• 멤브레인
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• 제30권6호
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• pp.373-384
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• 2020

바이오의약품 중에서도 항체의약품의 수요가 증가함에 따라 항체를 상업용으로 개발하기 위한 연구가 활발히 진행되고 있다. 항체의약품의 제조공정 중 downstream 공정은 의약품 성능에 직접적으로 영향을 미치기 때문에 중요하게 다뤄지며, 본 총설은 그 중에서도 농축 및 제제화를 목적으로 행해지는 한외여과 및 정용여과 공정에서 사용되는 한외여과막의 주요 제품 및 공정 특성을 살펴보고, 최근 연구 동향에 대해 소개하고자 한다.

• 센서학회지
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• 제31권6호
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• pp.361-365
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• 2022

Advanced packaging demands are driven by the need for dense integration systems. Consequently, stacked packaging technology has been proposed instead of reducing the ultra-fine patterns to secure economic feasibility. This study proposed an effective packaging process technology for semiconductor devices using a 9-inch dicing die attach film (DDAF), wherein the die attach and dicing films were combined. The process involved three steps: tape lamination, dicing, and bonding. Following the grinding of a silicon wafer, the tape lamination process was conducted, and the DDAF was arranged. Subsequently, a silicon wafer attached to the DDAF was separated into dies employing a blade dicing process with a two-step cut. Thereafter, one separated die was bonded with the other die as a substrate at 130 ℃ for 2 s under a pressure of 2 kgf and the chip was hardened at 120 ℃ for 30 min under a pressure of 10 kPa to remove air bubbles within the DAF. Finally, a curing process was conducted at 175 ℃ for 2 h at atmospheric pressure. Upon completing the manufacturing processes, external inspections, cross-sectional analyses, and thermal stability evaluations were conducted to confirm the optimality of the proposed technology for application of the DDAF. In particular, the shear strength test was evaluated to obtain an average of 9,905 Pa from 17 samples. Consequently, a 3D integration packaging process using DDAF is expected to be utilized as an advanced packaging technology with high reliability.

• Structural Engineering and Mechanics
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• 제86권5호
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• pp.687-704
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• 2023

This study aims to examine the structural response of glass fibre-reinforced polymer (Glass-FRP) reinforced geopolymer electronic waste aggregate concrete (GEWC) compression elements under axial compression for sustainable development. The research includes the fabrication of nine GEWC circular compression elements with different reinforcement ratios and a 3-D nonlinear finite element model using ABAQUS. The study involves a detailed parametric analysis to examine the impact of various parameters on the behavior of GEWC compression elements. The results indicate that reducing the vertical distance of glass-FRP ties improves the ductility of GEWC compression elements, and those with eight longitudinal rebars have higher axial load-carrying capacities. The finite element predictions were in good agreement with the testing results, and the put forwarded empirical model shows higher accuracy than previous models by involving the confinement effect of lateral glass-FRP ties on the axial strength of GEWC compression elements. This research work contributes to minimizing the carbon footprint of cement manufacturing and electronic waste materials for sustainable development.

• Structural Engineering and Mechanics
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• 제86권6호
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• pp.751-764
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• 2023

In practical engineering such as aerial refueling pipes, the boundary of the fluid-conveying pipe is difficult to be completely immovable. Pipes under movable and immovable boundaries are controlled by different dominant nonlinear factors, where the boundary mobility will affect the nonlinear dynamic characteristics, which should be focused on for adopting different strategies for vibration suppression and control. The nonlinear dynamic instability characteristics of functionally graded fluid-conveying pipes lying on a viscoelastic foundation under movable and immovable boundary conditions are systematically studied for the first time. Nonlinear factors involving nonlinear inertia and nonlinear curvature for pipes with a movable boundary as well as tensile hardening and nonlinear curvature for pipes with an immovable boundary are comprehensively considered during the derivation of the governing equations of the principal parametric resonance. The stability boundary and amplitude-frequency bifurcation diagrams are obtained by employing the two-step perturbation- incremental harmonic balance method (TSP-IHBM). Results show that the movability of the boundary of the pipe has a great influence on the vibration amplitude, bifurcation topology, and the physical meanings of the stability boundary due to different dominant nonlinear factors. This research has guidance significance for nonlinear dynamic design of fluid-conveying pipe with avoiding in the instability regions.

• Design & Manufacturing
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• 제16권2호
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• pp.53-59
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• 2022

Unlike other press forming processes, ISF (Incremental sheet forming) doesn't require a punch and die set. However, during the ISF processes unwanted bending deformation occurred around the target geometry. This paper is aimed to analyze the effect of the die structure, which is supported by bolts, on the geometric accuracy of the ISF processes. In this research, the ISF processes with Al5052 sheet of 0.5 mm, the tool diameter of 6 mm and the stepdown of 0.4 mm was employed. L-shaped, step-shaped, relief-shaped geometry were employed in experiments. Sectional view and the plastic strain were compared. From this research we find out that the bolt supported ISF processes increases the geometric accuracy of products very effectively.

• 접착 및 계면
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• 제23권4호
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• pp.101-107
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• 2022

Adhesive joints have many advantages such as weight savings, corrosion and fatigue resistance and now developed even withstand of high impact and dynamic loads. However, an adhesion has cumbersome and complicated surface preparation processes. The surface preparation step is critical in adhesive joint manufacturing in order to obtain the prescribed strength for adhesive joints. In this study, it was attempted to simplify and reduce the number of surface preparation steps, and abrasion and rapid adhesive application (ARAA) process is developed for an alternative solution. The abrasion processes are performed only for creating surface roughness in standard procedures (SP), although the abrasion processes cause surface activation itself. The results showed that there is no need the long procedures in laboratory or chemical agents for adhesion. After the abrasion process, the attracted and highly reactive fresh surface layer obtained, and its effect on bonding success is observed and analyzed in this research, in light of the essential physic and adhesion theories. Al 6061 aluminum adherends and epoxy-based adhesives were chosen for bonding processes, which is mostly used in light vehicle parts. The adherends were cleaned, treated and activated only with abrasion, and after the adhesive application the specimens were tested under quasi-static loading. The satisfied ARAA results were compared with that of the specimens fabricated by the standard procedure (SP) of adhesion processes of high impact loads.

• Tribology and Lubricants
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• 제39권6호
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• pp.244-249
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• 2023

This paper presents a comprehensive analysis of the impact of surface roughness on the friction and wear properties of SUS 321, an austenitic stainless steel variant produced using the laser powder bed fusion (LPBF) technique, which is a prevalent additive manufacturing method. After the LPBF fabrication, the specimens go a heat treatment process aimed at alleviating residual stress. Subsequently, they are polished extensively to achieve a refined and smooth surface. To deliberately introduce controlled variations in surface roughness, an etching process is employed. This multi-step method encompassed primary etching in a 3M hydrochloric acid solution, followed by secondary etching in a 35 wt% ferric chloride solution, with varying durations applied to different specimens. A comprehensive evaluation of the surface characteristics ensued, employing precise techniques such as surface roughness measurements and meticulous assessments of water droplet contact angles. Following the surface treatment procedures, a series of friction tests are performed to explore the tribological behavior of the etched specimens. This in-depth investigation reached its peak by revealing valuable insights. It clarified a strong correlation between intentionally altered surface roughness, achieved through etching processes, and the resulting tribological performance of LPBF-fabricated SUS 321 stainless steel. This significantly advances our grasp of material behavior in tribological applications.

• 한국재료학회지
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• 제34권7호
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• pp.370-376
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• 2024

In this study, we report significant improvements in lithium-ion battery anodes cost and performance, by fabricating nano porous silicon (Si) particles from Si wafer sludge using the metal-assisted chemical etching (MACE) process. To solve the problem of volume expansion of Si during alloying/de-alloying with lithium ions, a layer was formed through nitric acid treatment, and Ag particles were removed at the same time. This layer acts as a core-shell structure that suppresses Si volume expansion. Additionally, the specific surface area of Si increased by controlling the etching time, which corresponds to the volume expansion of Si, showing a synergistic effect with the core-shell. This development not only contributes to the development of high-capacity anode materials, but also highlights the possibility of reducing manufacturing costs by utilizing waste Si wafer sludge. In addition, this method enhances the capacity retention rate of lithium-ion batteries by up to 38 %, marking a significant step forward in performance improvements.

• 한국식품위생안전성학회지
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• 제27권2호
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• pp.161-168
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• 2012

떡은 수분활성도, pH, 보관온도 등이 미생물 증식에 적합하고 구입 후 별도 조리과정 없이 그대로 섭취하는 식품으로 미생물학적 안전문제를 자주 야기하고 있다. 본 연구는 국내 유통 떡에 문제시되는 미생물학적 위해요인을 제조공정별로 파악하고 그 위생관리 개선방안을 도출하고자 하였다. 3가지 떡 (시루떡, 가래떡, 경단)을 선정하여 원료, 제조공정 및 제조환경에 대한 미생물 오염도 분석을 실시하였다. 8가지 원재료의 오염도 분석결과 일반세균 2.5~4.5, 대장균군 ND~1.9, 진균수 1.2~2.1, B. cereus 1.0~2.1 log CFU/g수준으로 검출되었으며 E. coli, S. aureus, C. perfringens는 검출되지 않았다. 떡의 제조공정별 오염도 분석결과 원료의 불림 분쇄 공정에서 일반세균, 대장균군, 진균, B. cereus의 오염도가 증가하나 증자 후 감소하여 완제품에서 일반세균은 2.2~3.7, 대장균군 ND~1.8 log CFU/g 수준으로 나타났다. 제조환경의 미생물학적 오염도 분석결과 전처리실의 쌀분쇄기, 냉각수조, 펀칭기 등의 설비에서 오염수준이 높게 나타났으며, 전처리실 작업자의 개인 위생이 미흡한 것으로 나타났다. 작업장 공기 오염도 분석결과 청결구역 3곳에서 일반세균 34~46, 대장균군 2.5~7.0, 진균수 14~30 $CFU/plate{\cdot}5min$ 검출되어 권장 낙하세균기준을 초과하는 것으로 나타났다. 본 연구결과 떡의 원재료 및 완제품의 미생물학적 오염수준은 안전하나 제조환경의 오염도는 문제시되는 것으로 나타나 제품의 교차오염 가능성을 내포하고 있는 것으로 사료된다. 따라서 제조 설비 및 표면시설에 대한 체계적인 세척 및 소독을 실시하여 미생물학적 위해를 감소하고 작업자 위생 관리 교육 프로그램을 선행하여 작업자 개인의 위생 수준 향상, 작업장 내 공기중의 미생물 관리가 함께 이루어지도록 하는 것이 필요한 것으로 여겨진다.

• 한국건축시공학회지
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• 제17권2호
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• pp.191-197
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• 2017

건설공사는 제조업과는 달리 공사가 시작되어 종료될 때 까지 재해위험도가 일정하지 않고 공사단계에 따라 큰 변화가 있다. 건설업 산업안전보건관리비 계상 및 사용기준은 그동안 건설업의 안전문화 정착과 재해율 저감에 적지 않은 기여를 해왔으나, 현행 기준은 건설공사의 재해위험도 특성에 비해볼 때 이미 중대재해발생위험시기가 지난 이후에 뒤늦게 사용하게 되는 문제점이 있다. 본 연구는 건설공사의 공사단계별로 재해위험도에 대한 분석을 통하여 공사단계별 재해발생위험도와 안전관리비 사용기기 산출방식을 제시하는 것을 목적으로 진행하였다. 이를 위하여 1439건의 국내 중대재해사례를 분석하여 공사단계별 중대재해발생확률을 산출하였으며, 공정특성에 따른 적정 산업안전보건관리비의 적정 사용일정을 도출하는 방식을 제안하였다. 도출된 방식에 의해 산정된 산업안전보건관리비 사용일정을 현행 기준과 비교한 결과 최소 20%p 이상 앞서서 사용해야만 재해위험도에 따른 적절한 선행적 조치가 가능할 것으로 나타났다.