• Journal of the Korea Society of Computer and Information
• /
• v.15 no.7
• /
• pp.11-17
• /
• 2010

This paper proposes an improved SMO solving a quadratic optmization problem for class imbalanced learning. The SMO algorithm is aproporiate for solving the optimization problem of a support vector machine that assigns the different regularization values to the two classes, and the prosoposed SMO learning algorithm iterates the learning steps to find the current optimal solutions of only two Lagrange variables selected per class. The proposed algorithm is tested with the UCI benchmarking problems and compared to the experimental results of the SMO algorithm with the g-mean measure that considers class imbalanced distribution for gerneralization performance. In comparison to the SMO algorithm, the proposed algorithm is effective to improve the prediction rate of the minority class data and could shorthen the training time.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.8
• /
• pp.4001-4005
• /
• 2012

Backgrouds: The hedgehog (Hh) signaling pathway is composed of patched (PTCH) and smoothened (SMO), two transmembrane proteins, and downstream glioma-associated oncogene homolog (Gli) transcription factors. Hh signaling plays a pathological role in the occurrence and development of various cancers. Methods: To investigate the expression of SMO protein in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis, immunohistochemistry was performed with paraffin-embedded specimens of 96 cases. Relationships between SMO protein expression and clinicopathological parameters, postoperative liver metastasis were analyzed. Results: IHC examination showed that SMO protein expression was significantly increased in colon cancer tissues compared to normal colon tissues (P = 0.042), positively related to lymph node metastases (P = 0.018) and higher T stages (P = 0.026). Postoperative live metastasis-free survival was significantly longer in the low SMO expression group than in those with high SMO expression ($48.7{\pm}8.02$ months vs $28.0{\pm}6.86$ months, P=0.036). Multivariate analysis showed SMO expression level to be an independent prognostic factor for postoperative live metastasis-free survival (95% confidence interval [CI] =1.46-2.82, P = 0.008). Conclusions: Our results suggest that in patients with colon cancer, the SMO expression level is an independent biomarker for postoperative liver metastasis, and SMO might play an important role in colon cancer progression.

• KSBB Journal
• /
• v.24 no.3
• /
• pp.239-245
• /
• 2009

Enantiopure styrene oxide derivatives are versatile building blocks for the synthesis of enantiopure pharmaceuticals. Styrene monooxygenase (SMO) catalyzes an asymmetric addition of an oxygen atom into a double bond of vinylaromatic compounds. SMO is a commercially potential biocatalyst to synthesize a variety of enantiopure epoxides with high enantiopurity and recovery yield. In this paper development of SMO biocatalyst and commercial feasibility of SMO-catalyzed asymmetric synthesis of enantiopure stylers oxide derivatives are reviewed.

• Research in Plant Disease
• /
• v.25 no.4
• /
• pp.226-232
• /
• 2019

Among more than 30 viruses infecting strawberry, aphid-transmitted viruses including Strawberry mild yellow edge virus (SMYEV), Strawberry mottle virus (SMoV), Strawberry crinkle virus (SCV), and Strawberry vein banding virus (SVBV) have been considered as the most economically important viruses of strawberry in the world. To determine the incidence of these four viruses in major Korean strawberry cultivars, field surveys were conducted in major production areas during 2018-2019. In our surveys, SMYEV and SMoV were detected with low infection rates of 0.7% and 1.3%, respectively, whereas SCV and SVBV were not detected. No obvious symptoms were observed in the strawberry plants infected by SMYEV or SMoV. Since no sequences of SMoV Korean isolates have been reported, we initially determined nucleotide sequence of the 3' untranslated region (UTR) of seven SMoV isolates obtained during the surveys. The 3' UTR sequences (782 nt) of seven Korean isolates were phylogenetically compared with those of the previously reported SMoV isolates. Phylogenetic analysis revealed that most Korean isolates are closely related to Canadian isolates and only little evolutionary differentiation occurred among the Koreans isolates. This might be due to the low incidence of SMoV in strawberry in Korea.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.24 no.1
• /
• pp.33-39
• /
• 2019

We propose a mechanical parameter estimation algorithm for surface-mounted permanent magnet synchronous motors (SPMSMs) using a sliding-mode observer (SMO) and an adaptive filter. The SMO estimates system disturbances in real time, which contain the information on mechanical parameters. A desirable feature that distinguishes the proposed estimation algorithm from other existing mechanical parameter estimators is that the adaptive filter estimates electromagnetic torque to improve the estimation performance. Moreover, the SMO acts as a low-pass filter to suppress the chattering effect, which enables the smooth output signals of the SMO. We verify the mechanical parameter estimation performance for SPMSM by conducting extensive experiments for the proposed algorithm.

• Journal of Life Science
• /
• v.30 no.11
• /
• pp.973-982
• /
• 2020

In this study, we examined inhibition of adipocyte differentiation associated with the administration of camphor, a substance identified in extracts of the flowering plant Chrysanthemum indicum L. (CI). No camphor-mediated cytotoxicity was observed over a period of 1-10 days in studies targeting cells of the 3T3-L1 adipocyte-like line. Experiments that featured siRNA-mediated suppression of the transmembrane proteins Patched (PTCH) and Smoothened (SMO) resulted in inhibition and activation of differentiation, respectively. Interestingly, inhibition of PTCH typically activates SMO protein targeting and serves to activate hedgehog (HH)-mediated signaling. The results of our study suggest that activation of HH-mediated signaling can inhibit adipocyte differentiation. Furthermore, expression of glioma-associated oncogene homologue 1 (Gli1) was detected by flow cytometry in 62.7±1.5% of cells in response to administration of Lactobacillus rhamnosus (KCTC 3237) and in 60.4±2.2% of cells in response to camphor; these levels are higher than those detected in undifferentiated controls (24.9±3.1%). No change in the state of fermented camphor was identified by gas chromatography-mass spectrometry (GC-MS), but a 15.41% quantitative increase was confirmed in KCTC 3237. Overall, we conclude that administration of camphor resulted in overexpression of SMO and modulated the differential expression of Gli1. Animal studies focused on the impact of camphor as an agent to counteract obesity might be considered in the future. Indeed, camphor and similar physiologically active compounds from fermented CI might be developed as new and effective treatments for obesity.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.45 no.2
• /
• pp.144-153
• /
• 2018

The aim of this study was to understand the roles of Sonic Hedgehog (SHH) signaling during tooth root and periodontium formation. In this study, we generated the dental mesenchyme-specific Smoothened (Smo) activated/inactivated mice with the activity of Cre recombinase under the control of osteocalcin promoter. In the Smo activated mutant molar sections at the postnatal 28 days, we found extremely thin root dentin and widened pulp chamber. Picrosirius red staining showed loosely arranged fibers in the periodontal space and decreased cellular cementum with some root resorption. Immunohistochemical staining showed less localization of matrix proteins such as Bsp, Dmp1, Pstn, and Ank in the cementum, periodontal ligament, and/or cementoblast. In the Smo inactivated mutant mouse, there was not any remarkable differences in the localization of these matrix proteins compared with the wild type. These findings suggest that adequate suppressing regulation of SHH signaling is required in the development of tooth root and periodontium.

• YAKHAK HOEJI
• /
• v.45 no.5
• /
• pp.506-512
• /
• 2001

Ketoprofen (KP) was formulated as a transdermal patch using the percutaneous penetration enhancers sorbitan monmmleate(SMO), polyvinylpyrrolidone(PVP). The control patch without penetration enhancers showed a KP flux of 8.9$\pm$0.75$\mu\textrm{g}$/$\textrm{cm}^2$/h The flux was increased in proportion to the concentration of SMO added. Furthermore, lag times were decreased upon addition of SMO. Conversely; the skin flux of KP was decreased in proportion to the concentration of PVP added. Pharmacokinetic parameters including $C_{max}$, $T_{max}$, and AUC were increased when SMO was added. However, $C_{mas}$ significantly decreased by the addition of PVP. $T_{max}$ was not significantly different in 2%, 4%, and 8% PVP patches. Patches containing 4% PVP showed the highest AUC value (19.158$\mu\textrm{g}$.h/ml). We found that the effectiveness of the two percutaneous penetration enhancers for topical KP patches was similar, with the addition of appropriate amounts of HPC modifying both skin flux and lag time of KP in the patches. In conclusion, it is possible to manufacture KP patches exhibiting high AUC, high skin flux, and short lag time using percutaneous penetration enhancers of SMO and PVP.

• IEMEK Journal of Embedded Systems and Applications
• /
• v.18 no.6
• /
• pp.311-317
• /
• 2023

This paper presents a sliding mode observer (SMO) for reconstructing cyber attacks affecting a system. The system is first re-expressed such that its design freedom is easier to manipulate. The SMO is then used to reconstruct the cyber attack affecting the system. A simulation example is used to verify the performance of the SMO under two types of cyber attacks, and its results demonstrate the effectiveness of our proposed scheme.

• Proceedings of the KIEE Conference
• /
• 2011.07a
• /
• pp.806-807
• /
• 2011

This paper presents a new sensorless controller used with both the classical sliding mode observer(SMO) and the rate of current change in order to a reduced torque ripple for switched reluctance motor (SRM) sensorless drives. The new sensorless scheme consists of a sliding mode observer (SMO)-based position sensorless approach for high speeds along with a low-resolution discrete the rate of current change for low speeds and standstill. The new position estimation resets between the SMO and the low-resolution of current change according to the speed sign and the position error difference between the SMO and the low-resolution rate of current change. The simulation results show the robustness of this new high performance sensorless control approach with the hybrid sensorless control topology.