• Asian Pacific Journal of Cancer Prevention
• /
• 제16권18호
• /
• pp.8155-8161
• /
• 2016

The prognostic significance of AgNOR proteins in stage II-III rectal cancers treated with chemoradiotherapy was evaluated. Silver staining was applied to the $3{\mu}m$ sections of parafin blocked tissues from 30 rectal cancer patients who received 5-FU based chemoradiotherapy from May 2003 to June 2006. The microscopic displays of the cells were transferred into the computer via a video camera. AgNOR area (nucleolus organizer region area) and nucleus area values were determined as a nucleolus organizer regions area/total nucleus area (NORa/TNa). The mean NORa/TNa value was found to be $9.02{\pm}3.68$. The overall survival and disease free survival in the high NORa/TNa (>9.02) patients were 52.2 months and 39.4 months respectively, as compared to 100.7 months and 98.4 months in the low NORa/TNa (<9.02) cases. (p<0.001 and p<0.001 respectively). In addition, the prognosis in the high NORa/TNa patients was worse than low NORa/TNa patients (p<0.05). In terms of overall survival and disease-free survival, a statistically significant negative correlation was found with the value of NORa/TNa in the correlations tests. Cox regression analyses demostrated that overall survival and disease-free survival were associated with lymph node status (negative or positive) and the NORa/TNa value. We suggest that two-dimensional AgNOR evaluation may be a safe and usable parameter for prognosis and an indicator of cell proliferation instead of AgNOR dots.

• Journal of Korean Neurosurgical Society
• /
• 제49권5호
• /
• pp.273-277
• /
• 2011

Objective : A single balloon extrapedicular kyphoplasty has been introduced as one of the unilateral approaches for thoracic compression fractures; however, the unilateral extrapedicular technique in the lumbar area needs a further understanding of structures in the lumbar area. The purpose of the present study is to describe methods and pitfalls of this procedure based on the anatomy of the lumbar area and to analyze clinical outcome and complications. Methods : Anatomical evaluation was performed with 2 human cadavers. A retrospective review of unilateral extrapedicular approaches yielded 74 vertebral levels in 55 patients that were treated with unilateral extrapedicular vertebroplasty and kyphoplasty. Radiographic assessment included the restoration rate of vertebral height and correction of kyphosis. Results : Anatomical evaluation indicates that the safe needle entry zone of bone for the extrapedicular approach was located in the supero-lateral aspect of the junction between the pedicle and vertebral body. The unilateral extrapedicular procedure achieved adequate pain relief with a mean decreases in pain severity of $7.25{\pm}1.5$ and $2.0{\pm}1.4$, respectively. Complications were 1 retroperitoneal hematoma, 6 unilateral fillings and 3 epidural leak of the polymethylmethacrylate. Conclusion : The method of a unilateral extrapedicular approach in kyphoplasty and vertebroplasty in the lumbar area might be similar to that in thoracic approach using a route via the extrapedicular space. However, different anatomical characteristics of the lumbar area should be considered.

• 한국전자통신학회논문지
• /
• 제11권6호
• /
• pp.635-644
• /
• 2016

열차 속도 제어는 운영 트랙에서 안전 운동을 구축하기 위한 열차 보호의 중요한 일부분이다. 경사진 면적과 같은 열차를 보호하는 데 필요한 트랙의 특수한 조건이 있다. 더욱이 반달리즘 문제를 가진 개도국에서 특수한 조건은 트랙 사이드의 장비를 최소화하기 위한 설치가 요구된다. 더욱이 열대 국가에서 트랙 사이드는 수질에서 트랙 사이드 장비의 성능에 영향을 줄 것으로 보인다. 이러한 문제를 해결하기 위하여 적외선 시스템을 이용하여 경사진 면적에 대하여 열차 속도 제어를 제안한다. 전주 배열의 설치에 의해 이 시스템은 보다 적은 도전, 경제적인 민감성, 트랙 사이드의 장비의 최소 설치와 강우 환경에서 신뢰성을 제공한다. 본 논문은 경사진 면적에서 성능 평가를 측정하고 열차 속도를 제어하는데 중점을 준다. 제안한 열차 속도 제어 시스템은 시간 당 약 20km의 제어속도와 최대 3.6%의 경사진 면적에서 속도 제어와 감시가 가능하다.

• 한국농촌건축학회논문집
• /
• 제26권3호
• /
• pp.37-44
• /
• 2024

Currently, convergence research is being conducted in various research facilities in Korea, but it is true that there are very few multi-purpose convergence research facilities that can support such convergence research in universities, which are the most basic research group. In the case of multi-purpose convergence research facilities installed in universities, human resources from more diverse fields gather to conduct various studies than general research facilities, so the facilities should be planned to reflect these characteristics, and the space should be planned to promote human exchanges. The basic guidelines for planning multipurpose convergence research facilities installed in universities are as follows. First, multi-purpose convergence facilities in universities should be based on the habitability and convenience of users who use the facilities, and functionality, promotion of human resource exchange, symbolism, and eco-friendliness should be set as major planning factors. Second, in the case of internal planning, it is necessary to secure a efficient research and public space, a short and clear movement and evacuation plan, a future-oriented image and symbolism, an eco-friendly facility plan, efficiency through zoning and modularization, and future expansion. Third, in the case of size setting, it is appropriate to plan around 18,000m² of total floor area, and considered safe to plan around 45% of research & education area, 6% of support area, 5% of convenience area, 4% of exhibition area, and 40% of public areas by use, but additional reviews should be conducted according to the situation of each university or local region.

• 해양환경안전학회지
• /
• 제21권1호
• /
• pp.40-46
• /
• 2015

지구 온난화로 인해 북극해에 얼음이 빠르게 해빙되어 상업적 운항이 진행되고 있다. 극한의 조건에서도 북극해 항로를 개척하는 이유는 기존 항로보다 운항거리 단축되어 경제적으로 이익을 가지고 오기 때문이다. 이에 국제해사기구(IMO)에서는 북극해 항로를 안전하게 운항하기 위해 극지운항선박 안전기준(Polar Code)이 제정하였다. 본 연구에서는 북극해 안전 운항을 위해 항해사가 반드시 알아야 하는 얼음의 종류 및 극지운항선박 안전기준에 대해 설명하였다. 그리고 북극해를 운항하는 통항선의 안전 운항에 대한 이론적 지식을 시뮬레이션을 통해 검증하였다. 그 결과 안전 운항을 위해서 통항선들은 얼음 진입 전 감속을 통해 얼음을 분석하고 얼음을 안전하고 효율적으로 쇄빙하기 위해 직각으로 진입해야 함을 알 수 있었다. 또한, 얼음에 진입 후 항로(lead)운항에 대하여 시뮬레이션을 실시한 결과 변침이 곤란하여 전방의 통항선에 대한 긴급상황 대처 훈련이 필요한 것으로 판단된다. 향후 다양한 조건의 시나리오를 통해 면밀한 분석이 필요할 것으로 본다.

• 한국임상약학회지
• /
• 제26권1호
• /
• pp.24-32
• /
• 2016

Objective: The visually impaired have limited access to health care services and related information, and thus, they can have serious hurdles against properly taking medications. Despite that it is important to improve self-care ability of the visually impaired for correct medication use, there have been few studies investigating their needs for health care services in Korea, particularly focusing on proper medication usage. This study is to explore safety-related issues regarding mediation usage among the visually impaired based on in-depth interview. We particularly focus on any obstacles for safe use of medicines including experience on medication-related adverse effects in order to provide preliminary evidence for policy measures to improve proper medication use among the visually impaired. Methods: Study sample was visually impaired individuals who resided in Seoul area and were registered in the National Association of Visually Impaired. The association helped the process of recruiting the study participants. In-depth interview for each study participants was conducted. Each interview was recorded and later converted into a written script to extract core contents for the analysis. Results: The study participants comprised of three women (42.9%) and four men (57.1%). One was in his 20's, and there were four participants in 30's and two in 40's. Fully impaired participants were majority (5 out of 7). Limitation to physical access to health care providers and health information were the key factors to hamper safe medication utilization among the study participants. Difficulty reading medication information and may take the wrong medication or incorrect doses of medication, resulting in serious consequences, including overdose or inadequate treatment of health problems. Visually impaired patients report increased anxiety related to medication management and must rely on others to obtain necessary drug information. Pharmacists have a unique opportunity to pursue accurate medication adherence in this special population. This article reviews literature illustrating how severe medication mismanagement can occur in the visually impaired elderly and presents resources and solutions for pharmacists to take a larger role in adherence management in this population. Conclusion: The visually impaired had difficulties reading medication information and identifying medicines, and took incorrect doses of medications. Public support for safe medication use and medication management among the visually impaired is necessary.

• 한국정보과학회논문지:데이타베이스
• /
• 제33권6호
• /
• pp.631-643
• /
• 2006

시간이 변함에 따라 위치 좌표를 변경하는 모바일 환경에서 이동 객체는 자신의 위치를 기준으로 질의를 요청한다. 연속적인 스카이라인 질의 처리를 위한 효율적인 영역 결정 기법에서는 이동 객체의 속도와 방향과는 무관한 최적화된 스카이라인 영역(OSR: Optimal Skyline Region)을 미리 계산하여 질의에 답할 수 있다. 이에 따라 이동 객체의 위치를 중심으로 하고 가장 가까운 영역 변까지의 거리를 반경으로 하는 원(Vcircle: Validity Circle)을 유효 영역으로 결정하여 질의 발생 빈도를 감소하는 기법이 제안되고 있다. 그러나 원은 최초 질의가 발생한 시점의 이동 객체 위치에 따라 면적이 가변적이므로 질의 발생 빈도도 가변적이고, 객체가 최적화된 스카이라인 영역 내에서 이동하는 경우에 재질의가 빈번하게 발생하는 문제점이 발생한다. 예를 들어 사용자는 '현재 위치에서 가깝고 숙박료가 싸고, 해변과의 거리가 가까운 호텔을 검색하라'는 질의를 할 수 있다. 이 경우, 이동 객체와 대상 객체의 거리뿐만 아니라 대상 객체의 다중 속성을 고려해야하고, 스카이라인 질의 결과는 이동 객체의 현재 위치와 대상 객체의 거리에 따라 유효하지 않을 수 있으므로 이동 객체의 위치 변경에 따라 스카이라인을 재계산해야 하며, 새로운 결과를 요청하기 위해 연속적인 질의가 발생한다. 이 논문에서는 항상 볼록 다각형을 형성하는 최적화된 스카이라인 영역의 특징을 이용하여 스카이라인 영역의 최대내부원(IVcircle: Interior Validity Circle)을 정적 유효 영역으로 결정하는 기법을 제안한다. 실험을 통하여 영역내의 평균 질의 발생 빈도를 기존의 Vcircle을 이용한 동적 유효 영역 결정 기법보다 평균 52.55%가 감소함을 보인다.

• 해양환경안전학회지
• /
• 제30권4호
• /
• pp.358-364
• /
• 2024

선박 건조 과정에서 블록이나 장비를 지지하는 A형 캐리어 구조는 하중 변경과 시간이 지남에 따라 점차 변형이 증가하며, 이에 따라 블록과 접촉하는 면적이 감소하고 분산된 하중에서 집중된 하중으로 패턴이 변화한다. 이러한 현상은 실제 사용 하중을 오판할 가능성이 있다. 특히 A형 캐리어는 영세한 제조 업체에서 자주 사용하고 있으며, 별도의 엔지니어링 기능이 없는 상황이 대부분이라서 손쉽게 캐리어의 안전사용하중을 계산하는 방법의 개발이 필요하다. 본 연구는 A형 캐리어가 장기적으로 안전하게 사용할 수 있는 하중을 신속하게 평가하는 방법을 제안함으로써, 하중 분포의 변화에 따른 소성 변형과 그로 인한 안전 문제를 예측하고 대응할 수 있다. 제안된 방법은 캐리어의 중앙 집중하중과 전체 분포하중 조건에 대해서 유한요소해석(빔, 쉘 모델링)을 통한 결과를 기반으로 빔-이론을 수정하여 제안되었다. 빔 모델링에서 집중하중 조건은 보정계수 0.73, 분포하중에서는 0.69를 이론값에 곱해서 안전사용하중이 가능하다. 쉘 모델링의 경우, 집중하중은 0.75와 분포하중은 0.69를 사용할 수 있다. 본 연구는 선박 건조 작업 현장의 안전을 개선하고, 실제 작업 환경에서의 안전 사용 하중 판단에 신속하고 효과적인 결정을 내릴 수 있는 기초 자료로 활용될 수 있다.

• 한국환경보건학회지
• /
• 제5권1호
• /
• pp.76-85
• /
• 1978

This survey was undertaken for the period seven month beginning January 15, 1977 and ending July 31, 1977 to detect the general sanitary status of the villages and the villagers and, at the same time, analyse quality of water sources with emphasis on a total of 1,256 households dividing into three different groups: such as, 280 households were selected as random samples from the area of the sophisticated piped water supply system, 122 households from the area of the simplified water supply system and finally 854 households from the area of nonpi-ped water supply system. The following results were concluded after quality of water sources had been analysed and conditions of the environmental sanitation had been reviewed: 1. 11.2% of the respondents from the area of the sophisticated piped water supply system responded that quantity of drinking water lacked to meet their demand while 30.6% of the villagers from the area of nonpi-ped water supply system responded quantity of drinking water didn't meet their demand. 2. 30.8% of the.respondents from the area of the sophisticated water supply system responded that contaminating source located within 15 meters from the water source while 54.4% of the respondents from the non-piped water supply system claimed the same. 3. It was found that water from all sampling areas were positive in coliform group with exception of Moonsan which is one of the sophisticated piped water supply system groups and the number of general bacteria exceeded the government standard criteria of water quality in the area of the nonpi-ped water supply system. 4. In relation with time requirement to draw water in the area of non-piped water supply system, 76 respondents claimed it requires less than 15 minutes to draw water, 15.0% claimed 15 to 30 minutes and 9.0% claimed more than 30 minutes. 5. In relation with knowledge on sanitation of drinking water, 30.8% of respondents from the area of the sophisticated piped water supply system and 41.8% of respondents from the area of nonpiped water supply system denied possible existence of germ in drinking water they drink, while 17.4% of the respondents from the area of the sophisticated water supply system and 50.2% of non-peped water supply system thought it safe to drink water without any treatment. 6. 60.0% of the respondents from the area of non-piped water supply system and many of them believed that their health status will be improved by installation of a sophisticated water supply system in their area. 7. The respondents from the areas of piped water supply sytem expressed greater concern over drinking water sanitation than those from the areas of non-piped water supply system and sanitary conditions were found the same. It was, therefore, proved that knowledge of environmnntal sanitation contributed a great deal to improve sanitary conditions of the villages and villagers and at the same time health education, especially environmental sanitation, will be played a important role to improve their sanitary conditions.

• 한국전문물리치료학회지
• /
• 제13권4호
• /
• pp.71-78
• /
• 2006

This study examined the effects of socket flexion angle in trans-tibial prosthesis on stump/socket interface pressure. Ten trans-tibial amputees voluntarily participated in this study. F-socket system was used to measure static and dynamic pressure in stump/socket interface. The pressure was measured at anterior area (proximal, middle, and distal) and posterior area (proximal, middle, and distal) in different socket flexion angles ($5^{\circ}$, $0^{\circ}$, and $10^{\circ}$). Paired t-test was used to compare pressure differences in conventional socket flexion angle of $5^{\circ}$ with pressures in socket flexion angles of $0^{\circ}$ and $10^{\circ}$ (${\alpha}$=.05). Mean pressure during standing in socket flexion angle of $10^{\circ}$ decreased significantly in anterior middle area (19.7%), posterior proximal area (10.4%), and posterior distal area (16.3%) compared with socket flexion angle of $5^{\circ}$. Mean pressure during stance phase in socket flexion angle of $0^{\circ}$ increased significantly in anterior proximal area (19.3%) and decreased significantly in anterior distal area (19.7%) compared with socket flexion angle of $5^{\circ}$. Mean pressure during stance phase in socket flexion angle of $10^{\circ}$ decreased significantly in anterior proximal area (19.6%) and increased significantly in anterior distal area (8.2%) compared with socket flexion angle of $5^{\circ}$. Peak pressure during gait in socket flexion angle of $0^{\circ}$ increased significantly in anterior proximal area (23.0%) compared with socket flexion angle of $5^{\circ}$ and peak pressure during gait in socket flexion angle of $10^{\circ}$ decreased significantly in anterior proximal area (22.7%) compared with socket flexion angle of $5^{\circ}$. Mean pressure over 80% of peak pressure ($MP_{80+}$) during gait in socket flexion angle of $0^{\circ}$ increased significantly in anterior proximal area (23.9%) and decreased significantly in anterior distal area (22.5%) compared with socket flexion angle of $5^{\circ}$. $MP_{80+}$ during gait in socket flexion angle of $10^{\circ}$ decreased significantly in anterior distal area (34.1%) compared with socket flexion angle of $5^{\circ}$. Asymmetrical pressure change patterns in socket flexion angle of $0^{\circ}$ and $10^{\circ}$ were revealed in anterior proximal and distal region compared with socket flexion angle of $5^{\circ}$. To provide comfortable and safe socket for trans-tibial amputee, socket flexion angle must be considered.