• 전자공학회논문지SC
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• 제47권5호
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• pp.1-8
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• 2010

시장과 공장 환경 변화에 따라 생산관리의 용이성, 조작의 편리성, 높은 산업 안정성등의 요구가 본 논문에서는 네트워크기반의 시스템을 도입하여 단점을 보완한 새로운 고속, 초정밀 취출 로봇 제어기를 개발하였다. 개발된 제어기는 크게 티칭 팬던트와 중앙 서버 PC로 구분된다. 중앙 서버 PC는 관리자에게 전체 공정에 관련된 정보를 제공하게 된다. 티칭 팬던트는 중앙 서버 PC와 사출물 취출 로봇에 다리 역할로 사출로봇을 이용하는 사용자에게 제어 기능 및 사용자 인식, 금형파일 관리등 다양한 기능을 제공하게 된다. 사출물 취출을 위한 제어기 개발은 소프트웨어와 하드웨어 부분으로 나누어진다. 소프트웨어 개발은 3단계로 구분된다. 응용 프로그램과 유저 인터페이스 그리고 디바이스 드라이버로 구분되며, 간단한 디바이스 드라이버에는 따로 구분하지 않고 응용 프로그램에 포함되어 사용하도록 하였다. 하드웨어는 터치패널과 무선 네트워크를 도입하여 인터넷 접속 및 효율적인 공정 제어를 구축할 수 있도록 하였다. 기존의 시스템의 취출 싸이클이 5초였으나, 개선된 시스템을 도입하였을 경우 4초이내였으며, 다양한 무선 네트워크 기능으로 인한 공정 관리 및 생산 관리등 공정의 효율성을 높일 수 있었다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제30권12호
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• pp.1149-1157
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• 2003

하드웨어와 소프트웨어가 조합된 내장형 시스템이 복잡해지면서, 내장형 시스템에 탑재되는 내장형 소프트웨어 테스트가 중요하게 인식되고 있다. 특히, 원자력 발전소와 같이 안전 등급이 높은 시스템에 들어가는 소프트웨어 테스트는 필수적이다. 내장형 시스템 테스트의 경우 하드웨어와 소프트웨어의 상호작용에 의해 발생하는 오류를 발견하기 위한 효과적인 테스트 기법이 필요하다. 본 논문에서는, 하드웨어와 소프트웨어 사이의 상호작용에 의해 생성되는 오류를 발견하기 위하여, 오류 삽입 기법을 이용한 테스트 데이타 선정 기법을 제안하고, 이 기법을 Digital Plant Protection System에 적용하였으며, 실험을 통해 제안한 기법의 우수성을 분석한다.

• 대한약침학회지
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• 제18권2호
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• pp.76-85
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• 2015

Objectives: Radix Ginseng has been traditionally used as an adaptogen that acts on the adrenal cortex and stimulates or relaxes the nervous system to restore emotional and physical balance and to improve well-being in cases of degenerative disease and/or old age. Radix Ginseng has been used for a long time, but the safety of ginseng pharmacopuncture needs testing. This study was done to analyze the single-dose toxicity of water- soluble ginseng pharmacopuncture (GP) intramuscular injections in rats. Methods: All experiments were performed at Biotoxtech, an institution authorized to perform non clinical studies under the regulations of Good Laboratory Practice (GLP). Each group contained 10 Sprague-Dawley rats, 5 males and 5 females. GP was prepared in a sterile room at the Korean Pharmacopuncture Institute under regulations of Good Manufacturing Practice (GMP). GP dosages were 0.1, 0.5 and 1.0 mL for the experimental groups; normal saline was administered to the control group. The animals general condition was examined daily for 14 days, and the rats were weighed on the starting day and at 3, 7 and 14 days after administration of the pharmacopuncture. Hematological and biochemistry tests and autopsies were done to test the toxicological effect of GP after 14 days. This study was performed with approval from the Institutional Animal Ethics Committee of Biotextech. Results: No deaths were found in this single-dose toxicity test of intramuscular injections of GP, and no significant changes in the general conditions, body weights, hematological and biochemistry tests, and autopsies were observed. The local injection site showed no changes. Based on these results, the lethal dose was assumed to be over 1.0 mL/animal in both sexes. Conclusion: These results suggest that GP is relatively safe. Further studies, including a repeated toxicity test, are needed to provide more concrete evidence for the safety of GP.

• Nuclear Engineering and Technology
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• 제27권4호
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• pp.483-490
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• 1995

PKL III A 4.4 실험은 "증기발생기 세관파열사고 후 소외전원 가용의 조건 하에서 발전소가 비상냉각수 주입없이 수작동에 의해 제어될 수 있음을 확인하는 것이다. 실험 모사에 따른 NLOOP Code의 제한이나 능력의 검증을 위해, 실험에서 얻어진 PKL 설비의 거동은 NLOOP의 결과와 상호 비교되었다. NLOOP 코드는 한국원자력연구소와 독일 SIEMENS/KWU사에 의해 Westinghouse 형 발전소의 과도현상 해석용으로 개발되었으며, PKL III 설비모사를 위해 적절히 수정되었다. 자연대류에 의한RCS Loop의 냉각수 유량과 격리된 RCS Loop에서의 자연대류 중단현상을 특별히 주의깊게 연구하였다. 실험과 계산 결과의 비교는 NLOOP 코드의 의사능가 문제점들을 보여준다.보여준다.

• 한국항공우주학회지
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• 제36권12호
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• pp.1207-1215
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• 2008

우주환경에서 운용되는 위성은 상호 유기적으로 연결된 다양한 전자장비에서 방출하는 전도성/복사성 에너지 결합에 의해 다양한 잡음 신호를 발생하게 되는데, 이러한 잡음은 탑재체를 포함한 위성 시스템과 발사체의 전자기적인 영향에 의하여 주요 기능에 중대한 결함을 유발시킬 수 있다. 이에 위성 시스템은 개발 단계에서부터 전자파환경에 대한 영향을 최소화하기 위한 시스템 설계 검증이 요구된다. 위성 시스템에서 검증하여야 하는 전자파 환경 요소는 위성으로부터 방출되는 전도성/복사성 잡음과 이러한 잡음 환경에서 위성의 정상운용을 검증하는 감응성 잡음이 있다. 통신해양기상위성 시스템의 전자파 호환성 설계 검증은 PSR의 출력을 각 유닛에 분배하는 과정에서 전원선에서 방출하는 전도성 방출특성을 측정하여 시스템에서 통제하는 전자파 규격에 적합한지를 검증하고, 이러한 방출 레벨로부터 6 dB 시스템 안전성마진을 고려한 레벨의 전도성 잡음을 전원선에 인가하여 시스템의 성능을 검증하는 것이다. 아울러, 각 유닛의 전자파 복사 특성을 종합하여 시스템 수준의 복사성 잡음 수준을 예측하고 발사체 요구 규격과의 적합성을 분석하는 것이다. 본 논문에서는 통신해양기상위성의 전자파 환경시험 결과를 토대로 시스템 수준의 전자파 호환 특성 및 발사체와의 적합성 분석 결과를 제시하였으며, 잡음요소 분석 결과는 FM EMC 시험에 반영될 것이다.

• Nuclear Engineering and Technology
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• 제56권4호
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• pp.1513-1525
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• 2024

An improved mitigation system for thermally-induced steam generator tube rupture accidents was introduced to prevent direct environmental release of fission products bypassing the containment in the OPR1000. This involves injecting bypassed steam into the containment, cooling, and decontaminating it using a water coolant tank. To evaluate its performance, a severe accident analysis was performed using the MELCOR 2.2 code for OPR1000. Simulation results show that the proposed system sufficiently prevented the release of radioactive nuclides (RNs) into the environment via containment injection. The pool scrubbing system effectively decontaminated the injected RN and consequently reduced the aerosol mass in the containment atmosphere. However, the decay heat of the collected RNs causes re-vaporization. To restrict the re-vaporization, an external water source was considered, where the decontamination performance was significantly improved, and the RNs were effectively isolated. However, due to the continuous evaporation of the feed water caused by decay heat, a substantial amount of steam is released into the containment. Despite the slight pressurization inside the containment by the injected and evaporated steam, the steam decreased the hydrogen mole fraction, thereby reducing the possibility of ignition.

• 대한수의학회지
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• 제43권4호
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• pp.597-606
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• 2003

Although the antidepressant effects of imipramine (IMI) have been well known in several studies, the effects on cardiovascular system, particularly the vasorelaxant effects, have not known clearly. We hypothesis that IMI-induced vasorelaxation involves NO (nitrie oxide), activation of guanylate cyclase (GC) and $Ca^{2+}$ channel. The possible roles of the endothelium and $Ca^{2+}$ in IMI-induced responses were investigated using isolated rings of rat thoracic aorta and anesthesized rats. In KCl-precontracted rings. IMI produces endothelium-dependent and endothelium-independent relaxations in intact (+E) as well as endothelium-denuded (-E) rat aorta in a concentration-dependent manner. In phenylephrine (PE)-precontracted rings, the IMI-induced relaxation was significantly greater in +E rings. The IMI-induced relaxations were suppressed by nitric oxide synthase (NOS) inhibitors, N(G)-nitro-L-arginine (L-NNA), N(omega)-nitro-L-arginine methyl ester (L-NAME) and aminoguanidine, a non-selective GC inhibitor, methylene blue, $Na^+$ channel blockers, lidocaine and procaine, or $Ca^{2+}$ channel blockers, nifedipine and verapamil, in PE-precontracted +E rings, but not in PE-precontracted -E rings. These relaxations were also suppressed by lidocaine or procaine in -E aortic rings. However, IMI-induced relaxations were not inhibited by a PLC inhibitor 2-nitro-4-carboxyphenyl-n,n-diphenylcarbamate (NCDC), an inositol monophosphatase inhibitor, lithium, indomethacin and dexamethasone in +E and -E rings. In vivo, infusion of IMI elicited significant decrease in arterial blood pressure. After intravenous injection of saponin, NOS inhibitors. MB and nifedipine, infusion of IMI inhibited the IMI-lowered blood pressure markedly. These findings suggest that the endothelium-dependent relaxation induced by IMI is mediated by activation of NO/cGMP signaling cascade or inhibition of $Ca^{2+}$ entry through voltage-gated channel, and this mechanism may contribute to the hypotensive effects of IMI in rats.

• Toxicological Research
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• 제8권2호
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• pp.171-177
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• 1992

To investigate a short term screening method for carcinogenic quinone compounds, 8-hydroxydeoxyguanosine (8-OHdG), an oxidative DNA damage, was determined in the kidney and liver DNA isolated from Sprague-Dawley rats after i.p.injection of 7 mg/kg adriamycin (AM), 7mg/kg tetrahydropyranyladriamycin (THP), and 10mg/kg daunomycin (DM) by HPLC-electrochemical detector system. 8-OHdG was also determined from rat hepatocvtes and calf thymus DNA exposed to AM, DM and THP. When rats were treated with DM and THP, 8-OHdG was significantly increased in the kidney compared to control group, and remained at high level (7.9~9.0, 8-OHdG/dG${\times}10^4$)at the end of experiments (48hr after treatment). 8-OHdG level in cultured hepatocyte exposed to AM, DM and THP was 1.5~2 fold higher than control at all time points. (1,2,3,4hr after treatment). From calf thymus DNA exposed to AM, DM and THP, 8-OHdG was 2.5 fold higher than of control. These results suggest that quantitation of 8-OHdG may provide a useful marker for identifying target organ in oxidative chemical carcinogenesis and for short term screening of free radical generating carcinogens.

• 식품보건융합연구
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• 제6권5호
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• pp.19-25
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• 2020

The purpose of this study was to research and develop a step-type chemical liquid deodorizer including a liquid catalyst that can prevent civil complaints due to odor due to its excellent deodorizing performance. The main composition of chemical liquid deodorizer including liquid catalyst is cleaning deodorization, catalyst deodorization, chemical deodorization, water film plate, deodorization water circulation device, deodorization water injection device, catalyst management system, gas-liquid separation device, chemical supply device, deodorizer control panel, etc. It consists of a device. The air flow of the step-type liquid catalyst chemical liquid deodorizer is a technology that firstly removes basic odor substances, and the liquid catalyst installed in the subsequent process stably removes sulfur compounds, which are acidic odor substances, to discharge clean air. The efficiency of treating the complex odor of the prototype was 98.5% for the first and 99.6% for the second, achieving the target of 95%. The hydrogen sulfide treatment efficiency of the prototype was 100% for the first and 99.9% for the second, which achieved 95%, which was the target of the project. As a result, ammonia was removed by the reaction of ammonia and hydrogen sulfide.

• Animal Bioscience
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• 제35권10호
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• pp.1616-1627
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• 2022

Objective: This work was conducted to investigate the effects of oxidative stress on meat quality, mitochondrial function, calcium metabolism and ferroptosis of broilers. Methods: In this study, a total of 144 one-day-old male Ross 308 chicks were divided into 3 groups (control group, saline group, and hydrogen peroxide [H₂O₂] group) with 6 replicates of 8 broilers each. The study lasted for 42 d. The broilers in the saline and H₂O₂ groups were intraperitoneally injected with 0.75% saline and 10.0% H₂O₂ on the 16th and 37th day of the experimental period respectively, the injection volumes were 1.0 mL/kg of broiler body weight. On the 42nd day of the experimental period, two chicks were randomly selected from each cage, a total of thirty-six chicks were stunned by electric shock and slaughtered to collect breast muscle samples. Results: The H₂O₂ exposure reduced pH value, increased drip loss and shear force of breast meat (p<0.05), impaired the ultrastructure and function of mitochondria. The H₂O₂ exposure damaged the antioxidant system in mitochondria, excessive reactive oxygen species carbonylation modified calcium channels on mitochondria, which impaired the activities of key enzymes on calcium channel, resulted in the increased calcium concentration in cytoplasm and mitochondria (p<0.05). In addition, the H₂O₂ exposure increased the iron content and lipid peroxidation (p<0.05), which induced ferroptosis. Conclusion: Oxidative stress could impair meat quality by causing mitochondrial dysfunction, resulting in calcium metabolism disorder and ferroptosis.