• Title/Summary/Keyword: Safety evaluation test

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Single Dose Oral Toxicity Study of Cicadidae Periostracum Extracts in Sprague-Dawley Rats (선퇴 추출물의 Sprague-Dawley rat를 이용한 단회 경구 투여 독성시험)

  • Byung-Suk Jeon;Huiyeong Jeong;Sueun Lee;Yun-Soo Seo;Joong-Sun Kim;Hyeon Hwa Nam;Ji Hye Lee
    • The Korea Journal of Herbology
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    • v.39 no.3
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    • pp.107-114
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    • 2024
  • Objective : Cicadae Periostracum (CP), which is the discarded shell of the Cryptotympana atrata (Fabricius, 1775), is a recognized component of oriental medicine for treatment sore throat, itching, shock, sedation, edema. However, the safety and toxicity of CP have not yet been established. It has been reported that symptoms of addiction or side effects may occur in patients who take high doses of CP or who are hypersensitive to it. Therefore, we investigated the acute toxicity of an CP extracts in Sprague-Dawley (SD) rats. Methods : To study acute toxicity, five SD rats of each sex per group were treated with CP extracts at single doses of 0, 500, 1000, or 2000 mg/kg administrated by oral gavage, and body weight, clinical signs, and mortality were observed after dosing. At the end of 14-day observation period, all animals were sacrificed and complete hematological and macroscopic examinations were performed. Results : There were no dead animal and test article-related effects on body weight change or the gross finding. No toxicologically significant results were observed between control and treated groups in hematology. Although salivation related to stress at the highest dose was observed in clinical signs immediately after administration, it is considered to have no toxicological significance. Conclusion : As the results, we did not find any adverse effect at the dose levels of 500, 1000, or 2000 mg/kg in rats. The minimal lethal dose was considered to be over 2000 mg/kg body weight in rats.

Optimal Sensor Placement for Improved Prediction Accuracy of Structural Responses in Model Test of Multi-Linked Floating Offshore Systems Using Genetic Algorithms (다중연결 해양부유체의 모형시험 구조응답 예측정확도 향상을 위한 유전알고리즘을 이용한 센서배치 최적화)

  • Kichan Sim;Kangsu Lee
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.37 no.3
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    • pp.163-171
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    • 2024
  • Structural health monitoring for ships and offshore structures is important in various aspects. Ships and offshore structures are continuously exposed to various environmental conditions, such as waves, wind, and currents. In the event of an accident, immense economic losses, environmental pollution, and safety problems can occur, so it is necessary to detect structural damage or defects early. In this study, structural response data of multi-linked floating offshore structures under various wave load conditions was calculated by performing fluid-structure coupled analysis. Furthermore, the order reduction method with distortion base mode was applied to the structures for predicting the structural response by using the results of numerical analysis. The distortion base mode order reduction method can predict the structural response of a desired area with high accuracy, but prediction performance is affected by sensor arrangement. Optimization based on a genetic algorithm was performed to search for optimal sensor arrangement and improve the prediction performance of the distortion base mode-based reduced-order model. Consequently, a sensor arrangement that predicted the structural response with an error of about 84.0% less than the initial sensor arrangement was derived based on the root mean squared error, which is a prediction performance evaluation index. The computational cost was reduced by about 8 times compared to evaluating the prediction performance of reduced-order models for a total of 43,758 sensor arrangement combinations. and the expected performance was overturned to approximately 84.0% based on sensor placement, including the largest square root error.

Evaluation of Shear Deformation Energy and Fatigue Performance of Single-layer and Multi-layer Metal Bellows (단층 및 다층 금속 벨로우즈의 전단 변형 에너지 및 피로성능 평가)

  • Kyeong-Seok Lee;Jin-Seok Yu;Young-Soo Jeong
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.28 no.1
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    • pp.39-45
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    • 2024
  • Seismic safety of expansion joints for piping systems has been underscored by water pipe ruptures and leaks resulting from the Gyeongju and Pohang earthquakes. Metal bellows in piping systems are applied to prevent damage from earthquakes and road subsidence in soft ground. Designed with a series of corrugated segments called convolutions, metal bellows exhibit flexibility to accommodate displacements. Several studies have examined variations in convolution shapes and layers based on the intended performance to be evaluated. Nonetheless, the research on the seismic performance of complex bellows having multiple corrugation heights is limited. In this study, monotonic loading tests, cyclic loading tests, and fatigue tests were conducted to evaluate the shear performance in seismic conditions, of metal bellows with variable convolution heights. Single- and triple-layer bellows were considered for the experimentation. The results reveal that triple-layer bellows exhibit larger maximum deformation and fatigue life than single-layer bellows. However, the high stiffness of triple-layer bellows in resisting internal pressure poses certain disadvantages. The convolutions are less flexible at lower displacements and experience leakage at a rate related to the variable height of the convolutions in certain conditions. At lower deformation rates, the fatigue life is rated higher as the number of layers increase. It converges to a similar fatigue life at higher deformation rates.

Evaluation of the CNESTEN's TRIGA Mark II research reactor physical parameters with TRIPOLI-4® and MCNP

  • H. Ghninou;A. Gruel;A. Lyoussi;C. Reynard-Carette;C. El Younoussi;B. El Bakkari;Y. Boulaich
    • Nuclear Engineering and Technology
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    • v.55 no.12
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    • pp.4447-4464
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    • 2023
  • This paper focuses on the development of a new computational model of the CNESTEN's TRIGA Mark II research reactor using the 3D continuous energy Monte-Carlo code TRIPOLI-4 (T4). This new model was developed to assess neutronic simulations and determine quantities of interest such as kinetic parameters of the reactor, control rods worth, power peaking factors and neutron flux distributions. This model is also a key tool used to accurately design new experiments in the TRIGA reactor, to analyze these experiments and to carry out sensitivity and uncertainty studies. The geometry and materials data, as part of the MCNP reference model, were used to build the T4 model. In this regard, the differences between the two models are mainly due to mathematical approaches of both codes. Indeed, the study presented in this article is divided into two parts: the first part deals with the development and the validation of the T4 model. The results obtained with the T4 model were compared to the existing MCNP reference model and to the experimental results from the Final Safety Analysis Report (FSAR). Different core configurations were investigated via simulations to test the computational model reliability in predicting the physical parameters of the reactor. As a fairly good agreement among the results was deduced, it seems reasonable to assume that the T4 model can accurately reproduce the MCNP calculated values. The second part of this study is devoted to the sensitivity and uncertainty (S/U) studies that were carried out to quantify the nuclear data uncertainty in the multiplication factor keff. For that purpose, the T4 model was used to calculate the sensitivity profiles of the keff to the nuclear data. The integrated-sensitivities were compared to the results obtained from the previous works that were carried out with MCNP and SCALE-6.2 simulation tools and differences of less than 5% were obtained for most of these quantities except for the C-graphite sensitivities. Moreover, the nuclear data uncertainties in the keff were derived using the COMAC-V2.1 covariance matrices library and the calculated sensitivities. The results have shown that the total nuclear data uncertainty in the keff is around 585 pcm using the COMAC-V2.1. This study also demonstrates that the contribution of zirconium isotopes to the nuclear data uncertainty in the keff is not negligible and should be taken into account when performing S/U analysis.

Fire Risk Prediction and Fire Risk Rating Evaluation of Four Wood Types by Comparing Chung's Equation-IX and Chung's Equation-XII (Chung's Equation-IX과 Chung's Equation-XII의 비교에 의한 목재 4종의 화재위험성 예측 및 화재위험성 등급 평가)

  • JiSun You;Yeong-Jin Chung
    • Applied Chemistry for Engineering
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    • v.35 no.3
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    • pp.200-208
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    • 2024
  • Chung's equations-IX and Chung's equation-XII were utilized to predict the fire risk and evaluate fire risk ratings for four types of wood: camphor, cherry, rubber, and elm trees. The combustion tests were conducted using a cone calorimeter test method by ISO 5660-1 standards. The fire risk and fire risk rating (FRR) were compared for Fire Risk Index-IX (FRI-IX) and Fire Risk Index-XII (FRI-XII). The results yielded Fire Performance Index-XI (FPI-XI) ranging from 0.08 to 11.48 and Fire Growth Index-XI (FGI-XI) ranging from 0.67 to 111.89. The Fire Risk Index-XII (FRI-XII), indicating fire risk rating, exhibited an increasing order of cherry (0.45): Grade A (Ranking 5) < PMMA (1): Grade A (Ranking 4) < elm (1.23): Grade A (Ranking 3) < rubber (1.56): Grade A (Ranking 2) << camphor (148.23): Grade G (Ranking 1). Additionally, the fire risk index-IX (FRI-IX) was cherry (0): Grade A (Ranking 3) ≈ rubber (0): Grade A (Ranking 3) ≈ elm tree (0): Grade A (Ranking 3) < PMMA (1): Grade A (Ranking 2) << camphor tree (66.67): Grade G (Ranking 1). In general, camphor was found to have the highest fire risk. In conclusion, although the expression of the index is different as shown based on the standards of FRI-IX and FRI-XII, predictions based on fire risk assessment of combustible materials showed similar trends.

Combustion Characteristics of Useful Imported Woods (국내 유용 해외 목재 수종의 연소특성 평가)

  • Seo, Hyun Jeong;Kang, Mee Ran;Park, Jung-Eun;Son, Dong Won
    • Journal of the Korean Wood Science and Technology
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    • v.44 no.1
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    • pp.19-29
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    • 2016
  • The purpose of this study is to analyze the combustion and thermal properties in order to establish baseline data for the fire safety evaluation of imported wood. The combustion properties such as heat release rate, total heat release, gas yield, and mass loss were analyzed by the method of cone calorimeter test according to KS F ISO 5660-1 and thermogravimetric analysis (TGA). Analyzed species are five kinds of species as Merbau, Mempening, Garo Garo, Malas, and Dillenia. The heat released rate values showed the highest value of Malas as $375.52kW/m^2$, and Dillenia showed the lowest value as $133.30kW/m^2$. The data values were confirmed in the following order: Malas > Mempening > Garo Garo > Merbau > Dillenia. In case of the total heat release, it was measured in the following order: Mempening > Malas > Garo Garo > Merbau > Dillenia. The gas analysis results were that Dillenia showed the highest value of 0.034. Also, Mempening and Malas showed the lowest at 0.020 in the $CO/CO_2$. Min of mass reduction was shown as 74.79% Sargent cherry, on the other hand, Malas had a 83.52%. It showed a correlation between and of the CO and $CO_2$ generation and combustion characteristics of wood. The thermal decomposition temperature of the wood in the TGA were as follow that Merbau $348.07^{\circ}C$, Mempening $367.57^{\circ}C$, Garo Garo $350.59^{\circ}C$, Malas $352.41^{\circ}C$, Dillenia $364.33^{\circ}C$. The aim of this study is to determine the combustion properties of imported wood according to ISO 5660-1. And, based on the results of this study, we would proceed with further research for improving the fire safety of wood for construction.

Effects of High Pressure on Quality Stability of Fresh Fruit Puree and Vegetable Extracts During Storage (고압처리가 신선 과채음료의 저장기간 중 품질 안정성에 미치는 영향)

  • Kim, Young-Kyung;Lee, Yong-Hyun;Iwahashi, Yumiko
    • Food Science and Preservation
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    • v.17 no.2
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    • pp.190-195
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    • 2010
  • Pressure, used as a minimal processing technology in the food industry, is a valuable tool ensuring microbiologically safe, shelf-stable fruit and vegetable production. Pressure could be used to deliver a greater variety of minimally processed products, as demanded by today's consumers. Weevaluated the effect of <400 MPa pressure, applied during chilling, on fresh fruit purees (strawberry, kiwi, aloe, and pomegranate) and vegetable extracts (from carrot and spinach) during cold storage (<$10^{\circ}C$) for 15-20 days. Samples were prepared in a processing facility in which total plate counts of falling and floating bacteria were controlled at $1{\times}100-10^1$ CFU/plate and $1{\times}10^2-10^3$ $CFU/m^3$ under conditions of $21-25^{\circ}C$ and 55-60% relative humidity. The aerobic plate counts of raw materials were less than $1{\times}10^3$ CFU/g. Evaluation parameters included microbiological safety, vitamin content, and sensory qualities. Although the overall quality of non-treated samples deteriorated with storage time at $10^{\circ}C$, samples pressurized at 250-350 MPa at $5-7^{\circ}C$ for 10 min showed less change, with no significant difference in microbiological safety, vitamin content, or sensory quality. The use of pressure extended the shelf-life during storage at $10^{\circ}C$.

Microbiological Quality of Raw and Cooked Foods in Middle and High School Food Service Establishments (서울시 일부 중.고등학교의 급식용 식재료 및 조리식품의 미생물학적 품질)

  • Kim, Myung-Hee;Shin, Weon-Sun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.37 no.10
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    • pp.1343-1356
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    • 2008
  • The evaluation of microbiological quality for school food samples collected from 19 selected middle and high schools located in Seoul was undertaken. Eighty-nine food samples consisting of 38 non-pretreated vegetables, 13 pre-washed and cut vegetables, 9 meats and poultry, 3 fish and shellfish, 7 dried fish, and shellfish and 20 processed foods were collected. Aerobic plate count, total coliforms, and Escherichia coli (E. coli ) were detected using $Petrifilm^{TM}$, and the food-borne pathogens were screened by multiplex PCR with species-specific primer sets. Sequentially, the quantitative and confirmative test of the food-borne pathogens were carried out with the selective media and biochemical kits. The contamination of coliform counts was observed on the pre-washed vegetables ($3.4{\sim}4.3\;log\;CFU/g$) and meats ($2.2{\sim}4.3\;log\;CFU/g$). Also, the cooked foods were heavily contaminated with coliform, ranging from 1.0 to $5.5\;log\;CFU/g$. E. coli counts were found in 16 raw and cooked food samples, exceeding the microbiological standards for the guideline of safety management for school foods. Through PCR detection, B acillus cereus was detected in 32 raw and cooked foods, and quantitatively found in pre-washed carrot, radish, and pan-broiled dried shrimp and filefish ranging from $2.3{\sim}3.6\;log\;CFU/g$, respectively. E. coli O157:H7 was detected on frozen pork sample and was confirmed with API kit. Campylobacter jejuni was found in 3 ready-to-eat type vegetables. Vibrio parahaemolyticus were found in 4 pre-washed vegetables and 2 cooked foods, indicating unsatisfactory quality based upon the microbiological standards of ready-to-eat vegetables and cooked foods by Korea Food and Drug Administration. Salmonella spp. was detected in frozen chicken sample and confirmed by API kit and latex antisera agglutination.

Monitoring Country-of-origin Labels and Sanitation on the Meat Markets in Seoul, Korea (서울시 축산물(식육)판매업소의 원산지 표시실태 및 위생상태 모니터링)

  • Park, Jung-Min;Gu, Hyo-Jung;Jeong, Jong-Youn;Chang, Un-Jae;Suh, Hyung-Joo;Kang, Duk-Ho;Kim, Cheon-Jei;Kim, Jin-Man
    • Food Science of Animal Resources
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    • v.27 no.2
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    • pp.185-189
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    • 2007
  • Animals must be inspected prior to and after slaughter to make certain they are free of diseases and unacceptable defects. Since meats are potentially hazardous foods, they should not be accept if there are any signs of contamination, temperature abuse, or spoilage. This survey was aimed to monitor the current situation of country-of-origin labels and sanitation for the meat markets in Seoul, Korea. The markets were divided into groups as to 25 territories in Seoul and the size of markets (large size, medium size, and small size). In terms of size distribution, small butcher shops occupied the highest percentage. On the itemized suitability test of unpacked and packed beer in Seoul, most butcher shops showed good evaluation. However, labels indicating the grade, storage and cooking instruction for unpacked beef were not properly posted on the products. The results of monitoring sanitation conditions for butcher shops in Seoul showed relatively low suitability. Especially, there were serious lack of knowledge about wearing the sanitation clothings, caps, and shoes. The problem with food safety is so complicated that producers, consumers, merchandisers, the press, the government and the scholar should try to solve the problems altogether. Also, it is important to educate and provide them with correct understanding and information for food hygiene and safety.

Analysis of factors affecting customer satisfaction of HACCP applied restaurant in highway service area (HACCP 적용 고속도로 휴게소 식당의 고객 만족도에 영향을 주는 요인 분석)

  • Kim, Tae-Hyeong;Bae, Hyun-Joo
    • Journal of Nutrition and Health
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    • v.50 no.3
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    • pp.294-301
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    • 2017
  • Purpose: The purposes of this study were to investigate food consumption practices and analyze factors that influence customer satisfaction of an HACCP applied restaurant in a highway service area. Methods: A total of 207 customer responses were used for data analysis. Statistical analyses were conducted using the SPSS program (ver. 22.0) for $x^2$-test, Pearson correlation analysis, and multiple regression analysis. Results: Reasons for visiting the highway area were using the restroom (86.0%), purchasing of meals or snacks (70.1%), taking a rest (58.5%), and shopping (3.4%) and selection attributes of food sold in the highway service area were food taste (48.8%), food safety (33.3%), and waiting time for meal (10.7%). According to the results of the survey, udon (66.2%) was the most preferred meal, followed by instant noodles (56.0%), kimbap (50.7%), pork cutlet (38.2%), and bibimbap (29.0%). In addition, coffee (73.4%) was the most preferred among snacks and beverages, followed by beverages (58.9%), walnut cake (53.1%), mineral water (52.2%), and hotbar (52.2%). Satisfaction evaluation scores of foods sold in the highway service area were highest for appropriate portion size, followed by food safety, menu variety, food taste, and reasonable price. Overall customer satisfaction scores regarding the restaurant in the highway service area was 3.24 out of 5 points on average. According to the results of the multiple regressing analysis, food taste (p < 0.001) and reasonable price (p < 0.01) had significant positive effects on overall customer satisfaction. Conclusion: To enhance customer satisfaction, restaurant managers in the highway service area should implement HACCP, improve food taste, and set up a proper price for food sold at the restaurant in the highway service area.