• Title/Summary/Keyword: STRUCTRUE

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Ligand Design of 5,5'-Diphenylimidazolidine-2,4-dione Analogues as A New Class of Potent Inhibitors of Fatty Acid Amide Hydrolase (새로운 Fatty Acid Amide Hydrolase 저해제로서 5,5'-Diphenylimidazolidine-2,4-dione 유도체의 리간드 설계)

  • Cho, Jong-Un;Soung, Min-Gyu;Sung, Nack-Do
    • Applied Biological Chemistry
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    • v.51 no.2
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    • pp.119-123
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    • 2008
  • 3D-QSARs (3 dimensional quantitative structrue-activity relationships) on the inhibition activities of 3-substituted-5,5'-diphenylimidazolidine-2,4-dione derivatives (1-22) against FAAH (fatty acid amide hydrolase) were studied quantitatively using CoMFA (comparative molecular field analysis) and CoMSIA (comparative molecular similarity indice analysis) methods. The statistical results of the CoMFA 1A and CoMSIA 2F model are better predictability and fitness. And also, the designed X=I, Y=$N_{2}^{+}$-substituent (P1: $Pred.pI_{50}$=6.55), according to the contour maps with information of the two models, showed the most inhibition activity against FAAH.

Strut-Tie Model Evaluation of Haunch Effects in Concrete Structures (스트럿-타이 모델에 의한 콘크리트 구조물에서의 헌치부 영향 평가)

  • Yun, Young-Mook;Kim, Byung-Hun;Lee, Won-Seok
    • Journal of the Korea Concrete Institute
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    • v.15 no.2
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    • pp.183-196
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    • 2003
  • This paper evaluates the effects of haunches and the characteristic differences of haunch design regulations through design of pier and box structures with/without haunches. The design of the pier and box structures was conducted by using the linear elastic plane stress finite element analysis, the DIN 1045 and ACI 318-99 codes, the suggested experimental design equations, and the strut-tie model approach. To prove the validity of design results obtained by the strut-tie model approach, the ultimate strength of two haunched reinforced concrete beams tested to failure was evaluated by using the approach. According to the comparison and evaluation of the design results, it is concluded that the design results of haunched reinforced concrete structures by using conventional and design codes need to be complemented with those by using the strut-tie model approach that reflected the effects of haunches in design comparatively well through the actions of arch and direct transfer of applied loads.

The Announcement Effects of Stock Repurchase and Stock Dispositions on Shareholder Wealth (자기주식 취득 및 처분 공시가 주주의 부에 미치는 영향 - 취득 및 처분목적을 중심으로 -)

  • Sul, Won-Sik;Kim, Soo-Jung
    • The Korean Journal of Financial Management
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    • v.22 no.1
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    • pp.37-69
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    • 2005
  • This study intends to verify whether stock repurchase, as well as stock dispositions, affects shareholder's wealth and also whether repurchase/dispositions has varying impact de-pending on its purpose. According to empirical analysis, announcement of stock repurchase results in positive abnormal returns when the objective of stock repurchase is stock price stabilization or cancellation of shares. However, when the purpose of stock repurchase is granting incentives to executives/employees, we get the negative abnormal returns. Also, the termination of stock trust for reason of expiration or stock dispositions of which goal is to give incentives to executive/employees has a negative impact on stock price, whereas direct dispositions of stock to raise cash or to improve financial structrue are shown to significantly increase the wealth of shareholders. Cross-section analysis also confirms that stock repurchase and dispositions has different impact on excess returns depending on its purpose. The results of this study imply that the dispositions of stock should be regarded as an important financial strategic tool to be used by companies and what's more, such studies dealing with stock repurchase or dispositions should take firm's purpose into consideration in their approach.

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The Substitution Reaction of Equatorial-Skew-[Co(TRDTRA)($OH_2$)] Complex with $CN^-, NO^{-}_{2}$ and $NCS^-$ ion (Equatorial-Skew형 [Co(TRDTRA)($OH_2$)] 착물과 $CN^-, NO^{-}_{2}$ 그리고 $NCS^-$ 이온간의 치환반응)

  • Dong-Yeub Kim;Young-Jae Cho;Dong-Jin Lee;Chang-Eon Oh;Doh Myung-ki
    • Journal of the Korean Chemical Society
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    • v.36 no.3
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    • pp.405-411
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    • 1992
  • The substitution reaction and structrue of products obtained from the reaction of Equatorial-Skew-[Co(TRDTRA)($OH_2$)] (TRDTRA = trimethylenediaminetriacetate) with $CN^-, NO^{-}_{2}$ and $NCS^-$ ions have been investigated by means of electronic absorption spectroscopy and theoretical calculation based on the Yamatera's theory. According to kinetic data, the substitution reaction order for the complexes such as $CN^-, NO^{-}_{2}$ and $NCS^-$ was the first order, respectively, and overall reaction order was second order. It has been determined that the structure of products having $CN^{-} and NO^{-}_{2}$ ions was Polar-Chair type complexes which were accompanying with isomerization and having $NCS^-$ ion was Equatorial-Skew type complex which was not accompanying with isomerization.

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Development of SSR Markers and Their Use in Studying Genetic Diversity and Population of Finger Millet (Eleusine coracana L. Gaertn.)

  • Lee, Kyung Jun;Yoon, Mun-Sup;Shin, Myoung-Jae;Lee, Jung-Ro;Cho, Yang-Hee;Lee, Ho-Sun;Ma, Kyung-Ho;Lee, Gi-An
    • Plant Breeding and Biotechnology
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    • v.5 no.3
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    • pp.183-191
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    • 2017
  • Finger millet (Eleusine coracana L. Gaertn.) is an important cereal crop in eastern Africa and southern India with excellent grain storage capacity and the unique ability to thrive in extreme environmental conditions. In this study, we analyzed the genetic diversity and population structure of finger millet using 12 developed microsatellites. By sequencing 815 clones from an SSR-enriched genomic DNA library, we obtained 12 polymorphic SSR markers, which also revealed successful amplicons in finger millet accessions. Using the developed SSR markers, we estimated genetic diversity and population structure among 76 finger millet accessions in Asia, Africa, and unknown origins. The number of alleles ranged from 2 to 9, with an average of 3.3 alleles. The mean values of observed heterozygosity and expected heterozygosity were 0.27 and 0.35, respectively. The average polymorphism information content was 0.301 in all 76 finger millet accessions. AMOVA analysis showed that the percentage of molecular variance among the populations was 1%, that among individuals was 5%, and that within individuals was 94%. In STRUCTURE analysis, the 76 finger millet accessions were divided into two subpopulations which had an admixture of alleles. There was a correspondence among PCoA, AMOVA, and population structure. This study may form the basis for a finger millet breeding and improvement program.

An Experimental Study on Power Transmission Characteristics Flow Rate in Fluid Couplings (유체커플링에서 유량과 동력전달특성에 관한 실험적 연구)

  • Pak, Yong-Ho;Moon, Dong-Cheol;Yum, Man-Oh
    • Journal of the Korean Society for Precision Engineering
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    • v.12 no.11
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    • pp.27-35
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    • 1995
  • The fluid coupling combined with a pump and a turbine have many merits compared with other couplings, their uses are increesing rapidly in various industrial fields at home and abroad in pursuit of high-speed more efficiency durability of various mechanic devices. The authorities concerned have recognized the improtance of the fluid coupling and supported its developement and now some trial products began to show up. As the structrue and characteristics of the fluid coupling have little similarity to other kinds of couplings and its fluid behavior is unique, so its characteristic analysis is expected to be difficult. Until now no satisfactory study on the characteristics of the fluid coupling seems to have been conducted at home, so a study on this field needs to be done urgently. The purpose of this research is to construct the experimental test set-ups and establish a series of performance test program for the domestically developed fluid couplings and to provide a software to store and utilize these experimental data which can be used to improve the performance of the fluid coupling and solve on the job problems confronted in operation. The performance test consists of taking measurment of torque, rpm and efficiency of the fluid coupling for three different amount of working fluid inside with various loads to the output shaft and finally infestigating the torque, rpm and efficiency characteristics of the fluid coupling with respect to these parameters. The results of this study can contribute valuable references to the development of variable speed fluid coupling and torque converter currently pursued by the domestic industry.

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