• Annual Conference on Human and Language Technology
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• 2006.10e
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• pp.183-188
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• 2006

본 논문에서 위치 정보 데이터란 텔레메틱스 분야의 응용을 위하여 웹상에서 수집한 Point-of-Interest (POI) 데이터로서 행정구역 및 지명 인명, 상호명과 같은 위치 검색에 사용되는 어휘로 구성된다. 본 논문은 음성 인식 시스템을 구성하는 발음 사전의 개발에 관한 것으로 250k 위치 정보데이터로부터 운율어를 이용하여 불규칙 발음과 발음 변이를 포함하는 가능한 모든 발음을 생성하는 방법을 제안하는 것을 목적으로 한다. 원래 모든 POI 는 한 번씩만 데이터에 포함되어 있으므로, 그 가운데 불규칙 발음을 포함하는 POI를 검출하거나 발음을 생성하기 위해서는 각각의 POI 하나하나를 일일이 검토하는 방법밖에 없는데, 대부분의 POI 가 복합명사구로 이루어졌다는 점에 착안하여 운율어를 이용한 결과, 불규칙 발음 검출과 다중 발음 생성을 효율적으로 수행할 수 있었다. 이러한 연구는 음성처리 영역에서는 위치정보데이터의 음성인식 성능을 향상하는 데 직접적인 기여를 할 수 있고, 무엇보다도 음성학과 음운론 이론을 음성 인식 분야에 접목한 학제적 연구로서 그 의미가 있다고 할 수 있다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.63-68
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• 2005

The nanoindentation technique is widely used to investigate the mechanical properties of nano-microscale materials. The nanoindentation method for assessing mechanical properties at low loads and shallow depths is already well established fur the characterization of thin films as well as bulk materials. In this study, we evaluated residual stress in DLC and Au thin films usign nanoindentation technique with a new stress-relaxation model. Moreover, We suggest a composite hardness equation and quantify the magnitude of hardness increase by using an equation based on the interface hardness and the interface thickness, derived by comparing results derived from this equation and those determined in nanoindentation tests. Finally, We present an indentation size effect (ISE) model that extends the available contact depth for ISE application down to several tens of nanometers by considering the tip bluntness effect.

• Journal of Positioning, Navigation, and Timing
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• v.7 no.4
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• pp.277-284
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• 2018

The Satellite-based Augmentation System (SBAS), as a safety critical system, should be verified on an ongoing basis to ensure the adequate performance. This study proposes two methods to evaluate the performance of SBAS satellite correction. Analysis methods based on precise ephemeris and measurement were applied to present an evaluation method for SBAS satellite correction, and a test was performed based on real data. The precise ephemeris-based analysis method had no limitations on the position of the test user and showed a high precision, enabling an accurate performance analysis in various positions. Although the measurement-based analysis method has the advantage of fast data interval, it showed a relatively lower accuracy due to the effects of various error factors. Compared with the precise ephemeris-based analysis method, there was a large difference of more than 5 m at the beginning of smoothing filter, and a difference less than 50 cm when filtered for more than an hour.

• Journal of Positioning, Navigation, and Timing
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• v.8 no.2
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• pp.59-68
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• 2019

This paper proposed a method to estimate the vertical delay from the slant delay, which can improve accuracy of the ionospheric correction of SBAS. Proposed method used Chapman profile which is a model for the vertical electron density distribution of the ionosphere. In the proposed method, we assumed that parameters of Chapman profile are given and the vertical ionospheric can be modeled with linear function. We also divided ionosphere into multi-layer. For the verification, we converted slant ionospheric delays to vertical ionospheric delays by using the proposed method and generated the ionospheric correction of SBAS with vertical delays. We used International Reference Ionosphere (IRI) model for the simulation to verification. As a result, the accuracy of ionospheric correction from proposed method has been improved for 17.3% in daytime, 10.2% in evening, 2.1% in nighttime, compared with correction from thin shell model. Finally, we verified the method in the SBAS user domain, by comparing slant ionospheric delays of users. Using the proposed method, root mean square value of slant delay error decreased for 23.6% and max error value decreased for 27.2%.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.80.1-80.1
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• 2021

Intensive Monitoring Survey of Nearby Galaxies (IMSNG) is a program monitoring nearby galaxies with a high cadence within a day. The main goal of the project is to constrain the SNe explosion mechanism and properties of their progenitors by catching the early lights from the shock-heated cooling emission. The observation campaign began in 2014 with two 1-m class telescopes in the northern hemisphere. Now more than ten telescopes are monitoring galaxies with 60 IMSNG targets, which have a high probability of supernova explosion every night all around the world. Since the project started, the following observations have been carried out on 14 SNe Ia(including -pec), 27 core-collapse supernovae (CCSNe), and around 40 transients in other types. In this poster, we present the current status of IMSNG SNe data first and then focus more on the CCSNe. CCSNe are the explosion of massive stars, more massive than eight times of the Sun. They have been studied for more than a half decades but still have key questions to be solved, such as distinct types, the characteristics driving their diversity, and so on. Here, we show our ongoing studies of CCSNe in IMSNG, focusing on their usefulness as distance indicators and properties of early light curves.

• Biomolecules & Therapeutics
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• v.26 no.6
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• pp.591-598
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• 2018

Epigenetic silencing is considered to be a major mechanism for loss of activity in tumor suppressors. Reversal of epigenetic silencing by using inhibitors of DNA methyltransferase (DNMT) or histone deacetylases (HDACs) such as 5-Aza-CdR and FK228 has shown to enhance cytotoxic activities of several anticancer agents. This study aims to assess the combinatorial effects of genesilencing reversal agents (5-Aza-CdR and FK228) and oxaliplatin in gastric cancer cells, i.e., Epstein-Barr virus (EBV)-negative SNU-638 and EBV-positive SNU-719 cells. The doublet combinatorial treatment of 5-Aza-CdR and FK228 exhibited synergistic effects in both cell lines, and this was further corroborated by Zta expression induction in SNU-719 cells. Three drug combinations as 5-Aza-CdR/FK228 followed by oxaliplatin, however, resulted in antagonistic effects in both cell lines. Simultaneous treatment with FK228 and oxaliplatin induced synergistic and additive effects in SNU-638 and SNU-719 cells, respectively. Three drug combinations as 5-Aza-CdR prior to FK228/oxaliplatin, however, again resulted in antagonistic effects in both cell lines. This work demonstrated that efficacy of doublet synergistic combination using DNMT or HDACs inhibitors can be compromised by adding the third drug in pre- or post-treatment approach in gastric cancer cells. This implies that the development of clinical trial protocols for triplet combinations using gene-silencing reversal agents should be carefully evaluated in light of their potential antagonistic effects.

• Korean Journal of Veterinary Research
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• v.52 no.4
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• pp.223-230
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• 2012

The worldwide distribution and continuing genetic mutation of avian influenza virus (AIV) has been posed a great threat to human and animal health. A comparison of 3 isolates of AIV H9N2, A/chicken/Korea/KBNP-0028/00 (H9N2) (KBNP-0028), A/chicken/Korea/SNU8011/08 (H9N2) (SNU 8011) and an inactivated oil vaccine strain A/chicken/Korea/01310/01 (H9N2) (01310), was performed. The former 2 AIVs were isolated from field cases before and after the application of an inactivated H9N2 vaccine in 2007, respectively. The antigenic relationship, viral shedding, tissue tropism and genetic analysis were examined. The comparison of virus shedding from the cloaca and the oropharynx revealed that both isolates were more frequently isolated from the upper respiratory tract (90~100%) 1 day post inoculation (DPI) compared with isolation 5 DPI from gastrointestinal tracts (10~60%). Moreover, the isolate KBNP-0028 were recovered from all organs including bone marrow, brain and kidneys, indicating higher ability for broad tissue dissemination than that of SNU 8011. KBNP-0028 replicated earlier than other strains and with a higher titer than SNU 8011. In full-length nucleotide sequences of the NA gene and a partial sequence of the HA gene of SNU 8011, we found that there might be significant changes in tissue tropism, virus replication and genetic mutation in AIV H9N2 isolates.

• Journal of Pharmacopuncture
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• v.15 no.3
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• pp.19-30
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• 2012

Objectives: Many efforts have shown multi-oncologic roles of galectin-3 for cell proliferation, angiogenesis, and apoptosis. However, the mechanisms by which galectin-3 is involved in cell proliferation are not yet fully understood, especially in human colon cancer cells. Methods: To cluster genes showing positively or negatively correlated expression with galectin-3, we employed human colon cancer cell lines, SNU-61, SNU-81, SNU-769B, SNU-C4 and SNU-C5 in high-throughput gene expression profiling. Gene and protein expression levels were determined by using real-time quantitative polymerase chain reaction (PCR) and western blot analysis, respectively. The proliferation rate of human colon cancer cells was measured by using a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results: Expression of ${\gamma}$-aminobutyric acid B receptor 1 (GABABR1) showed a positive correlation with galectin-3 at both the transcriptional and the translational levels. Down-regulation of galectin-3 decreased not only GABABR1 expression but also the proliferation rate of human colon cancer cells. However, Korean herbal extract, HangAmDan-B (HAD-B), decreased expression of GABABR1 without any expressional change of galectin-3, and offset ${\gamma}$-aminobutyric acid (GABA)-enhanced human colon cancer cell proliferation. Conclusions: Our present study confirmed that GABABR1 expression was regulated by galectin-3. HAD-B induced galectin-3-independent down-regulation of GABABR1, which resulted in a decreased proliferation of human colon cancer cells. The therapeutic effect of HAD-B for the treatment of human colon cancer needs to be further validated.

• Archives of Pharmacal Research
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• v.27 no.9
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• pp.893-900
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• 2004

2- or 6-Substituted BZT-N derivatives were synthesized, and their cytotoxic activity against can-cer L1210 and SNU-1 cells was examined. The antitumor action was also assessed in mice bearing S-180 cells in peritoneal cavity. In a comparison, it was found that 6-substituted BZT-N derivatives exhibited higher potencies in both bioactivities than 2-substituted BZT-N derivatives against L1210 cells in in vitro and S-180 in vitro tests exception of compound 36. Interestingly, it was observed that 2-substituted compound 36, which has methyl group at RI position, exhib-ited a better antitumor activity than 6-substituted compounds against L1210 and SNU-1 in vitro. The EDso value of 2-substituted compound 36 against L1210 was found to be comparable to the EDso value of adriamycin and was even better against the solid cancer cell line SNU-1. It was also observed that 2-substituted compound 36 showed better antitumor activity in mice bearing S-180 cells in the peritoneal cavity. The T/C (％) value of 2-substituted compound 36 was simi-lar to that of adriamycin. Quantitative structure-activity relationship (QSAR) tests reveal that the experimental E $D_{50}$ values against SNU-1 closely correlate with both the calculated HOMO ener-gies ( $E_{HOMO}$) and the measured H-NMR chemical shift of 3-H ($\delta$$_{H}$). The results suggests that a compound having higher $E_{HOMO}$ and $\delta$$_{H}$ values usually should have a lower E $D_{50}$ (SNU-1) value.lue.lue.lue.

• Journal of Chest Surgery
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• v.49 no.2
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• pp.73-79
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• 2016

Background: The aim of this study was to report our early experiences with the endovascular repair of ruptured descending thoracic aortic aneurysms (rDTAAs), which are a rare and life-threatening condition. Methods: Among 42 patients who underwent thoracic endovascular aortic repair (TEVAR) between October 2010 and September 2015, five patients (11.9%) suffered an rDTAA. Results: The mean age was $72.4{\pm}5.1years$, and all patients were male. Hemoptysis and hemothorax were present in three (60%) and two (40%) patients, respectively. Hypovolemic shock was noted in three patients who underwent emergency operations. A hybrid operation was performed in three patients. The mean operative time was $269.8{\pm}72.3minutes$. The mean total length of aortic coverage was $186.0{\pm}49.2mm$. No 30-day mortality occurred. Stroke, delirium, and atrial fibrillation were observed in one patient each. Paraplegia did not occur. Endoleak was found in two patients (40%), one of whom underwent an early and successful reintervention. During the mean follow-up period of $16.8{\pm}14.8months$, two patients died; one cause of death was a persistent type 1 endoleak and the other cause was unknown. Conclusion: TEVAR for rDTAA was associated with favorable early mortality and morbidity outcomes. However, early reintervention should be considered if persistent endoleak occurs.