• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.17
• /
• pp.7837-7841
• /
• 2015

Objective: To assess the safety of Liena polypeptide injection (produced by JILIN FSENS PHARMACEUTICAL CO.,LTD) combined with chemotherapy in treating patients with advanced cancers. Method: A consecutive cohort of patients with advanced cancers were treated with Liena polypeptide injection combined with chemotherapy. And chemotherapy for patients with advanced cancers were adopted from regimens suggested by NCCN guideline. Liena polypeptide injection was intravenously injected at a dosage of 2ml plus 100ml normal saline for continuous 7 days during chemotherapy as one course. After at least two courses of treatment, safety and side effects were evaluated. Results: There were 20 female and 14 male patients with advanced cancer recruited into this study, including 10 patients with breast, 8 patients with colorectal, 8 patients with lung, 4 patients with gastric, and 1 patient with esophageal cancer, as well as 1 patient with non-Hodgkin's lymphoma, 1 patient with low pharyngeal and 1 patient with urethral cancer. The median age of patients was 59 (40-82) years. Incidences of Grade 1 to 2 myelosuppression was observed in 5/34 patients, and Grade 1 to 2 elevation of hepatic enzyme was recorded in 3/34 patients. Adverse effects on the gastrointestinal tract were documented in 5/34 patients, and were Grade 1. No Grade 3-4 toxicities were diagnosed. No treatment related death was found. Conclusions: Liena polypeptide injection combined with chemotherapy was safe in treating several sites of tumors, that mainly included lung, colorectal and breast cancer. However, further study should be conducted to clarify the effectiveness of this treatment.

• Journal of Biosystems Engineering
• /
• v.21 no.2
• /
• pp.155-166
• /
• 1996

A direct injection sprayer was designed using the concepts of injection mixing and total flow control, flowrate-based system compensating for the variation of forwarding speed. A metered rate, proportionally to the actual diluent flow rate, of a tracer chemical was injected directly into the diluent stream. The injection of chemical may improve the precision and safety of chemical application process. The control system was evaluated for the variables of the control interval, tolerances and sensitivities of flow regulation valve and injection pump. Performance of the system was assessed as that the response time of flow rate, response time of injection rate, absolute steady state error, and the coefficient of variance(C.V.) of concentration were 8.5 and -0.53 seconds, 0.067 lpm(0.8%) and 3.15%, respectively, at optimal parameters of control interval of 1.0 sec, fast sensitivity of flow regulation valve, medium sensitivity of injection pump and medium tolerance of flow rate. Performance of the system can be improved by increasing the sensitivity of flow regulating valve and employing a high resolution velocimeter, such as Doppler radar.

• Journal of the Korean Society of Safety
• /
• v.37 no.5
• /
• pp.80-88
• /
• 2022

The Korean nuclear industry had developed the SPACE (Safety and Performance Analysis Code for nuclear power plants) code, which adopts a two-fluid, three-field model that is comprised of gas, continuous liquid and droplet fields and has the capability to simulate three-dimensional models. According to the revised law by the Nuclear Safety and Security Commission (NSSC) in Korea, the multiple failure accidents that must be considered for the accident management plan of a nuclear power plant was determined based on the lessons learned from the Fukushima accident. Generally, to improve the reliability of the calculation results of a safety analysis code, verification is required for the separate and integral effect experiments. Therefore, the goal of this work is to verify the calculation capability of the SPACE code for multiple failure accidents. For this purpose, an experiment was conducted to simulate a Control Element Drive Mechanism (CEDM) break with a safety injection failure using the ATLAS test facility, which is operated by Korea Atomic Energy Research Institute (KAERI). This experiment focused on the comparison between the experiment results and code calculation results to verify the performance of the SPACE code. The results of the overall system transient response using the SPACE code showed similar trends with the experimental results for parameters such as the system pressure, mass flow rate, and collapsed water level in component. In conclusion, it can be concluded that the SPACE code has sufficient capability to simulate a CEDM break with a safety injection failure accident.

• Journal of Food Hygiene and Safety
• /
• v.10 no.2
• /
• pp.61-64
• /
• 1995

The present study was conducted to examine the effect of recombinant bovine somatotrpin(${\gamma}$BST), which was administered to cow to promote milk production, on bST levels in milk. Fourteen cows were divided cows were divided into two groups: 1) control cows received neither ${\gamma}$bST nor vehicle, 2) treated cows were administered twice at two-week interval with 500 mg ${\gamma}$bST each cow byj after lst injection. Milk samples were taken on day 0 (prior to injection), day 7 (7 days after lst injection), day 21 (7 days after 2nd injection) and day 35 (21 days after 2nd injection). Milk bST concentration was measured by the radioimmunoassay method. There was no statistical difference(p<0.05) in milk bST levels between two groups showing bST levels in the range of 1.8 ng/m/ to 3.1 ng/m/. That is, ${\gamma}$bST administration did not increase bST levels in milk.

• Transactions of Materials Processing
• /
• v.19 no.3
• /
• pp.152-159
• /
• 2010

Rapid mold heating has been recent issue to enable the injection molding of thin-walled parts or micro/nano structures. High-frequency induction is an efficient way to heat mold surface by electromagnetic induction in a non-contact manner, and has been recently applied to the injection molding due to its capability of rapid heating and cooling of mold surface. The present study covers a three-dimensional finite element analysis to investigate heating efficiency and structural safety of the induction heating process of an injection mold. To simulate the induction heating process, an integrated simulation method is proposed by effectively connecting an electromagnetic field analysis, a transient heat transfer analysis and a thermal stress analysis. The estimated temperature changes are compared with experimental measurements for various types of induction coil, from which heating efficiency according to the coil shape is discussed. The resulting thermal stress distributions of the mold plate for various types of induction coils are also evaluated and discussed in terms of the structural safety.

• Journal of the Korean Society of Safety
• /
• v.28 no.4
• /
• pp.58-65
• /
• 2013

Transportation and further expansion of social infrastructure was needed along the development of urbanization and population concentration. To use the underground space due to the lack of availability of land, it is inevitable to intersect between present structure and tunnel during construction. Soil grouting is one of the ground improvement methods to reinforce weak soil around the underground structures by injection of grouting liquid. Some of central columns of an upper structure are damaged during injection of grouting liquid by injection pressure. To investigate and improve the stability of the tunnel, three dimensional analysis are performed with full construction stages which includes the construction of present underpass, damaging columns of the underpass, reinforcing the columns by H-pile and shear walls, and excavation and construct tunnel. The arrangement of grouting holes such as curtain and horizontal type affects largely to the stability of upper structure and horizontal arrangement diminish the shear forces which is the cause of damage of central columns. The liquid injection type of reinforcement for tunnel is not recommended while the presence of upper structure with columns. Wall type reinforcing is utilize for permant support of upper structures which is affected by grouting injection pressure. H-pile is utilize for temporary support, but not for permanent since the sharing of shear forces is not much to shear wall during tunnel construction.

• Proceedings of the Korean Nuclear Society Conference
• /
• 2001.05a
• /
• pp.235.1-235
• /
• 2001

• Clinical and Experimental Reproductive Medicine
• /
• v.43 no.4
• /
• pp.247-252
• /
• 2016

Objective: Heparin can modulate proteins, and influence processes involved in implantation and trophoblastic development. This study aimed to assess the improvement of clinical pregnancy and implantation rates after local intrauterine injection of low-molecular-weight heparin (LMWH) in patients undergoing intracytoplasmic sperm injection (ICSI). Methods: A randomised case/control design was followed in women scheduled for ICSI. The study arm was injected with intrauterine LMWH during mock embryo transfer immediately following the ovum pickup procedure, while the control arm was given an intrauterine injection with a similar volume of tissue culture media. Side effects, the clinical pregnancy rate, and the implantation rate were recorded. Results: The pregnancy rate was acceptable (33.9%) in the LMWH arm with no significant reported side effects, confirming the safety of the intervention. No statistically significant differences were found in the clinical pregnancy and implantation rates between both groups (p= 0.182 and p= 0.096, respectively). The odds ratio of being pregnant after intrauterine injection with LMWH compared to the control group was 0.572 (95% confidence interval [CI], 0.27-1.22), while the risk ratio was 0.717 (95% CI, 0.46-1.13; p= 0.146). No statistical significance was found between the two groups in other factors affecting implantation, such as day of transfer (p= 0.726), number of embryos transferred (p= 0.362), or embryo quality. Conclusion: Intrauterine injection of LMWH is a safe intervention, but the dose used in this study failed to improve the outcome of ICSI. Based on its safety, further research involving modification of the dosage and/or the timing of administration could result in improved ICSI success rates.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.18 no.2
• /
• pp.129-143
• /
• 2019

As the importance of autonomous vehicle safety is emphasized, the application of ISO-26262, a development verification guideline for improving safety and reliability, and the safety verification of autonomous vehicles are becoming increasingly important, in particular, SAE standard level 3 or higher level autonomous vehicles detect and decision the surrounding environment instead of the human driver. Therefore, if there is and failure or malfunction in the autonomous driving function, safety may be seriously affected. So autonomous vehicles, it is essential to apply and verity the safety concept against failure and malfunctions. In this study, we study the fault injection scenarios for safety evaluation and verification of autonomous vehicles using ISO-26262 part3 process and STPA were studied and safety measures for safety concept design were studied through simulation bases fault injection test.

• Journal of Pharmacopuncture
• /
• v.16 no.3
• /
• pp.7-10
• /
• 2013

Objectives: This study aimed to evaluate the evidence available in the literature for the safety and efficacy of Dioscoreae Rhizoma (DR) for the treatment of peripheral neuropathy. Methods: Literature searches were performed in MEDLINE and three Korean medical databases up to April 2013. All studies evaluating the effects on peripheral neuropathy or the safety of DR monopreparations were considered. Results: Three studies - DR extract per os (po) on diabetic neuropathy in mice, DR extract injection on the peripheral sciatic nerve after crush injury in rats and DR extract injection to patients with peripheral facial paralysis proved that DR treatments were effective for the treatment of nerve injuries. Conclusions: In conclusion, we found the DR has a strong positive potential for the treatment of peripheral neuropathy, but studies addressing direct factors related to the nerve still remain insufficient.