• Korean Journal of Construction Engineering and Management
• /
• v.6 no.4 s.26
• /
• pp.172-180
• /
• 2005

The purpose of this study is to suggest a new SRC(Steel Ready mixed Concrete) lining board. The research method of this study includes problem analysis of existing lining boards a constant load test and a fatigue test. The results of this study are as follow : 1) the suggested new lining board improves the function and reduce slipperiness than existing lining boards. 2) the strength of the new SRC lining board is analyzed as superior than existing lining boards from the results of constant load test and fatigue test.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.27 no.3
• /
• pp.256-264
• /
• 2022

The frequency power control method (FCM) which has a wide operating frequency range is adopted for induction heating (IH) cooktops. When FCM is applied to the full-bridge series resonant converter (FB-SRC) based IH system, high-frequency switching of the inverter is required compared to the half-bridge SRC (HB-SRC)-based IH system. Therefore, the switching loss of the inverter increases, and applying FCM under the condition that the inverter operating frequency range is limited is difficult. Therefore, this paper proposes a control strategy with the phase shift power control method considering that limited frequency conditions are presented. Loss analysis following the control method is performed through simulation and mathematical analysis. In addition, the validity of the proposed control strategy is verified by analyzing the heating performance following the control method through the test results of the 3,200[W] prototype.

• Steel and Composite Structures
• /
• v.47 no.3
• /
• pp.423-436
• /
• 2023

In this research, we tested 10 simply supported concrete-encased composite columns under monotonic eccentric loads and investigated their shear behaviour. The specimens tested were two reinforced concrete specimens, three steel-reinforced concrete (SRC) specimens with an H-shaped steel section (also called a beam section), and five SRC specimens with a cruciform-shaped steel section (also called a column section). The experimental variables included the transverse steel shape's depth and the longitudinal steel flange's width. Experimental observations indicated the following. (1) The ultimate load-carrying capacity was controlled by web compression failure, defined as a situation where the concrete within the diagonal strut's upper end was crushed. (2) The composite effect was strong before the crushing of the concrete outside the steel shape. (3) We adjusted the softened strut-and-tie SRC (SST-SRC) model to yield more accurate strength predictions than those obtained using the strength superposition method. (4) The MSST-SRC model can more reasonably predict shear strength at an initial concrete softening load point. The rationality of the MSST-SRC model was inferred by experimentally observing shear behaviour, including concrete crushing and the point of sharp variation in the shear strain.

• Proceedings of the Korean Society For Composite Materials Conference
• /
• 2000.11a
• /
• pp.177-182
• /
• 2000

This paper predicted the equivalent stiffness of spatially reinforced composites (SRC) using the volume average of a fiber rod and matrix stiffness, and the strength of SRC using the stiffness reduction and the modified Tsai-Wu composite failure theory. Those equivalent engineering constants are used to analyze the mechanical behavior and the failure of SRC structures. Because the distribution of equivalent engineering constants is varying with the change in SRC shape, we made a program that predicts engineering constants of SRC. Both 3-D and 4-D SRC show the smallest tensile modulus and the largest shear modulus at the maximum rotated direction from each rod. Also the strength properties show the same tendency.

• Proceedings of the KIPE Conference
• /
• 2012.11a
• /
• pp.173-174
• /
• 2012

본 논문에서는 전기자동차용 부하 직렬 공진형 컨버터(Series-loaded Resonant Converter, SRC)타입의 탑재형 충전기 (On-Board Charger, OBC)의 추가 회로 없이 경부하 효율을 향상시키기 위한 스위칭 방법들을 비교 분석한다. 시스템에 적용할 스위칭 제어 방법은 Asymmetrical Duty Cycle Control (ADC)과 Asymmetrical Voltage-Cancellation Control (AVC) 방법이다. 각 제어 방법을 기존의 3.3kW SRC-OBC의 적용하여 경부하 영역에서의 효율을 확인하고 각 제어 방법의 타당성을 검증한다.

• Steel and Composite Structures
• /
• v.21 no.2
• /
• pp.267-287
• /
• 2016

The seismic performance of the ordinary steel reinforced concrete (SRC) columns has no significant improvement compared to the reinforced concrete (RC) columns mainly because I, H or core cross-shaped steel cannot provide sufficient confinement for core concrete. Two improved SRC columns by constructing with new-type shaped steel were put forward on this background, and they were named as enlarging cross-shaped steel and diagonal cross-shaped steel for short. The seismic behavior and carrying capacity of new-type SRC columns have been researched theoretically and experimentally, while the shear behavior remains unclear when the new-type columns are joined onto SRC beams. This paper presents an experimental study to investigate the shear capacity of new-type SRC joints. For this purpose, four new-type and one ordinary SRC joints under low reversed cyclic loading were tested, and the failure patterns, load-displacement hysteretic curves, joint shear deformation and steel strain were also observed. The ultimate shear force of joint specimens was calculated according to the beam-end counterforce, and effects of steel shape, load angel and structural measures on shear capacity of joints were analyzed. The test results indicate that: (1) the new-type SRC joints display shear failure pattern and has higher shear capacity than the ordinary one; (2) the oblique specimens have good bearing capacity if designed reasonably; and (3) the two proposed construction measures have little effect on the shear capacity of SRC joints embedded with diagonal cross-shaped steel. Based on the mechanism observed from the test, the formulas for calculating ultimate shear capacity considering the main factors (steel web, stirrup and axial compression ratio) were derived, and the calculated results agreed well with the experimental and simulated data.

• Biomolecules & Therapeutics
• /
• v.23 no.5
• /
• pp.414-420
• /
• 2015

Flavonoids, such as fisetin (3,7,3',4'-tetrahydroxyflavone), are plant secondary metabolites. It has been reported that fisetin is able to perform numerous pharmacological roles including anti-inflammatory, anti-microbial, and anti-cancer activities; however, the exact anti-inflammatory mechanism of fisetin is not understood. In this study, the pharmacological action modes of fisetin in lipopolysaccharide (LPS)-stimulated macrophage-like cells were elucidated by using immunoblotting analysis, kinase assays, and an overexpression strategy. Fisetin diminished the release of nitric oxide (NO) and reduced the mRNA levels of inducible NO synthase (iNOS), tumor necrosis factor (TNF)-${\alpha}$, and cyclooxygenase (COX)-2 in LPS-stimulated RAW264.7 cells without displaying cytotoxicity. This compound also blocked the nuclear translocation of p65/nuclear factor (NF)-${\kappa}B$. In agreement, the upstream phosphorylation events for NF-${\kappa}B$ activation, composed of Src, Syk, and I${\kappa}B{\alpha}$, were also reduced by fisetin. The phospho-Src level, triggered by overexpression of wild-type Src, was also inhibited by fisetin. Therefore, these results strongly suggest that fisetin can be considered a bioactive immunomodulatory compound with anti-inflammatory properties through suppression of Src and Syk activities.

• Journal of Applied Biological Chemistry
• /
• v.48 no.3
• /
• pp.120-126
• /
• 2005

Endothelial nitric oxide synthase (eNOS) plays a critical role in vascular biology and pathophysiology. Its activity is regulated by multiple mechanisms such as calcium/calmodulin, protein-protein interactions, sub-cellular locations and phosphorylation at various sites. Phosphorylation of eNOS-Ser1177 (based on mouse sequence) has been identified as an important mechanism of eNOS activation. However, signaling pathway leading to it phosphorylation remains controversial. The regulation of eNOS-Ser1177 phosphorylation by Src and protein kinase A (PKA) was investigated in the present study using cultured mouse aorta endothelial cells. Expression of a constitutively active Src mutant in the cells enhanced phosphorylation of eNOS and protein kinase B (Akt). The Src-stimulated phosphorylation was not attenuated by the expression of a dominant negative PKA regulatory subunit. Neither activation nor inhibition of PKA activity had any significant effect on tyrosine phosphorylation of activation or inactivation site in Src. Based on the results of this study, it is suggested that Src/Akt pathway and PKA signaling may regulate eNOS phosphorylation independently. The existence of multiple mechanisms for eNOS phosphorylation may guarantee endothelial nitric oxide production in various cellular contexts which is essential for maintenance of vascular health.

• Proceedings of the KIPE Conference
• /
• 2012.07a
• /
• pp.23-24
• /
• 2012

본 논문에서는 전기자동차용 탑재형 충전기회로 (On-Board Charger, OBC) 에 사용되는 부하 직렬 공진형 컨버터 (Series loaded Resonant DC-DC Converter, SRC) 의 정전압 제어를 위해 기존에 듀티를 고정하고 주파수만을 제어하던 방법에 듀티도 같이 제어하는 비대칭 듀티 제어 방법 (Asymmetrical Duty Cycle Control) 을 적용하였다. 적용한 SRC-OBC의 등가화 모델의 수식적 분석을 통해 제안한 회로의 동작영역을 도출하여 결과로 얻어진 동작영역에서 제안한 회로의 부하에 따른 효율을 기존 주파수 제어 방법과 비교 분석을 통하여 적용한 제어 방법의 타당성을 검증한다.

• Biomolecules & Therapeutics
• /
• v.23 no.6
• /
• pp.539-548
• /
• 2015

Prostaglandin $E_2$ ($PGE_2$), a major product of cyclooxygenase, binds to four different prostaglandin $E_2$ receptors (EP1, EP2, EP3, and EP4) which are G-protein coupled transmembrane receptors (GPCRs). Although GPCRs including EP receptors have been shown to be associated with their specific G proteins, recent evidences suggest that GPCRs can regulate MAPK signaling via non-G protein coupled pathways including Src. EP2 is differentially expressed in various tissues and the expression of EP2 is induced by extracellular stimuli. We hypothesized that an increased level of EP2 expression may affect MAPK signaling. The overexpression of EP2 in HEK 293 cells resulted in significant increase in intracellular cAMP levels response to treatment with butaprost, a specific EP2 agonist, while overexpression of EP2 alone did not increase intracellular cAMP levels. However, EP2 overexpression in the absence of $PGE_2$ induced an increase in the level of p38 phosphorylation as well as the kinase activity of p38, suggesting that up-regulation of EP2 may promote p38 activation via non-G protein coupled pathway. Inhibition of Src completely blocked EP2-induced p38 phosphorylation and overexpression of Src increased the level of p38 phosphorylation, indicating that Src is upstream kinase for EP2-induced p38 phosphorylation. EP2 overexpression also increased the Src activity and EP2 protein was co-immunoprecipitated with Src. Furthermore, sequential co-immunoprecipitation studies showed that EP2, Src, and ${\beta}$-arrestin can form a complex. Our study found a novel pathway in which EP2 is associated with Src, regulating p38 pathway.