• Molecules and Cells
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• v.46 no.1
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• pp.57-64
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• 2023

In eukaryotic cells, a key RNA processing step to generate mature mRNA is the coupled reaction for cleavage and polyadenylation (CPA) at the 3' end of individual transcripts. Many transcripts are alternatively polyadenylated (APA) to produce mRNAs with different 3' ends that may either alter protein coding sequence (CDS-APA) or create different lengths of 3'UTR (tandem-APA). As the CPA reaction is intimately associated with transcriptional termination, it has been widely assumed that APA is regulated cotranscriptionally. Isoforms terminated at different regions may have distinct RNA stability under different conditions, thus altering the ratio of APA isoforms. Such differential impacts on different isoforms have been considered as post-transcriptional APA, but strictly speaking, this can only be considered "apparent" APA, as the choice is not made during the CPA reaction. Interestingly, a recent study reveals sequential APA as a new mechanism for post-transcriptional APA. This minireview will focus on this new mechanism to provide insights into various documented regulatory paradigms.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.1
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• pp.24-33
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• 2005

This paper presents dimming control system for automotive 35[W] metal halide discharge(MHD) lamp electronic ballast using digital control method. HID system has been becoming increasingly popular due to its superior performance(high luminous efficacy, good color rendering and long life etc.)over the conventional halogen system. However, this lamp demands a highly efficient ballast and very complex control circuitry that can control complex transient state in applying to automotive. Therefore, in this paper, digital control method for the HID lamp ballast is presented for optimal control that can adapt complex transient state, steady state and various environments. In developed dimming system, the system is designed to control the lamp output voltage step by step using microcontroller according to cds sensor. Therefore the designed dimming control system give good driving condition to diver and realize the power control effectively. The results of the proposed system is verified through various simulation results and the experiment results.

• Journal of Energy Engineering
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• v.20 no.4
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• pp.353-357
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• 2011

An embedded two-axis solar tracking system was developed by using AVR micro controller for enhancing solar energy utilization. The system consists of an Atmega128 micro controller, two step motors, two step drive modules, CdS sensors, GPS module and other accessories needed for functional stability. This system is controlled by both an astronomical method and an optical method. Initial operation is performed by the result from the astronomical method, which is followed by the fine controlled operation using the signals from Cds sensors. The GPS sensor generates UTC, longitude and latitude data where the solar tracker is installed. A database of solar altitude, azimuth, and sunrise and sunset times is provided by UART (Universal Asynchronous Receiver/Transmitter).

• Journal of Sensor Science and Technology
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• v.14 no.4
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• pp.272-277
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• 2005

A CMOS active pixel sensor has been designed and fabricated using standard 2-poly and 4-metal $0.35{\mu}m$ CMOS processing technology. The CMOS active pixel sensor has been made up of a unit pixel having a highly sensitive PMOSFET photo-detector and electronic shutters that can control the light exposure time to the PMOSFET photo-detector, correlated-double sampling (CDS) circuits, and an 8-bit two-step flash analog to digital converter (ADC) for digital output. This sensor can obtain a stable photo signal in a wide range of light intensity. It can be realized with a special function of an electronic shutter which controls the light exposure-time in the pixel. Moreover, this sensor had obtained the digital output using an embedded ADC for the system integration. The designed and fabricated image sensor has been implemented as a $128{\times}128$ pixel array. The area of the unit pixel is $7.60{\mu}m{\times}7.85{\mu}m$ and its fill factor is about 35 %.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.6
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• pp.1179-1194
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• 1992

QUICKER scheme has several attractive properties. However, under highly convective conditions, it produces overshoots and possibly some oscillations on each side of steps in the dependent variable when the flow is convected at an angle oblique to the grid line. Fortunately, it is possible to modify the QUICKER scheme using non-linear and linear functional relationship. Details of the development of polynomial upwinding scheme are given in this paper, where it is seen that this non-linear scheme has also third order accuracy. This polynomial upwinding scheme is used as the basis for the SHARPER and SMARTER schemes. Another revised scheme was developed by partial modification of QUICKER scheme using CDS and UPWIND schemes(QUICKUP). These revised schemes are tested at the well known bench mark flows, Two-Dimensional Pure Convection Flows in Oblique-Step, Lid Driven Cavity Flows and Buoyancy Driven Cavity Flows. For pure convection oblique step flow test problem, QUICKUP, SMARTER and SHARPER schemes remain absolutely monotonic without overshoot and oscillation. QUICKUP scheme is more accurate than any other scheme in their relative accuracy. In high Reynolds number Lid Driven Cavity Flow, SMARTER and SHARPER schemes retain lower computational cost than QUICKER and QUICKUP schemes, but computed velocity values in the revised schemes produced less predicted values than QUICKER scheme which is strongly effected by overshoot and undershoot values. Also, in Buoyancy Driven Cavity Flow, SMARTER, SHARPER and QUICKUP schemes give acceptable results.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.1
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• pp.83-91
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• 2014

This paper presents a capacitive readout circuit for tri-axes microaccelerometer with sub-fF offset calibration capability. A charge sensitive amplifier (CSA) with correlated double sampling (CDS) and digital to equivalent capacitance converter (DECC) is proposed. The DECC is implemented using 10-bit DAC, charge transfer switches, and a charge-storing capacitor. The DECC circuit can realize the equivalent capacitance of sub-fF range with a smaller area and higher accuracy than previous offset cancelling circuit using series-connected capacitor arrays. The readout circuit and MEMS sensing element are integrated in a single package. The supply voltage and the current consumption of analog blocks are 3.3 V and $230{\mu}A$, respectively. The sensitivities of tri-axes are measured to be 3.87 mg/LSB, 3.87 mg/LSB and 3.90 mg/LSB, respectively. The offset calibration which is controlled by 10-bit DECC has a resolution of 12.4 LSB per step with high linearity. The noise levels of tri-axes are $349{\mu}g$/${\sqrt}$Hz, $341{\mu}g$/${\sqrt}$Hz and $411{\mu}g$/${\sqrt}$Hz, respectively.

• Molecules and Cells
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• v.43 no.1
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• pp.23-33
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• 2020

NF-κB signaling through both canonical and non-canonical pathways plays a central role in immune responses and inflammation. NF-κB-inducing kinase (NIK) stabilization is a key step in activation of the non-canonical pathway and its dysregulation implicated in various hematologic malignancies. The tumor suppressor, p53, is an established cellular gatekeeper of proliferation. Abnormalities of the TP53 gene have been detected in more than half of all human cancers. While the non-canonical NF-κB and p53 pathways have been explored for several decades, no studies to date have documented potential cross-talk between these two cancer-related mechanisms. Here, we demonstrate that p53 negatively regulates NIK in an miRNA-dependent manner. Overexpression of p53 decreased the levels of NIK, leading to inhibition of the non-canonical NF-κB pathway. Conversely, its knockdown led to increased levels of NIK, IKKα phosphorylation, and p100 processing. Additionally, miR-34b induced by nutlin-3 directly targeted the coding sequences (CDS) of NIK. Treatment with anti-miR-34b-5p augmented NIK levels and subsequent non-canonical NF-κB signaling. Our collective findings support a novel cross-talk mechanism between non-canonical NF-κB and p53.