• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.196-196
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• 2012

Graphene, two-dimensional one-atom-thick planar sheet of carbon atoms densely packed in a honeycomb crystal lattice, has grabbled appreciable attention due to its extraordinary mechanical, thermal, electrical, and optical properties. Based on the graphene's high carrier mobility, high frequency graphene field effect transistors have been developed. Graphene is useful for photonic components as well as for the applications in electronic devices. Graphene's unique optical properties allowed us to develop ultra wide-bandwidth optical modulator, photo-detector, and broadband polarizer. Graphene can support SPP-like surface wave because it is considered as a two-dimensional metal-like systems. The SPPs are associated with the coupling between collective oscillation of free electrons in the metal and electromagnetic waves. The charged free carriers in the graphene contribute to support the surface waves at the graphene-dielectric interface by coupling to the electromagnetic wave. In addition, graphene can control the surface waves because its charge carrier density is tunable by means of a chemical doping method, varying the Fermi level by applying gate bias voltage, and/or applying magnetic field. As an extended application of graphene in photonics, we investigated the characteristics of the graphene-based plasmonic waveguide for optical signal transmission. The graphene strips embedded in a dielectric are served as a high-frequency optical signal guiding medium. The TM polarization wave is transmitted 6 mm-long graphene waveguide with the averaged extinction ratio of 19 dB at the telecom wavelength of $1.31{\mu}m$. 2.5 Gbps data transmission was successfully accomplished with the graphene waveguide. Based on these experimental results, we concluded that the graphene-based plasmonic waveguide can be exploited further for development of next-generation integrated photonic circuits on a chip.

• 폴리머
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• 제37권1호
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• pp.94-99
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• 2013

폴리디아세틸렌(polydiacetylene, PDA)은 자기조립된 디아세틸렌(diacetylene) 단량체의 광중합에 의해 만들어진다. 디아세틸렌 단량체들이 조직적으로 배열되면 254 nm의 자외선 노광에 의해 1,4-첨가 중합이 일어나 고분자 주사슬에 이중결합과 삼중결합이 교대로 존재하는 폴리디아세틸렌이 만들어진다. 폴리디아세틸렌 수용액은 일반적으로 약 640 nm에서 최대흡수파장을 지니는 청색을 띠게 되며 여기에 온도나 pH의 변화, 다른 물질의 결합 등 외부 자극에 의해 약 550 nm의 최대 흡수 파장을 띠는 적색으로 색 전이가 일어나게 된다. 본 연구에서, 우리는 고체상 펩티드 합성을 이용하여 PCDA(10,12-pentacosadyinoic acid) 리포좀의 표면에 양이온성 올리고펩티드를 도입하였다. 또한 다양한 몰 비율로 리포좀 수용액을 제조하여 동물 세포에 트랜스펙션한 결과, 향상된 유전자 전달 효율과 낮은 독성을 보이는 것을 확인하였고, PCDA의 특성을 이용하여 세포에 처리 후 세포 관련 비표지 형광을 관찰하였다.

• 여성건강간호학회지
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• 제2권1호
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• pp.5-24
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• 1996

The Delivery Process can be viewed as one of the developmental crisis that forces the majority of women. During the labor and delivery process the women may face a variety of problems and pain with all its subjectivity. This developmental crisis may lead a pregnant women to have a negative experience in delivery. For nurses, to help to pregnant women check with the crisis and perceived support and to positive experience. This study intended to analyze the pregnant women's delivery experience according to supporter during labor. The subjects for this study were 45 pregnant women who had normal delivery without complications, within 37 to 42 weeks of pregnancy. Data Collection was done from April 24th to May 20th 1995 by two instruments, a support measurement scale and a delivery experience measurement scale which were consisted it 18-items scale developed by researcher. The data was analyzed by SPPS program using descriptive statistic Kruskal-Wallis one way analysis and Spearman Correlation Coefficient. The result of this study are as follows. 1. Support distribution by support contents is shown is order of holding the hands (97.8%), help to urination(86.7%), bed arrangement(57.8%), massaging the arms and legs(55.6%), changes in posture(44.4%), teaching how to produce power(44.4%), while emotional support is disclosed in order of sympathy(97.8%), encouragement(82.2%), hearing the needs(60.0%), However, information support was as low as less than 33.3%. 2. The extent of delivery experience a Pregnant woman perceives is revealed in order of a sense of comfortableness(44%), satisfaction(43.2%), reduction of fear(43.2%), familiarity (42.8%), self-confidence (42.5%), decrease of laborpain(39.9%). 3. The extent of delivery support a pregnant woman perceives reveals that physical support($x^2$=22.4452, P=.000) and information support($x^2$=7.5187, P=.0233) Show a significant difference among the mothers group, the mothers-in-law group, the husbands group, but to significant difference was found in emotional support among them. 4. The extent of delivery experience a pregnant woman perceives represents a significant difference in order of the mothers group, the mothers in-law group, and the husbands group($x^2$=13.4255, P=.0012). 5. A positive correlation was manifested between the extent of support and delivery experience a pregnant woman perceives(r=.8643, P=.000). This information can be utilized as data to further the understanding delivery experience according to supporter. In Consequence, it is recommended that the range of family support limited to husband should be expended including mother and mother-in-law.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1001-1006
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• 2015

Background: With development and application of new and effective anti-cancer drugs, the median survival post-progression (SPP) is often prolonged, and the role of the median SPP on surrogacy performance should be considered. To evaluate the impact of the median SPP on the correlation between progression-free survival (PFS) and overall survival (OS), we performed simulations for treatment of four types of cancer, advanced gastric cancer (AGC), metastatic colorectal cancer (MCC), glioblastoma (GBM), and advanced non-small-cell lung cancer (ANSCLC). Materials and Methods: The effects of the median SPP on the statistical properties of OS and the correlation between PFS and OS were assessed. Further, comparisons were made between the surrogacy performance based on real data from meta-analyses and simulation results with similar scenarios. Results: The probability of a significant gain in OS and HR for OS was decreased by an increase of the SPP/OS ratio or by a decrease of observed treatment benefit for PFS. Similarly, for each of the four types of cancer, the correlation between PFS and OS was reduced as the median SPP increased from 2 to 12 months. Except for ANSCLC, for which the median SPP was equal to the true value, the simulated correlation between PFS and OS was consistent with the values derived from meta-analyses for the other three kinds of cancer. Further, for these three types of cancer, when the median SPP was controlled at a designated level (i.e., < 4 months for AGC, < 12 months for MCC, and <6 months for GBM), the correlation between PFS and OS was strong; and the power of OS reached 34.9% at the minimum. Conclusions: PFS is an acceptable surrogate endpoint for OS under the condition of controlling SPPs for AGC, MCC, and GBM at their limit levels; a similar conclusion cannot be made for ANSCLC.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 2001년도 Proceedings of 2001 International Symposium
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• pp.149-153
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• 2001

To investigate the mode of bactericidal action for antimicrobial peptide, pediocin, synthetic and mutant pediocins were prepared by direct chemical synthesis. Native pediocin was purified from Pedio-coccus acidilactici M and its conformational structure and bactericidal functions were analyzed and compared to synthetic pediocin. Schematic mode of pediocin actions, how pediocin binds on the target cell membrane, penetrates and makes tunnel are proposed. For these purposes, primary and secondary structures of pediocin was analyzed and disulfide bond assignment was also done. The pediocin purified from P. acidilactici M had high effective bactericidal ability against gram positive bacteria, especially Listeria monocytogenes and was very stable at extreme pHs and even at high temperatures such as autoclaving temperature (121$^{\circ}C$). Pediocin was consisted of 44 amino acids with four cysteines. Novel synthetic peptides were achieved by solid phase peptide synthesis(SPPS) method. To explain the function of cysteine in C-terminal region, mutant pediocin, Ped[C24A＋C44A], was synthesized and their structural and biological functions were analyzed. Second mutant pediocin, Ped[KllE], was prepared to explain the function of lysine at 11 of N-terminal part of pediocin, especially loop of $\beta$-sheet, and to predict the initial binding site of pediocin. The native and synthetic pediocins was showed random coil conformation by spectropolarimetry in moderate conditions. This conformation was observed in extreme conditions such as high temperature and low and high pHs, also. Circular dichroism(CD) data also showed the existence of $\beta$-turn structure in N-terminal part both native and synthetic pediocins. A structural model for pediocin predicts that 18 amino acids in the N-terminal part of the peptide assume a three-strand $\beta$-sheet conformation. This random coil in C-terminal part of pediocin was converted to folding structure, helix structure, in nonpolar solvents such as alcohol and TFE. The disulfide bond between $^{9}$ Cys and $^{14}$ Cys was concrete and inevitable, however, evidences of disulfide bond between $^{24}$ Cys and $^{44}$ Cys was not. Data of Ped[C24A＋C44A], pediocin mutant showed that $^{44}$ Cys was required during killing the target cells but not inevitable, since Ped[C24A＋C44A] still have bactericidal activity but much less than native pediocin. Another pediocin mutant, Ped[KllE], had still bactericidal activity, was controversial to propose that positive charge like as $^{11}$ Lys in loop or hinge in bacteriocin bound or helped to binding to microorganism with electrostatic interaction between cell membrane especially teichoic acid and positive amino acid nonspecifically. The conformation of pediocin among native, synthetic and mutant pediocins did not show big difference. The conformations between oxidized and reduced pediocin were almost similar regardless of native or synthetic.

• 한국화재소방학회논문지
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• 제31권2호
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• pp.106-112
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• 2017

본 연구는 소방공무원의 직무스트레스와 자아탄력성과의 관계에서 소진이 매개역할을 하는지에 대해 알아보고, 이를 통해 소방공무원의 자아탄력성 증진을 위한 정책대안을 마련하는데 목적으로 경기도 북부지역 현직 소방공무원 365명을 대상으로 설문조사를 실시하여 SPSS 22.0를 통해 상관관계분석 및 회귀분석을 실시하였다. 연구문제는 '소방공무원의 소진과 자아탄력성은 유의한 상관관계를 보일 것이다.'와 '소방공무원의 직무스트레스가 자아탄력성에 미치는 영향에서 소진은 유의미한 효과가 있을 것이다.' 이다. 연구 결과, 직무스트레스 하위요인 중 직무 불안정성과 보상 부적절성 요인이 고갈, 냉소, 직업 효능감 등의 소진척도에 영향을 주고, 이는 긍정적인 미래지향성, 감정조절, 흥미와 관심 등을 나타내는 자아탄력성을 낮추게 하는 것으로 나타났다. 이에 따른 정책적 함의는 먼저, 소방공무원의 직무수행상 안정성에 대한 확신이 주어져야 한다는 점, 업무성과에 대한 사회적 경제적 적절한 보상이 이루어져야 한다는 점, 소방공무원의 정서적 신체적 피로감과 긴장감 해소를 위한 내실 있는 지원 대책이 필요한 것으로 나타났다.

• 한국학교ㆍ지역보건교육학회지
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• 제4권
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• pp.1-20
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• 2003

This study was not intended to analyze out the realities of the safety accidents in school. The purpose of this study was to find out the personality of elementary school students in 6th grade and analyze the relationship between the personality of elementary school students and the safety accidents in the school. We made a visit 12 elementary school personally in the B city of Gyeonggi Province and gave out 552 questionaries in order to accomplish the purpose of this study. And we analyzed the 501 answer data except the unfittable data 51 sheets-in case of no answer or untruthfulness. The inspection of the personality used the Eysenck Personality Questionnaire(EPQ) and the questionnaires of the safety accidents in the school were reorganized of the questionnaires which were used in Chun-Ok, Joen(1997) and One-Yong, Kim(1999)'s study to correspond with our purpose of study. Answer sheets were gone through the t and x2 test by using the program of SPPS. First, elementary school students are in the formative period in the life of a man. So many students's personality was in the middle group rather than in high and low group. In regard of the distintion between the boy students and the girl students, the boy students had higher score in Psychoticism(P) but the girl students had higher score in Neutroticism(N). And Lie(L) was showing a little more score in the girl students. Second, there was significant difference in the investigation of safety accidents in school according to sex distinction. 1) Comparing the boy students and the girl students, the rate of accidents was higher in boy rather than girl. And there was significant difference. 2) Comparing the grade of the school, the rate of accidents was higher in upper grade than lower grade both girls and boys. 3) In the kind of accidents, the traumatic Injuries were very popular and the next were contusions. There was significant difference in the traumatic injury and nosebleed. 4) The results of injured parts showed that the injuries of foot, leg, hand, arm hold a large majority. And there was a significant difference in head, face, foot, leg and etc. 5) Most accidents broke out during the break time and then accidents happened after school were the next. The flowings were lunch time and class time. There was a significant difference in accidents happened during the class, break time and lunch time. 6) Comparing the subjects, the most accidents broke out in the class of physics. 7) Among the cause of accidents, one's own carelessness was showing the highest rate. There was a significant distintion in the fight and game. 8) The safety accidents took place most in playground, and there was a significant difference. 9) Being slight wound was showing almost in the degrees of damage. And there was a significant difference. Third, the boy students were not showing the significant difference in relation to the personality, the frequency of accidents and the degrees of damage. But the girl students were showing the significant difference in relation to the Extraversion-Introversion(E) and the frequency of accidents. And there were a significant difference between E and N. Also they were showing the intense damages.

• 대한간호학회지
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• 제23권4호
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• pp.631-648
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• 1993

This study is a descriptive study to provide basic data related to types of uniforms worn by nurses. Nurses, other medical center personnel, patients and their famillies were asked for their opinion on changing nurses’ uniforms and how the image of nurses is 1 elated to the type of uniform worn by the nurses. The data for this study were collected during the period from Feb. 25, 1993 to Mar. 26, 1993 at Y-University Medical Center from 132 nurses, 137 other medical center personnel, 117 patients and their families. The instruments used for this study were the Nurses’ Image Scale(NIS) developed by Bown(1986), and an instrument to measure opinions of uniform and cap using photographs of nurses’ uniforms that was developed by the researcher through a literture review. Data were analyzed using the SPPS / PC package, Statistics used for analysis were frequencies, percentages, paired t -test, and oneway ANOVA The results of this study are summarized as follows ; 1. Of the nurses, 84.3%, along with, 51.5% of the medical center personnel, 39.1% of the patients and their families agreed to a change in the color of nurses uniforms. 2. Similarly, 87.4% of the nurses,27.7% of the medical center personnel, 19.3% of the patients and their families were in favor of nurses not wearing caps. 3. Only 11.8% of nurses answered that a white uniform was important to the professional image of nursing. Only 2.4% of the nurses answered that a cap was very important to the professional image of nursing. 4. Only 1.6% of the nurses answered that a white uniform and cap were important to show the role of nurses in the twenty first century. 5. About 1/3, 36.5%, of the medical center personnel, the patient and their families answered that changing the color of the nurses' uniform will make a change in the image of nurses. 6. A White uniform and cap were seen as being im-portant in distinguishing nurses from other medical personnel in the hospital by 76.5% of the medical personnel, the patients and their families. 7. Nurses gave high marks to the idea of no cap regardless of the color of the uniform which would still portray the symbol of the nurses’ role, identity and would differentiate the role from other jobs. The patients and their families gave high marks to a white uniform with cap. 8. Generally, nurses, medical center personnel and patients and their families thought that a colored uniform with cap presented a good image of nurses. 9. There was a significant difference in the response among the three groups(F=24.65, P〈.001) to the figure in a white uniform with a cap, and the patients and their families thought it was the best portrayal of the image of nurses. There was a significant difference among the three groups(F=9.03, P〈.001) to the figure in a white uniform with no cap and the nurses indicated that it was the beat portrayed of the image of nurses. There was no significant difference among the three groups to the figure in a colored uniform with cap. There was a significant difference(F=17.50, P〈. 001) to the figure in a colored uniform with no cap, and the nurses indicated that it was the best portrayal of the image of nurses. In summary, the nurses wanted to change the color of uniform and not to wear a cap. But many of the medical center personnel, patients and their families indicated they did not agree with this idea. Therefore, changing the type of uniform worn by nurses should be done only after consideration has been given to the relation of the change to the professional role of nurses and the image of nurses held people in general. Suggestions arising from this study are as follows : 1. The relation between the role of nurses and their uniform was surveyed, and these results can be used as data when considering a change in uniforms. 2. A change in uniforms should be tried based on the norm established about uniforms. 3. The nurses did not want to wear a cap, but before a decision is definitely made it is necessary to study the philosophy related to the symbol of the cap because the figure of a nurse with a cap portrayed a positive image of the nurses. If the cap is kept, the symbol of the cap should be redefined. 4. In this study, only the image related to the uniform was examined, but in future studies it will be necessary to examine the practicality of various types of uniforms.

• 한국식품저장유통학회지
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• 제23권5호
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• pp.718-726
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• 2016

단호박 분말을 이용하여 식물성 젖산균의 발효 최적화를 통한 점질물 dextran, 만니톨을 생산함으로서 물성과 맛이 개선된 푸딩형태의 단호박 젖산 발효물을 제조하였다. 단호박 농도에 따라서 젖산 발효물에 영향을 주었으며, 단호박 분말 15% 조건이 가장 양호한 물리화학적 특성을 보였다. $25^{\circ}C$에서 3일 동안 발효를 수행하였을 때 15% 단호박 분말의 젖산 발효물의 pH, 산도는 각각 3.85, 1.30%이었으며, 생균수는 $4.64{\times}10^9CFU/mL$로 높은 값을 나타내었다. 단호박 분말 paste의 발효 초기에 L값 25.02, a값 4.66, b값 13.35를 나타내었으며, 발효가 진행되면서 L값을 제외하고 감소하는 경향을 보였다. 10%, 15% 단호박 분말의 발효물은 발효 1일에 설탕의 소진율 100%를 보였으며, 발효 3일에 불용성 dextran을 각각 5.6%, 8.9%를 보였으며, 수용성 dextran은 4.5% 수준으로 유사하였다. 15% 단호박 분말의 3일 후에 발효물에 과당과 만니톨 함량은 각각 1.76%, 3.11%를 나타내었다. 15% 단호박 젖산 발효물의 점조도는 초기 $48.6Pa{\cdot}s^n$로서 가장 높은 값을 보였으며, 발효 1일 $75.1Pa{\cdot}s^n$에로 증가하였으며, 발효 3일에는 $188.8Pa{\cdot}s^n$으로 크게 증가하면서 푸딩 형태의 물성을 나타내었다. 단호박 젖산 발효물의 관능평가를 통해서 15% 단호박 젖산 발효물이 색, 단맛, 조직감에서 높은 점수로 평가되었다. 결론적으로 15% 단호박 분말과 20% 설탕혼합액을 이용하여 3일 동안 젖산 발효시킴으로서 설탕은 100% 전환되었으며, protiotic 생균 $4.6{\times}10^9CFU/mL$을 포함한 만니톨, 점질물 dextran의 생성을 통해서 기능성, 맛과 조직감이 강화된 푸딩형태의 단호박 젖산발효제품을 개발할 수 있었다.