• Nutrition Research and Practice
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• v.11 no.2
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• pp.90-96
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• 2017

BACKGROUND/OBJECTIVES: Although the antioxidative effects of lycopene are generally known, the molecular mechanisms underlying the anti-inflammatory properties of lycopene are not fully elucidated. This study aimed to examine the role and mechanism of lycopene as an inhibitor of inflammation. METHODS/MATERIALS: Lipopolysaccharide (LPS)-stimulated SW 480 human colorectal cancer cells were treated with 0, 10, 20, and $30{\mu}M$ lycopene. The MTT assay was performed to determine the effects of lycopene on cell proliferation. Western blotting was performed to observe the expression of inflammation-related proteins, including nuclear factor-kappa B ($NF-{\kappa}B$), inhibitor kappa B ($I{\kappa}B$), mitogen-activated protein kinase (MAPK), extracellular signal-related kinase (ERK), c-jun NH2-terminal kinase (JNK), and p38 (p38 MAP kinase). Real-time polymerase chain reaction was performed to investigate the mRNA expression of tumor necrosis factor ${\alpha}$ ($TNF-{\alpha}$), interleukin-1 beta ($IL-1{\beta}$), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). Concentrations of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) were determined via enzyme-linked immunosorbent assays. RESULTS: In cells treated with lycopene and LPS, the mRNA expression of $TNF-{\alpha}$, $IL-1{\beta}$, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P < 0.05). The concentrations of $PGE_2$ and NO decreased according to the lycopene concentration (P < 0.05). The protein expressions of $NF-{\kappa}B$ and JNK were decreased significantly according to lycopene concertation (P < 0.05). CONCLUSIONS: Lycopene restrains $NF-{\kappa}B$ and JNK activation, which causes inflammation, and suppresses the expression of $TNF-{\alpha}$, $IL-1{\beta}$, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.

• Journal of the Korea Safety Management & Science
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• v.15 no.1
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• pp.11-19
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• 2013

In modern systems design and development, one of the key issues is considered to be related with how to reflect faithfully the stakeholder requirements including customer requirements therein, thereby successfully implementing the system functions derived from the requirements. On the other hand, the issue of safety management is also becoming greatly important these days, particularly in the operational phase of the systems under development. An approach to safety management can be based on the use of the failure mode effect and analysis (FMEA), which has been a core method adopted in automotive industry to reduce the potential failure. The fact that a successful development of cars needs to consider both the complexity and failure throughout the whole life cycle calls for the necessity of applying the systems engineering (SE) process. To meet such a need, in this paper a method of FMEA is developed based on the SE concept. To do so, a process model is derived first in order to identify the required activities that must be satisfied in automotive design while reducing the possibility of failure. Specifically, the stakeholder requirements were analyzed first to derive a set of functions, which subsequentially leads to the task of identifying necessary HW/SW components. Then the derived functions were allocated to appropriate HW/SW components. During this design process, the traceability between the functions and HW/SW components were generated. The traceability can play a key role when FMEA is performed to predict the potential failure that can be described with the routes from the components through the linked functions. As a case study, the developed process model has been applied in a project carried out in practice. The results turned out to demonstrate the usefulness of the approach.

• Journal of The Korean Association of Information Education
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• v.19 no.3
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• pp.373-384
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• 2015

Computer education is gradually focusing on a wide variety of areas of expertise such as production of visual media and software development, instead of on the use of ICT like before. Particularly, computer courses related to production of image media require a complex practice procedure and repeated practice, making the future hands-on work difficult. Therefore, this study tried to verify the effect of the change in running methods of the "computer graphic" course from offline to blended learning. This analyzed the students' lecture satisfaction survey results of before and after the change. As a result, blended learning was well received and led to the small variations in the scores of the satisfaction surveys between the lecturers. Additionally, many students responded that the blended learning was more effective in their satisfaction surveys.

• 한국정보교육학회:학술대회논문집
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• 2021.08a
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• pp.341-348
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• 2021

With the advent of the pandemic era, non-face-to-face classes are being conducted, and many studies are being conducted on the effects of non-face-to-face classes in many subjects. Since the programming class is a subject that combines knowledge transfer and practice. In the case of non-face-to-face classes, I wanted to know how students perceive them through a survey. The number of students who answered that traditional face-to-face classes were good in terms of ease of question and answer, understanding of class content and immersion in class, and more students answered that non-face-to-face classes were good in terms of securing practice time and class control. It is expected that using the results of this study will help plan effective programming lessons.

• The Journal of Industrial Distribution & Business
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• v.10 no.11
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• pp.71-80
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• 2019

Purpose: The purpose of this study is to design the curriculum of Basic College Software Programming to develop creative and logical-thinking. This course is guided by algorithmic thinking and logical thinking that can be solved by computing for problem-solving, and it helps to develop by software through basic programming education. Through the stage of problem analysis, abstraction, algorithm, data structure, and algorithm implementation, the curriculum is designed to help learners experience algorithm problem-solving in various areas to develop diffusion thinking. For Learners aim to achieve the balanced development of divergent and convergent-thinking needed in their creative problem-solving skills. Research design, data and methodology: This study is to design a basic software education for improving algorithm-thinking for non-major. The curriculum designed in this paper is necessary to non-majors students who have completed the 'Creative Thinking and Coding Course' Design Thinking based are targeted. For this, contents were extracted through advanced research analysis at home and abroad, and experts in computer education, computer engineering, SW education, and education were surveyed in the form of quasi-openness. Results: In this study, based on ADD Thinking's algorithm thinking, we divided the unit college majors into five groups so that students of each major could accomplish the goal of "the ability to internalize their own ideas into computing," and extracted and designed different content areas, content elements and sub-components from each group. Through three expert surveys, we established a strategy for characterization by demand analysis and major/textbook category and verified the appropriateness of the design direction to ensure that the subjects and contents of the curriculum are appropriate for each family in order to improve algorithm-thinking. Conclusions: This study helps develop software by enhancing the ability of students who practice various subjects and exercises to explore creative expressions in various areas, such as 'how to think like a computer' that can implement and execute their ideas in computing. And it helps increase the ability to think logical and algorithmic computing based on creative solutions, improving problem-solving ability based on computing thinking and fundamental understanding of computer coding and development of logical thinking ability through programming.

• Journal of Practical Engineering Education
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• v.14 no.2
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• pp.305-312
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• 2022

In this paper, we focused on training to create and optimize a basic data prediction model. And we proposed a gradient descent training method of machine learning that is widely used to optimize data prediction models. It visually shows the entire operation process of gradient descent used in the process of optimizing parameter values required for data prediction models by applying the differential method and teaches the effective use of mathematical differentiation in machine learning. In order to visually explain the entire operation process of gradient descent, we implement gradient descent SW in a spreadsheet. In this paper, first, a two-variable gradient descent training method is presented, and the accuracy of the two-variable data prediction model is verified by comparison with the error least squares method. Second, a three-variable gradient descent training method is presented and the accuracy of a three-variable data prediction model is verified. Afterwards, the direction of the optimization practice for gradient descent was presented, and the educational effect of the proposed gradient descent method was analyzed through the results of satisfaction with education for non-majors.

• Journal of Industrial Convergence
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• v.19 no.6
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• pp.59-66
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• 2021

Globally, the prolonged pandemic of COVID-19 (COVID-19) has had a great impact on all industries. In particular, in the field of education, online classes (non-face-to-face) had some negative perceptions of online classes, such as lack of preparation for learning and student dissatisfaction with the class. According to the current situation survey in 2020, non-face-to-face classes accounted for about 56% of the class, and streaming real-time classes and video content-based classes accounted for most of the class. This study empirically analyzes the problems to be solved by online classes through the 2020-2021 survey (software application practical class university students), and explains the detailed program and development plan (implementation result). This study intends to contribute to the development of online learning development of each educational institution after the end of the corona crisis.

• Journal of Wetlands Research
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• v.19 no.1
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• pp.37-44
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• 2017

Nonpoint source (NPS) pollution continues to degrade the water quality. NPS pollutants signals high concerns against a sustainable environment. Low impact development (LID) is the leading management practice which regulates and treats stormwater runoff especially in highly impervious urban areas. Constructed wetlands are known to have efficient removal capability of NPS pollutants. Likewise, these LID facilities were intended to maintain the predeveloped hydrologic regime through series of mechanisms such as particle settling, filtration, plant uptake, and etc. In this study, the objective was to investigate the characteristics, fate and treatment performance of the two in-campus constructed wetlands (SW1 and SW2) which were installed adjacent to impervious roads and parking lots to treat stormwater runoff. A total of 42 storm events were monitored starting from July 2010 until November 2015. Manual grab sampling was utilized at the inlet and outlet units of each LID facilities. Based on the results, the wetlands were found to be effective in reducing 37% and 41% of the total runoff volume and peak flows, respectively. Aside from this, outflow EMCs were generally lower than the inflow EMCs in most events suggesting that the two wetlands improved the water quality of stormwater runoff. The average removal efficiency of pollutants in facilities were 63~79% in TSS, 38~54% in TN, 54% in TP and 32%~81% in metals. The results of this study recommend the use of constructed wetlands as efficient treatment facility for urban areas for its satisfactory performance in runoff and pollutant reduction.

• Journal of Broadcast Engineering
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• v.15 no.2
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• pp.205-216
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• 2010

In this paper, a method of MPEG-2 Transport Stream (TS) multiplexing for Ultra HDTV (UHDTV) and its design and implementation as a SW tool is described. In practice, UHD video may be divided into several HD videos and each video is encoded in parallel. Therefore, it is necessary to synchronize and multiplex multiple bitstreams encoding each HD video for transmitting and storing UHD video. In this paper, it is assumed that 4 HD videos partitioning a UHD spatially are encoded as H.264/AVC and two 5.0 channel audios are encoded by AC-3. Therefore, 4 H.264/AVC elementary streams (ESs) and 2 AC-3 ESs is mainly considered in the TS multiplexing of UHD. For the carriage of H.264/AVC and AC-3 over MPEG-2 TS, PES packetization and TS multiplexing are designed and implemented based on the extended specification of the MPEG-2 Systems and ATSC (Digital audio compressed standard), respectively. The implemented UHD TS multiplexing tool emulates real time HW operation in the time unit corresponding to the duration of one TS packet transmission in a given TS rate. In particular, in order to satisfy the timing model, the buffers defined in the TS System Target Decoder (T-STD) are monitored and their statuses are considered in the scheduling of TS multiplexing. For UHD multiplexing, two kinds of multiplexing structures, which are UHD re-multiplexing and UHD program multiplexing, are implemented and their strength and weakness are investigated. The developed UHD TS multiplexing tool is tested and verified in terms of the syntax and semantics conformance and functionalities by using a commercial analyzer and real-time presentation tools.

• Journal of Digital Convergence
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• v.17 no.3
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• pp.181-189
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• 2019

The purpose of this study is to derive obstacle factors to 'high value vocational training' and to suggest development strategies. The training aims to solve the quantitative and qualitative problems of female employment by providing professional training in high value areas such as ICT, SW and knowledge service. To verify the training to meet these objectives, 48 processes operated in 2018 were analyzed and field monitoring was conducted. As a result of the analysis, problems were identified and improvements were derived in terms of learners management, training course design, field practice operation, and performance evaluation. Based on these results, researchers suggested four ways to develop high value vocational training. First, select learners based on combined talent and second, strengthen the project of linking enterprises and structured field practices. Third, establish a performance evaluation system of its own and manage performance and fourth, expand support for excellent training courses and provide consulting for course development. The results of this study are expected to be used as a reference for establishing policies for high value occupational training. In the future, quantitative research should be conducted to clarify the performance and problems.