• Journal of Microbiology and Biotechnology
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• 제32권9호
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• pp.1168-1177
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• 2022

Parkinson's disease (PD) is the second-most prevalent neurodegenerative disease and is characterized by dopaminergic neuronal death in the midbrain. Recently, the association between alterations in PD pathology and the gut microbiota has been explored. Microbiota-targeted interventions have been suggested as a novel therapeutic approach for PD. Agathobaculum butyriciproducens SR79^T (SR79) is an anaerobic bacterium. Previously, we showed that SR79 treatment induced cognitive improvement and reduced Alzheimer's disease pathologies in a mouse model. In this study, we hypothesized that SR79 treatment may have beneficial effects on PD pathology. To investigate the therapeutic effects of SR79 on PD, 6-hydroxydopamine (6-OHDA)-induced mouse models were used. D-Amphetamine sulfate (d-AMPH)-induced behavioral rotations and dopaminergic cell death were analyzed in unilateral 6-OHDA-lesioned mice. Treatment with SR79 significantly decreased ipsilateral rotations induced by d-AMPH. Moreover, SR79 treatment markedly activated the AKT/GSK3β signaling pathway in the striatum. In addition, SR79 treatment affected the Nrf2/ARE signaling pathway and its downstream target genes in the striatum of 6-OHDA-lesioned mice. Our findings suggest a protective role of SR79 in 6-OHDA-induced toxicity by regulating the AKT/Nrf2/ARE signaling pathway and astrocyte activation. Thus, SR79 may be a potential microbe-based intervention and therapeutic strategy for PD.

• 한국세라믹학회:학술대회논문집
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• 한국세라믹학회 2004년도 추계총회 및 연구발표회 초록집
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• pp.79.2-79.2
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• 2004

• 한국자기학회:학술대회 개요집
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• 한국자기학회 1997년도 춘계연구발표회 논문개요집
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• pp.78-79
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• 1997

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2000년도 춘계연구발표회 논문개요집
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• pp.78-79
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• 2000

• Journal of Radiation Protection and Research
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• 제19권3호
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• pp.199-208
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• 1994

한국 환경을 고려하여 개발된 동적 섭식경로 모델을 이용하여 한국인이 섭취하는 음식물에 대한 유도개입준위를 산정하였다. 섭식경로에 있어 중요한 피폭효과를 가지는 I-131은 유아의 갑상선에 대한 예탁선량당량에 대해, Cs-137과 Sr-90은 전신에 대한 예탁선량당량에 근거한 선량개입준위로부터 연령군별로 13개 음식물에 대해 유도개입준위를 산정하였다. 성인은 Cs-137과 Sr-90의 음식물에 대한 유도개입준위 산정에 있어 가장 중요한 연령 군으로 평가되었다. 성인의 경우 쌀에서 Cs-137과 Sr-90의 유도개입준위는 여름철 침적의 경우 각각 2390, 47 Bq/kg, 겨울철 침적의 경우 각각 198, 79 Bq/kg으로 침적시점과 핵종에 따라 매우 다른 값의 변화를 보여주었다.

• 동굴
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• 제79호
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• pp.77-81
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• 2007

In this paper deals with behavior of the magnetic abrasive using Sr-Ferrite on polishing charateristiccs in a internal finishing of staninless steel pipe a tying magnetic abrasive polishing. The magnetic polishing is the useful method to finish some machinery fabrications by using magnetic power. This method is one of the precision techniques and has in aim for clean technology in the transportation of the pure gas in the clean pipes. The magnetic abrasive polishing method is not so common in the field of machine that it is not known to widely. There are rarely researcher in this field because of non-effectiveness of magnetic abrasive. Therefore, in this paper we deals with the development of the magnetic abrasive with the use of Sr-Ferrite. In this development, abrasive grain SiC has been made by using the resin bond fabricated at low temperature. And magnetic abrasive powder was fabricated from the Sr-Ferrite which was crushed into 200 mesh. The XRD analysis result shows that only SiC abrasive and Sr-Ferrite crystal peaks were detected, explaining that resin bond was not any more to contribute chemical reaction. From MACRO analysis, we found that SiC abrasive and Sr-Ferrite were strongly bonding with each other.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2003년도 제25회 학술발표회 초록집
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• pp.79-79
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• 2003

• 대한자원환경지질학회:학술대회논문집
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• 대한자원환경지질학회 2000년도 춘계 공동학술발표회
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• pp.110-110
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• 2000

Temporal and spatial distribution patterns of the magmatic rocks and associated ore deposits in the Mesozoic magmatic - metallogenic belt along the Yangtz River, Anhui Province are used to determine and discuss the crust - mantle interaction processes. The magmatic rocks are Cu - Au mineralized high - K calc - alkalic intermediate ¬acidic (CAK) and Fe - Cu mineralized high - Na alkalic - calc intermediate - basic intrusive rocks (FCN) in the central part of the belt and grade to Cu - Mo - Pb - Zn - Ag mineralized calc - alkalic granitoids (CMG) and A - type granites (AG) in the southern and northern parts of the belt. Samples from the CAK and CMG yield Rb - Sr isochron ages of 137 - 140Ma with $(^{87}Sr/^{86}Sr)_{o}$ = 0.7060 - 0.7101, while those from the FCN and AG yield the ages of 120 - 129Ma with $(^{87}Sr/^{86}Sr)_{o}$ = 0.7047 - 0.7077. The Sr isotope ratios, CriTh ratios 0.4 - 3.1), Eu/Eu* ratios < 0.79 - 1.05) and initial epsilon (Nd) values (-16.6 - -6.3) for the CAK and CMG are consistent with magma derivation from old metamorphic basement rocks rich in metallogenic elements through a two - stage process of mantle - derived magma underplating caused by primary lithosphere extension and subsequent partial melting. On the basis of Sr isotope data, CriTh ratios (3.4 - 13.8), Eu/Eu* ratios (0.86 - 1.13) and initial epsilon (Nd) values (-7.7 - +1.4), the FCN and AG are considered to be formed through syntexis with material input from the mantle that resulted from further lithosphere extension followed by mantle - derived magma underplating on a large scale.

• Clinical and Experimental Pediatrics
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• 제51권3호
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• pp.237-242
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• 2008

To investigate the trends in the survival rate (SR) for very low birth weight infants (VLBW) and extremely low birth weight infants (ELBWI) in Korea, a total of 43 articles pertaining to SR were analyzed, covering the years from 1967 to 2007. The changes in SR were compared using 5 year periods. The SR for VLBWI has increased remarkably, from 31.8% in early 1960 to 65.8% in early 1990 and 78.8% in early 2000. The SR for ELBWI has increased from 8.2% in early 1960 to 37.4% in early 1990 and 62.4% in early 2000. The SR has improved steeply since early 1990. When the SRs for VLBWI in Korea were compared with those in the U.S.A. and Japan, the figures were 40%, 72%, and 79% in 1985; 65.8%, 82%, and 86% in 1990; 71.3%, 86%, and 88% in 1995; 78.8%, 86%, and 89% in 2000, respectively. Although the recent SRs for VLBWI and ELBWI in Korea has improved rapidly, they have not yet reached the levels in these highly developed countries. To obtain accurate statistics that could be represented as an SR for premature infants in Korea, we have to develop a nationwide network database project.

• Journal of Radiation Protection and Research
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• 제29권3호
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• pp.197-204
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• 2004

고리, 영광, 울진, 월성, 고성 및 제주의 6개 지역 토양에 대해 $^{137}Cs$ 방사능 분석을 실시하였으며 그 중 고성 및 제주 지역 토양에 대해 $^{90}Sr$ 분석을 실시하였다. 각 지역은 지리적 위치, 환경조건 및 생성 모암이 각기 다른 특징을 갖고 있으며 $^{137}Cs$ 농도는 불검출 ${\sim}$ 185 Bq/kg의 범위를 보였으며 $^{90}Sr$은 2.79 - 8.n Bq/kg의 농도 범위를 보였다. $^{137}Cs$ 및 $^{90}Sr$ 농도는 지역별로 다소의 차이는 있으나 표층에서 가장 높고 깊이가 증가함에 따라 감소하였다. 지역별 $^{137}Cs$ 농도분포는 강수량, 유기물함량 등의 요인과 양의 상관관계를 보였고 토양의 입도 및 점토함량과는 관련성을 보이지 않았다. 지역별로는 제주지역 토양의 $^{137}Cs$ 농도가 가장 높고 그 다음은 고성지역이었다. 제주지역의 $^{137}Cs$ 농도는 고성에 비해 2배 가량 높았으나, 토성의 차이로 인해 현존량은 두 지역이 비슷한 값을 보였다.