• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6359-6364
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• 2015

Background: Preclinical studies have shown that the combination of an aromatase inhibitor (AI) and capecitabine in estrogen receptor (ER)- positive cell lines enhance antitumor efficacy. This retrospective analysis of a group of patients with metastatic breast cancer (MBC) evaluated the efficacy and safety of combined AI with capecitabine. Materials and Methods: Patients with hormone receptor-positive metastatic breast cancer treated between 1st January 2005 and 31st December 2010 with a combination of capecitabine and AI were evaluated and outcomes were compared with those of women treated with capecitabine in conventional dose or AI as a monotherapy. Results: Of 72 patients evaluated, 31 received the combination treatment, 22 AI and 19 capecitabine. The combination was used in 20 patients as first-line and 11 as second-line treatment. Mean age was 46.2 years with a range of 28-72 years. At the time of progression, 97% had a performance status of <2 and 55% had visceral disease. No significant difference was observed between the three groups according to clinical and pathological features. Mean follow up was 38 months with a range of 16-66 months. The median PFS of first-line treatment was significantly better for the combination (PFS 21 months vs 8.0 months for capecitabine and 15.0 months for AI). For second-line treatment, the PFS was longer in the combination compared with capecitabine and Al groups (18 months vs. 5.0 months vs. 11.0 months, respectively). Median 2 year and 5 year survival did not show any significant differences among combination and monotherapy groups. The most common adverse events for the combination group were grade 1 and 2 hand-for syndrome (69%), grade 1 fatigue (64%) and grade 1 diarrhoea (29%). Three grade 3 hand-foot syndrome events were reported. Conclusions: Combination treatment with capecitabine and AI used as a first line or second line treatment was safe with much lowered toxicity. Prospective randomized clinical trials should evaluate the use of combination therapy in advanced breast cancer to confirm these findings.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.72-79
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• 2010

The significant of continuous welded rail (CWR) management is growing because KORAIL has the plan to convert the whole of conventional railway lines into CWRs through continuous activities since constructed the CWR track with 1.8km in Gyeongbu line in 1966. The CWR recently is needed a efficient management method because it is difficult to manage the CWR by the poor of technic and equipment, limited maintain labor force and shorted the maintain work time of CWR caused by industrialization, greenhouse effect and global warming In this point, The 70ton Tenser's which is using in the rail site has been analysised with no extra tenser's capacity in case of the under low temperature and exceed the length of 1km as a result of reviewing the CWR-related rules and standards, a series of records of safety accidents, operation obstacles, and the situation of broken rails published by KORAIL, existing rail temperature measurements, and CWR researches. Therefore avoid the excessive plan of the first set-up section, choice the proper time in the normal temperature that is possible to weld the rail, turning the difference of rail temperature and Installation temperature down is desirable.

• Proceedings of the KSR Conference
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• 2007.11a
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• pp.1099-1104
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• 2007

The visual implementation of 3-dimensional national environment is focused by the requirement and importance in the fields such as, national development plan, telecommunication facility deployment plan, railway construction, construction engineering, spatial city development, safety and disaster prevention engineering. The currently used DEM system using contour lines, which embodies national geographic information based on the 2-D digital maps and facility information has limitation in implementation in reproducing the 3-D spatial city. Moreover, this method often neglects the altitude of the rail way infrastructure which has narrow width and long length. There it is needed to apply laser measurement technique in the spatial target object to obtain accuracy. Currently, the LiDAR data which combines the laser measurement skill and GPS has been introduced to obtain high resolution accuracy in the altitude measurement. In this paper, we first investigate the LiDAR based researches in advanced foreign countries, then we propose data a generation scheme and an algorithm for the optimal manage and synthesis of railway facility system in our 3-D spatial terrain information. For this object, LiDAR based height data transformed to DEM, and the realtime unification of the vector via digital image mapping and raster via exactness evaluation is transformed to make it possible to trace the model of generated 3-dimensional railway model with long distance for 3D tract model generation.

• Journal of Korean Society of Transportation
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• v.28 no.4
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• pp.141-156
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• 2010

In this paper, understanding there is a limitation with a comprehensive and network approach for the evaluation of existing vehicle and pedestrian environments, the authors focus on developing an integrated approach to assessing these environments. The network evaluation here means the assessment at a three-dimensional level that includes evaluation methods of lines/axes in a spatial concept as well as integration of evaluation indicators being used for vehicles and the walking environment. Grey System Theory (GST) was applied based on the theoretical background for network and comprehensive integrated evaluation, and the evaluation of the vehicle and pedestrian environment was performed by assigning target areas to walking preference zones. As a result of the comprehensive evaluation and analysis by GST, even if the service level is the same as the operating indicators (Highway Capacity Manual) of the vehicle and pedestrian environment, or relatively better, it was identified that the total score could be varied over Grey Category because the observed data are calculated after considering the weights between evaluation indicators by the range of Grey Category on the comprehensive evaluation. Considering comprehensively these points, although the indicators on the operation of roads are relatively good, in the event that the indicators on the safety of roads are bad, it was known that the scores over Grey Category also could be changed. The result is that this evaluation method can be used to evaluate the network concept per lane (per axis) as well as to diagnose the current state by type of urban street in the future.

• Journal of the Korean GEO-environmental Society
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• v.17 no.7
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• pp.5-13
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• 2016

This research is focused on the seepage behavior of embankment which had the weak zone with big permeability. The distributed TDR (Time Domain Reflectometer) and point sensors such as settlement gauge, pore water pressuremeter, vertical total stressmeter, and FDR (Frequency Domain Reflectometer) sensor were used to measure the seepage characteristics and embankment behavior. Also, the measured data were compared to the data of 2-D and 3-D numerical analysis. The dimension of model embankment was 7 m length, 5 m width and 1.5 m height, which is composed of fine-grained sands and the water level of embankment was 1.3 m height. The seepage behavior of measuring and numerical analysis were very similar, it means that the proper sensing system can monitor the real-time safety of embankment. The result by 2-D and 3-D numerical analysis showed similar saturation processing, however in case of weak zone, the phreatic lines of 2-D showed faster movement than that of 3-D analysis, and finally they converged.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.8
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• pp.423-432
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• 2016

Due to the increase in the number of transfer lines and ground level connections with mixed-use high-rise buildings, the Seoul Metro suffers from loaded signage fatigue because of the presence of too many signs. The purpose of this research is to propose ways of improving the wayfinding on the Seoul subway station by examining the signage and (applying the) universal design (UD) concept. A review of the literature explored five universal design components, viz. the accessibility, safety, equitability, perception, and aesthetics. The field investigation found that the ceiling and wall type and general information boards were high on the information hierarchy. The survey respondents merely perceived universal design concept, however, most needed principle. The IPA found that the signs should be appropriately laid out, spaced and located from the perspective of accessibility, and their unity and harmony were other aspects that could be improved while general information boards should include important landmarks outside. In conclusion, this study suggests that the universal design signage concept should be applied to every station and that specific stations should have a duly sign system.

• International Journal of Highway Engineering
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• v.14 no.3
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• pp.131-140
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• 2012

Lane markings such as edgelines, centerlines, and lines that delineate lanes generally provide drivers with the various information for safe driving. Drivers can easily recognize the lane markings through the color differences between the markings and road surfaces during the daytime. However, it is a bit difficult for drivers to perceive them during the nighttime due to the lack of artificial lights. Although the glass beads with the 1.5-refractive index have been used to improve the visibility of the lane markings during the nighttime, it is still difficult for drivers to recognize the lane markings properly, especially during the rainy nighttime, which may often lead to traffic accidents. To improve the retroreflectivity and visibility of the lane markings during the rainy nighttime, the high refractive beads with the 2.4-refractive index are essentially required, but they do not work appropriately during the dry nighttime. Thus, the mixed materials with the 1.5, 1.9, and 2.4-refractive beads should be considered for the satisfactory implementation of the lane markings. This study reveals the best mixing rates of the beads by conducting benefit-cost analysis under various weather conditions in Korea. The analysis results show that the lane markings with the 100% of the 2.4-refractive beads provide the highest visibility of lane markings regardless of the roadway conditions, but the benefit-cost (B/C) ratio of the bead mixture is merely 0.46. The best mixing rate of the beads, from the highest B/C ratio viewpoint, was identified as the mixture with a 80% of 1.5-refractive beads and a 20% of 2.4-refractive beads. Some limitations and future research agenda have also been discussed.

• Fire Science and Engineering
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• v.31 no.6
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• pp.40-46
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• 2017

As one of the solutions to deal with economic loss caused by traffic congestion in metropolitan area, a deep underground road has been planned and implemented at home and abroad. The part of them has been pushed ahead with a double-deck scheme which has an advantage in constructability and cost efficiency comparing to traditional road tunnel. However, the double-deck tunnel has a lower floor height than the general road tunnel due to the special structure used as the upper and lower lines by installing the middle slab on one excavation section. Therefore, it is relatively weak against fire accidents and ventilation problems occurring in tunnels. Thus study to develop the life safety system optimized to a double-deck tunnel has been systematically carried out in order to overcome their weak point. In this study, automatic monitoring fire extinguisher (AMFE) is developed to suppress a fire and prevent its spread at early stage of tunnel fire, conducting the performance test through vehicle fire tests as verification. The tests were conducted with AMFE being 30 m apart from the vehicle and 10 m apart from engine room. As a results, it was confirmed that AMFE enables to suppress a fire and prevent its spread in both cases.

• Journal of Korean Society of Transportation
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• v.31 no.3
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• pp.65-73
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• 2013

Exclusive median bus lanes were installed to mitigate congestions on urban traffic networks. However, capacity analysis of signalized intersections having exclusive median bus lanes have not been provided in current capacity analysis process(analyses). This study aims to develop a method of capacity analysis for lane groups consisting of only buses at the signalized intersections having exclusive median bus lanes. Finding basic saturation flow rates for buses is critical since the operational characteristics between automobiles and buses are fairly different. A total of 8 intersections in Seoul were chosen as study sites. Saturation headways, distances between bus-stop and stopline, and grades of each approach were measured at the sites. It was found that the basic saturation headway and the basic saturation flow rate of buses were 3.27 s/veh and 1,100pc/h/ln, respectively. Adjustment factor for upstream bus-stop locations was estimated with 0.50 and 0.75 when the distances between bus-stop and stopline are 20m and 70m, respectively. This study explains that bus saturation flow rates are decreased in half if the bus stop locates within 20 meters from stop lines.

• Journal of the Korean Geosynthetics Society
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• v.9 no.3
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• pp.77-85
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• 2010

The change of water level in reservoirs is an important factor causing failure of bank slopes, i.e. landslide. The water level of Three Gorges reservoir in China fluctuate between 145 m and 175 m, as a matter of flood control. During its normal operational state, the rate of water level fluctuation is supposed to range from 0.67 m/d to 3.0 m/d. Majiagou slope is located on the left bank of Zhaxi River, 2.1 km up from the outlet. Zhaxi River is a tributary of the Yangtze River within the Three Gorges area, of which the water level changes with the reservoir. At the back of Majiagou slope, a 20 m long and 3~10 cm wide fissure developed just after the reservoir water level rose from 95 m to 135 m in 2003. This big fissure was a full suggestion of potential failure of this slope. In this study, unsaturated-saturated seepage analyses were carried out to simulate the change of pore-water pressures in the bank slope subjected to the reservoir water level change. The obtained pore-water pressures were then used to evaluate the change in factor of safety (FS) with reservoir water level. It was found that the phreatic line showed a delayed response with respect to the change of the reservoir water level, because the seepage through soil layer was generally slower than water flows itself. During the rising and drawdown process, the phreatic lines take the shapes of concave and convex, respectively. And the fluctuation of reservoir water level just affected the front part of the bank slope, but had little influence on the back of the slope.