample weight, the VC-P&T configuration was able to collect volatile substances more efficiently than the HT3. The VC-P&T-GC-MS system is believed to be useful for VOCs measurement of inhomogeneous large sample or devices used inside clean rooms.

Quality Control of Dose Calibrator using 3D Printery (3D 프린터를 이용한 Dose Calibrator의 품질관리)

  • Ryu, Chan-Ju
    • Journal of the Korean Society of Radiology
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    • v.15 no.3
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    • pp.307-312
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    • 2021
  • In nuclear medicine, radioactive isotope tracers are administered to the human body to obtain and evaluate disease morphological information and biological function information. Dose calibrator is a device used to measure the radioactivity of a single nuclide in medical institutions. Administration of the correct dose to the human body acts as an important factor in diagnosis and treatment, and measurement through a dose calibrator before administration is the most important factor. Dose calibrator performs daily quality control after installation in each medical institution. Quality control is a means of guaranteeing quality control after installation, and is essential for improving the quality of treatment and promoting patient safety. Therefore, accurate and standardized performance evaluation methods should be established. In this study, 3D printing was used for quantitative evaluation of quality control by increasing the accuracy and standardization of quality control. When the 3D printer was installed and reproducibility was tested, the error range of the expected value and reading value decreased by 0.302% in the F-18 nuclide and 0.09% in the 99mTc-pertechnate nuclide than when the 3D printer was installed. The error rate for other nuclides was also found to have a low error rate for reproducibility tests when 3D printing was installed.

Correlation between Proximity Noise Measurement Method (CPX) and Roadside Measurement Method (SPB) for Road Traffic Noise (도로교통소음에 대한 근접소음 측정법(CPX)과 통과소음 측정법(SPB)의 상관관계)

  • Yoo, In-Kyoon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.12
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    • pp.310-319
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    • 2020
  • Korea estimates the traffic noise by measuring the total traffic noise when the traffic passes (SPB; Statistical Pass-By). Another method (CPX; Close Proximity) directly measures the tire/road noise by installing a microphone near the tire. The CPX method is not a formal test method in Korea. There has been little research between CPX and SPB. This study proposes a method for estimating SPB, using the CPX, which is easy to measure. This study used the results of a large-scale test conducted by Korea Expressway Corporation (KEC) and a research paper on CPX in this section. The results by the KEC showed that the low noise pavement has a noise reduction of 10.4dB. In CPX research, the noise reduction was 10.7dB and was similar to 10.4dB in SPB. This study shows why the noise reduction is the same regardless of the position, the reason that the amount of noise reduction is similar, the difference of the noise according to the position of the microphone using the concept of noise summation and distance reduction. This study shows that including the CPX as a variable in the traffic noise prediction program is very important to improve noise prediction reliability.

Development and Validation of a Questionnaire on the Feasibility of a Mobile Dietary Self-Monitoring Application (식습관 관리 애플리케이션의 적용 가능성에 대한 설문지 개발 및 타당성 연구)

  • Lee, Heejin;Ahn, Jeong Sun;Lee, Jung Eun
    • Korean Journal of Community Nutrition
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    • v.27 no.2
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    • pp.146-157
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    • 2022
  • Objectives: This study aimed to develop and assess the content validity and internal consistency of a questionnaire on the feasibility of mobile dietary self-monitoring applications. Methods: We developed a feasibility questionnaire to assess the overall usage, convenience, usefulness, and satisfaction of mobile dietary applications. The initial draft of the questionnaire contained 17 items with yes/no, multiple-choice, and open-ended questions and 52 items on 5-point Likert scales. To validate the content, ten experts evaluated the relevance of the items for each subscale using a 5-point scale. We calculated the item-level content validity index (I-CVI) and scale-level content validity index (S-CVI). A total of 102 adults answered the questionnaires which reflected the experts' reviews. We conducted an exploratory factor analysis to determine the underlying structure of responses and categorized convenience, usefulness, and satisfaction. We also calculated Cronbach's alpha coefficient to examine the internal consistency of items in each subscale. Results: The S-CVI score of the items was 0.86, and we removed items with an I-CVI score of < 0.80. We combined, revised, or separated some remaining items and added one item as per the experts' comments. As a result, we included 16 items about overall usage and 42 sub-questions. Based on the responses of the 102 adults, we performed exploratory factor analysis using the principal axis method. We retained items with a factor loading of > 0.40, resulting in a final set of 35 questions (convenience: 15, usefulness: 12, satisfaction: 8 items). The Cronbach's alpha values of the three scales were 0.93, 0.91, and 0.91 for 1) usefulness, 2) convenience, and 3) satisfaction, respectively. Conclusions: We developed a feasibility questionnaire for mobile dietary self-monitoring applications and examined its content validity and internal consistency. Our questionnaire has the potential to measure the feasibility of mobile dietary self-monitoring applications.

Development of The Safe Driving Reward System for Truck Digital Tachograph using Hyperledger Fabric (하이퍼레저 패브릭을 이용한 화물차 디지털 운행기록 단말기의 안전운행 보상시스템 구현)

  • Kim, Yong-bae;Back, Juyong;Kim, Jongweon
    • Journal of Internet Computing and Services
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    • v.23 no.3
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    • pp.47-56
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    • 2022
  • The safe driving reward system aims to reduce the loss of life and property by reducing the occurrence of accidents by motivating safe driving and encouraging active participation by providing direct reward to vehicle drivers who have performed safe driving. In the case of the existing digital tachograph, the goal is to limit dangerous driving by recording the driving status of the vehicle whereas the safe driving reward system is a support measure to increase the effect of accident prevention and induces safe driving with financial reward when safe driving is performed. In other words, in an area where accidents due to speeding are high, direct reward is provided to motivate safe driving to prevent traffic accidents when safe driving instructions such as speed compliance, maintaining distance between vehicles, and driving in designated lanes are performed. Since these safe operation data and reward histories must be managed transparently and safely, the reward evidences and histories were constructed using the closed blockchain Hyperledger Fabric. However, while transparency and safety are guaranteed in the blockchain system, low data processing speed is a problem. In this study, the sequential block generation speed was as low as 10 TPS(transaction per second), and as a result of applying the acceleration function a high-performance network of 1,000 TPS or more was implemented.

A Study on Next-Generation Data Protection Based on Non File System for Spreading Smart Factory (스마트팩토리 확산을 위한 비파일시스템(None File System) 기반의 차세대 데이터보호에 관한 연구)

  • Kim, Seungyong;Hwang, Incheol;Kim, Dongsik
    • Journal of the Society of Disaster Information
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    • v.17 no.1
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    • pp.176-183
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    • 2021
  • Purpose: The introduction of smart factories that reflect the 4th industrial revolution technologies such as AI, IoT, and VR, has been actively promoted in Korea. However, in order to solve various problems arising from existing file-based operating systems, this research will focus on identifying and verifying non-file system-based data protection technology. Method: The research will measure security storage that cannot be identified or controlled by the operating system. How to activate secure storage based on the input of digital key values. Establish a control unit that provides input and output information based on BIOS activation. Observe non-file-type structure so that mapping behavior using second meta-data can be performed according to the activation of the secure storage. Result: First, the creation of non-file system-based secure storage's data input/output were found to match the hash function value of the sample data with the hash function value of the normal storage and data. Second, the data protection performance experiments in secure storage were compared to the hash function value of the original file with the hash function value of the secure storage after ransomware activity to verify data protection performance against malicious ransomware. Conclusion: Smart factory technology is a nationally promoted technology that is being introduced to the public and this research implemented and experimented on a new concept of data protection technology to protect crucial data within the information system. In order to protect sensitive data, implementation of non-file-type secure storage technology that is non-dependent on file system is highly recommended. This research has proven the security and safety of such technology and verified its purpose.