• Molecules and Cells
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• v.25 no.4
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• pp.479-486
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• 2008

Mitogen-activated protein kinases (MAPKs) play an indispensable role in activation of the myogenic program, which is responsive to mechanical stimulation. Although there is accumulating evidence of mechanical force-mediated cellular responses, the role of MAPK in regulating the myogenic process in myoblasts exposed to cyclic stretch is unclear. Cyclic stretch induced the proliferation of C2C12 myoblasts and inhibited their differentiation into myotubes. In particular, it induced persistent phosphorylation of p38 kinase, and decreased the level of phosphorylation of extracellular-signal regulated kinase (ERK). Partial inhibition of p38 phosphorylation increased cellular levels of MyoD and p-ERK in stretched C2C12 cells, along with increased myotube formation. Treatment with $10{\mu}M$ PD98059 prevented myogenin expression in response to a low dose of SB203580 ($3{\mu}M$) in the stretched cells, suggesting that adequate ERK activation is also needed to allow the cells to differentiate into myotubes. These results suggest that cyclic stretch inhibits the myogenic differentiation of C2C12 cells by activating p38-mediated signaling and inhibiting ERK phosphorylation. We conclude that p38 kinase, not ERK, is the upstream signal transducer regulating cellular responses to mechanical stretch in skeletal muscle cells.

• Journal of the Korean Society of Clothing and Textiles
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• v.41 no.4
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• pp.752-770
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• 2017

This study provides a size specification and ease for the development of pants for working clothes in the construction industry according to season. We collected and measured the size specification of 4 types of Spring/Fall pants, 4 types of winter brushed bonding pants, and 4 types of winter padded pants. Subjective comfort evaluation and analysis of ease sensation were performed for all products on 12 subjects. The average size specifications for the pants according to seasons were as follows. Spring/Fall pants had 74.0/80.0cm waist size (relaxed/maximum stretched) and 104.0cm hip size. Winter brushed bonding pants had 76.0/83.4cm for waist size and 106.0cm for hip size. Winter padded pants had 71.5/84.0cm for waist size and 112.8cm for hip size. When designing a pattern by comparing product size specification and subject body size, the recommended ease is 0.2/7.2cm for waist size (relaxed, maximum stretched) and 13.6cm for hip size for Spring/Fall pants, and 0.2/6.2cm for waist size and 11.6cm for hip size of winter brushed bonding pants, and -5.3/7.2cm for waist size and 19.4cm for the hip size of winter padded pants.

• The Journal of Natural Sciences
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• v.8 no.1
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• pp.145-151
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• 1995

The stretching of synthetic fibers by hot dry process is very difficult, because these fibers have high glass transition temperature at above $150^{\circ}C$. But, we used a swell-wet stretching precess; the fibers are stretched in a swelling agent such as organic solvents at lower temperature. In this study, 100% acryl fibers were uniaxially stretched with free width at $70^{\circ}C$ by swell-wet process in organic solvents. The stretchability was estimated by stretching work. This work is concerned with stretching stress and strain, and initial modulus. We found that it is a good parameter for the estimatation of high strength to the acrylic fiber. The effects of stretching conditions on the molecular orientation for high strength and mechanical properties of PAN fibers were measured.

• Korean Journal of Optics and Photonics
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• v.4 no.4
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• pp.447-451
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• 1993

Long pulse XeCl excimer laser with 150 ns (FWHM) pulse duration is developed using a simple capacitor-charge transfer circuit. We measured the laser pulse width varying the gas mixture ratio and capacitance ratio, which dominantly affect the pulse width. In this way we can easily stretch the pulse width from short pulse to long pulse. The pulse width was stretched by 120 ns as the partial pressure of HC1 and Xe gas was reduced under constant gas mixture ratio ([Xe]/[HCl]= 15), and by varying the capacitance ratio (Cm/Cp) under fixed pressure, the pulse width was stretched by 60 ns.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.9
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• pp.1627-1634
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• 2017

In this work, a junctionless transistor with different film thickness of amorphous InGaZnO has been fabricated and it's instability has been analyzed with different film thickness under positive and negative gate stress as well as light illumination. It was found that the threshold voltage shift and the variation of drain current have been increased with decrease of film thickness under the condition of gate stress and light illumination. The reasons for the observed results have been explained by stretched-exponential model and device simulation. Due to the reduced carrier trapping time with decrease of film thickness, electrons and holes can be activated easily. Due to the increase of vertical channel electric field reaching the back interface with decrease of film thickness, more electrons and holes can be accumulated in back interface. When one decides the film thickness for the fabrication of junctionless transistor, the more significant device instability with decrease of film thickness should be consdered.

• Journal of the Korea Society of Computer and Information
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• v.20 no.5
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• pp.13-20
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• 2015

In this paper, we propose an algorithm that can recognize not only the number of stretched fingers but also determination of attached fingers for extracting features required for hand gesture recognition. The proposed algorithm detects the hand area in the input image by the skin color range filter based on a color model and labeling, and then recognizes various hand gestures by extracting the number of stretched fingers and determination of attached fingers using curvature information extracted from outlines and feature points. Experiment results show that the recognition rate and the frame rate are similar to those of the conventional algorithm, but the number of gesture cases that can be defined by the extracted characteristics is about four times higher than the conventional algorithm, so that the proposed algorithm can recognize more various gestures.

• Polymer(Korea)
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• v.24 no.3
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• pp.342-349
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• 2000

Hollow fiber membranes were prepared via thermally-induced phase separation process followed by stretching process from isotactic polypropylene and soybean oil system. Various operating parameters were examined in terms of their effects on the structure variation and performances of the membrane, and were optimized. Melt viscosity of the melt sample had influence on the formation of the microfibrils, and addition of nucleating agent increased the nucleation density to enhance the interspherulitic pore formation by stretching. Annealing the membrane at its stretched state relaxed the stress induced by stretching and helped the membrane maintain the stretched structure without shrinking. Solid-liquid Phase separation is more prevalent when the nucleating agent was added, and coagulation bath temperature determined the nucleation density, which affected the pore formation by stretching. In the absence of nucleating agent, nucleation was not effective and liquid-liquid phase separation governed the structure formation, which showed the opposite trend to that of the case with nucleating agent.

• Composites Research
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• v.34 no.2
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• pp.108-114
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• 2021

Graphene flakes are generally mass-produced by converting graphene oxide into reduced graphene oxide using chemical or thermal reduction. These graphene flakes can be stacked to form a free-standing graphene paper, which can be used for various applications. However, a graphene paper lacks stretchability, which hinders its application in stretchable devices. In this work, we introduced wrinkles in a graphene paper to make it stretchable. A graphene paper fabricated by vacuum-filtering a graphene dispersion was placed on a pre-stretched adhesive film. When the pre-stretched adhesive film returned to the original state, the graphene paper was wrinkled. The effect of the pre-stretching and wet condition of the graphene papers was experimentally investigated by using scanning electron microscopy. In addition, we observed the change of the period of the wrinkles in the graphene paper depending on the pre-stretching.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.58 no.1
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• pp.1-9
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• 2022

In this study, the selection action on the mesh in the net pot for whelk (Buccinum opisthoplectum) is experimentally considered, and the selectivity was compared by the SELECT model and the Nashimoto's method with the probability model according to the contact shape of the mesh and the whelk. The experiments of the mesh size selectivity was conducted for two mesh sizes: 70 mm (inner stretched size 65.4 mm) and 44 mm (inner stretched size 39.5 mm). Selectivity experiments were conducted three times in total for each mesh size used 264 whelks. In addition, Nashimoto's method analyzed the retention probability using probability model for whether the mesh passed or not based on the carapace width of the whelk. As a result of the selectivity analysis, the 50% selection carapace width for the mesh size of 70 mm was similar to 43.62 mm in the SELECT model and 42.64 mm in the Nashimoto's method. However, the 44 mm mesh with relatively small mesh size showed differences of 40.01 mm and 26.80 mm, respectively. As for the mesh size selectivity of whelk, it was found that the smaller the mesh size, the lower the selectivity. In addition, in the selectivity study on the mesh size of whelk, an evaluation method that closely considers the contact shape between the mesh and the target species is required.

• International Journal of Stem Cells
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• v.16 no.2
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• pp.202-214
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• 2023

Background and Objectives: To investigate the role of exosomes from periodontal ligament cells (PDLCs) in bone marrow mesenchymal stem cell (BMSC) migration. Methods and Results: Human PDLCs were applied cyclic tension stretching. Exosomes were extracted from cultured PDLCs by ultracentrifugation, then characterized for their size, morphology and protein markers by NTA, TEM and western blotting. The process that PKH26-labeled exosomes taken up by BMSCs was assessed by confocal microscope. BMSC migration was examined by Transwell assay. Exosomes derived from PDLCs were identified. Cyclic tension stretch application on PDLCs can enhance the migration ability of BMSCs through exosomes. The exosomal miRNA expression profiles of unstretched and stretched PDLCs were tested by miRNA microarray. Four miRNAs (miR-4633-5p, miR-30c-5p, miR-371a-3p and let-7b-3p) were upregulated and six (miR-4689, miR-8485, miR-4655-3p, miR-4672, miR-3180-5p and miR-4476) were downregulated in the exosomes after stretching. Sixteen hub proteins were found in the miRNA-mRNA network. Gene Ontology and KEGG pathway analyses demonstrated that the target genes of differentially expressed exosomal miRNAs closely related to the PI3K pathway and vesicle transmission. Conclusions: The exosomes derived from cyclic tension-stretched PDLCs can promote the migration of BMSCs. Alternation of microRNA profiles provides a basis for further research on the regulatory function of the exosomal miRNAs of PDLCs during orthodontic tooth movement.