• Journal of Microbiology and Biotechnology
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• v.32 no.9
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• pp.1168-1177
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• 2022

Parkinson's disease (PD) is the second-most prevalent neurodegenerative disease and is characterized by dopaminergic neuronal death in the midbrain. Recently, the association between alterations in PD pathology and the gut microbiota has been explored. Microbiota-targeted interventions have been suggested as a novel therapeutic approach for PD. Agathobaculum butyriciproducens SR79^T (SR79) is an anaerobic bacterium. Previously, we showed that SR79 treatment induced cognitive improvement and reduced Alzheimer's disease pathologies in a mouse model. In this study, we hypothesized that SR79 treatment may have beneficial effects on PD pathology. To investigate the therapeutic effects of SR79 on PD, 6-hydroxydopamine (6-OHDA)-induced mouse models were used. D-Amphetamine sulfate (d-AMPH)-induced behavioral rotations and dopaminergic cell death were analyzed in unilateral 6-OHDA-lesioned mice. Treatment with SR79 significantly decreased ipsilateral rotations induced by d-AMPH. Moreover, SR79 treatment markedly activated the AKT/GSK3β signaling pathway in the striatum. In addition, SR79 treatment affected the Nrf2/ARE signaling pathway and its downstream target genes in the striatum of 6-OHDA-lesioned mice. Our findings suggest a protective role of SR79 in 6-OHDA-induced toxicity by regulating the AKT/Nrf2/ARE signaling pathway and astrocyte activation. Thus, SR79 may be a potential microbe-based intervention and therapeutic strategy for PD.

• Proceedings of the Korean Ceranic Society Conference
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• 2004.10a
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• pp.79.2-79.2
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• 2004

• Proceedings of the Korean Magnestics Society Conference
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• 1997.05a
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• pp.78-79
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• 1997

• Proceedings of the Korean Magnestics Society Conference
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• 2000.05a
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• pp.78-79
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• 2000

• Journal of Radiation Protection and Research
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• v.19 no.3
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• pp.199-208
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• 1994

The derived intervention levels in Korean foodstuffs were estimated using the dynamic ingestion pathway model which was developed considering Korean environment. The derived intervention levels were estimated from the intervention level of dose based on the thyroid committed dose equivalent of infant in the case of I-131, and the whole body committed dose equivalent for age groups and 13 kinds foodstuffs in the cases of Cs-137 and Sr-90. The derived intervention levels were shown as a considerable variation with deposition time and radionuclide. The adult was the most important age group in the estimation of derived intervention levels for Cs-137 and Sr-90. In the adult, the derived intervention levels for rice were 2390 and 47 Bq/kg for Cs-137 and Sr-90 in the case of deposition in summer, respectively, and 198 and 79 Bq/kg in the case of deposition in winter, respectively.

• Journal of the Speleological Society of Korea
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• no.79
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• pp.77-81
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• 2007

In this paper deals with behavior of the magnetic abrasive using Sr-Ferrite on polishing charateristiccs in a internal finishing of staninless steel pipe a tying magnetic abrasive polishing. The magnetic polishing is the useful method to finish some machinery fabrications by using magnetic power. This method is one of the precision techniques and has in aim for clean technology in the transportation of the pure gas in the clean pipes. The magnetic abrasive polishing method is not so common in the field of machine that it is not known to widely. There are rarely researcher in this field because of non-effectiveness of magnetic abrasive. Therefore, in this paper we deals with the development of the magnetic abrasive with the use of Sr-Ferrite. In this development, abrasive grain SiC has been made by using the resin bond fabricated at low temperature. And magnetic abrasive powder was fabricated from the Sr-Ferrite which was crushed into 200 mesh. The XRD analysis result shows that only SiC abrasive and Sr-Ferrite crystal peaks were detected, explaining that resin bond was not any more to contribute chemical reaction. From MACRO analysis, we found that SiC abrasive and Sr-Ferrite were strongly bonding with each other.

• Proceedings of the Korean Vacuum Society Conference
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• 2003.08a
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• pp.79-79
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• 2003

• Proceedings of the KSEEG Conference
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• 2000.04a
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• pp.110-110
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• 2000

Temporal and spatial distribution patterns of the magmatic rocks and associated ore deposits in the Mesozoic magmatic - metallogenic belt along the Yangtz River, Anhui Province are used to determine and discuss the crust - mantle interaction processes. The magmatic rocks are Cu - Au mineralized high - K calc - alkalic intermediate ¬acidic (CAK) and Fe - Cu mineralized high - Na alkalic - calc intermediate - basic intrusive rocks (FCN) in the central part of the belt and grade to Cu - Mo - Pb - Zn - Ag mineralized calc - alkalic granitoids (CMG) and A - type granites (AG) in the southern and northern parts of the belt. Samples from the CAK and CMG yield Rb - Sr isochron ages of 137 - 140Ma with $(^{87}Sr/^{86}Sr)_{o}$ = 0.7060 - 0.7101, while those from the FCN and AG yield the ages of 120 - 129Ma with $(^{87}Sr/^{86}Sr)_{o}$ = 0.7047 - 0.7077. The Sr isotope ratios, CriTh ratios 0.4 - 3.1), Eu/Eu* ratios < 0.79 - 1.05) and initial epsilon (Nd) values (-16.6 - -6.3) for the CAK and CMG are consistent with magma derivation from old metamorphic basement rocks rich in metallogenic elements through a two - stage process of mantle - derived magma underplating caused by primary lithosphere extension and subsequent partial melting. On the basis of Sr isotope data, CriTh ratios (3.4 - 13.8), Eu/Eu* ratios (0.86 - 1.13) and initial epsilon (Nd) values (-7.7 - +1.4), the FCN and AG are considered to be formed through syntexis with material input from the mantle that resulted from further lithosphere extension followed by mantle - derived magma underplating on a large scale.

• Clinical and Experimental Pediatrics
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• v.51 no.3
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• pp.237-242
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• 2008

To investigate the trends in the survival rate (SR) for very low birth weight infants (VLBW) and extremely low birth weight infants (ELBWI) in Korea, a total of 43 articles pertaining to SR were analyzed, covering the years from 1967 to 2007. The changes in SR were compared using 5 year periods. The SR for VLBWI has increased remarkably, from 31.8% in early 1960 to 65.8% in early 1990 and 78.8% in early 2000. The SR for ELBWI has increased from 8.2% in early 1960 to 37.4% in early 1990 and 62.4% in early 2000. The SR has improved steeply since early 1990. When the SRs for VLBWI in Korea were compared with those in the U.S.A. and Japan, the figures were 40%, 72%, and 79% in 1985; 65.8%, 82%, and 86% in 1990; 71.3%, 86%, and 88% in 1995; 78.8%, 86%, and 89% in 2000, respectively. Although the recent SRs for VLBWI and ELBWI in Korea has improved rapidly, they have not yet reached the levels in these highly developed countries. To obtain accurate statistics that could be represented as an SR for premature infants in Korea, we have to develop a nationwide network database project.

• Journal of Radiation Protection and Research
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• v.29 no.3
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• pp.197-204
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• 2004

Vertical distributions of $^{137}Cs\;and\;^{90}Sr$ activities are studied for the soils of six areas, Korea (Gori, Yeonggwang, Uljin, Weolseong, Goseong and Jeju). The soils from 6 areas are at geographically different locations with the different environmental conditions and parent rook. The activities of $^{137}Cs\;and\;^{90}Sr$ vary N.D.(below detection limit) to 185 Bq/kg and 2.79 - 8.06 Bq/kg, respectively. Activities of $^{137}Cs\;and\;^{90}Sr$ show the highest value at the surface soil and decrease with depth. $^{137}Cs$ activities at the top surface soils are positively correlated with annual precipitation and organic carbon content with little relationship with mean grain size and the clay content. The highest $^{137}Cs$activities are found at the Jeju site, followed by the Goseong site of which soils have much different parent rock and textural properties. Though the activities of $^{137}Cs\;and\;^{90}Sr$ on the basis of dry weight are higher in Jeju soils than in Goseong soils, their inventories are similar in both soils due to their textural differences.