• Archives of Pharmacal Research
• /
• 제19권4호
• /
• pp.261-263
• /
• 1996

SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C/sub 50/H/sub 66/N/sub 11/S/sub 2/). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.

• 방송공학회논문지
• /
• 제11권3호
• /
• pp.302-310
• /
• 2006

국내 위성 디지털 멀티미디어 방송 (DMB : Digital Multimedia Broadcasting)의 전송 표준방식은 DS-CDM-QPSK 방식으로 위성중계기와 지상중계기 (Gap-filler)를 통하여 다채널 고품질의 멀티미디어 방송 서비스를 제공할 수 있다. 그러나 다중 경로 페이딩 채널 환경에서는 방송 채널을 식별하는 Walsh 부호간의 직교성이 상실되고 다중 채널 간섭 (MCI : Multi-channel Interference)이 증가하여 수신 성능이 저하된다. 본 논문에서는 위성 DMB의 수신 성능을 향상시키기 위해 탭 선택 알고리즘을 사용한 칩 등화 수신기를 제안하고 기존의 Rake 수신기와 수신 성능을 비교 분석한다.

• Biomolecules & Therapeutics
• /
• 제27권3호
• /
• pp.302-310
• /
• 2019

Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P) and -resistant (A375P/Mdr with acquired resistance and SK-MEL-2 with intrinsic resistance) melanoma cell lines, to reveal the genes and pathways potentially involved in intrinsic and acquired resistance to BRAF inhibitors. A total of 546 differentially expressed genes (DEGs), including 239 up-regulated and 307 down-regulated genes, were identified in both intrinsic and acquired resistant cells. Gene ontology (GO) analysis revealed that the top 10 biological processes associated with these genes included angiogenesis, immune response, cell adhesion, antigen processing and presentation, extracellular matrix organization, osteoblast differentiation, collagen catabolic process, viral entry into host cell, cell migration, and positive regulation of protein kinase B signaling. In addition, using the PAN-THER GO classification system, we showed that the highest enriched GOs targeted by the 546 DEGs were responses to cellular processes (ontology: biological process), binding (ontology: molecular function), and cell subcellular localization (ontology: cellular component). Ingenuity pathway analysis (IPA) network analysis showed a network that was common to two BRAF inhibitorresistant cells. Taken together, the present study may provide a useful platform to further reveal biological processes associated with BRAF inhibitor resistance, and present areas for therapeutic tool development to overcome BRAF inhibitor resistance.